Activating Compound | Comment | Organism | Structure |
---|---|---|---|
B2-peptide | - |
Homo sapiens |
Application | Comment | Organism |
---|---|---|
drug development | compounds inhibiting the activity of prostate-specific antigen, prevent the anti-angiogenic effect of prostate-specific antigen in an angiogenesis model | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in HUVEC cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2-methoxyphenyl)(3-phenyl-1H-1,2,4-triazol-1-yl)methanone | - |
Homo sapiens | |
(3,4-dimethoxyphenyl)(5-(4-fluorobenzylamino)-3-phenyl-1H-1,2,4-triazol-1-yl)methanone | - |
Homo sapiens | |
(5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(2-chlorophenyl)methanone | - |
Homo sapiens | |
(5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(2-methoxyphenyl)methanone | - |
Homo sapiens | |
(5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(3,4-dimethoxyphenyl)methanone | 360 nanomol inhibits by 83% | Homo sapiens | |
(5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(4-chlorophenyl)methanone | - |
Homo sapiens | |
(5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(4-fluorophenyl)methanone | - |
Homo sapiens | |
(5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(4-methoxyphenyl)methanone | 360 nanomol inhibits by 56% | Homo sapiens | |
(5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(4-nitrophenyl)methanone | - |
Homo sapiens | |
(5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(p-tolyl)methanone | - |
Homo sapiens | |
(5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(phenyl)methanone | - |
Homo sapiens | |
(5-amino-3-phenyl-1H-1,2,4-triazol-1-yl)(3,4-dimethoxyphenyl)methanone | - |
Homo sapiens | |
1-(3-chlorobenzyl)-3-phenyl-1H-pyrazol-5-amine | - |
Homo sapiens | |
1-benzyl-3-phenyl-1H-pyrazol-5-amine | - |
Homo sapiens | |
2-(2-methyl-3-nitrophenyl)-4-oxo-4H-3,1-benzoxazin-6-yl acetate | - |
Homo sapiens | |
2-(2-methyl-3-nitrophenyl)-4H-3,1-benzoxazin-4-one | 360 nanomol inhibits by 61% | Homo sapiens | |
2-(2-methylphenyl)-4H-3,1-benzoxazin-4-one | - |
Homo sapiens | |
2-(2-nitrophenyl)-4H-3,1-benzoxazin-4-one | - |
Homo sapiens | |
2-(3-methylphenyl)-4H-3,1-benzoxazin-4-one | - |
Homo sapiens | |
2-(3-nitrophenyl)-4H-3,1-benzoxazin-4-one | - |
Homo sapiens | |
2-(4-bromophenyl)quinazolin-4(3H)-one | - |
Homo sapiens | |
2-(4-methylphenyl)-4H-3,1-benzoxazin-4-one | - |
Homo sapiens | |
2-phenyl-4H-3,1-benzoxazin-4-one | - |
Homo sapiens | |
2-phenylquinazolin-4(3H)-one | - |
Homo sapiens | |
4-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)phenyl acetate | - |
Homo sapiens | |
6-bromo-2-(2-methyl-3-nitrophenyl)-4H-3,1-benzoxazin-4-one | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.4 | - |
4-morpholinecarbonyl-HSSKLQ-AMC | prostate-specific antigen without inhibitor | Homo sapiens | |
1.5 | - |
4-morpholinecarbonyl-HSSKLQ-AMC | prostate-specific antigen and inhibitor 2-(2-methyl-3-nitrophenyl)-4H-3,1-benzoxazin-4-one (25 micromol) | Homo sapiens | |
1.6 | - |
4-morpholinecarbonyl-HSSKLQ-AMC | prostate-specific antigen and inhibitor 2-(2-methyl-3-nitrophenyl)-4H-3,1-benzoxazin-4-one (5 micromol) | Homo sapiens | |
2.6 | - |
4-morpholinecarbonyl-HSSKLQ-AMC | prostate-specific antigen and inhibitor (5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(4-methoxyphenyl)methanone (5 micromol) | Homo sapiens | |
