Reference on EC 3.4.24.56 - insulysin
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ding, L.; Becker, A.B.; Suzuki, A.; Roth, R.A.
Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III
J. Biol. Chem.
267
2414-2420
1992
Homo sapiens
Affholter, J.A.; Fried, V.A.; Roth, R.A.
Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III
Science
242
1415-1418
1988
Homo sapiens
Duckworth, W.C.; Hamel, F.G.; Bennett, R.; Ryan, M.P.; Roth, R.A.
Human red blood cell insulin-degrading enzyme and rat skeletal muscle insulin protease share antigenic sites and generate identical products from insulin
J. Biol. Chem.
265
2984-2987
1990
Homo sapiens, Rattus norvegicus
Becker, A.B.; Roth, R.A.
Insulysin and pitrilysin: insulin-degrading enzymes of mammals and bacteria
Methods Enzymol.
248
693-703
1995
Drosophila melanogaster, Homo sapiens, Mammalia, Rattus norvegicus
Rawlings, N.D.; Barrett, A.J.
Homologues of insulinase, a new superfamily of metalloendopeptidases
Biochem. J.
275
389-391
1991
Homo sapiens
Ryan, M.P.; Duckworth, W.C.
Partial characterization of an endogenous inhibitor of a calcium-dependent form of insulin protease
Biochem. Biophys. Res. Commun.
116
195-203
1983
Rattus norvegicus
Kolb, H.J.; Standl, E.
Purification to homogeneity of an insulin-degrading enzyme from human erythrocytes
Hoppe-Seyler's Z. Physiol. Chem.
361
1029-1039
1980
Homo sapiens
Brush, J.S.; Nascimento, C.G.
Studies of the properties of the insulin protease of rat liver
Biochim. Biophys. Acta
704
398-402
1982
Rattus norvegicus
Chowdhary, B.K.; Smith, G.D.; Peters, T.J.
Subcellular localization and partial characterization of insulin proteolytic activity in rat liver
Biochim. Biophys. Acta
840
180-186
1985
Rattus norvegicus
Duckworth, W.C.; Stentz, F.B.; Heinemann, M.; Kitabchi, A.E.
Initial site of insulin cleavage by insulin protease
Proc. Natl. Acad. Sci. USA
76
635-639
1979
Rattus norvegicus
Duckworth, W.C.; Heinemann, M.A.; Kitabchi, A.E.
Purification of insulin-specific protease by affinity chromatography
Proc. Natl. Acad. Sci. USA
69
3698-3702
1972
Rattus norvegicus
Baskin, F.K.; Kitachi, A.E.
Substrate studies for insulin-specific protease
Eur. J. Biochem.
37
489-496
1973
Rattus norvegicus
Brush, J.S.; Shah, R.J.
Purification and characterization of inhibitors of insulin specific protease in human serum
Biochem. Biophys. Res. Commun.
53
894-903
1973
Rattus norvegicus
Baskin, F.K.; Duckworth, W.C.; Kitabchi, A.E.
Sites of cleavage of glucagon by insulin-glucagon protease
Biochem. Biophys. Res. Commun.
67
163-169
1975
Rattus norvegicus
Bennett, R.G.; Hamel, F.G.; Duckworth, W.C.
Identification and isolation of a cytosolic proteolytic complex containing insulin degrading enzyme and the multicatalytic proteinase
Biochem. Biophys. Res. Commun.
202
1047-1053
1994
Rattus norvegicus
Werlen, R.C.; Offord, R.E.; Rose, K.
Preparation and characterization of novel substrates of insulin proteinase (EC 3.4.99.45)
Biochem. J.
302
907-911
1994
Rattus norvegicus, Sus scrofa
Ebrahim, A.; Hamel, F.G.; Bennett, R.G.; Duckworth, W.C.
Identification of the metal associated with the insulin degrading enzyme
Biochem. Biophys. Res. Commun.
181
1398-1406
1991
Homo sapiens, Rattus norvegicus
Rawlings, N.D.; Barrett, A.J.
Potential metal ligands in the insulinase superfamily of endopeptidases
Biochem. Soc. Trans.
19
289S
1991
Drosophila melanogaster, Rattus norvegicus
Ogawa, W.; Shii, K.; Yonezawa, K.; Baba, S.; Yokono, K.
Affinity purification of insulin-degrading enzyme and its endogenous inhibitor from rat liver
J. Biol. Chem.
267
1310-1316
1992
Rattus norvegicus
Perlman, R.K.; Gehm, B.D.; Kuo, W.L.; Rosner, M.R.
Functional analysis of conserved residues in the active site of insulin-degrading enzyme
J. Biol. Chem.
268
21538-21544
1993
Drosophila melanogaster, Homo sapiens, Rattus norvegicus
Authier, F.; Rachubinski, R.A.; Posner, B.I.; Bergeron, J.M.
