Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60911 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Homo sapiens | - |
colorectal cancer cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
RKO cell | - |
Homo sapiens | - |
SW-620 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
cathepsin L2 | - |
Homo sapiens |
cathepsin like 2 | - |
Homo sapiens |
cathepsin V | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | E2F1 activates cathepsin like 2 gene promoter activity | up |
General Information | Comment | Organism |
---|---|---|
malfunction | RNAi-mediated depletion of the enzyme effectively abrogates ectopic E2F1-induced apoptosis, coupled with reduced lysosomal membrane permeabilization and mitochondrial membrane depolarization. Enzyme knockdown also inhibits apoptosis mediated by the endogenous E2F1 activated by DNA damage. Enzyme depletion in cancer cells results in inhibition of histone deacetylase inhibitor-induced apoptosis | Homo sapiens |
physiological function | cathepsin like 2 is required for E2F1-induced apoptosis by engaging lysosomal membrane permeabilization. Its level also modulates the cellular sensitivity to histone deacetylase inhibitor | Homo sapiens |