3.4.22.B72: SENP3 peptidase

This is an abbreviated version!
For detailed information about SENP3 peptidase, go to the full flat file.

Reaction

The enzyme catalyzes the desumoylation of SUMO2 or SUMO3-modified target proteins, but has only weak activity against SUMO1 conjugates. SENP2 catalyzes deconjugation of SUMO2 from nucleophosmin 1. =

Synonyms

SENP3, sentrin-specific protease 3, small ubiquitin-like modifier-specific protease 3, SUMO-2/3-specific protease, SUMO-specific isopeptidase, SUMO-specific protease 3, SUMO-specific proteases 3, SUMO2/3-specific protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B72 SENP3 peptidase

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Results	in table
1	Activating Compound
3	AA Sequence
2	Cloned(Commentary)
202	Disease/ Diagnostics
8	Expression
26	General Information
3	General Stability
1	Inhibitors
14	Localization
9	Natural Substrates/ Products (Substrates)
187	Organism
3	Posttranslational Modification
1	Protein Variants
1	Reaction
20	Reference
44	Source Tissue
20	Substrates and Products (Substrate)
22	Synonyms

Natural Substrates Products

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Natural Substrates Products on EC 3.4.22.B72 - SENP3 peptidase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(SUMO-2)-nucleophosmin 1 conjugate + H2O

SUMO-2 + nucleophosmin 1

Homo sapiens

-

SENP3 as an essential factor for ribosome biogenesis. It is suggested that deconjugation of SUMO2 from nucleophosmin 1 (NPM1) by SENP3 is critically involved in 28S rRNA maturation

679510

-

-

?

(SUMO-2)-p300 protein + H2O

(SUMO-2) + p300 protein

Homo sapiens

Q9H4L4

removing SUMO2/3 from p300 enhances its binding to HIF-1alpha. SENP3 is a redox sensor that regulates hypoxia-inducible factor-1alpha transcriptional activity under oxidative stress through the de-SUMOylation of p300

714827

-

-

?

(SUMO-2/3)-promyelocytic leukemia protein + H2O

SUMO-2/3 + promyelocytic leukemia protein

Homo sapiens

Q9H4L4

SENP3 appears to be a key mediator in mild oxidative stress-induced cell proliferation via regulation of the SUMOylation status of promyelocytic leukemia protein. SENP3-mediated de-conjugation of SUMO2/3 from PML is responsible for accelerated cell proliferation and decreased promyelocytic leukemia bodies under mild oxidative stress

715504

-

-

?

(SUMO2)-Borealin protein + H2O

SUMO2 + Borealin protein

Homo sapiens

Q9H4L4

Borealin is dynamically modified by SUMO2/3 during mitosis

716162

-

-

?

SUMOylated FOXC2 + H2O

FOXC2 + SUMO

Homo sapiens

-

deSUMOylation by enzyme SENP3

732595

-

-

?

SUMOylated GTPase Drp1 + H2O

GTPase Drp1 + SUMO

Homo sapiens

-

the substrate is a key target for SENP3-mediated deSUMOylation

731711

-

-

?

SUMOylated RbBP5 + H2O

RbBP5 + SUMO

Homo sapiens

-

deSUMOylation by enzyme SENP3, the protein is part of SET1/MLL complexes

732510

-

-

?

additional information

?

-

2 entries

additional information

?

-

Mus musculus

-

SUMO-2/3-conjugated targets are more successfully deconjugated by SENP3 than SUMO-1-containing species

731628

-

-

?

additional information

?

-

Mus musculus ICR

-

SUMO-2/3-conjugated targets are more successfully deconjugated by SENP3 than SUMO-1-containing species

731628

-

-

?