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Literature summary for 3.4.22.B72 extracted from

  • Haindl, M.; Harasim, T.; Eick, D.; Muller, S.
    The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing (2008), EMBO Rep., 9, 273-279.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B72

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus the nucleolar SUMO-specific protease SENP3 is associated with nucleophosmin, a crucial factor in ribosome biogenesis Homo sapiens 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(SUMO-2)-nucleophosmin 1 conjugate + H2O Homo sapiens SENP3 as an essential factor for ribosome biogenesis. It is suggested that deconjugation of SUMO2 from nucleophosmin 1 (NPM1) by SENP3 is critically involved in 28S rRNA maturation SUMO-2 + nucleophosmin 1
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(SUMO-2)-nucleophosmin 1 conjugate + H2O
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 Homo sapiens SUMO-2 + nucleophosmin 1
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 ?
(SUMO-2)-nucleophosmin 1 conjugate + H2O SENP3 as an essential factor for ribosome biogenesis. It is suggested that deconjugation of SUMO2 from nucleophosmin 1 (NPM1) by SENP3 is critically involved in 28S rRNA maturation Homo sapiens SUMO-2 + nucleophosmin 1
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 ?

General Information

General Information Comment Organism
malfunction depletion of SENP3 by short interfering RNA interferes with nucleolar ribosomal RNA processing and inhibits the conversion of the 32S rRNA species to the 28S form, thus phenocopying the processing defect observed on depletion of nucleophosmin 1 (NPM1) Homo sapiens
physiological function SENP3 as an essential factor for ribosome biogenesis. It is suggested that deconjugation of SUMO2 from nucleophosmin 1 (NPM1) by SENP3 is critically involved in 28S rRNA maturation Homo sapiens