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3.4.22.B72: SENP3 peptidase

This is an abbreviated version!
For detailed information about SENP3 peptidase, go to the full flat file.

Word Map on EC 3.4.22.B72

Reaction

The enzyme catalyzes the desumoylation of SUMO2 or SUMO3-modified target proteins, but has only weak activity against SUMO1 conjugates. SENP2 catalyzes deconjugation of SUMO2 from nucleophosmin 1. =

Synonyms

SENP3, sentrin-specific protease 3, small ubiquitin-like modifier-specific protease 3, SUMO-2/3-specific protease, SUMO-specific isopeptidase, SUMO-specific protease 3, SUMO-specific proteases 3, SUMO2/3-specific protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B72 SENP3 peptidase

General Stability

General Stability on EC 3.4.22.B72 - SENP3 peptidase

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
SENP3 is continuously degraded through the ubiquitin proteasome pathway under basal condition. Reactive oxygen species inhibit this degradation
Senp3 is destabilized in an nucleophosmin-dependent manner by a process involving sequential p19Arf-induced Senp3 phosphorylation, ubiquitination and proteasomal degradation
SENP3 is maintained at a low basal level under non-stress condition due to heat shock protein 90 (Hsp90)-independent Hsc70-interacting protein (CHIP)-mediated ubiquitination. Upon mild oxidative stress, SENP3 undergoes thiol modification, which recruits Hsp90. Hsp90/SENP3 association protects SENP3 from CHIP-mediated ubiquitination and subsequent degradation. This effect of Hsp90 requires the presence of CHIP