3.4.22.B72: SENP3 peptidase
This is an abbreviated version!
For detailed information about SENP3 peptidase, go to the full flat file.
Word Map on EC 3.4.22.B72
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3.4.22.B72
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sumoylation
-
senps
-
deconjugation
-
isopeptidase
-
de-sumoylation
-
ranbp2
-
de-conjugating
- 3.4.22.B72
-
sumoylation
-
senps
-
deconjugation
- isopeptidase
-
de-sumoylation
- ranbp2
-
de-conjugating
Reaction
The enzyme catalyzes the desumoylation of SUMO2 or SUMO3-modified target proteins, but has only weak activity against SUMO1 conjugates. SENP2 catalyzes deconjugation of SUMO2 from nucleophosmin 1. =
Synonyms
SENP3, sentrin-specific protease 3, small ubiquitin-like modifier-specific protease 3, SUMO-2/3-specific protease, SUMO-specific isopeptidase, SUMO-specific protease 3, SUMO-specific proteases 3, SUMO2/3-specific protease
ECTree
3.4.22.B72 SENP3 peptidaseAdvanced search results
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Reference on EC 3.4.22.B72 - SENP3 peptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Haindl, M.; Harasim, T.; Eick, D.; Muller, S.
The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing
EMBO Rep.
9
273-279
2008
Homo sapiens
Kuo, M.L.; den Besten, W.; Thomas, M.C.; Sherr, C.J.
Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3
Cell Cycle
7
3378-3387
2008
Mus musculus (Q9EP97), Mus musculus
Huang, C.; Han, Y.; Wang, Y.; Sun, X.; Yan, S.; Yeh, E.T.; Chen, Y.; Cang, H.; Li, H.; Shi, G.; Cheng, J.; Tang, X.; Yi, J.
SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation
EMBO J.
28
2748-2762
2009
Homo sapiens (Q9H4L4)
Yan, S.; Sun, X.; Xiang, B.; Cang, H.; Kang, X.; Chen, Y.; Li, H.; Shi, G.; Yeh, E.T.; Wang, B.; Wang, X.; Yi, J.
Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90
EMBO J.
29
3773-3786
2010
Homo sapiens (Q9H4L4)
Han, Y.; Huang, C.; Sun, X.; Xiang, B.; Wang, M.; Yeh, E.T.; Chen, Y.; Li, H.; Shi, G.; Cang, H.; Sun, Y.; Wang, J.; Wang, W.; Gao, F.; Yi, J.
SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress
J. Biol. Chem.
285
12906-12915
2010
Homo sapiens (Q9H4L4), Homo sapiens
Yun, C.; Wang, Y.; Mukhopadhyay, D.; Backlund, P.; Kolli, N.; Yergey, A.; Wilkinson, K.D.; Dasso, M.
Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases
J. Cell Biol.
183
589-595
2008
Homo sapiens
Klein, U.R.; Haindl, M.; Nigg, E.A.; Muller, S.
RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin
Mol. Biol. Cell
20
410-418
2009
Homo sapiens (Q9H4L4)
Yang, Y.Q.; Li, H.; Zhang, X.; Wang, C.X.; Sun, Q.; Li, S.; Li, W.; Li, W.; Ding, K.; Liu, M.; Yu, Z.; Hang, C.H.
Expression and cell distribution of SENP3 in the cerebral cortex after experimental subarachnoid hemorrhage in rats: a pilot study
Cell. Mol. Neurobiol.
35
407-416
2015
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Yu, Z.; Li, H.; Yan, H.Y.; Yang, Y.Q.; Zhang, D.D.; Huang, L.T.; Xie, G.B.; Liu, M.; Tohti, M.; Hang, C.H.
Expression and cell distribution of SENP3 in brain tissue after traumatic brain injury in mice: a pilot study
Cell. Mol. Neurobiol.
35
733-740
2015
Mus musculus, Mus musculus ICR
Guo, C.; Hildick, K.L.; Luo, J.; Dearden, L.; Wilkinson, K.A.; Henley, J.M.
SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia
EMBO J.
32
1514-1528
2013
Homo sapiens
Nayak, A.; Viale-Bouroncle, S.; Morsczeck, C.; Muller, S.
The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation
Mol. Cell
55
47-58
2014
Homo sapiens
Sun, Z.; Hu, S.; Luo, Q.; Ye, D.; Hu, D.; Chen, F.
Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation
Oncol. Rep.
29
1701-1706
2013
Homo sapiens
Ren, Y.H.; Liu, K.J.; Wang, M.; Yu, Y.N.; Yang, K.; Chen, Q.; Yu, B.; Wang, W.; Li, Q.W.; Wang, J.; Hou, Z.Y.; Fang, J.Y.; Yeh, E.T.; Yang, J.; Yi, J.
De-SUMOylation of FOXC2 by SENP3 promotes the epithelial-mesenchymal transition in gastric cancer cells
Oncotarget
5
7093-7104
2014
Homo sapiens
Akiyama, H.; Nakadate, K.; Sakakibara, S.I.
Synaptic localization of the SUMOylation-regulating protease SENP5 in the adult mouse brain
J. Comp. Neurol.
526
990-1005
2018
Mus musculus (Q9EP97), Mus musculus
Yu, X.; Lao, Y.; Teng, X.L.; Li, S.; Zhou, Y.; Wang, F.; Guo, X.; Deng, S.; Chang, Y.; Wu, X.; Liu, Z.; Chen, L.; Lu, L.M.; Cheng, J.; Li, B.; Su, B.; Jiang, J.; Li, H.B.; Huang, C.; Yi, J.; Zou, Q.
SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation
Nat. Commun.
9
3157
2018
Mus musculus (Q9EP97)
Wu, D.; Huang, C.J.; Khan, F.A.; Jiao, X.F.; Liu, X.M.; Pandupuspitasari, N.S.; Brohi, R.D.; Huo, L.J.
SENP3 grants tight junction integrity and cytoskeleton architecture in mouse Sertoli cells
Oncotarget
8
58430-58442
2017
Mus musculus (Q9EP97), Mus musculus
Liu, Y.; Yu, F.; Han, Y.; Li, Q.; Cao, Z.; Xiang, X.; Jiang, S.; Wang, X.; Lu, J.; Lai, R.; Wang, H.; Cai, W.; Bao, S.; Xie, Q.
SUMO-specific protease 3 is a key regulator for hepatic lipid metabolism in non-alcoholic fatty liver disease
Sci. Rep.
6
37351
2016
Rattus norvegicus (G3V7S5), Homo sapiens (Q9H4L4), Homo sapiens
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