4.2 | - |
4-morpholinecarbonyl-HSSKLQ-AMC | prostate-specific antigen and inhibitor (5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(3,4-dimethoxyphenyl)methanone (5 micromol) | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
from seminal plasma | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
seminal plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-morpholinecarbonyl-HSSKLQ-AMC + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | proteolytic activity of prostate-specific antigen is essential for inhibition of angiogenesis | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KLK3 | - |
Homo sapiens |
prostate-specific antigen | - |
Homo sapiens |
PSA | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0003 | - |
- |
Homo sapiens | 2-(2-methyl-3-nitrophenyl)-4H-3,1-benzoxazin-4-one | |
0.0005 | - |
- |
Homo sapiens | (5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(3,4-dimethoxyphenyl)methanone | |
0.0009 | - |
- |
Homo sapiens | (5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(4-methoxyphenyl)methanone | |
0.0022 | - |
- |
Homo sapiens | (5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(4-chlorophenyl)methanone | |
0.0038 | - |
- |
Homo sapiens | (5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(p-tolyl)methanone | |
0.0041 | - |
- |
Homo sapiens | (5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(4-fluorophenyl)methanone | |
0.0054 | - |
- |
Homo sapiens | 2-(2-methyl-3-nitrophenyl)-4-oxo-4H-3,1-benzoxazin-6-yl acetate | |
0.0096 | - |
- |
Homo sapiens | (5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(phenyl)methanone | |
0.0142 | - |
- |
Homo sapiens | 2-(2-nitrophenyl)-4H-3,1-benzoxazin-4-one | |
0.0163 | - |
- |
Homo sapiens | (5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(2-chlorophenyl)methanone | |
0.0169 | - |
- |
Homo sapiens | (5-amino-3-phenyl-1H-1,2,4-triazol-1-yl)(3,4-dimethoxyphenyl)methanone | |
0.0291 | - |
- |
Homo sapiens | 2-(2-methylphenyl)-4H-3,1-benzoxazin-4-one | |
0.0298 | - |
- |
Homo sapiens | (5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(2-methoxyphenyl)methanone | |
0.049 | - |
- |
Homo sapiens | 6-bromo-2-(2-methyl-3-nitrophenyl)-4H-3,1-benzoxazin-4-one | |
0.08 | - |
- |
Homo sapiens | (2-methoxyphenyl)(3-phenyl-1H-1,2,4-triazol-1-yl)methanone | |
0.08 | - |
- |
Homo sapiens | (3,4-dimethoxyphenyl)(5-(4-fluorobenzylamino)-3-phenyl-1H-1,2,4-triazol-1-yl)methanone | |
0.08 | - |
- |
Homo sapiens | (5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(4-nitrophenyl)methanone | |
0.08 | - |
- |
Homo sapiens | 1-(3-chlorobenzyl)-3-phenyl-1H-pyrazol-5-amine | |
0.08 | - |
- |
Homo sapiens | 1-benzyl-3-phenyl-1H-pyrazol-5-amine | |
0.08 | - |
- |
Homo sapiens | 2-(3-methylphenyl)-4H-3,1-benzoxazin-4-one | |
0.08 | - |
- |
Homo sapiens | 2-(3-nitrophenyl)-4H-3,1-benzoxazin-4-one | |
0.08 | - |
- |
Homo sapiens | 2-(4-bromophenyl)quinazolin-4(3H)-one | |
0.08 | - |
- |
Homo sapiens | 2-(4-methylphenyl)-4H-3,1-benzoxazin-4-one | |
0.08 | - |
- |
Homo sapiens | 2-phenyl-4H-3,1-benzoxazin-4-one | |
0.08 | - |
- |
Homo sapiens | 2-phenylquinazolin-4(3H)-one | |
0.08 | - |
- |
Homo sapiens | 4-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)phenyl acetate |