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3.4.24.79: pappalysin-1

This is an abbreviated version!
For detailed information about pappalysin-1, go to the full flat file.

Word Map on EC 3.4.24.79

Reaction

Cleavage of the Met135-/-Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143-/-Lys bond in IGFBP-5 =

Synonyms

IGF binding protein-4 protease, IGF binding protein-4 specific proteinase, IGF-BP-4 proteinase, IGFBP proteinase, IGFBP-4 protease, insulin-like growth factor binding protein-4 protease, insulin-like growth factor-binding protein proteinase, More, PAPP-A, PAPP-A2, PAPPA, pappalysin-1, pregnancy associated plasma protein-A, pregnancy-associated plasma protein A, pregnancy-associated plasma protein-A, pregnancy-associated plasma protein-A2, pregnancy-related serine protease, protein IGF-BP 4 proteinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.79 pappalysin-1

Cloned

Cloned on EC 3.4.24.79 - pappalysin-1

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and anaylsis, sequence comparisons
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expressed in mouse arterial smooth muscle cells
expressed in SKOV-3 cells
expression of His-tagged wild-type and mutant chimeric PAPP-A and PAPP-A2 in HEK-293T cells
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expression of PAPP-A wild-type and mutant E483A in HEK-293T cells, co-expression with inhibitor proMBP
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expression of the enzyme in transgenic mice, expression of FLAG-tagged enzyme in primary mouse osteoblasts
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expression of the His6-tagged PAPP-A laminin G domain in Escherichia coli, expression of wild-type andtruncation mutant enzymes, comparising residues 1-310, in HEK293T cells
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overexpression in transgenic mice heart, brain, liver, kidney, forearm, and spleen, expression analysis, overview
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