3.4.22.B72: SENP3 peptidase

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For detailed information about SENP3 peptidase, go to the full flat file.

Reaction

The enzyme catalyzes the desumoylation of SUMO2 or SUMO3-modified target proteins, but has only weak activity against SUMO1 conjugates. SENP2 catalyzes deconjugation of SUMO2 from nucleophosmin 1. =

Synonyms

SENP3, sentrin-specific protease 3, small ubiquitin-like modifier-specific protease 3, SUMO-2/3-specific protease, SUMO-specific isopeptidase, SUMO-specific protease 3, SUMO-specific proteases 3, SUMO2/3-specific protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B72 SENP3 peptidase

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Results	in table
1	Activating Compound
3	AA Sequence
2	Cloned(Commentary)
202	Disease/ Diagnostics
8	Expression
26	General Information
3	General Stability
1	Inhibitors
14	Localization
9	Natural Substrates/ Products (Substrates)
187	Organism
3	Posttranslational Modification
1	Protein Variants
1	Reaction
20	Reference
44	Source Tissue
20	Substrates and Products (Substrate)
22	Synonyms

Expression

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Expression on EC 3.4.22.B72 - SENP3 peptidase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

correlation between the clinicopathological features and SENP3 expression, overview

Homo sapiens

-

732594

expression of SUMO2/3-specific protease, SENP3 increases after treatment with 50 mM H2O2, and this increase occurs in a dose-dependent manner

Homo sapiens

Q9H4L4

714827

low doses of hydrogen peroxide induce an increase of the SENP3 protein

Homo sapiens

Q9H4L4

715504

SENP3 is over-accumulated in a variety of primary human cancers including colon adenocarcinoma

Homo sapiens

Q9H4L4

715504

the enzyme is significantly upregulated in subarachnoid hemorrhage, the expression of SENP3 is increased in the brain cortex, in neurons, rather than astrocytes nor microglia

2 entries

traumatic brain injury upregulates the enzyme expression in the brain, especially in the neurons and astrocytes

2 entries

the enzyme is significantly upregulated in subarachnoid hemorrhage, the expression of SENP3 is increased in the brain cortex, in neurons, rather than astrocytes nor microglia

Rattus norvegicus

-

731627

the enzyme is significantly upregulated in subarachnoid hemorrhage, the expression of SENP3 is increased in the brain cortex, in neurons, rather than astrocytes nor microglia

Rattus norvegicus Sprague-Dawley

-

-

traumatic brain injury upregulates the enzyme expression in the brain, especially in the neurons and astrocytes

Mus musculus

-

731628

traumatic brain injury upregulates the enzyme expression in the brain, especially in the neurons and astrocytes

Mus musculus ICR

-

-