3.4.24.79: pappalysin-1
This is an abbreviated version!
For detailed information about pappalysin-1, go to the full flat file.
Word Map on EC 3.4.24.79
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3.4.24.79
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women
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trimester
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fetal
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chorionic
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translucency
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nuchal
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first-trimester
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singleton
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trisomy
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artery
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ultrasound
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beta-hcg
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uterine
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preeclampsia
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gonadotrophin
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prenatal
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false-positive
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aneuploidy
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beta-human
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coronary
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fetuses
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doppler
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pulsatility
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preterm
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igfbps
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igf-i
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igf-binding
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crown-rump
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second-trimester
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inhibin
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alpha-fetoprotein
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centile
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obstetric
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screen-positive
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stillbirth
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amniocentesis
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euploid
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sonograph
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venosus
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metzincin
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afro-caribbeans
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medicine
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pregnancy-specific
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sflt-1
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adam12
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small-for-gestational-age
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monochorionic
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delfia
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triploidy
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molecular biology
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diagnostics
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oestriol
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small-for-gestational
- 3.4.24.79
- women
-
trimester
- fetal
- chorionic
-
translucency
-
nuchal
-
first-trimester
-
singleton
-
trisomy
- artery
-
ultrasound
-
beta-hcg
- uterine
- preeclampsia
-
gonadotrophin
-
prenatal
-
false-positive
-
aneuploidy
-
beta-human
- coronary
- fetuses
-
doppler
-
pulsatility
-
preterm
-
igfbps
- igf-i
-
igf-binding
-
crown-rump
-
second-trimester
-
inhibin
- alpha-fetoprotein
-
centile
-
obstetric
-
screen-positive
- stillbirth
-
amniocentesis
-
euploid
-
sonograph
-
venosus
-
metzincin
-
afro-caribbeans
- medicine
-
pregnancy-specific
- sflt-1
- adam12
-
small-for-gestational-age
-
monochorionic
-
delfia
-
triploidy
- molecular biology
- diagnostics
-
oestriol
-
small-for-gestational
Reaction
Cleavage of the Met135-/-Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143-/-Lys bond in IGFBP-5 =
Synonyms
IGF binding protein-4 protease, IGF binding protein-4 specific proteinase, IGF-BP-4 proteinase, IGFBP proteinase, IGFBP-4 protease, insulin-like growth factor binding protein-4 protease, insulin-like growth factor-binding protein proteinase, More, PAPP-A, PAPP-A2, PAPPA, pappalysin-1, pregnancy associated plasma protein-A, pregnancy-associated plasma protein A, pregnancy-associated plasma protein-A, pregnancy-associated plasma protein-A2, pregnancy-related serine protease, protein IGF-BP 4 proteinase
ECTree
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Engineering
Engineering on EC 3.4.24.79 - pappalysin-1
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E483Q
additional information
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a mutant chimeric variant of PAPP-A, which is replaced in part by PAPP-A2 sequences, retains functionality as a protease but is unable to bind surface-associated glycosaminoglycan and shows no macrophage association or internalization
additional information
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construction of chimeras between PAPP-A and PAPP-A2 of human and murine sequences, overview
additional information
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construction of transgenic mice overexpressing the enzyme, osteoblasts of transgenic mice show increased IGFBP-4 proteolysis and increased free IGF-I concentration. Calvarial bone thickness, bone marrow cavity, and skull bone mineral density are significantly increased in transgenic mice, bone size-related parameters in femur and tibia such as total bone area and periosteal circumference are significantly increased in transgenic mice. Bone formation rate and osteoid surface are increased by more than 2fold, whereas bone resorbing surface is unaffected. These anabolic effects are sustained with aging, phenotype overview
additional information
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PAPP-A overexpression in transgenic mice leads to increased somatic groath and skeletal muscle mass, phenotype, overview
additional information
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construction of enzyme knockout mice, dwarf phenotype with decreased body size and IGF-II deficiency, overview
additional information
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construction of PAPP-A knockout mice, which show impaired post-fracture, bony bridging of a mid-shaft fracture callus, the mutant mice show reduced amount of intramembranous bone formation, cartilage production, endochondral ossification and remodeling compared to wild-type mice, overview