Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.79 extracted from

  • Qin, X.; Wergedal, J.E.; Rehage, M.; Tran, K.; Newton, J.; Lam, P.; Baylink, D.J.; Mohan, S.
    Pregnancy-associated plasma protein-A increases osteoblast proliferation in vitro and bone formation in vivo (2006), Endocrinology, 147, 5653-5661.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.79

Application

Application Comment Organism
medicine enhancing IGF bioavailability by PAPP-A can be a powerful strategy in the treatment of certain metabolic diseases such as osteoporosis Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of the enzyme in transgenic mice, expression of FLAG-tagged enzyme in primary mouse osteoblasts Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of transgenic mice overexpressing the enzyme, osteoblasts of transgenic mice show increased IGFBP-4 proteolysis and increased free IGF-I concentration. Calvarial bone thickness, bone marrow cavity, and skull bone mineral density are significantly increased in transgenic mice, bone size-related parameters in femur and tibia such as total bone area and periosteal circumference are significantly increased in transgenic mice. Bone formation rate and osteoid surface are increased by more than 2fold, whereas bone resorbing surface is unaffected. These anabolic effects are sustained with aging, phenotype overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
IGF-binding protein-2 + H2O Homo sapiens
-
 ?
-
 ?
IGF-binding protein-4 + H2O Homo sapiens
-
 ?
-
 ?
IGF-binding protein-5 + H2O Homo sapiens
-
 ?
-
 ?
additional information Homo sapiens PAPP-A enhances IGF action by increasing its bioavailability, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
osteoblast expression analysis, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IGF-binding protein-2 + H2O
-
 Homo sapiens ?
-
 ?
IGF-binding protein-4 + H2O
-
 Homo sapiens ?
-
 ?
IGF-binding protein-5 + H2O
-
 Homo sapiens ?
-
 ?
additional information PAPP-A enhances IGF action by increasing its bioavailability, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PAPP-A
-
 Homo sapiens
pregnancy-associated plasma protein-A
-
 Homo sapiens