Endosomal proteolysis of insulin by an acidic thiol metalloprotease unrelated to insulin degrading enzyme
J. Biol. Chem.
269
3010-3016
1994
Drosophila melanogaster, Homo sapiens, Rattus norvegicus
McKenzie, R.A.; Burghen, G.A.
Partial purification and characterization of insulin protease and its intracellular inhibitor from rat liver
Arch. Biochem. Biophys.
229
604-611
1984
Rattus norvegicus
Garcia, J.V.; Fenton, B.W.; Rosner, M.R.
Isolation and characterization of an insulin-degrading enzyme from Drosophila melanogaster
Biochemistry
27
4237-4244
1988
Drosophila melanogaster
Duckworth, W.C.; Garcia, J.V.; Liepnieks, J.J.; Hamel, F.G.; Hermodson, M.A.; Frank, B.H.; Rosner, M.R.
Drosophila insulin degrading enzyme and rat skeletal muscle insulin protease cleave insulin at similar sites
Biochemistry
28
2471-2477
1989
Drosophila melanogaster, Rattus norvegicus
Ansorge, S.; Bohley, P.; Kirschke, H.; Langner, J.; Wiederanders, B.
The insulin and glucagon degrading proteinase of rat liver: a metal-dependent enzyme
Biomed. Biochim. Acta
43
39-46
1984
Rattus norvegicus
Mannor, G.; Movsas, B.; Yalow, R.S.
Characterization of insulinase from mammalian and non-mammalian livers
Life Sci.
34
1341-1345
1984
Canis lupus familiaris, Cavia porcellus, Oryctolagus cuniculus, Frog, Rattus norvegicus, Sus scrofa
Yokono, K.; Imamura, Y.; Shii, K.; Sakai, H.; Baba, S.
Purification and characterization of insulin-degrading enzyme from pig skeletal muscle
Endocrinology
108
1527-1532
1981
Sus scrofa
Brush, J.S.
Studies on inhibitors of the insulin protease of rat liver
Biochem. Pharmacol.
26
2349-2354
1977
Rattus norvegicus
Burghen, G.A.; Kitabchi, A.E.; Brush, J.S.
Characterization of a rat liver protease with specificity for insulin
Endocrinology
91
633-642
1972
Rattus norvegicus
Brush, J.S.; Sonne, O.; Gliemann, J.
Degradation of the four monoiodoinsulin isomers by the insulin protease of rat liver
Biochim. Biophys. Acta
757
269-273
1983
Rattus norvegicus
Chesneau, V.; Vekrellis, K.; Rosner, M.R.; Selkoe, D.J.
Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization
Biochem. J.
351
509-516
2000
Homo sapiens
Camberos, M.C.; Perez, A.A.; Udrisar, D.P.; Wanderley, M.I.; Cresto, J.C.
ATP inhibits insulin-degrading enzyme activity
Exp. Biol. Med.
226
334-341
2001
Rattus norvegicus, Rattus norvegicus Wistar
Bennett, R.G.; Duckworth, W.C.; Hamel, F.G.
Degradation of amylin by insulin-degrading enzyme
J. Biol. Chem.
275
36621-36625
2000
Rattus norvegicus
Edbauer, D.; Willem, M.; Lammich, S.; Steiner, H.; Haass, C.
Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)
J. Biol. Chem.
277
13389-13393
2002
Rattus norvegicus
Song, E.S.; Juliano, M.A.; Juliano, L.; Hersh, L.B.
Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development
J. Biol. Chem.
278
49789-49794
2003
Rattus norvegicus
Miller, B.C.; Eckman, E.A.; Sambamurti, K.; Dobbs, N.; Chow, K.M.; Eckman, C.B.; Hersh, L.B.; Thiele, D.L.
Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo
Proc. Natl. Acad. Sci. USA
100
6221-6226
2003
Rattus norvegicus, Mus musculus (Q8CGB9), Mus musculus
Kurochkin, I.V.
Insulin-degrading enzyme: embarking on amyloid destruction
Trends Biochem. Sci.
26
421-425
2001
Drosophila melanogaster, Homo sapiens, Rattus norvegicus
Farris, W.; Mansourian, S.; Leissring, M.A.; Eckman, E.A.; Bertram, L.; Eckman, C.B.; Tanzi, R.E.; Selkoe, D.J.
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein
Am. J. Pathol.
164
1425-1434
2004
Rattus norvegicus (P35559)
Yao, H.; Hersh, L.B.
Characterization of the binding of the fluorescent ATP analog TNP-ATP to insulysin
Arch. Biochem. Biophys.
