3.4.24.56: insulysin

This is an abbreviated version!
For detailed information about insulysin, go to the full flat file.

Word Map on EC 3.4.24.56

3.4.24.56

alzheimer

neprilysin

abeta

hippocampus

dementia

mellitus

cerebral

morris

amyloid-beta

metalloprotease

maze

neuroprotective

amyloidogenic

tau

beta-amyloid

neurodegenerative

presenilin

endothelin-converting

senile

gamma-secretase

beta-protein

125i-insulin

abeta-degrading

hyperinsulinemia

metalloendopeptidase

bacitracin

beta-secretase

late-onset

amylin

microglia

medicine

adam10

non-amyloidogenic

glutathione-insulin

enzyme-1

b-chains

analysis

ad-like

anti-ide

exosite

beta-peptide

abeta1-40

Reaction

Degradation of insulin, glucagon and other polypeptides. No action on proteins =

Synonyms

ADE, amyloid degrading enzyme, cgd6_5510, EC 3.4.22.11, EC 3.4.99.10, EC 3.4.99.45, gamma-endorphin-generating enzyme, IDE, INS20-19, insulin degrading enzyme, Insulin protease, Insulin proteinase, Insulin-degrading enzyme, Insulin-degrading neutral proteinase, Insulin-glucagon protease, Insulin-specific protease, Insulinase, Insulysin, Metalloinsulinase, More, pitrilysin metallopeptidase 1, Pitrm1

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.56 insulysin

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Results	in table
73	Activating Compound
256	AA Sequence
17	Application
1	CAS Registry Number
60	Cloned(Commentary)
12	Crystallization (Commentary)
557	Disease/ Diagnostics
13	Expression
45	General Information
1	General Stability
58	IC50 Value
274	Inhibitors
10	kcat/KM [mM/s]
12	Ki Value [mM]
94	KM Value [mM]
88	Localization
64	Metals/Ions
44	Molecular Weight [Da]
138	Natural Substrates/ Products (Substrates)
338	Organism
135	PDB ID
29	pH Optimum
2	pH Range
3	pH Stability
2	Posttranslational Modification
94	Protein Variants
43	Purification (Commentary)
5	Reaction
1	Reaction Type
171	Reference
187	Source Tissue
16	Specific Activity [micromol/min/mg]
3	Storage Stability
416	Substrates and Products (Substrate)
40	Subunits
203	Synonyms
22	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
98	Turnover Number [1/s]

IC50 Value

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of the Enzyme Summary Page.

IC50 Value on EC 3.4.24.56 - insulysin

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0.0004

((((S)-1-benzylcarbamoyl-2-(1H-imidazol-4-yl)-ethylcarbamoyl)-methyl)-(3-phenyl-propyl)-amino)-acetic acid

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0005

((((S)-2-(1H-imidazol-4-yl)-1-(3-methyl-(1,2,4)oxadiazol-5-yl)-ethylcarbamoyl)-methyl)-(3-phenyl-propyl)-amino)-acetic acid

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0001

((((S)-2-(1H-imidazol-4-yl)-1-methylcarbamoylethylcarbamoyl)-methyl)-(3-phenyl-propyl)-amino)-acetic acid

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0016

((((S)-2-hydroxy-1-(1H-imidazol-4-ylmethyl)-ethylcarbamoyl)-methyl)-(3-phenyl-propyl)-amino)-acetic acid

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0014

(benzyl-(((S)-1-benzylcarbamoyl-2-(1H-imidazol-4-yl)-ethylcarbamoyl)-methyl)-amino)-acetic acid

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0014

(benzyl-(((S)-1-carbamoyl-2-(1H-imidazol-4-yl)-ethylcarbamoyl)-methyl)-amino)-acetic acid

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0069

(benzyl-(((S)-1-dimethylcarbamoyl-2-(1H-imidazol-4-yl)-ethylcarbamoyl)-methyl)-amino)-acetic acid

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0006

(benzyl-(((S)-2-(1H-imidazol-4-yl)-1-methylcarbamoylethylcarbamoyl)-methyl)-amino)-acetic acid

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0041

(benzyl-(((S)-2-hydroxy-1-(1H-imidazol-4-ylmethyl)-ethylcarbamoyl)-methyl)-amino)-acetic acid

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0029

(S)-2-(2-((4-tert-butyl-benzyl)-carboxymethyl-amino)-acetylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0125

(S)-2-(2-(benzyl-(2-hydroxy-3,4-dioxo-cyclobut-1-enyl)-amino)-acetylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0003

(S)-2-(2-(benzyl-carboxymethyl-amino)-acetylamino)-3-(1H-imidazol-4-yl)-propionic acid isopropyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0029

(S)-2-(2-(benzyl-carboxymethyl-amino)-acetylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0008

(S)-2-(2-(benzyl-carboxymethyl-amino)-acetylamino)-3-(1H-imidazol-4-yl)-propionic acid tert-butyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0006

