3.4.22.43: cathepsin V

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For detailed information about cathepsin V, go to the full flat file.

Reaction

The recombinant enzyme hydrolyses proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec) =

Synonyms

cathepsin L2, cathepsin L2/V, cathepsin like 2, cathepsin U, cathepsin V, cathepsin V/L2, cathepsin-V, CatV, CL2, CTSL2, CTSV, CV/L2, hcatV, More, stratum corneum thiol protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.43 cathepsin V

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Results	in table
1	Activating Compound
12	AA Sequence
3	Application
1	CAS Registry Number
17	Cloned(Commentary)
3	Crystallization (Commentary)
127	Disease/ Diagnostics
6	Expression
14	General Information
16	IC50 Value
63	Inhibitors
8	kcat/KM [mM/s]
17	Ki Value [mM]
13	KM Value [mM]
11	Localization
1	Metals/Ions
15	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
37	Organism
6	PDB ID
9	pH Optimum
3	pH Range
6	pH Stability
6	Posttranslational Modification
4	Protein Variants
6	Purification (Commentary)
2	Reaction
1	Reaction Type
37	Reference
86	Source Tissue
5	Specific Activity [micromol/min/mg]
64	Substrates and Products (Substrate)
8	Subunits
33	Synonyms
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
13	Turnover Number [1/s]

pH Range

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pH Range on EC 3.4.22.43 - cathepsin V

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

4 - 6

Homo sapiens

-

cathepsin V is active at pH 4.0 and 6.0

717159

4 - 7.2

Homo sapiens

O60911

less than 50% of maximal activity above and below

137269

additional information

Homo sapiens

-

bell-shaped pH profile

668763