Cloned (Comment) | Organism |
---|---|
IDE expression analysis in neuron tissue, overview | Homo sapiens |
IDE expression analysis in neuron tissue, overview | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta + H2O | Homo sapiens | - |
amyloid beta peptide fragments | - |
? | |
amyloid beta + H2O | Rattus norvegicus | - |
amyloid beta peptide fragments | - |
? | |
insulin + H2O | Homo sapiens | - |
insulin peptide fragments | - |
? | |
insulin + H2O | Rattus norvegicus | - |
insulin peptide fragments | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebellum | - |
Rattus norvegicus | - |
granulocyte | from type 2 diabetes mellitus patients and control subjects | Homo sapiens | - |
hippocampus | - |
Rattus norvegicus | - |
neuron | primary culture, immunohistochemic expression analysis, overview | Homo sapiens | - |
neuron | primary culture, immunohistochemic expression analysis, overview | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta + H2O | - |
Homo sapiens | amyloid beta peptide fragments | - |
? | |
amyloid beta + H2O | - |
Rattus norvegicus | amyloid beta peptide fragments | - |
? | |
insulin + H2O | - |
Homo sapiens | insulin peptide fragments | - |
? | |
insulin + H2O | - |
Rattus norvegicus | insulin peptide fragments | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDE | - |
Homo sapiens |
IDE | - |
Rattus norvegicus |
Insulin-degrading enzyme | - |
Homo sapiens |
Insulin-degrading enzyme | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | IDE levels are decreased in type 2 diabetes mellitus. IDE levels are significantly inversely correlated with plasma insulin, fasting blood glucose, triglyceride, total cholesterol, low-density lipoprotein, but not high-density lipoprotein | down |
Homo sapiens | peroxisome proliferator-activated receptor gamma, PPARgamma, increases IDE levels acting as a positive regulator. PPARgamma participates in the insulin-induced IDE expression in neurons, it binds to the IDE gene promoter flanking a functional PPRE in primary neurons | up |
Rattus norvegicus | peroxisome proliferator-activated receptor gamma, PPARgamma, increases IDE levels acting as a positive regulator. PPARgamma participates in the insulin-induced IDE expression in neurons, it binds to the IDE gene promoter flanking a functional PPRE in primary neurons | up |
General Information | Comment | Organism |
---|---|---|
malfunction | deficiency in IDE function is associated with Alzheimer's disease and type 2 diabetes mellitus pathology. IDE levels are decreased in type 2 diabetes mellitus. Regulation of IDE by PPARgamma and their roles in Alzheimer's disease and type 2 diabetes mellitus pathology | Homo sapiens |
metabolism | IDE levels are significantly inversely correlated with plasma insulin, fasting blood glucose, triglyceride, total cholesterol, low-density lipoprotein, but not high-density lipoprotein, indicating IDE is possibly involved in insulin turnover and its effects on carbohydrate and lipid metabolism, overview | Homo sapiens |
physiological function | IDE plays a key role in degrading both amyloid beta and insulin | Homo sapiens |
physiological function | IDE plays a key role in degrading both amyloid beta and insulin | Rattus norvegicus |