451
175-181
2006
Rattus norvegicus
Morelli, L.; Llovera, R.E.; Alonso, L.G.; Frangione, B.; de Prat-Gay, G.; Ghiso, J.; Castano, E.M.
Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia
Biochem. Biophys. Res. Commun.
332
808-816
2005
Homo sapiens, Rattus norvegicus
Li, P.; Kuo, W.L.; Yousef, M.; Rosner, M.R.; Tang, W.J.
The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition
Biochem. Biophys. Res. Commun.
343
1032-1037
2006
Homo sapiens
Leissring, M.A.; Farris, W.; Wu, X.; Christodoulou, D.C.; Haigis, M.C.; Guarente, L.; Selkoe, D.J.
Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria
Biochem. J.
383
439-446
2004
Homo sapiens
Farris, W.; Leissring, M.A.; Hemming, M.L.; Chang, A.Y.; Selkoe, D.J.
Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein
Biochemistry
44
6513-6525
2005
Homo sapiens (P14735), Homo sapiens
Li, Q.; Ali, M.A.; Cohen, J.I.
Insulin degrading enzyme is a cellular receptor mediating Varicella-zoster virus infection and cell-to-cell spread
Cell
127
305-316
2006
Homo sapiens
Udrisar, D.P.; Wanderley, M.I.; Porto, R.C.; Cardoso, C.L.; Barbosa, M.C.; Camberos, M.C.; Cresto, J.C.
Androgen- and estrogen-dependent regulation of insulin-degrading enzyme in subcellular fractions of rat prostate and uterus
Exp. Biol. Med.
230
479-486
2005
Rattus norvegicus
Song, E.S.; Juliano, M.A.; Juliano, L.; Fried, M.G.; Wagner, S.L.; Hersh, L.B.
ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety
J. Biol. Chem.
279
54216-54220
2004
Rattus norvegicus
Song, E.S.; Daily, A.; Fried, M.G.; Juliano, M.A.; Juliano, L.; Hersh, L.B.
Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions
J. Biol. Chem.
280
17701-17706
2005
Rattus norvegicus
Kim, S.; Lapham, A.N.; Freedman, C.G.; Reed, T.L.; Schmidt, W.K.
Yeast as a tractable genetic system for functional studies of the insulin-degrading enzyme
J. Biol. Chem.
280
27481-27490
2005
Rattus norvegicus
Duckworth, W.C.; Fawcett, J.; Reddy, S.; Page, J.C.
Insulin-degrading activity in wound fluid
J. Clin. Endocrinol. Metab.
89
847-851
2004
Homo sapiens
Song, E.S.; Hersh, L.B.
Insulysin: an allosteric enzyme as a target for Alzheimers disease
J. Mol. Neurosci.
25
201-206
2005
Mus musculus
Lynch, J.A.; George, A.M.; Eisenhauer, P.B.; Conn, K.; Gao, W.; Carreras, I.; Wells, J.M.; McKee, A.; Ullman, M.D.; Fine, R.E.
Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures
J. Neurosci. Res.
83
1262-1270
2006
Homo sapiens
Shen, Y.; Joachimiak, A.; Rosner, M.R.; Tang, W.J.
Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism
Nature
443
870-874
2006
Homo sapiens
Gao, W.; Eisenhauer, P.B.; Conn, K.; Lynch, J.A.; Wells, J.M.; Ullman, M.D.; McKee, A.; Thatte, H.S.; Fine, R.E.
Insulin degrading enzyme is expressed in the human cerebrovascular endothelium and in cultured human cerebrovascular endothelial cells
Neurosci. Lett.
371
6-11
2004
Homo sapiens
Fawcett, J.; Permana, P.A.; Levy, J.L.; Duckworth, W.C.
Regulation of protein degradation by insulin-degrading enzyme: analysis by small interfering RNA-mediated gene silencing
Arch. Biochem. Biophys.
468
128-133
2007
Homo sapiens
Song, E.S.; Cady, C.; Fried, M.G.; Hersh, L.B.
Proteolytic fragments of insulysin (IDE) retain substrate binding but lose allosteric regulation
Biochemistry
45
15085-15091
2006
Rattus norvegicus
Hersh, L.B.
The insulysin (insulin degrading enzyme) enigma
Cell. Mol. Life Sci.
63
2432-2434
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Camberos, M.d.; Cresto, J.C.
Insulin-degrading enzyme hydrolyzes ATP
Exp. Biol. Med.
232
281-292
2007
Rattus norvegicus
Hwang, D.Y.; Seo, S.; Kim, Y.; Kim, C.; Shim, S.; Jee, S.; Lee, S.; Sin, J.; Cho, J.; Kang, B.; Jang, I.; Cho, J.
