3.4.24.79: pappalysin-1
This is an abbreviated version!
For detailed information about pappalysin-1, go to the full flat file.
Word Map on EC 3.4.24.79
-
3.4.24.79
-
women
-
trimester
-
fetal
-
chorionic
-
translucency
-
nuchal
-
first-trimester
-
singleton
-
trisomy
-
artery
-
ultrasound
-
beta-hcg
-
uterine
-
preeclampsia
-
gonadotrophin
-
prenatal
-
false-positive
-
aneuploidy
-
beta-human
-
coronary
-
fetuses
-
doppler
-
pulsatility
-
preterm
-
igfbps
-
igf-i
-
igf-binding
-
crown-rump
-
second-trimester
-
inhibin
-
alpha-fetoprotein
-
centile
-
obstetric
-
screen-positive
-
stillbirth
-
amniocentesis
-
euploid
-
sonograph
-
venosus
-
metzincin
-
afro-caribbeans
-
medicine
-
pregnancy-specific
-
sflt-1
-
adam12
-
small-for-gestational-age
-
monochorionic
-
delfia
-
triploidy
-
molecular biology
-
diagnostics
-
oestriol
-
small-for-gestational
- 3.4.24.79
- women
-
trimester
- fetal
- chorionic
-
translucency
-
nuchal
-
first-trimester
-
singleton
-
trisomy
- artery
-
ultrasound
-
beta-hcg
- uterine
- preeclampsia
-
gonadotrophin
-
prenatal
-
false-positive
-
aneuploidy
-
beta-human
- coronary
- fetuses
-
doppler
-
pulsatility
-
preterm
-
igfbps
- igf-i
-
igf-binding
-
crown-rump
-
second-trimester
-
inhibin
- alpha-fetoprotein
-
centile
-
obstetric
-
screen-positive
- stillbirth
-
amniocentesis
-
euploid
-
sonograph
-
venosus
-
metzincin
-
afro-caribbeans
- medicine
-
pregnancy-specific
- sflt-1
- adam12
-
small-for-gestational-age
-
monochorionic
-
delfia
-
triploidy
- molecular biology
- diagnostics
-
oestriol
-
small-for-gestational
Reaction
Cleavage of the Met135-/-Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143-/-Lys bond in IGFBP-5 =
Synonyms
IGF binding protein-4 protease, IGF binding protein-4 specific proteinase, IGF-BP-4 proteinase, IGFBP proteinase, IGFBP-4 protease, insulin-like growth factor binding protein-4 protease, insulin-like growth factor-binding protein proteinase, More, PAPP-A, PAPP-A2, PAPPA, pappalysin-1, pregnancy associated plasma protein-A, pregnancy-associated plasma protein A, pregnancy-associated plasma protein-A, pregnancy-associated plasma protein-A2, pregnancy-related serine protease, protein IGF-BP 4 proteinase
ECTree
Advanced search results
Natural Substrates Products
Natural Substrates Products on EC 3.4.24.79 - pappalysin-1
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
insulin-like growth factor-binding protein-4 + H2O
?
-
-
-
?
IGF-binding protein-4 + H2O
?
-
PAPP-A promotes cell growth causing the release of bound insulin-like growth factors
-
-
?
IGF-binding protein-4 + H2O
?
-
regulation of insulin-like growth factor bioavailability through cleavage of the inhibitory binding protein is an important mechanism for the control of growth and development of vertebrate cells
-
-
?
IGF-binding protein-5 + H2O
?
-
PAPP-A promotes cell growth causing the release of bound insulin-like growth factors
-
-
?
IGF-binding protein-5 + H2O
?
-
regulation of insulin-like growth factor bioavailability through cleavage of the inhibitory binding protein is an important mechanism for the control of growth and development of vertebrate cells
-
-
?
?
-
-
-
-
?
insulin-like growth factor binding protein-4 + H2O
?
-
-
-
?
?
-
-
enzyme activity is a determinant of follicular fate
-
-
?
additional information
?
-
-
PAPP-A stimulated by follicle stimulating hormone plays a crucial role for the insulin-like growth factor-I system in bovine follicular development
-
-
?
additional information
?
-
-
enzyme enhances bioactivity of insulin-like growth factors in vitro
-
-
?
additional information
?
-
-
enzyme may be involved in modulating cellular response to insulin-like growth factor-I
-
-
?
additional information
?
-
-
interaction between insulin-like growth factor-II and insulin-like growth factor binding protein-4 is required for proteolysis
-
-
?
additional information
?
-
-
interaction between insulin-like growth factor-II and insulin-like growth factor binding protein-4 is required for proteolysis
-
-
?
additional information
?
-
-
activated macrophage regulation of PAPP-A expression, co-localization of macophages and PAPP-A is involved in development of vulnerable plaques, overview
-
-
?
additional information
?
-
-
in human pregnancy, the majority of PAPP-A circulates as a disulfide-bonded complex with its inhibitor, the proform of eosinophil major basic protein, i.e. proMBP
-
-
?
additional information
?
-
-
inhibition of IGF signaling is relevant in human disease, and several drugs in development target the IGF receptor, overview
-
-
?
additional information
?
-
-
PAPP-A enhances IGF action by increasing its bioavailability, overview
-
-
?
additional information
?
-
-
PAPP-A is involved in acute coronary syndrome, and is associated with atherosclerotic peripheral arterial disease, PAD, i.e. chronic limb ischemia, overview
-
-
?
additional information
?
-
-
pregnancy-associated plasma protein-A, PAPP-A, levels and the PAPP-A to eosinophile major basic protein, proMBP, ratio is increased in patients with acute coronary syndrome, overview
-
-
?
additional information
?
-
-
regulation of enzyme expression, e.g. by pro-inflammatory cytokines involved in repair responses, especially TNFalpha and interleukin 1-beta, the enzyme is involved in cardiovascular disease, overview
-
-
?
additional information
?
-
-
the enzyme is involved in coronary artery disease, e.g. angina pectoris or acute myocardia infarction, independent of gender or age, PAPP-A/proMBP levels do not correlate with cardiac troponin I in patients, the PAPP-A/proMBP complex is involved in processes preceding vulnerable plaque development in acute coronary syndrome, overview
-
-
?
additional information
?
-
-
pregnancy associated plasma protein-A is involved in regulation of IGF bioavailability and in skeletal development and injury repair, responses is necessary for expeditious fracture healing in mice, mechanism for PAPP-A regulation of IGF action, overview
-
-
?