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BRENDA support

Literature summary for 3.4.21.77 extracted from

  • Thanigasalam, R.; Mancuso, P.; Tsao, K.; Rashid, P.
    Prostate-specific antigen velocity (PSAV): a practical role for PSA? (2009), ANZ. J. Surg., 79, 703-706.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information serum PSA also increases with benign prostatic hypertrophy, prostatitis, prostate trauma and drugs Homo sapiens

Application

Application Comment Organism
medicine early detection and treatment of prostate cancer is critical to prognosis, with an initial PSA reading being important to the patients management plan. There is limited evidence that the additional use of prostate-specific antigen velocity compared with a single PSA measurement increases sensitivity and specificity of cancer detection. But PSAV remains a useful practical tool in the management of men with prostate cancer: PSA kinetics are also useful in monitoring men on active surveillance in assessing the status of their disease and the presence of cancer progression Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate
-
Homo sapiens
-
serum
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
prostate-specific antigen
-
Homo sapiens
PSA
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Homo sapiens

General Information

General Information Comment Organism
physiological function risk of prostate cancer increases as PSA, and/or abnormal digital rectal examination increases, but PSA and digital rectal examination are not 100% sensitive for prostate cancer. 16% of cancers are missed by using age-specific PSA and digital rectal examination alone Homo sapiens