Significant change in insulin production, glucose tolerance and ER stress signaling in transgenic mice coexpressing insulin-siRNA and human IDE
Int. J. Mol. Med.
19
65-73
2007
Homo sapiens
Jee, S.; Hwang, D.; Seo, S.; Kim, Y.; Kim, C.; Kim, B.; Shim, S.; Lee, S.; Sin, J.; Bae, C.; Lee, B.; Jang, M.; Kim, M.; Yim, S.; Jang, I.; Cho, J.; Chae, K.
Microarray analysis of insulin-regulated gene expression in the liver: the use of transgenic mice co-expressing insulin-siRNA and human IDE as an animal model
Int. J. Mol. Med.
20
829-835
2007
Homo sapiens
Radulescu, R.T.; Hufnagel, C.; Luppa, P.; Hellebrand, H.; Kuo, W.L.; Rosner, M.R.; Harbeck, N.; Giersig, C.; Meindl, A.; Schmitt, M.; Weirich, G.
Immunohistochemical demonstration of the zinc metalloprotease insulin-degrading enzyme in normal and malignant human breast: correlation with tissue insulin levels
Int. J. Oncol.
30
73-80
2007
Homo sapiens
Im, H.; Manolopoulou, M.; Malito, E.; Shen, Y.; Zhao, J.; Neant-Fery, M.; Sun, C.Y.; Meredith, S.C.; Sisodia, S.S.; Leissring, M.A.; Tang, W.J.
Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE
J. Biol. Chem.
282
25453-25463
2007
Homo sapiens (P14735), Homo sapiens
Kim, M.; Hersh, L.B.; Leissring, M.A.; Ingelsson, M.; Matsui, T.; Farris, W.; Lu, A.; Hyman, B.T.; Selkoe, D.J.; Bertram, L.; Tanzi, R.E.
Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families
J. Biol. Chem.
282
7825-7832
2007
Homo sapiens
Bernstein, H.G.; Lendeckel, U.; Bukowska, A.; Ansorge, S.; Ernst, T.; Stauch, R.; Truebner, K.; Steiner, J.; Dobrowolny, H.; Bogerts, B.
Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary
J. Chem. Neuroanat.
35
216-224
2008
Homo sapiens
Grasso, G.; Rizzarelli, E.; Spoto, G.
AP/MALDI-MS complete characterization of the proteolytic fragments produced by the interaction of insulin degrading enzyme with bovine insulin
J. Mass Spectrom.
42
1590-1598
2007
Homo sapiens
Vepsaelaeinen, S.; Parkinson, M.; Helisalmi, S.; Mannermaa, A.; Soininen, H.; Tanzi, R.E.; Bertram, L.; Hiltunen, M.
Insulin-degrading enzyme is genetically associated with Alzheimers disease in the Finnish population
J. Med. Genet.
44
606-608
2007
Homo sapiens
Leal, M.C.; Dorfman, V.B.; Gamba, A.F.; Frangione, B.; Wisniewski, T.; Castano, E.M.; Sigurdsson, E.M.; Morelli, L.
Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology
J. Neuropathol. Exp. Neurol.
65
976-987
2006
Mus musculus
Li, Q.; Krogmann, T.; Ali, M.A.; Tang, W.J.; Cohen, J.I.
The amino terminus of varicella-zoster virus (VZV) glycoprotein E is required for binding to insulin-degrading enzyme, a VZV receptor
J. Virol.
81
8525-8532
2007
Homo sapiens
Qiu, W.Q.; Folstein, M.F.
Insulin, insulin-degrading enzyme and amyloid beta-peptide in Alzheimers disease: review and hypothesis
Neurobiol. Aging
27
190-198
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Zhao, Z.; Xiang, Z.; Haroutunian, V.; Buxbaum, J.D.; Stetka, B.; Pasinetti, G.M.
Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimers disease
Neurobiol. Aging
28
824-830
2007
Homo sapiens
Marlowe, L.; Peila, R.; Benke, K.S.; Hardy, J.; White, L.R.; Launer, L.J.; Myers, A.
Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk
Neurodegener. Dis.
3
320-326
2006
Homo sapiens
Cordes, C.M.; Bennett, R.G.; Siford, G.L.; Hamel, F.G.
Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation
Biochem. Pharmacol.
77
1064-1073
2009
Rattus norvegicus
Malito, E.; Ralat, L.A.; Manolopoulou, M.; Tsay, J.L.; Wadlington, N.L.; Tang, W.J.
Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme
Biochemistry
47
12822-12834
2008
Homo sapiens
Weirich, G.; Mengele, K.; Yfanti, C.; Gkazepis, A.; Hellmann, D.; Welk, A.; Giersig, C.; Kuo, W.L.; Rosner, M.R.; Tang, W.J.; Schmitt, M.
Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines
Biol. Chem.
389
1441-1445
2008
Homo sapiens
Qin, W.; Jia, J.
Down-regulation of insulin-degrading enzyme by presenilin 1 V97L mutant potentially underlies increased levels of amyloid beta 42
Eur. J. Neurosci.
27
2425-2432
2008
Homo sapiens
Llovera, R.E.; de Tullio, M.; Alonso, L.G.; Leissring, M.A.; Kaufman, S.B.; Roher, A.E.; de Prat Gay, G.; Morelli, L.; Castano, E.M.
The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis
J. Biol. Chem.
283
17039-17048
2008
Rattus norvegicus
Grasso, G.; Rizzarelli, E.; Spoto, G.
The proteolytic activity of insulin-degrading enzyme: a mass spectrometry study
J. Mass Spectrom.
44
735-741
2009
Rattus norvegicus
Ciaccio, C.; Tundo, G.R.; Grasso, G.; Spoto, G.; Marasco, D.; Ruvo, M.; Gioia, M.; Rizzarelli, E.; Coletta, M.
Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity
J. Mol. Biol.
385
1556-1567
2009
Homo sapiens
Miners, J.S.; Kehoe, P.G.; Love, S.
Immunocapture-based fluorometric assay for the measurement of insulin-degrading enzyme activity in brain tissue homogenates
J. Neurosci. Methods
169
177-181
2008
Homo sapiens
Bulloj, A.; Leal, M.C.; Surace, E.I.; Zhang, X.; Xu, H.; Ledesma, M.D.; Castano, E.M.; Morelli, L.
Detergent resistant membrane-associated IDE in brain tissue and cultured cells: relevance to Abeta and insulin degradation
Mol. Neurodegener.
3
22
2008
Mus musculus, Rattus norvegicus
Zhao, J.; Li, L.; Leissring, M.A.
Insulin-degrading enzyme is exported via an unconventional protein secretion pathway
Mol. Neurodegener.
4
04
2009
Homo sapiens, Mus musculus
Dorfman, V.B.; Pasquini, L.; Riudavets, M.; Lopez-Costa, J.J.; Villegas, A.; Troncoso, J.C.; Lopera, F.; Castano, E.M.; Morelli, L.
Differential cerebral deposition of IDE and NEP in sporadic and familial Alzheimer's disease
Neurobiol. Aging
31
1743-1757
2010
Homo sapiens
Vepsaelaeinen, S.; Hiltunen, M.; Helisalmi, S.; Wang, J.; van Groen, T.; Tanila, H.; Soininen, H.
Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimers disease-like neuropathology
Neurosci. Lett.
438
216-220
2008
Mus musculus
Bennett, R.G.; Heimann, D.G.; Hamel, F.G.
Degradation of relaxin family peptides by insulin-degrading enzyme
Ann. N. Y. Acad. Sci.
1160
38-41
2009
Rattus norvegicus
Du, J.; Zhang, L.; Liu, S.; Zhang, C.; Huang, X.; Li, J.; Zhao, N.; Wang, Z.
PPARgamma transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons
Biochem. Biophys. Res. Commun.
383
485-490
2009
Homo sapiens, Rattus norvegicus
Radulescu, R.T.; Duckworth, W.C.; Levy, J.L.; Fawcett, J.
Retinoblastoma protein co-purifies with proteasomal insulin-degrading enzyme: implications for cell proliferation control
Biochem. Biophys. Res. Commun.
395
196-199
2010
Homo sapiens
Bora, R.P.; Prabhakar, R.
Elucidation of interactions of Alzheimer amyloid beta peptides (Abeta40 and Abeta42) with insulin degrading enzyme: a molecular dynamics study
Biochemistry
49
3947-3956
2010
Homo sapiens (P14735)
Zuo, X.; Jia, J.
Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease
Brain Res.
1249
1-8
2009
Homo sapiens
Chou, Y.H.; Kuo, W.L.; Rosner, M.R.; Tang, W.J.; Goldman, R.D.
Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme
FASEB J.
23
3734-3742
2009
Rattus norvegicus, Xenopus laevis
Wang, R.; Wang, S.; Malter, J.S.; Wang, D.S.
Effects of 4-hydroxy-nonenal and Amyloid-beta on expression and activity of endothelin converting enzyme and insulin degrading enzyme in SH-SY5Y cells
J. Alzheimers Dis.
17
489-501
2009
Homo sapiens
Amata, O.; Marino, T.; Russo, N.; Toscano, M.
Human insulin-degrading enzyme working mechanism
J. Am. Chem. Soc.
131
14804-14811
2009
Homo sapiens
Manolopoulou, M.; Guo, Q.; Malito, E.; Schilling, A.B.; Tang, W.J.
Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme
J. Biol. Chem.
284
14177-14188
2009
Homo sapiens
Ralat, L.A.; Ren, M.; Schilling, A.B.; Tang, W.J.
Protective role of Cys-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation
J. Biol. Chem.
284
34005-34018
2009
Homo sapiens
Guo, Q.; Manolopoulou, M.; Bian, Y.; Schilling, A.B.; Tang, W.J.
Molecular basis for the recognition and cleavages of IGF-II, TGF-alpha, and amylin by human insulin-degrading enzyme
J. Mol. Biol.
395
430-443
2010
Homo sapiens
Bernstein, H.G.; Ernst, T.; Lendeckel, U.; Bukowska, A.; Ansorge, S.; Stauch, R.; Have, S.T.; Steiner, J.; Dobrowolny, H.; Bogerts, B.
Reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia
J. Psychiatr. Res.
43
1095-1105
2009
Homo sapiens, Rattus norvegicus
Lu, X.; Huang, Y.; Liu, Y.; Wu, X.; Shi, X.
Variants in the insulin-degrading enzyme gene are associated with metabolic syndrome in Chinese elders
Metab. Clin. Exp.
58
1465-1469
2009
Homo sapiens
Du, J.; Zhang, L.; Liu, S.; Wang, Z.
Palmitic acid and docosahexaenoic acid opposingly regulate the expression of insulin-degrading enzyme in neurons
Pharmazie
65
231-232
2010
Rattus norvegicus
Cabrol, C.; Huzarska, M.A.; Dinolfo, C.; Rodriguez, M.C.; Reinstatler, L.; Ni, J.; Yeh, L.A.; Cuny, G.D.; Stein, R.L.; Selkoe, D.J.; Leissring, M.A.
Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening
PLoS ONE
4
e5274
2009
Homo sapiens
Carrasquillo, M.M.; Belbin, O.; Zou, F.; Allen, M.; Ertekin-Taner, N.; Ansari, M.; Wilcox, S.L.; Kashino, M.R.; Ma, L.; Younkin, L.H.; Younkin, S.G.; Younkin, C.S.; Dincman, T.A.; Howard, M.E.; Howell, C.C.; Stanton, C.M.; Watson, C.M.; Crump, M.; Vitart, V.; Hayward, C.; Hastie, N.D.; Rudan, I.; Campbell, H.; , P.
Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimers disease
PLoS ONE
5
e8764
2010
Homo sapiens
Zhang, W.J.; Luo, X.; Guo, Z.Y.
In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme
Protein J.
29
93-98
2010
Homo sapiens
Hulse, R.E.; Ralat, L.A.; Wei-Jen, T.
Structure, function, and regulation of insulin-degrading enzyme
Vitam. Horm.
80
635-648
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Alper, B.J.; Rowse, J.W.; Schmidt, W.K.
Yeast Ste23p shares functional similarities with mammalian insulin-degrading enzymes
Yeast
26
595-610
2009
Rattus norvegicus
Song, E.; Rodgers, D.; Hersh, L.
Mixed dimers of insulin-degrading enzyme reveal a cis activation mechanism
J. Biol. Chem.
286
13853-13858
2011
Homo sapiens
Ralat, L.A.; Guo, Q.; Ren, M.; Funke, T.; Dickey, D.M.; Potter, L.R.; Tang, W.J.
Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response
J. Biol. Chem.
286
4670-4679
2011
Homo sapiens
Noinaj, N.; Song, E.S.; Bhasin, S.; Alper, B.J.; Schmidt, W.K.; Hersh, L.B.; Rodgers, D.W.
Anion activation site of insulin-degrading enzyme
J. Biol. Chem.
287
48-57
2012
Rattus norvegicus
Bora, R.; Ozbil, M.; Prabhakar, R.
Elucidation of insulin degrading enzyme catalyzed site specific hydrolytic cleavage of amyloid beta peptide: A comparative density functional theory study
J. Biol. Inorg. Chem.
15
485-495
2010
Homo sapiens
Ralat, L.A.; Kalas, V.; Zheng, Z.; Goldman, R.D.; Sosnick, T.R.; Tang, W.J.
Ubiquitin is a novel substrate for human insulin-degrading enzyme
J. Mol. Biol.
406
454-466
2011
Homo sapiens
Kummer, M.P.; Huelsmann, C.; Hermes, M.; Axt, D.; Heneka, M.T.
Nitric Oxide Decreases the Enzymatic Activity of Insulin Degrading Enzyme in APP/PS1 Mice
J. Neuroimmune Pharmacol.
7
165-172
2012
Homo sapiens, Mus musculus
Song, E.; Rodgers, D.; Hersh, L.
