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Literature summary for 3.4.22.B72 extracted from
- The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation (2014), Mol. Cell, 55, 47-58.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| SUMOylated RbBP5 + H2O | Homo sapiens | deSUMOylation by enzyme SENP3, the protein is part of SET1/MLL complexes | RbBP5 + SUMO | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| U2-OS cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| SUMOylated RbBP5 + H2O | deSUMOylation by enzyme SENP3 | Homo sapiens | RbBP5 + SUMO | - |
? | |
| SUMOylated RbBP5 + H2O | deSUMOylation by enzyme SENP3, the protein is part of SET1/MLL complexes | Homo sapiens | RbBP5 + SUMO | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SENP3 | - |
Homo sapiens |
| SUMO-specific isopeptidase | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | in the absence of SENP3, the association of menin and Ash2L with the DLX3 geneis impaired, leading to decreased H3K4 methylation and reduced recruitment of active RNA polymerase II | Homo sapiens |
| physiological function | SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation of and DLX3 and RUNX2 expression in human dental follicle stem cells. SUMO-specific isopeptidase SENP3 controls H3K4 methylation by regulating histone-modifying SET1/MLL complexes. SET1/MLL complexes are composed of a histone methyltransferase and the regulatory components WDR5, RbBP5, Ash2L, and DPY-30. MLL1/MLL2 complexes contain menin as additional component and are particularly important for the activationof HOX genes | Homo sapiens |
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Release 2023.1 (January 2023)
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