3.4.24.79: pappalysin-1
This is an abbreviated version!
For detailed information about pappalysin-1, go to the full flat file.
Word Map on EC 3.4.24.79
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3.4.24.79
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women
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trimester
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fetal
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chorionic
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translucency
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nuchal
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first-trimester
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singleton
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trisomy
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artery
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ultrasound
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beta-hcg
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uterine
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preeclampsia
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gonadotrophin
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prenatal
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false-positive
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aneuploidy
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beta-human
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coronary
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fetuses
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doppler
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pulsatility
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preterm
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igfbps
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igf-i
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igf-binding
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crown-rump
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second-trimester
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inhibin
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alpha-fetoprotein
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centile
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obstetric
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screen-positive
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stillbirth
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amniocentesis
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euploid
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sonograph
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venosus
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metzincin
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afro-caribbeans
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medicine
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pregnancy-specific
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sflt-1
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adam12
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small-for-gestational-age
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monochorionic
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delfia
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triploidy
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molecular biology
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diagnostics
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oestriol
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small-for-gestational
- 3.4.24.79
- women
-
trimester
- fetal
- chorionic
-
translucency
-
nuchal
-
first-trimester
-
singleton
-
trisomy
- artery
-
ultrasound
-
beta-hcg
- uterine
- preeclampsia
-
gonadotrophin
-
prenatal
-
false-positive
-
aneuploidy
-
beta-human
- coronary
- fetuses
-
doppler
-
pulsatility
-
preterm
-
igfbps
- igf-i
-
igf-binding
-
crown-rump
-
second-trimester
-
inhibin
- alpha-fetoprotein
-
centile
-
obstetric
-
screen-positive
- stillbirth
-
amniocentesis
-
euploid
-
sonograph
-
venosus
-
metzincin
-
afro-caribbeans
- medicine
-
pregnancy-specific
- sflt-1
- adam12
-
small-for-gestational-age
-
monochorionic
-
delfia
-
triploidy
- molecular biology
- diagnostics
-
oestriol
-
small-for-gestational
Reaction
Cleavage of the Met135-/-Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143-/-Lys bond in IGFBP-5 =
Synonyms
IGF binding protein-4 protease, IGF binding protein-4 specific proteinase, IGF-BP-4 proteinase, IGFBP proteinase, IGFBP-4 protease, insulin-like growth factor binding protein-4 protease, insulin-like growth factor-binding protein proteinase, More, PAPP-A, PAPP-A2, PAPPA, pappalysin-1, pregnancy associated plasma protein-A, pregnancy-associated plasma protein A, pregnancy-associated plasma protein-A, pregnancy-associated plasma protein-A2, pregnancy-related serine protease, protein IGF-BP 4 proteinase
ECTree
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Localization
Localization on EC 3.4.24.79 - pappalysin-1
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additional information
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the PAPP-A-proMBP complex is formed at the cell surface in vivo rather than in the circulation, the redox potential of the tissue microenvironment controls the process, chondroitin or dermatan sulfate do not have any effect on complex formation
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detachment of pregnancy-associated plasma protein-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor, mechanism, overview, the PAPP-A-proMBP complex is unable to bind to the cell surface
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surface association of PAPP-A accounts for its colocalization with activated macrophages in human atherosclerotic plaque, immunohistochemic analysis, overview