3.4.21.77: semenogelase
This is an abbreviated version!
For detailed information about semenogelase, go to the full flat file.
Word Map on EC 3.4.21.77
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3.4.21.77
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gleason
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prostatectomy
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androgen
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rectal
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radiotherapy
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preoperative
-
hyperplasia
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transrectal
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urinary
-
metastases
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adenocarcinoma
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lymph
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node
-
castration-resistant
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testosterone
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postoperative
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ultrasound
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oncology
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univariate
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high-risk
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urological
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pelvic
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beam
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surveillance
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progression-free
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staging
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high-grade
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lncap
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low-risk
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docetaxel
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nadir
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cancer-specific
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brachytherapy
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transurethral
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androgen-independent
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ultrasound-guided
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multiparametric
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neoadjuvant
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intermediate-risk
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nomogram
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suspicious
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urologist
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mcrpc
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antiandrogens
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ultrasonography
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lymphadenectomy
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erectile
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incontinence
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actuarial
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cause-specific
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analysis
-
medicine
-
diagnostics
-
drug development
- 3.4.21.77
-
gleason
-
prostatectomy
- androgen
- rectal
-
radiotherapy
-
preoperative
- hyperplasia
-
transrectal
- urinary
- metastases
- adenocarcinoma
- lymph
- node
-
castration-resistant
- testosterone
-
postoperative
-
ultrasound
-
oncology
-
univariate
-
high-risk
- urological
-
pelvic
-
beam
-
surveillance
-
progression-free
-
staging
-
high-grade
-
lncap
-
low-risk
- docetaxel
-
nadir
-
cancer-specific
-
brachytherapy
-
transurethral
-
androgen-independent
-
ultrasound-guided
-
multiparametric
-
neoadjuvant
-
intermediate-risk
-
nomogram
-
suspicious
-
urologist
-
mcrpc
-
antiandrogens
-
ultrasonography
-
lymphadenectomy
-
erectile
- incontinence
-
actuarial
-
cause-specific
- analysis
- medicine
- diagnostics
- drug development
Reaction
Preferential cleavage: -Tyr-/- =
Synonyms
7S nerve growth factor gamma chain, antigen (human clone lambdaHPSA-1 prostate-specific protein moiety reduced), antigen PSA (human clone 5P1 protein moiety reduced), antigen PSA (human prostate-specific), gama-SM protein, gamma-NGF, gamma-seminoglycoprotein (human protein moiety reduced), gamma-seminoprotein, gamma-SM, GK3, glandular kallikrein, glandular kallikrein 3, hK3/PSA, K3, K4, kallikrein 3, kallikrein-related peptidase 3, kallikrein-related peptidase-3, KLK3, P-30 antigen, prostate specific antigen, prostate stem cell antigen, prostate-specific antigen, prostate-specific antigen kallikrein, Prostate-specific membrane antigen, PSA, PSA-SV5, PSCA, PSMA, S01.162, seminal proteinase, seminin, six-transmembrane epithelial antigen of the prostate, STEAP, tissue kallikrein
ECTree
3.4.21.77 semenogelaseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 3.4.21.77 - semenogelase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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kallikrein-related peptidase 3 is present in hippocampal pyramidal neurons
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secretory epithelial cells, concentration of enzyme in nonprostatic tissue represents less than 1% of the amount in normal prostate
breast carcinoma cell line, enzyme is upregulated by progestins and androgens
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activation peptide of PSA is filtered from the bloodstream by the kidney, and is detectable in the urine of patients with prostate cancer, but not controls. Serum PSA concentration is dependent on how much PSA gains access to the bloodstream and how efficiently it is removed
additional information
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prostate-specific antigen is absent in the blood of healthy subjects. Low frequency of positive results in patients with prostate cancer and high frequency of positive results in patients with benign prostatic hyperplasia
breast carcinoma cell line, enzyme is upregulated by progestins and androgens
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the enzyme forms complexes with alpha1-antichymotrypsin in prostate
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produces equal amounts of zymogen proPSA and one-chain mature enzyme form, no intermediate forms
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like normal prostate secretory-luminal epithelial cells, produces very high levels of PSA. High levels of active PSA in the milieu surrounding osseous and soft tissue metastases
the enzyme forms complexes with alpha1-antichymotrypsin in prostate
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concentration of enzyme in nonprostatic tissue represents less than 1% of the amount in normal prostate
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696923, 697379, 697779, 707185, 707836, 707995, 708000, 708155, 708157, 708802, 708803, 708807, 708808, 710462, 717064, 717086, 717573, 718049
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enzyme is mainly complexed to alpha1-antichymotrypsin, i.e. ACT, a small part of free enzyme
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N-linked glycans from prostate-specific antigen isolated from normal control, benign prostatic disease and prostate cancer. For prostate-specific antigen, 40 putative glycoforms
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prostate cancer patients, serum prostate-specific antigen values range from 0.1 to 700 ng/ml. Prostate-specific antigen absent from female serum
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white men with a total PSA concentration of 0-10 ng/mL, having prostate cancer or no evidence of malignancy, but in great part with benign prostatic hyperplasia
additional information
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splice variant PSA-SV5 is absent in normal breast cells and in breast and ovarian cancer cell lines
additional information
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prostate-specific antigen shows low specificity, besides increased levels in prostate cancer, prostate-specific antigen levels are also increased in benign prostatic hyperplasia, and in general inflammatory responses. Shows low sensitivity, prostate-specific antigen levels are highly variable over time, prostate-specific antigen poorly distinguishes indolent from aggressive cancers
additional information
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different PSA isoforms in seminal fluid, which differ with respect to glycosylation and/or internal cleavages, and enzymatic activity
additional information
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patients aged more than 75 years and with PSA value lower than 2.0 ng/ml
