3.4.22.B72: SENP3 peptidase

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For detailed information about SENP3 peptidase, go to the full flat file.

Word Map on EC 3.4.22.B72

3.4.22.B72

sumoylation

senps

deconjugation

isopeptidase

de-sumoylation

ranbp2

de-conjugating

Reaction

The enzyme catalyzes the desumoylation of SUMO2 or SUMO3-modified target proteins, but has only weak activity against SUMO1 conjugates. SENP2 catalyzes deconjugation of SUMO2 from nucleophosmin 1. =

Synonyms

SENP3, sentrin-specific protease 3, small ubiquitin-like modifier-specific protease 3, SUMO-2/3-specific protease, SUMO-specific isopeptidase, SUMO-specific protease 3, SUMO-specific proteases 3, SUMO2/3-specific protease

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.B72 SENP3 peptidase

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Results	in table
1	Activating Compound
3	AA Sequence
2	Cloned(Commentary)
202	Disease/ Diagnostics
8	Expression
26	General Information
3	General Stability
1	Inhibitors
14	Localization
9	Natural Substrates/ Products (Substrates)
187	Organism
3	Posttranslational Modification
1	Protein Variants
1	Reaction
20	Reference
44	Source Tissue
20	Substrates and Products (Substrate)
22	Synonyms

Source Tissue

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Source Tissue on EC 3.4.22.B72 - SENP3 peptidase

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the enzyme accumulates in a variety of cancers

732595

cerebral cortex

4 entries

colonic adenocarcinoma cell

Homo sapiens

Q9H4L4

SENP3 is over-accumulated in a variety of primary human cancers including colon adenocarcinoma. SENP3-mediated de-SUMO2/3 of promyelocytic leukemia might contribute to the development or progression of human cancers

correlation between SENP3 expression and gastric cancer metastasis

oral squamous cell carcinoma cell

Homo sapiens

immunohistochemical evaluation of SENP3 in patients and oral epithelial tissue adjacent to tumor, overview

additional information

2 entries