3.4.22.43: cathepsin V
This is an abbreviated version!
For detailed information about cathepsin V, go to the full flat file.
Word Map on EC 3.4.22.43
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3.4.22.43
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cathepsins
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papain-like
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elastases
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elastolytic
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legumain
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l-like
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medicine
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diagnostics
- 3.4.22.43
- cathepsins
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papain-like
- elastases
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elastolytic
- legumain
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l-like
- medicine
- diagnostics
Reaction
The recombinant enzyme hydrolyses proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec) =
Synonyms
cathepsin L2, cathepsin L2/V, cathepsin like 2, cathepsin U, cathepsin V, cathepsin V/L2, cathepsin-V, CatV, CL2, CTSL2, CTSV, CV/L2, hcatV, More, stratum corneum thiol protease
ECTree
3.4.22.43 cathepsin VAdvanced search results
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results (Source Tissue
Source Tissue on EC 3.4.22.43 - cathepsin V
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
cathepsin V localized to endothelial cells in areas rich of neovascularization
from healthy subjects and Besnier-Boeck-Schaumann (BBS) disease patients, the latter show decreased cathepsin V concentrations, while contents of endostatin, an inhibitor of lung epithelial cells, are increased
recombinant human cathepsin V for inhibition studies, N-terminal propeptide domains as inhibitors of cathepsin V
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in the human thymic cortex, CTSV is the predominately expressed protease
additional information
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normal and keratoconus corneas, the latter show a 1.5fold increased cathepsin V expression level, expression pattern, overview
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localization of the enzyme in the root sheets of the hair follicle
plasminogen processing by cathepsin V, angiogenesis inhibition activity determined in
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in plaque areas of diseased blood vessels, cathepsin expression levels during differentiation, overview
CTSV is highly expressed across the entire epidermis in normal skin. But CTSV expression levels are lower in the basal layer than those in the stratum corneum side in the hyperpigmented region
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in extracellular space associated to corneodesmosomes, co-localization of the enzyme and inhibitor cystatin M/E
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co-localization of the enzyme and inhibitor cystatin M/E, which are separately transported within lamellar granules
additional information
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no expression in colon, lung, trachea, ureter, testis, heart, muscle, aorta, spleen, and mammary gland
