3.4.24.56: insulysin
This is an abbreviated version!
For detailed information about insulysin, go to the full flat file.
Word Map on EC 3.4.24.56
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3.4.24.56
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alzheimer
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neprilysin
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abeta
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hippocampus
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dementia
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mellitus
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cerebral
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morris
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amyloid-beta
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metalloprotease
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maze
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neuroprotective
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amyloidogenic
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tau
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beta-amyloid
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neurodegenerative
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presenilin
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endothelin-converting
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senile
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gamma-secretase
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beta-protein
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125i-insulin
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abeta-degrading
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hyperinsulinemia
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metalloendopeptidase
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bacitracin
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beta-secretase
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late-onset
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amylin
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microglia
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medicine
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adam10
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non-amyloidogenic
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glutathione-insulin
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enzyme-1
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b-chains
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analysis
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ad-like
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anti-ide
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exosite
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beta-peptide
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abeta1-40
- 3.4.24.56
- alzheimer
- neprilysin
- abeta
- hippocampus
- dementia
- mellitus
- cerebral
-
morris
- amyloid-beta
- metalloprotease
-
maze
-
neuroprotective
-
amyloidogenic
- tau
- beta-amyloid
- neurodegenerative
-
presenilin
-
endothelin-converting
-
senile
- gamma-secretase
- beta-protein
- 125i-insulin
-
abeta-degrading
- hyperinsulinemia
- metalloendopeptidase
- bacitracin
- beta-secretase
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late-onset
- amylin
- microglia
- medicine
- adam10
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non-amyloidogenic
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glutathione-insulin
- enzyme-1
- b-chains
- analysis
-
ad-like
-
anti-ide
-
exosite
- beta-peptide
- abeta1-40
Reaction
Degradation of insulin, glucagon and other polypeptides. No action on proteins =
Synonyms
ADE, amyloid degrading enzyme, cgd6_5510, EC 3.4.22.11, EC 3.4.99.10, EC 3.4.99.45, gamma-endorphin-generating enzyme, IDE, INS20-19, insulin degrading enzyme, Insulin protease, Insulin proteinase, Insulin-degrading enzyme, Insulin-degrading neutral proteinase, Insulin-glucagon protease, Insulin-specific protease, Insulinase, Insulysin, Metalloinsulinase, More, pitrilysin metallopeptidase 1, Pitrm1
ECTree
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a form of the enzyme derived from an alternative translational start site that can localize to mitochondria instead of the cytosol
cloning from C6 glioma cells, expression of recombinant GST-tagged wild-type IDE, and of recombinant IDE mutant E111Q
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determination of allele frequencies for Caucasians and Japanese, genotyping, single nucleotide polymorphism in the IDE gene, no association of IDE haplotypes with the risk of dementia, overview
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Drosophila melanogaster
Eimeria bovis
expressed in and isolated from Escherichia coli as C-terminal polyhistidine tagged fusion partners lacking N-terminal mitochondrial targeting sequence
expression in Escherichia coli
expression of His-tagged wild-type and mutant IDEs in Escherichia coli strain Rosetta (DE3)
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expression of the enzyme in transgenic mice under control of the H1 CMV promoter
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expression of the N-terminally His6-tagged enzyme in Spodopterafrugiperda Sf9 cells using the baculovirus transfection system
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expression of wild-type and mutant enzymes in HEK-293swe.3 cells, that stably expresses Myc-epitope tagged human APP-695 harboring the FAD-linked, socalled Swedish mutation
genetic linkage and association of Alzheimer disease on chromosome 10q23-24 in the region harboring the IDE gene
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genotyping, IDE shows a large genetic variability
glutathione S-transferase-tagged human insulin-degrading enzyme in pGEX-6p-1 vector is transformed into Escherichia coli BL21-CodonPlus (DE3) competent cells
human
IDE expression analysis in neuron tissue, overview
IDE gene is localized on chromosome 10q24, genotyping of IDE in the Finnish population, overview
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IDE genotyping, expression of promoter constructs in Hela cells and SH-SY5Y cells
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polyhistidine- and haemagglutinin-tagged recombinant wild-type and catalytically inactive mutants expressed in bacteria
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recombinant expression of His6-tagged IDE in Escherichia coli strain BL21(DE3)
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recombinantly expressed
the gene encoding IDE is located on chromosome 10q23-q25, a gene locus linked to schizophrenia
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wild-type and E111Q glutathione S-transferase tagged human insulin-degrading enzyme are expressed in Escherichia coli BL21 (DE3) codon plus competent cells
a form of the enzyme derived from an alternative translational start site that can localize to mitochondria instead of the cytosol
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a form of the enzyme derived from an alternative translational start site that can localize to mitochondria instead of the cytosol
-
a form of the enzyme derived from an alternative translational start site that can localize to mitochondria instead of the cytosol
-