Any feedback?
Literature summary for 3.4.22.B72 extracted from
- De-SUMOylation of FOXC2 by SENP3 promotes the epithelial-mesenchymal transition in gastric cancer cells (2014), Oncotarget, 5, 7093-7104.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | generation of HEK293T-sh-SENP3 stable cells | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| SUMOylated FOXC2 + H2O | Homo sapiens | deSUMOylation by enzyme SENP3 | FOXC2 + SUMO | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| carcinoma cell | the enzyme accumulates in a variety of cancers | Homo sapiens | - |
| gastric cancer cell | correlation between SENP3 expression and gastric cancer metastasis | Homo sapiens | - |
| MGC-803 cell | - |
Homo sapiens | - |
| SGC-7901 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| SUMOylated FOXC2 + H2O | deSUMOylation by enzyme SENP3 | Homo sapiens | FOXC2 + SUMO | - |
? | |
| SUMOylated FOXC2 + H2O | deSUMOylation by enzyme SENP3, deconjugation of SUMO2/3 | Homo sapiens | FOXC2 + SUMO | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SENP3 | - |
Homo sapiens |
| SUMO2/3-specific protease | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | expression of mesenchymal marker genes and cell migration ability are enhanced in SENP3-overexpressing gastric cancer cells and attenuated in SENP3-knockdown cells | Homo sapiens |
| metabolism | correlation between SENP3 expression and gastric cancer metastasis | Homo sapiens |
| additional information | SENP3, a redox-sensitive SUMO2/3-specific protease | Homo sapiens |
| physiological function | the enzyme potentiates the transcriptional activity of FOXC2 through deSUMOylation, in favor of the induction of specific mesenchymal gene expression in gastric cancer metastasis. And the enzyme upregulates the transcription of N-cadherin through deSUMOlyation of FOXC2 | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
