3.4.21.77: semenogelase
This is an abbreviated version!
For detailed information about semenogelase, go to the full flat file.
Word Map on EC 3.4.21.77
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3.4.21.77
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gleason
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prostatectomy
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androgen
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rectal
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radiotherapy
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preoperative
-
hyperplasia
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transrectal
-
urinary
-
metastases
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adenocarcinoma
-
lymph
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node
-
castration-resistant
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testosterone
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postoperative
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ultrasound
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oncology
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univariate
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high-risk
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urological
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pelvic
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beam
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surveillance
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progression-free
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staging
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high-grade
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lncap
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low-risk
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docetaxel
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nadir
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cancer-specific
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brachytherapy
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transurethral
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androgen-independent
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ultrasound-guided
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multiparametric
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neoadjuvant
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intermediate-risk
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nomogram
-
suspicious
-
urologist
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mcrpc
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antiandrogens
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ultrasonography
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lymphadenectomy
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erectile
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incontinence
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actuarial
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cause-specific
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analysis
-
medicine
-
diagnostics
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drug development
- 3.4.21.77
-
gleason
-
prostatectomy
- androgen
- rectal
-
radiotherapy
-
preoperative
- hyperplasia
-
transrectal
- urinary
- metastases
- adenocarcinoma
- lymph
- node
-
castration-resistant
- testosterone
-
postoperative
-
ultrasound
-
oncology
-
univariate
-
high-risk
- urological
-
pelvic
-
beam
-
surveillance
-
progression-free
-
staging
-
high-grade
-
lncap
-
low-risk
- docetaxel
-
nadir
-
cancer-specific
-
brachytherapy
-
transurethral
-
androgen-independent
-
ultrasound-guided
-
multiparametric
-
neoadjuvant
-
intermediate-risk
-
nomogram
-
suspicious
-
urologist
-
mcrpc
-
antiandrogens
-
ultrasonography
-
lymphadenectomy
-
erectile
- incontinence
-
actuarial
-
cause-specific
- analysis
- medicine
- diagnostics
- drug development
Reaction
Preferential cleavage: -Tyr-/- =
Synonyms
7S nerve growth factor gamma chain, antigen (human clone lambdaHPSA-1 prostate-specific protein moiety reduced), antigen PSA (human clone 5P1 protein moiety reduced), antigen PSA (human prostate-specific), gama-SM protein, gamma-NGF, gamma-seminoglycoprotein (human protein moiety reduced), gamma-seminoprotein, gamma-SM, GK3, glandular kallikrein, glandular kallikrein 3, hK3/PSA, K3, K4, kallikrein 3, kallikrein-related peptidase 3, kallikrein-related peptidase-3, KLK3, P-30 antigen, prostate specific antigen, prostate stem cell antigen, prostate-specific antigen, prostate-specific antigen kallikrein, Prostate-specific membrane antigen, PSA, PSA-SV5, PSCA, PSMA, S01.162, seminal proteinase, seminin, six-transmembrane epithelial antigen of the prostate, STEAP, tissue kallikrein
ECTree
3.4.21.77 semenogelaseAdvanced search results
results (
results (Activating Compound
Activating Compound on EC 3.4.21.77 - semenogelase
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
AUY922
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reduces PSA concentration in a dose-dependent manner (2fold more than insulin-like growth factor-binding protein 2) and is accompanied by androgen receptor decrease
dihydrotestosterone
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hormonal treatment of BT-474 cells with dihydrotestosterone (an androgen) for 48 h triggers an increase of prostate-specific antigen concentration in the supernatant of these cells
norgestrel
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hormonal treatment of BT-474 cells with norgestrel (an androgenic progestin) for 48 h triggers an increase of prostate-specific antigen concentration in the supernatant of these cells
CVAYCIEHHCWTC
with disulfide bridges between cysteines 1-13 and 5-10, stimulates the activity of the enzyme towards small peptide substrates, and also enhances the proteolytic activity towards protein substrates
CVFAHNYDYLVC
stimulates the activity of the enzyme towards small peptide substrates, and also enhances the proteolytic activity towards protein substrates. No activation of the enzyme by the inactive derivative of peptide B2-NH2, CVFAHNADALVC, with a disulfide bridge between cysteines 1-12
additional information
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inactive proPSA enzyme can be activated by recombinant kallikrein 2 to the mature form
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additional information
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monoclonal antibody 8G8F5 enhances enzymatic activity. It recognizes an epitope composed of five discontinuous segments including residues from the kallikrein loop and stabilizes PSA in an open and active conformation that accelerates catalysis
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additional information
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rate of PSA increase is related to the aggressiveness of the prostate cancer and associated with clinical stage, biopsy grade and initial PSA
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additional information
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PSA is produced at high levels by both androgen-dependent and -independent prostate cancers
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additional information
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PSA-alpha1-antichymotrypsin complex is cleared from the blood, but as its concentration increases its clearance mechanism becomes saturated and only then do the PSA-alpha1-antichymotrypsin complexes accumulate in the blood
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additional information
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serum PSA also increases with benign prostatic hypertrophy, prostatitis, prostate trauma and drugs
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additional information
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the prostate that produce several proteases can activate proPSA. A peptide that stimulates the activity of PSA enhaces the antiangiogenic effect
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additional information
nidogen-1, galectin-3 or their fragments produced by the enzyme do not have any effect on endothelial cell tube formation
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