3.4.21.77: semenogelase

This is an abbreviated version!
For detailed information about semenogelase, go to the full flat file.

Word Map on EC 3.4.21.77

3.4.21.77

gleason

prostatectomy

androgen

rectal

radiotherapy

preoperative

hyperplasia

transrectal

urinary

metastases

adenocarcinoma

lymph

node

castration-resistant

testosterone

postoperative

ultrasound

oncology

univariate

high-risk

urological

pelvic

beam

surveillance

progression-free

staging

high-grade

lncap

low-risk

docetaxel

nadir

cancer-specific

brachytherapy

transurethral

androgen-independent

ultrasound-guided

multiparametric

neoadjuvant

intermediate-risk

nomogram

suspicious

urologist

mcrpc

antiandrogens

ultrasonography

lymphadenectomy

erectile

incontinence

actuarial

cause-specific

analysis

medicine

diagnostics

drug development

Reaction

Preferential cleavage: -Tyr-/- =

Synonyms

7S nerve growth factor gamma chain, antigen (human clone lambdaHPSA-1 prostate-specific protein moiety reduced), antigen PSA (human clone 5P1 protein moiety reduced), antigen PSA (human prostate-specific), gama-SM protein, gamma-NGF, gamma-seminoglycoprotein (human protein moiety reduced), gamma-seminoprotein, gamma-SM, GK3, glandular kallikrein, glandular kallikrein 3, hK3/PSA, K3, K4, kallikrein 3, kallikrein-related peptidase 3, kallikrein-related peptidase-3, KLK3, P-30 antigen, prostate specific antigen, prostate stem cell antigen, prostate-specific antigen, prostate-specific antigen kallikrein, Prostate-specific membrane antigen, PSA, PSA-SV5, PSCA, PSMA, S01.162, seminal proteinase, seminin, six-transmembrane epithelial antigen of the prostate, STEAP, tissue kallikrein

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.77 semenogelase

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Results	in table
20	Activating Compound
5	AA Sequence
58	Application
2	CAS Registry Number
10	Cloned(Commentary)
1	Crystallization (Commentary)
38100	Disease/ Diagnostics
8	Expression
27	General Information
1	General Stability
39	IC50 Value
263	Inhibitors
4	kcat/KM [mM/s]
133	Ki Value [mM]
13	KM Value [mM]
6	Localization
21	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
97	Organism
5	PDB ID
6	pH Optimum
3	pI Value
6	Posttranslational Modification
23	Purification (Commentary)
12	Reaction
1	Reaction Type
92	Reference
1	Renatured (Commentary)
119	Source Tissue
2	Specific Activity [micromol/min/mg]
2	Storage Stability
122	Substrates and Products (Substrate)
8	Subunits
182	Synonyms
4	Temperature Optimum [°C]
5	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.21.77 - semenogelase

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0.08

(2-methoxyphenyl)(3-phenyl-1H-1,2,4-triazol-1-yl)methanone

Homo sapiens

701037

0.1

(2R,3R)-ethyl 3-benzyl-4-oxo-1-tosylazetidine-2-carboxylate

Homo sapiens

682769

0.0011

(2S,3S)-ethyl 3-benzyl-4-oxo-1-tosylazetidine-2-carboxylate

Homo sapiens

682769

0.08

(3,4-dimethoxyphenyl)(5-(4-fluorobenzylamino)-3-phenyl-1H-1,2,4-triazol-1-yl)methanone

Homo sapiens

701037

0.0022

(3-benzyl-1-(ethylsulfonyl)-4-oxoazetidin-2-yl)methyl benzoate

Homo sapiens

682769

0.0163

(5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(2-chlorophenyl)methanone

Homo sapiens

701037

0.0298

(5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(2-methoxyphenyl)methanone

Homo sapiens

701037

0.0005

(5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(3,4-dimethoxyphenyl)methanone

Homo sapiens

701037

0.0022

(5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(4-chlorophenyl)methanone

Homo sapiens

701037

0.0041

(5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(4-fluorophenyl)methanone

Homo sapiens

701037

0.0009

(5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(4-methoxyphenyl)methanone

