3.4.24.79: pappalysin-1
This is an abbreviated version!
For detailed information about pappalysin-1, go to the full flat file.
Word Map on EC 3.4.24.79
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3.4.24.79
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women
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trimester
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fetal
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chorionic
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translucency
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nuchal
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first-trimester
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singleton
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trisomy
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artery
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ultrasound
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beta-hcg
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uterine
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preeclampsia
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gonadotrophin
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prenatal
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false-positive
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aneuploidy
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beta-human
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coronary
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fetuses
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doppler
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pulsatility
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preterm
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igfbps
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igf-i
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igf-binding
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crown-rump
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second-trimester
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inhibin
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alpha-fetoprotein
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centile
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obstetric
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screen-positive
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stillbirth
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amniocentesis
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euploid
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sonograph
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venosus
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metzincin
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afro-caribbeans
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medicine
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pregnancy-specific
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sflt-1
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adam12
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small-for-gestational-age
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monochorionic
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delfia
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triploidy
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molecular biology
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diagnostics
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oestriol
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small-for-gestational
- 3.4.24.79
- women
-
trimester
- fetal
- chorionic
-
translucency
-
nuchal
-
first-trimester
-
singleton
-
trisomy
- artery
-
ultrasound
-
beta-hcg
- uterine
- preeclampsia
-
gonadotrophin
-
prenatal
-
false-positive
-
aneuploidy
-
beta-human
- coronary
- fetuses
-
doppler
-
pulsatility
-
preterm
-
igfbps
- igf-i
-
igf-binding
-
crown-rump
-
second-trimester
-
inhibin
- alpha-fetoprotein
-
centile
-
obstetric
-
screen-positive
- stillbirth
-
amniocentesis
-
euploid
-
sonograph
-
venosus
-
metzincin
-
afro-caribbeans
- medicine
-
pregnancy-specific
- sflt-1
- adam12
-
small-for-gestational-age
-
monochorionic
-
delfia
-
triploidy
- molecular biology
- diagnostics
-
oestriol
-
small-for-gestational
Reaction
Cleavage of the Met135-/-Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143-/-Lys bond in IGFBP-5 =
Synonyms
IGF binding protein-4 protease, IGF binding protein-4 specific proteinase, IGF-BP-4 proteinase, IGFBP proteinase, IGFBP-4 protease, insulin-like growth factor binding protein-4 protease, insulin-like growth factor-binding protein proteinase, More, PAPP-A, PAPP-A2, PAPPA, pappalysin-1, pregnancy associated plasma protein-A, pregnancy-associated plasma protein A, pregnancy-associated plasma protein-A, pregnancy-associated plasma protein-A2, pregnancy-related serine protease, protein IGF-BP 4 proteinase
ECTree
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diagnostics
medicine
molecular biology
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increased pregnancy-associated plasma protein-A is a marker for peripheral atherosclerosis, Linz Peripheral Arterial Disease Study
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administation of insulin-like growth factor binding protein (IGFBP)-4 causes significant increase in bone formation parameters, possibly through increased IGF bioavailability via proteolysis of insulin-like growth factor binding protein (IGFBP)-4
medicine
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enhancing IGF bioavailability by PAPP-A can be a powerful strategy in the treatment of certain metabolic diseases such as osteoporosis
medicine
