3.4.24.56: insulysin
This is an abbreviated version!
For detailed information about insulysin, go to the full flat file.
Word Map on EC 3.4.24.56
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3.4.24.56
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alzheimer
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neprilysin
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abeta
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hippocampus
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dementia
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mellitus
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cerebral
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morris
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amyloid-beta
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metalloprotease
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maze
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neuroprotective
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amyloidogenic
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tau
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beta-amyloid
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neurodegenerative
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presenilin
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endothelin-converting
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senile
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gamma-secretase
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beta-protein
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125i-insulin
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abeta-degrading
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hyperinsulinemia
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metalloendopeptidase
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bacitracin
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beta-secretase
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late-onset
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amylin
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microglia
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medicine
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adam10
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non-amyloidogenic
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glutathione-insulin
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enzyme-1
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b-chains
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analysis
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ad-like
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anti-ide
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exosite
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beta-peptide
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abeta1-40
- 3.4.24.56
- alzheimer
- neprilysin
- abeta
- hippocampus
- dementia
- mellitus
- cerebral
-
morris
- amyloid-beta
- metalloprotease
-
maze
-
neuroprotective
-
amyloidogenic
- tau
- beta-amyloid
- neurodegenerative
-
presenilin
-
endothelin-converting
-
senile
- gamma-secretase
- beta-protein
- 125i-insulin
-
abeta-degrading
- hyperinsulinemia
- metalloendopeptidase
- bacitracin
- beta-secretase
-
late-onset
- amylin
- microglia
- medicine
- adam10
-
non-amyloidogenic
-
glutathione-insulin
- enzyme-1
- b-chains
- analysis
-
ad-like
-
anti-ide
-
exosite
- beta-peptide
- abeta1-40
Reaction
Degradation of insulin, glucagon and other polypeptides. No action on proteins =
Synonyms
ADE, amyloid degrading enzyme, cgd6_5510, EC 3.4.22.11, EC 3.4.99.10, EC 3.4.99.45, gamma-endorphin-generating enzyme, IDE, INS20-19, insulin degrading enzyme, Insulin protease, Insulin proteinase, Insulin-degrading enzyme, Insulin-degrading neutral proteinase, Insulin-glucagon protease, Insulin-specific protease, Insulinase, Insulysin, Metalloinsulinase, More, pitrilysin metallopeptidase 1, Pitrm1
ECTree
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Expression
Expression on EC 3.4.24.56 - insulysin
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all-trans retinoic acid treatment down-regulates enzyme expression in neuroblastoma cells
amyloid beta-induced oxidation of IDE by 4-hydroxy-nonenal does not affect IDE activity in human neuroblastoma SH-SY5Y cells, but rapidly induces IDE expression
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docosahexaenoic acid induces the expression of IDE in primary hippocampal neurons and prevents Alzheimer's disease
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enzyme activity and protein level are increased in the liver of diet-induced obese mice. Pioglitazone (10 mg/kg/day) administration for 2 months significantly enhances the enzyme activity (75%), protein (180%) and mRNA expression (100%). Free fatty acid (palmitate, 0.3 mM) induces protein expression, but reduces the mRNA. Glucagon and forskolin (100 ng/ml) also induce protein expression
enzyme expression is stress-inducible (heat shock at 48°C for 15 and 30 min, increasing concentrations of H2O2, and serum starvation for 60 min) and up-regulated in some central nervous system tumors
IDE levels are decreased in type 2 diabetes mellitus. IDE levels are significantly inversely correlated with plasma insulin, fasting blood glucose, triglyceride, total cholesterol, low-density lipoprotein, but not high-density lipoprotein
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palmitic acid suppresses the expression of IDE and induces Alzheimer's disease
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peroxisome proliferator-activated receptor gamma, PPARgamma, increases IDE levels acting as a positive regulator. PPARgamma participates in the insulin-induced IDE expression in neurons, it binds to the IDE gene promoter flanking a functional PPRE in primary neurons
reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia
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reduced neuronal expression of insulin-degrading enzyme in the left and right dorsolateral prefrontal cortex, but not in other brain areas investigated, of haloperidol-treated rats
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peroxisome proliferator-activated receptor gamma, PPARgamma, increases IDE levels acting as a positive regulator. PPARgamma participates in the insulin-induced IDE expression in neurons, it binds to the IDE gene promoter flanking a functional PPRE in primary neurons
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peroxisome proliferator-activated receptor gamma, PPARgamma, increases IDE levels acting as a positive regulator. PPARgamma participates in the insulin-induced IDE expression in neurons, it binds to the IDE gene promoter flanking a functional PPRE in primary neurons
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