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3.4.24.56: insulysin

This is an abbreviated version!
For detailed information about insulysin, go to the full flat file.

Word Map on EC 3.4.24.56

Reaction

Degradation of insulin, glucagon and other polypeptides. No action on proteins =

Synonyms

ADE, amyloid degrading enzyme, cgd6_5510, EC 3.4.22.11, EC 3.4.99.10, EC 3.4.99.45, gamma-endorphin-generating enzyme, IDE, INS20-19, insulin degrading enzyme, Insulin protease, Insulin proteinase, Insulin-degrading enzyme, Insulin-degrading neutral proteinase, Insulin-glucagon protease, Insulin-specific protease, Insulinase, Insulysin, Metalloinsulinase, More, pitrilysin metallopeptidase 1, Pitrm1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.56 insulysin

Expression

Expression on EC 3.4.24.56 - insulysin

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
all-trans retinoic acid treatment down-regulates enzyme expression in neuroblastoma cells
amyloid beta-induced oxidation of IDE by 4-hydroxy-nonenal does not affect IDE activity in human neuroblastoma SH-SY5Y cells, but rapidly induces IDE expression
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docosahexaenoic acid induces the expression of IDE in primary hippocampal neurons and prevents Alzheimer's disease
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enzyme activity and protein level are increased in the liver of diet-induced obese mice. Pioglitazone (10 mg/kg/day) administration for 2 months significantly enhances the enzyme activity (75%), protein (180%) and mRNA expression (100%). Free fatty acid (palmitate, 0.3 mM) induces protein expression, but reduces the mRNA. Glucagon and forskolin (100 ng/ml) also induce protein expression
enzyme expression is stress-inducible (heat shock at 48°C for 15 and 30 min, increasing concentrations of H2O2, and serum starvation for 60 min) and up-regulated in some central nervous system tumors
IDE levels are decreased in type 2 diabetes mellitus. IDE levels are significantly inversely correlated with plasma insulin, fasting blood glucose, triglyceride, total cholesterol, low-density lipoprotein, but not high-density lipoprotein
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insulin does not regulate enzyme expression in hepatocytes
palmitic acid suppresses the expression of IDE and induces Alzheimer's disease
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peroxisome proliferator-activated receptor gamma, PPARgamma, increases IDE levels acting as a positive regulator. PPARgamma participates in the insulin-induced IDE expression in neurons, it binds to the IDE gene promoter flanking a functional PPRE in primary neurons
reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia
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reduced neuronal expression of insulin-degrading enzyme in the left and right dorsolateral prefrontal cortex, but not in other brain areas investigated, of haloperidol-treated rats
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tissue necrosis factor-alpha (10 ng/ml) decreases protein expression