3.4.22.43: cathepsin V
This is an abbreviated version!
For detailed information about cathepsin V, go to the full flat file.
Word Map on EC 3.4.22.43
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3.4.22.43
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cathepsins
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papain-like
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elastases
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elastolytic
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legumain
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l-like
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medicine
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diagnostics
- 3.4.22.43
- cathepsins
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papain-like
- elastases
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elastolytic
- legumain
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l-like
- medicine
- diagnostics
Reaction
The recombinant enzyme hydrolyses proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec) =
Synonyms
cathepsin L2, cathepsin L2/V, cathepsin like 2, cathepsin U, cathepsin V, cathepsin V/L2, cathepsin-V, CatV, CL2, CTSL2, CTSV, CV/L2, hcatV, More, stratum corneum thiol protease
ECTree
3.4.22.43 cathepsin VAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.22.43 - cathepsin V
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Elastin + H2O
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elastin degradation activity leading to loss of elasticity in atherosclerosis
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plasminogen + H2O
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capability of recombinant human cathepsin V to hydrolyze plasminogen analyzed, physiological role for cathepsin V related to the control of neovascularization in cornea suggested
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plasminogen + H2O
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cathepsin V hydrolyzes plasminogen at Phe94-Glu95, Ser358-Thr359, and Val468-Leu469 generating angiostatin-related fragments
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?
additional information
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the corneal enzyme stays within cells and is not secreted, suggesting that components of the corneal epithelium are likely substrates
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?
additional information
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the predominant expression in thymus suggests a role in the immune system, the expression in testes suggests a role in fertilization processes, the expression in cancer cells together with its absence in normal cells suggests a role in tumor processes
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?
additional information
?
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the enzyme and inhibitor cystatin M/E are involved in regulation of epidermal differentiation
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?
additional information
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the enzyme can stimulate H2O2 production, enzyme expression is increased in keratoconus corneas compared to healthy ones, oxidative stress might be involved in the disorder
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additional information
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direct interaction of cathepsin V with TLR4 and its adaptor protein MyD88
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additional information
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direct interaction of cathepsin V with TLR4 and its adaptor protein MyD88
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?
