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Literature summary for 3.4.22.B72 extracted from

  • Yu, Z.; Li, H.; Yan, H.Y.; Yang, Y.Q.; Zhang, D.D.; Huang, L.T.; Xie, G.B.; Liu, M.; Tohti, M.; Hang, C.H.
    Expression and cell distribution of SENP3 in brain tissue after traumatic brain injury in mice: a pilot study (2015), Cell. Mol. Neurobiol., 35, 733-740.
    View publication on PubMed
Search for more literature for 3.4.22.B72

Cloned(Commentary)

Cloned (Comment) Organism
SENP3 quantitative real-time PCR expression analysis Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus SUMO-2/3-conjugated targets are more successfully deconjugated by SENP3 than SUMO-1-containing species ?
-
 ?
additional information Mus musculus ICR SUMO-2/3-conjugated targets are more successfully deconjugated by SENP3 than SUMO-1-containing species ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus ICR
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Mus musculus
-
brain spatial and temporal expression patterns of SENP3, overview Mus musculus
-
cerebral cortex dynamic changes in SENP3 expression in the cerebral cortex and in its cellular localization in traumatic brain injury compared to normal, overview Mus musculus
-
additional information immunohistochemical and expression anaysis of the enzyme in brain tissues, overview Mus musculus
-
neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information SUMO-2/3-conjugated targets are more successfully deconjugated by SENP3 than SUMO-1-containing species Mus musculus ?
-
 ?
additional information enzyme SENP3 deconjugates SUMO2/3 from protein substrates Mus musculus ?
-
 ?
additional information SUMO-2/3-conjugated targets are more successfully deconjugated by SENP3 than SUMO-1-containing species Mus musculus ICR ?
-
 ?
additional information enzyme SENP3 deconjugates SUMO2/3 from protein substrates Mus musculus ICR ?
-
 ?

Synonyms

Synonyms Comment Organism
SENP3
-
 Mus musculus
SUMO-specific proteases 3
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus traumatic brain injury upregulates the enzyme expression in the brain, especially in the neurons and astrocytes up

General Information

General Information Comment Organism
evolution the enzyme is a member of the small ubiquitin-like modifier-specific protease family Mus musculus
physiological function the enzyme SENP3 is critical for maintaining the level of SUMOylated and un-SUMOylated substrates required for normal physiology because of its isopeptidase activity, whereby it cleaves the isopeptide bond between SUMO and substrate proteins, as a result, SENP3 may weaken the neuroprotective effect of SUMO-2/3 Mus musculus