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3.4.24.79: pappalysin-1

This is an abbreviated version!
For detailed information about pappalysin-1, go to the full flat file.

Word Map on EC 3.4.24.79

Reaction

Cleavage of the Met135-/-Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143-/-Lys bond in IGFBP-5 =

Synonyms

IGF binding protein-4 protease, IGF binding protein-4 specific proteinase, IGF-BP-4 proteinase, IGFBP proteinase, IGFBP-4 protease, insulin-like growth factor binding protein-4 protease, insulin-like growth factor-binding protein proteinase, More, PAPP-A, PAPP-A2, PAPPA, pappalysin-1, pregnancy associated plasma protein-A, pregnancy-associated plasma protein A, pregnancy-associated plasma protein-A, pregnancy-associated plasma protein-A2, pregnancy-related serine protease, protein IGF-BP 4 proteinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.79 pappalysin-1

Expression

Expression on EC 3.4.24.79 - pappalysin-1

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
after intravenous unfractionated heparin and low molecular weight heparin free PAPP-A increases significantly (85 to 310fold from baseline)
enzyme blood plasma levels are elevated in patients with acute coronary syndrome
enzyme concentrations are reduced in the first trimester of pregnancies affected by fetal Down's syndrome. interferon-gamma decreases enzyme expression in human fibroblasts
enzyme expression in cultured human dermal fibroblasts, human coronary artery endothelial, osteoblasts, and smooth muscle cells is stimulated by tumor necrosis factor-alpha, interleukin-1beta, interleukin-4, and transforming growth factor-beta. Enzyme expression is upregulated in response to acute injury. Gene expression is induced by forskolin and prostaglandin E2 in human osteoblasts, by bone morphogenic protein-2 in human mesenchymal stem cells, and by follicle-stimulating hormone in bovine granulosa cells in culture
enzyme expression significantly decreases with age in bone and skeletal muscle
enzyme expression significantly increases with age in kidney, brain and gonads
injection of heparin (5000 IU) elicits increase in enzyme concentrations
the concentration of enzyme antigen in follicular fluid increases upon stimulation of ovulation with human chorionic gonadotrophin, but at the same time the enzyme activity is decreased