Homo sapiens

701037

0.08

(5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(4-nitrophenyl)methanone

Homo sapiens

701037

0.0038

(5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(p-tolyl)methanone

Homo sapiens

701037

0.0096

(5-amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)(phenyl)methanone

Homo sapiens

701037

0.0169

(5-amino-3-phenyl-1H-1,2,4-triazol-1-yl)(3,4-dimethoxyphenyl)methanone

Homo sapiens

701037

0.08

1-(3-chlorobenzyl)-3-phenyl-1H-pyrazol-5-amine

Homo sapiens

701037

0.08

1-benzyl-3-phenyl-1H-pyrazol-5-amine

Homo sapiens

701037

0.0054

2-(2-methyl-3-nitrophenyl)-4-oxo-4H-3,1-benzoxazin-6-yl acetate

Homo sapiens

701037

0.0003

2-(2-methyl-3-nitrophenyl)-4H-3,1-benzoxazin-4-one

Homo sapiens

701037

0.0291

2-(2-methylphenyl)-4H-3,1-benzoxazin-4-one

Homo sapiens

701037

0.0142

2-(2-nitrophenyl)-4H-3,1-benzoxazin-4-one

Homo sapiens

701037

0.08

2-(3-methylphenyl)-4H-3,1-benzoxazin-4-one

Homo sapiens

701037

0.08

2-(3-nitrophenyl)-4H-3,1-benzoxazin-4-one

Homo sapiens

701037

0.08

2-(4-bromophenyl)quinazolin-4(3H)-one

Homo sapiens

701037

0.08

2-(4-methylphenyl)-4H-3,1-benzoxazin-4-one

Homo sapiens

701037

0.08

2-phenyl-4H-3,1-benzoxazin-4-one

Homo sapiens

701037

0.08

2-phenylquinazolin-4(3H)-one

Homo sapiens

701037

0.0035

4-((1-(2-(3-(benzyloxycarbonyl)phenyl)acetyl)-3-(4-hydroxybenzyl)-4-oxoazetidine-2-carbonyloxy)methyl)benzoic acid

Homo sapiens

682769

0.0058

4-((3-benzyl-1-(2-(3-((4-carboxybenzyloxy)carbonyl)phenyl)acetyl)-4-oxoazetidine-2-carbonyloxy)methyl)benzoic acid

Homo sapiens

682769

0.009

4-((3-benzyl-1-(2-(3-(benzyloxycarbonyl)phenyl)acetyl)-4-oxoazetidine-2-carbonyloxy)methyl)benzoic acid

Homo sapiens

682769

0.08

4-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)phenyl acetate

Homo sapiens

701037

0.049

6-bromo-2-(2-methyl-3-nitrophenyl)-4H-3,1-benzoxazin-4-one

Homo sapiens

701037

0.000001

AUY922

Homo sapiens

708155

0.00034

benzyl 1-(2-(3-(benzyloxycarbonyl)phenyl)acetyl)-3-(4-hydroxybenzyl)-4-oxoazetidine-2-carboxylate

Homo sapiens

682769

0.01

benzyl 1-benzoyl-3-(4-hydroxybenzyl)-4-oxoazetidine-2-carboxylate

Homo sapiens

682769

0.00143

benzyl 3-benzyl-1-(2-(3-(benzyloxycarbonyl)phenyl)acetyl)-4-oxoazetidine-2-carboxylate

Homo sapiens

682769

0.00308

benzyl 3-benzyl-4-oxo-1-(phenylsulfonyl)azetidine-2-carboxylate

Homo sapiens

682769

0.15

dithiothreitol

Homo sapiens

P07288

at 25°C, in 0.1 ml 0.1 M Tris buffer, pH 7.8

696026

0.00025

R/S-diphenyl[N-benzyloxycarbonylamino(4-carbamoylphenyl)methyl]phosphonate

Homo sapiens

P07288

pH and temperature not specified in the publication

732227