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a detailed analysis is performed of first trimester screening results in singleton pregnancies conceived using assisted reproductive technologies and non-assisted reproductive technologies pregnancies. A record linkage study compared outcomes in 1739 assisted reproductive technologies-conceived and 50.253 naturally conceived pregnancies. Assisted reproductive technologies pregnancies have reduced first trimester screening PAPP-A levels leading to an increased likelihood of receiving a false-positive result and having a CVS/amniocentesis. Lower PAPP-A may reflect impairment of early implantation with some forms of assisted reproductive technologies
medicine
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a prospective screening study for trisomy 21 in singleton pregnancies is carried out by a combination of maternal age, fetal nuchal translucency, free beta-hCG and PAPP-A in a one-stop-clinic for first-trimester assessment of risk at 11-13 weeks of gestation. All three trisomies (13,18 and 21) are associated with increased maternal age, increased fetal nuchal translucency and decreased maternal serum PAPP-A
medicine
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contribution of maternal variables that influence the measured concentration of free beta-human chorionic gonadotropin and PAPP-A, and the interaction between these covariates, in first-trimester biochemical screening for trisomy 21 are analysed. In a multicenter study of prospective first-trimester biochemical screening for trisomy 21 it is shown that it is essential to adjust the measured values of free beta-human chorionic gonadotropin and PAPP-A for maternal and pregnancy characteristics
medicine
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it is examined whether maternal Rhesus status has any effect on the levels of first-trimester markers free beta-human chorionic gonadotropin, PAPP-A and nuchal translucency. First-trimester markers from pregnant women are converted into multiples of medians and corrected for maternal weight, ethnicity, and smoking status. Totally, 15045 normal, singleton pregnancies are retrieved with full records. Maternal Rhesus status does not influence the levels of free beta-human chorionic gonadotropin and PAPP-A in the first trimester of pregnancy in this almost exclusively Caucasian population studied. Therefore, correction for maternal Rhesus status is not suggested
medicine
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levels of PAPP-A and C-reactive protein in pre-eclampsia and their association with the mean arterial blood pressure are determined. 67 women with pre-eclampsia symptoms are matched with 56 normal pregnant controls for gestational age, maternal age and parity. Both of the groups are third trimester. PAPP-A and C-reactive protein are measured in serum. Maternal serum levels of PAPP-A and C-reactive protein are increased in women with pre-eclampsia compared to controls
medicine
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PAPP-A levels in adults with growth hormone deficiency at baseline and after growth hormone replacement is evaluated: 14 growth hormone deficiency adults are evaluated at baseline and after 1 year of growth hormone therapy. All patients are compared at baseline with 28 age-, sex- and body mass index (BMI)-matched control subjects. At baseline, growth hormone deficiency adults show higher PAPP-A levels and higher leptin, fibrinogen and highly sensitive C-reactive protein values than controls. Therapy with growth hormone reduces PAPP-A and fibrinogen levels while increased BMI and reduced waist-hip ratio are observed
medicine
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PAPP-A, IGF1, inflammatory markers and adiponectin concentrations in type 2 diabetic patients with and without carotid plaques are compared and the relationship between these serum parameters and ultrasound carotid markers of atherosclerosis is evaluated. 125 consecutive type 2 diabetic patients are examined. Serum PAPP-A and IGF1 do not appear to be useful serum biomarkers for carotid atherosclerosis in type 2 diabetic patients with stable glycemic control, despite scientific evidence of their local role in atherosclerosis
medicine
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the effect of smoking on three first trimester screening markers for Downs syndrome that constitute the Combined test, namely nuchal translucency (NT), PAPP-A and free beta human chorionic gonadotophin is examined. In addition it is determined which of these markers need to be adjusted for smoking and by how much. The effect of adjusting for smoking on the Combined test is small, with an estimated less than 0.5% increase in the detection rate for a 3% false-positive rate and less than 0.2% decrease in the false-positive rate for an 85% detection rate
medicine
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the performance of first-trimester combined screening by maternal age, fetal nuchal translucency (NT) thickness and maternal serum free beta-human chorionic gonadotropin and PAPP-A is examined
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heparin administration is associated with a significant increase in PAPP-A levels, presumably because of the detachment of PAPP-A from the vessel wall
molecular biology
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mice born with the deletion of the gene for PAPP-A, a model of reduced local IGF activity, live approximately 30% longer than their wild-type littermates. Food intake, and total energy expenditure and resting energy expenditure as measured by calorimetry are not different between PAPP-A knockout and wild-type mice. There is an increase in spontaneous physical activity in PAPP-A knockout mice. Both wild-type and PAPP-A knockout mice exhibit mild insulin resistance with age. Oral glucose tolerance and insulin sensitivity are not significantly different between the two groups of mice, although there appeared to be a decrease in the average size of the pancreatic islets in PAPP-A knockout mice. Thus, neither reduced rate of living nor altered glucose-insulin homeostasis can be considered key determinants of the enhanced longevity of PAPP-A knockout mice