3.4.22.43: cathepsin V

This is an abbreviated version!
For detailed information about cathepsin V, go to the full flat file.

Reaction

The recombinant enzyme hydrolyses proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec) =

Synonyms

cathepsin L2, cathepsin L2/V, cathepsin like 2, cathepsin U, cathepsin V, cathepsin V/L2, cathepsin-V, CatV, CL2, CTSL2, CTSV, CV/L2, hcatV, More, stratum corneum thiol protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.43 cathepsin V

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Results	in table
1	Activating Compound
12	AA Sequence
3	Application
1	CAS Registry Number
17	Cloned(Commentary)
3	Crystallization (Commentary)
127	Disease/ Diagnostics
6	Expression
14	General Information
16	IC50 Value
63	Inhibitors
8	kcat/KM [mM/s]
17	Ki Value [mM]
13	KM Value [mM]
11	Localization
1	Metals/Ions
15	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
37	Organism
6	PDB ID
9	pH Optimum
3	pH Range
6	pH Stability
6	Posttranslational Modification
4	Protein Variants
6	Purification (Commentary)
2	Reaction
1	Reaction Type
37	Reference
86	Source Tissue
5	Specific Activity [micromol/min/mg]
64	Substrates and Products (Substrate)
8	Subunits
33	Synonyms
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
13	Turnover Number [1/s]

IC50 Value

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of the Enzyme Summary Page.

IC50 Value on EC 3.4.22.43 - cathepsin V

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0039

1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-methyl-9-acridone

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.0025

1,3,5-trihydroxy-4-methoxy-10-methyl-2,8-bis(3-methylbut-2-enyl)acridin-9(10H)-one

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.0052

2,3-dihydro-4,9-dihydroxy-2-(2-hydroxy-propan-2-yl)-11-methoxy-10-methylfuro[3,2-b]acridin-5(10H)-one

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.0028

3,4-dihydro-3,5,8-trihydroxy-6-methoxy-2,2,7-trimethyl-2H-pyrano[2,3-a]acridin-12(7H)-one

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.024

4-fluoro-N-prop-2-yn-1-yl-N2-[(1S)-2,2,2-trifluoro-1-[4'-(methanesulfonyl)[1,1'-biphenyl]-4-yl]ethyl]-L-leucinamide

Homo sapiens

P07711

50 mM MES pH 5.5, 25 mM EDTA and 2.5 mM DTT. 0.05% Tween 20 (v/v), 37°C

753977

0.048

5-hydroxynoracronycine

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.0012

citibrasine

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.0022

citrusinine-I

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.01

citrusinine-II

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.025

glycocitrine-I

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.0022

glycocitrine-IV

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.000016

N-(3-bromoprop-2-yn-1-yl)-4-fluoro-N2-[(1S)-2,2,2-trifluoro-1-[4'-(methanesulfonyl)[1,1'-biphenyl]-4-yl]ethyl]-L-leucinamide

Homo sapiens

P07711

50 mM MES pH 5.5, 25 mM EDTA and 2.5 mM DTT. 0.05% Tween 20 (v/v), 37°C

753977

0.00091

N-(cyanomethyl)-4-fluoro-N2-[(1S)-2,2,2-trifluoro-1-[4'-(methanesulfonyl)[1,1'-biphenyl]-4-yl]ethyl]-L-leucinamide

Homo sapiens

P07711

50 mM MES pH 5.5, 25 mM EDTA and 2.5 mM DTT. 0.05% Tween 20 (v/v), 37°C

753977

0.046

N-but-3-yn-2-yl-4-fluoro-N2-[(1S)-2,2,2-trifluoro-1-[4'-(methanesulfonyl)[1,1'-biphenyl]-4-yl]ethyl]-L-leucinamide

Homo sapiens

P07711

50 mM MES pH 5.5, 25 mM EDTA and 2.5 mM DTT. 0.05% Tween 20 (v/v), 37°C

753977

0.0006

odanacatib

Homo sapiens

P07711

50 mM MES pH 5.5, 25 mM EDTA and 2.5 mM DTT. 0.05% Tween 20 (v/v), 37°C

753977

0.044

pyranofoline

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374