3.4.24.79: pappalysin-1

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For detailed information about pappalysin-1, go to the full flat file.

Word Map on EC 3.4.24.79

3.4.24.79

women

trimester

fetal

chorionic

translucency

nuchal

first-trimester

singleton

trisomy

artery

ultrasound

beta-hcg

uterine

preeclampsia

gonadotrophin

prenatal

false-positive

aneuploidy

beta-human

coronary

fetuses

doppler

pulsatility

preterm

igfbps

igf-i

igf-binding

crown-rump

second-trimester

inhibin

alpha-fetoprotein

centile

obstetric

screen-positive

stillbirth

amniocentesis

euploid

sonograph

venosus

metzincin

afro-caribbeans

medicine

pregnancy-specific

sflt-1

adam12

small-for-gestational-age

monochorionic

delfia

triploidy

molecular biology

diagnostics

oestriol

small-for-gestational

Reaction

Cleavage of the Met135-/-Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143-/-Lys bond in IGFBP-5 =

Synonyms

IGF binding protein-4 protease, IGF binding protein-4 specific proteinase, IGF-BP-4 proteinase, IGFBP proteinase, IGFBP-4 protease, insulin-like growth factor binding protein-4 protease, insulin-like growth factor-binding protein proteinase, More, PAPP-A, PAPP-A2, PAPPA, pappalysin-1, pregnancy associated plasma protein-A, pregnancy-associated plasma protein A, pregnancy-associated plasma protein-A, pregnancy-associated plasma protein-A2, pregnancy-related serine protease, protein IGF-BP 4 proteinase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.79 pappalysin-1

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Results	in table
11	Activating Compound
26	AA Sequence
17	Application
1	CAS Registry Number
8	Cloned(Commentary)
4506	Disease/ Diagnostics
8	Expression
7	General Information
3	General Stability
25	Inhibitors
2	Ki Value [mM]
7	KM Value [mM]
15	Localization
22	Metals/Ions
5	Molecular Weight [Da]
50	Natural Substrates/ Products (Substrates)
67	Organism
8	PDB ID
5	pH Optimum
2	Posttranslational Modification
10	Protein Variants
4	Purification (Commentary)
6	Reaction
67	Reference
2	Renatured (Commentary)
82	Source Tissue
4	Specific Activity [micromol/min/mg]
2	Storage Stability
82	Substrates and Products (Substrate)
5	Subunits
113	Synonyms
5	Temperature Optimum [°C]
3	Temperature Stability [°C]
5	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.4.24.79 - pappalysin-1

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1,10-phenanthroline

2 entries

3,4-dichloroisocoumarin

Sus scrofa

638947

alpha1-Aantichymotrypsin

potent inhibitor

beta-mercaptoethanol

beta-phorbol-12,13-didecanoate

Homo sapiens

Q13219

100 nM, time-dependent inhibition, possibly through induction of pro-eosinophil major basic protein

EDTA

EGTA

5 mM

heparin

up to 60% inhibition

IGF-I

the rate of IGFBP-4 proteolysis is dramatically increased upon addition of IGF-I or -II with IGF-II being more potent than IGF-I, while IGFBP-5 cleavage is slightly inhibited, overview

683161

IGF-II

Homo sapiens

the rate of IGFBP-4 proteolysis is dramatically increased upon addition of IGF-I or -II with IGF-II being more potent than IGF-I, while IGFBP-5 cleavage is slightly inhibited, overview

683161

PAC1

Homo sapiens

specific monoclonal antibody inhibiting PAPP-A activity against IGFBP-4, only slight inhibition of IGFBP-5 proteolysis

683675

pro-eosinophil major basic protein

Homo sapiens

physiological inhibitor

638941

proform of eosinophil major basic protein

SDS

stanniocalcin 1

stanniocalcin 2

stanniocalcin-1

stanniocalcin-2

additional information

2 entries