A monomeric variant of insulin degrading enzyme (IDE) loses its regulatory properties
PLoS ONE
5
e9719
2010
Rattus norvegicus
Cordes, C.; Bennett, R.; Siford, G.; Hamel, F.
Redox regulation of insulin degradation by insulin-degrading enzyme
PLoS ONE
6
e18138
2011
Rattus norvegicus
Noinaj, N.; Bhasin, S.K.; Song, E.S.; Scoggin, K.E.; Juliano, M.A.; Juliano, L.; Hersh, L.B.; Rodgers, D.W.
Identification of the allosteric regulatory site of insulysin
PLoS ONE
6
e20864
2011
Rattus norvegicus
Grasso, G.; Satriano, C.; Milardi, D.
A neglected modulator of insulin-degrading enzyme activity and conformation: The pH
Biophys. Chem.
203-204
33-40
2015
Homo sapiens (P14735)
Charton, J.; Gauriot, M.; Totobenazara, J.; Hennuyer, N.; Dumont, J.; Bosc, D.; Marechal, X.; Elbakali, J.; Herledan, A.; Wen, X.; Ronco, C.; Gras-Masse, H.; Heninot, A.; Pottiez, V.; Landry, V.; Staels, B.; Liang, W.; Leroux, F.; Tang, W.; Deprez, B.; De
Structure-activity relationships of imidazole-derived 2-[N -carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme
Eur. J. Med. Chem.
90
547-567
2014
Homo sapiens (P14735), Homo sapiens
Tundo, G.; Sbardella, D.; Ciaccio, C.; Bianculli, A.; Orlandi, A.; Desimio, M.; Arcuri, G.; Coletta, M.; Marini, S.
Insulin-degrading enzyme (IDE): A novel heat shock-like protein
J. Biol. Chem.
288
2281-2289
2013
Homo sapiens (P14735), Homo sapiens
Galagovsky, D.; Katz, M.; Acevedo, J.; Sorianello, E.; Glavic, A.; Wappner, P.
The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner
Mol. Biol. Cell
25
916-924
2014
Drosophila melanogaster (P22817)
Abdul-Hay, S.O.; Sahara, T.; McBride, M.; Kang, D.; Leissring, M.A.
Identification of BACE2 as an avid beta-amyloid-degrading protease
Mol. Neurodegener.
7
46
2012
Homo sapiens (Q9Y5Z0)
Wei, X.; Ke, B.; Zhao, Z.; Ye, X.; Gao, Z.; Ye, J.
Regulation of insulin degrading enzyme activity by obesity-associated factors and pioglitazone in liver of diet-induced obese mice
PLoS ONE
9
e95399
2014
Mus musculus (Q9JHR7), Mus musculus
McCord, L.; Liang, W.; Dowdell, E.; Kalas, V.; Hoey, R.; Koide, A.; Koide, S.; Tang, W.
Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme
Proc. Natl. Acad. Sci. USA
110
13827-13832
2013
Homo sapiens (P14735), Homo sapiens
Krasinski, C.A.; Ivancic, V.A.; Zheng, Q.; Spratt, D.E.; Lazo, N.D.
Resveratrol sustains insulin-degrading enzyme activity toward Abeta42
ACS Omega
3
13275-13282
2018
Homo sapiens (P14735)
Sharma, S.K.; Chorell, E.; Wittung-Stafshede, P.
Insulin-degrading enzyme is activated by the C-terminus of alpha-synuclein
Biochem. Biophys. Res. Commun.
466
192-195
2015
Homo sapiens (P14735)
Kurochkin, I.V.; Guarnera, E.; Wong, J.H.; Eisenhaber, F.; Berezovsky, I.N.
Toward allosterically increased catalytic activity of insulin-degrading enzyme against amyloid peptides
Biochemistry
56
228-239
2017
Homo sapiens (P14735), Homo sapiens
Stefanidis, L.; Fusco, N.D.; Cooper, S.E.; Smith-Carpenter, J.E.; Alper, B.J.
Molecular determinants of substrate specificity in human insulin-degrading enzyme
Biochemistry
57
4903-4914
2018
Homo sapiens (P14735), Homo sapiens
Hubin, E.; Cioffi, F.; Rozenski, J.; van Nuland, N.A.; Broersen, K.
Characterization of insulin-degrading enzyme-mediated cleavage of Abeta in distinct aggregation states
Biochim. Biophys. Acta
1860
1281-1290
2016
Homo sapiens (P14735), Homo sapiens
Ivancic, V.A.; Krasinski, C.A.; Zheng, Q.; Meservier, R.J.; Spratt, D.E.; Lazo, N.D.
Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme
Biosci. Rep.
38
BSR20181416
2018
Homo sapiens (P14735)
Grasso, G.; Lanza, V.; Malgieri, G.; Fattorusso, R.; Pietropaolo, A.; Rizzarelli, E.; Milardi, D.
The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin
Chem. Commun. (Camb.)
51
15724-15727
2015
Homo sapiens (P14735)
Zhang, H.; Liu, D.; Huang, H.; Zhao, Y.; Zhou, H.
Characteristics of insulin-degrading enzyme in Alzheimers Disease a meta-analysis
Curr. Alzheimer Res.
15
610-617
2018
Homo sapiens (P14735), Homo sapiens
Hogan, M.F.; Meier, D.T.; Zraika, S.; Templin, A.T.; Mellati, M.; Hull, R.L.; Leissring, M.A.; Kahn, S.E.
Inhibition of insulin-degrading enzyme does not increase islet amyloid deposition in vitro
Endocrinology
157
3462-3468
2016
Mus musculus (Q9JHR7), Mus musculus
Tundo, G.R.; Di Muzio, E.; Ciaccio, C.; Sbardella, D.; Di Pierro, D.; Polticelli, F.; Coletta, M.; Marini, S.
Multiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin
FEBS J.
283
3755-3770
2016
Homo sapiens (P14735)
Zhang, S.; Wang, Y.; Wu, H.; Li, N.; Jiang, J.; Guo, Y.; Feng, Y.; Xiao, L.
Characterization of a species-specific insulinase-like protease in Cryptosporidium parvum
Front. Microbiol.
10
354
2019
Cryptosporidium parvum (Q5CPE7), Cryptosporidium parvum
Durham, T.B.; Toth, J.L.; Klimkowski, V.J.; Cao, J.X.; Siesky, A.M.; Alexander-Chacko, J.; Wu, G.Y.; Dixon, J.T.; McGee, J.E.; Wang, Y.; Guo, S.Y.; Cavitt, R.N.; Schindler, J.; Thibodeaux, S.J.; Calvert, N.A.; Coghlan, M.J.; Sindelar, D.K.; Christe, M.; Kiselyov, V.V.; Michael, M.D.; Sloop, K.W.
Dual exosite-binding inhibitors of insulin-degrading enzyme challenge its role as the primary mediator of insulin clearance in vivo
J. Biol. Chem.
290
20044-20059
2015
Homo sapiens (P14735), Mus musculus (Q9JHR7)
Yang, D.; Qin, W.; Shi, X.; Zhu, B.; Xie, M.; Zhao, H.; Teng, B.; Wu, Y.; Zhao, R.; Yin, F.; Ren, P.; Liu, L.; Li, Z.
Stabilized beta-hairpin peptide inhibits insulin degrading enzyme
J. Med. Chem.
61
8174-8185
2018
Mus musculus (Q9JHR7), Mus musculus
Maianti, J.P.; Tan, G.A.; Vetere, A.; Welsh, A.J.; Wagner, B.K.; Seeliger, M.A.; Liu, D.R.
Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme
Nat. Chem. Biol.
15
565-574
2019
Homo sapiens (P14735)
Deprez-Poulain, R.; Hennuyer, N.; Bosc, D.; Liang, W.G.; Enee, E.; Marechal, X.; Charton, J.; Totobenazara, J.; Berte, G.; Jahklal, J.; Verdelet, T.; Dumont, J.; Dassonneville, S.; Woitrain, E.; Gauriot, M.; Paquet, C.; Duplan, I.; Hermant, P.; Cantrelle, F.X.; Sevin, E.; Culot, M.; Landry, V.; Herl, H.e.r.l.e.
Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice
Nat. Commun.
6
8250
2015
Mus musculus (Q9JHR7)
Guan, H.; Chow, K.M.; Song, E.; Verma, N.; Despa, F.; Hersh, L.B.
The Mitochondrial peptidase pitrilysin degrades islet amyloid polypeptide in beta-cells
PLoS ONE
10
e0133263 p
2015
Mus musculus (Q8K411)
Suire, C.N.; Nainar, S.; Fazio, M.; Kreutzer, A.G.; Paymozd-Yazdi, T.; Topper, C.L.; Thompson, C.R.; Leissring, M.A.
Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display
PLoS ONE
13
e0193101
2018
Mus musculus (Q9JHR7), Mus musculus
Song, E.S.; Jang, H.; Guo, H.F.; Juliano, M.A.; Juliano, L.; Morris, A.J.; Galperin, E.; Rodgers, D.W.; Hersh, L.B.
Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes
Proc. Natl. Acad. Sci. USA
114
E2826-E2835
2017
Rattus norvegicus (P35559)
html completed
