3.4.22.43: cathepsin V

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For detailed information about cathepsin V, go to the full flat file.

Reaction

The recombinant enzyme hydrolyses proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec) =

Synonyms

cathepsin L2, cathepsin L2/V, cathepsin like 2, cathepsin U, cathepsin V, cathepsin V/L2, cathepsin-V, CatV, CL2, CTSL2, CTSV, CV/L2, hcatV, More, stratum corneum thiol protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.43 cathepsin V

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Results	in table
1	Activating Compound
12	AA Sequence
3	Application
1	CAS Registry Number
17	Cloned(Commentary)
3	Crystallization (Commentary)
127	Disease/ Diagnostics
6	Expression
14	General Information
16	IC50 Value
63	Inhibitors
8	kcat/KM [mM/s]
17	Ki Value [mM]
13	KM Value [mM]
11	Localization
1	Metals/Ions
15	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
37	Organism
6	PDB ID
9	pH Optimum
3	pH Range
6	pH Stability
6	Posttranslational Modification
4	Protein Variants
6	Purification (Commentary)
2	Reaction
1	Reaction Type
37	Reference
86	Source Tissue
5	Specific Activity [micromol/min/mg]
64	Substrates and Products (Substrate)
8	Subunits
33	Synonyms
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
13	Turnover Number [1/s]

Purification

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Purification on EC 3.4.22.43 - cathepsin V

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PURIFICATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Homo sapiens

-

137272

gel filtration, pre-activated before use

Homo sapiens

O60911

683662

gel filtration, recombinant human cathepsin V

Homo sapiens

O60911

683210

Ni-NTA column chromatography

Homo sapiens

O60911

732867

recombinant enzyme from Pichia pastoris to homogeneity, activated mature native enzyme by hyrophobic interaction chromatography, recombinant GST-tagged enzyme from Escherichia coli by glutathione affinity chromatography

Homo sapiens

-

668763

recombinant enzyme from Pichia pastoris, further purified by gel filtration after activation by pepsin treatment

Homo sapiens

-

669257