3.4.22.B72: SENP3 peptidase

This is an abbreviated version!
For detailed information about SENP3 peptidase, go to the full flat file.

Word Map on EC 3.4.22.B72

3.4.22.B72

sumoylation

senps

deconjugation

isopeptidase

de-sumoylation

ranbp2

de-conjugating

Reaction

The enzyme catalyzes the desumoylation of SUMO2 or SUMO3-modified target proteins, but has only weak activity against SUMO1 conjugates. SENP2 catalyzes deconjugation of SUMO2 from nucleophosmin 1. =

Synonyms

SENP3, sentrin-specific protease 3, small ubiquitin-like modifier-specific protease 3, SUMO-2/3-specific protease, SUMO-specific isopeptidase, SUMO-specific protease 3, SUMO-specific proteases 3, SUMO2/3-specific protease

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.B72 SENP3 peptidase

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Results	in table
1	Activating Compound
3	AA Sequence
2	Cloned(Commentary)
202	Disease/ Diagnostics
8	Expression
26	General Information
3	General Stability
1	Inhibitors
14	Localization
9	Natural Substrates/ Products (Substrates)
187	Organism
3	Posttranslational Modification
1	Protein Variants
1	Reaction
20	Reference
44	Source Tissue
20	Substrates and Products (Substrate)
22	Synonyms

Inhibitors

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Inhibitors on EC 3.4.22.B72 - SENP3 peptidase

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additional information

Homo sapiens

PERK activation is required for decreased SENP3 activity, overexpression of HA-tagged PERK causes loss of Flag-tagged SENP3 activity in HEK293 cells via a mechanism dependent on PERK kinase activity, which is blocked by overexpression of the PERK inhibitor p58IPK

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