(S)-2-(2-(benzyl-carboxymethyl-amino)-acetylamino)-3-(3H-imidazol-4-yl)-propionic acid isobutyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0363

(S)-2-(2-(benzyl-carboxymethyl-amino)-acetylamino)-5-guanidino-pentanoic acid methyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0032

(S)-2-(2-(benzyl-hydroxycarbamoylmethyl-amino)-acetylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0006

(S)-2-(2-(carboxymethyl-(1-methyl-3-phenyl-propyl)-amino)-acetylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0012

(S)-2-(2-(carboxymethyl-(2-(1H-indol-3-yl)-ethyl)-amino)-acetylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.001

(S)-2-(2-(carboxymethyl-(3-phenyl-propyl)-amino)-acetylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0004

(S)-2-(2-(carboxymethyl-(3-phenyl-propyl)-amino)-acetylamino)-3-(1H-imidazol-4-yl)-propionic acid tert-butyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0025

(S)-2-(2-(carboxymethyl-(4-fluoro-benzyl)-amino)-acetylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0017

(S)-2-(2-(carboxymethyl-(4-methyl-benzyl)-amino)-acetylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0006

(S)-2-(2-(carboxymethyl-(4-phenyl-butyl)-amino)-acetylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.002

(S)-2-(2-(carboxymethyl-(4-trifluoromethyl-benzyl)-amino)-acetylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0004

(S)-2-(2-(carboxymethyl-(n-hexyl)-amino)-acetylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0012

(S)-2-(2-(carboxymethyl-naphthalen-2-ylmethyl-amino)-acetylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0014

(S)-2-(2-(carboxymethyl-phenethyl-amino)-acetylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0063

(S)-2-(2-(carboxymethyl-pyridin-4-ylmethyl-amino)-acetylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.0036

3-(((S)-1-methoxy-1-oxo-3-imidazol-2-yl)carbamoyl)-1,2,3,4-tetrahydroisoquinoline-2-ethanoic acid

Homo sapiens

in HEPES 50 mM, NaCl 100 mM, pH 7.4, at 37°C

0.00006

Ac-EWRFCGdPPECLYLVCG-NH2(Cys5-Cys10 disulfide)

Mus musculus

pH 7.5, 23°C

0.000077

Ac-EWRFCGGGdPPECLYLVCG-NH2(Cys5-Cys12-disulfide)

Mus musculus

pH 7.5, 23°C

0.11 - 0.4

bacitracin

show

0.00023

EALYLVCG-NH2

Mus musculus

pH 7.5, 23°C

0.00017

EALYLVCGdPPFRWE-NH2

Mus musculus

pH 7.5, 23°C

0.000022

EWRF-cyclo(DGdPPEDap)LYLVCG-NH2

Mus musculus

pH 7.5, 23°C

0.000044

EWRF-cyclo(DGGGdPPEDap)LYLVCG-NH2

Mus musculus

pH 7.5, 23°C

0.000601

EWRFdPPEALY-NH2

Mus musculus

pH 7.5, 23°C

0.000086

EWRFdPPEALYLV-NH2

Mus musculus

pH 7.5, 23°C

0.0003

EWRFGGEALYLVCG-NH2

Mus musculus

pH 7.5, 23°C

0.9

hydrogen peroxide

Homo sapiens

-

pH 8.0, 37°C

0.0000444

InsL3

Rattus norvegicus

-

pH not specified in the publication, temperature not specified in the publication

-

0.000018

methyl [(2S)-2-(5-[5-[4-([(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl]amino)phenyl]pentyl]-2-fluorophenyl)-3-(quinolin-3-yl)propyl]carbamate

Homo sapiens

37°C, pH 7.5

0.000015

methyl [(2S)-2-[4-([5-[4-([(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl]amino)phenyl]pentyl]oxy)phenyl]-3-(quinolin-3-yl)butyl]carbamate

Homo sapiens

37°C, pH 7.5

0.04

protein ANP

Homo sapiens

-

pH not specified in the publication, 37°C

-

0.12

protein BNP

Homo sapiens

-

pH not specified in the publication, 37°C

-

0.07

protein CNP

Homo sapiens

-

pH not specified in the publication, 37°C

-

1.3

protein DNP

Homo sapiens

-

pH not specified in the publication, 37°C

-

0.000182

relaxin

Rattus norvegicus

-

pH not specified in the publication, temperature not specified in the publication

-

0.0000537

relaxin-3

Rattus norvegicus

-

pH not specified in the publication, temperature not specified in the publication

-

1.2

S-nitrosoglutathione

Homo sapiens

-

pH 8.0, 37°C

0.001 - 0.1

Ub1-72

show

-

0.09

ubiquitin

Homo sapiens

-

pH not specified in the publication, 37°C

0.8

urodilatin

Homo sapiens

-

pH not specified in the publication, 37°C

-

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Release 2023.1 (January 2023)