3.4.22.B72: SENP3 peptidase
This is an abbreviated version!
For detailed information about SENP3 peptidase, go to the full flat file.
Word Map on EC 3.4.22.B72
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3.4.22.B72
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sumoylation
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senps
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deconjugation
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isopeptidase
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de-sumoylation
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ranbp2
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de-conjugating
- 3.4.22.B72
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sumoylation
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senps
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deconjugation
- isopeptidase
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de-sumoylation
- ranbp2
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de-conjugating
Reaction
The enzyme catalyzes the desumoylation of SUMO2 or SUMO3-modified target proteins, but has only weak activity against SUMO1 conjugates. SENP2 catalyzes deconjugation of SUMO2 from nucleophosmin 1. =
Synonyms
SENP3, sentrin-specific protease 3, small ubiquitin-like modifier-specific protease 3, SUMO-2/3-specific protease, SUMO-specific isopeptidase, SUMO-specific protease 3, SUMO-specific proteases 3, SUMO2/3-specific protease
ECTree
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Localization
Localization on EC 3.4.22.B72 - SENP3 peptidase
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reactive oxygen species cause SENP3 to redistribute from the nucleoli to the nucleoplasm, allowing it to regulate nuclear events
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SENP3 localizes within the granular component of the nucleolus, a subnucleolar compartment that contains B23/nucleophosmin
reactive oxygen species cause SENP3 to redistribute from the nucleoli to the nucleoplasm, allowing it to regulate nuclear events
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the nucleolar SUMO-specific protease SENP3 is associated with nucleophosmin, a crucial factor in ribosome biogenesis
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reactive oxygen species regulate enzyme SENP3 stability and localization. Reactive oxygen species induce SENP3 redistribution from the nucleoli to the nucleoplasm
SENP3 is predominantly expressed in the nucleus of Sertoli and spermatocyte cells in adult mouse testis