3.4.21.37: leukocyte elastase
This is an abbreviated version!
For detailed information about leukocyte elastase, go to the full flat file.
Word Map on EC 3.4.21.37
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3.4.21.37
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pulmonary
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cathepsin
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airway
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pancreatic
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lavage
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myeloperoxidase
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hne
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emphysema
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fibrosis
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cystic
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bronchoalveolar
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granule
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elastin
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sputum
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bronchial
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thrombin
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chymotrypsin
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coagulation
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1-antitrypsin
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neutropenia
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interleukin-8
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1-proteinase
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degranulation
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c-reactive
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cardiopulmonary
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elastolytic
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antiprotease
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serpins
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mucus
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slpi
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alpha1-antitrypsin
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azurophilic
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aa
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neutrophil-derived
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elastases
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2-macroglobulin
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bronchiectasis
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fmlp
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elastase-induced
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netosis
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antineutrophil
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proteinase-3
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thrombin-antithrombin
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ulinastatin
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crevicular
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neutrophil-mediated
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ne-induced
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beta-thromboglobulin
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drug development
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wegener
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2-antiplasmin
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diagnostics
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medicine
- 3.4.21.37
- pulmonary
- cathepsin
- airway
- pancreatic
-
lavage
- myeloperoxidase
- hne
- emphysema
- fibrosis
-
cystic
-
bronchoalveolar
- granule
- elastin
- sputum
- bronchial
- thrombin
- chymotrypsin
- coagulation
-
1-antitrypsin
- neutropenia
- interleukin-8
-
1-proteinase
-
degranulation
-
c-reactive
-
cardiopulmonary
-
elastolytic
-
antiprotease
- serpins
- mucus
- slpi
- alpha1-antitrypsin
-
azurophilic
- aa
-
neutrophil-derived
- elastases
-
2-macroglobulin
- bronchiectasis
- fmlp
-
elastase-induced
-
netosis
-
antineutrophil
- proteinase-3
-
thrombin-antithrombin
- ulinastatin
-
crevicular
-
neutrophil-mediated
-
ne-induced
-
beta-thromboglobulin
- drug development
-
wegener
-
2-antiplasmin
- diagnostics
- medicine
Reaction
Hydrolysis of proteins, including elastin. Preferential cleavage Val-/- > Ala-/- =
Synonyms
bone marrow serine protease, EC 3.4.21.11, EC 3.4.4.7, ELA2, Elane, elastase, elaszym, granulocyte elastase, H2A specific protease, H2Asp, HLE, HNE, leukocyte elastase, lysosomal elastase, N-elastase, NE, neutrophil elastase, neutrophil-elastase, neutrophil-released elastase, PMN elastase, PMN-elastase, PMNE, polymorphonuclear leukocyte elastase, polymorphonuclear neutrophil elastase, serine elastase
ECTree
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Engineering
Engineering on EC 3.4.21.37 - leukocyte elastase
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A127P
a naturally occuring disease causing mutation, the mutation increase beta-aggregation propensity in the enzyme
A213V
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the mutant shows increased kcat and Km values compared to the wild type enzyme
A57T
a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability
C151S
a naturally occuring disease causing mutation, the mutation causes loss of stability
C151Y
a naturally occuring disease causing mutation, the mutation causes loss of stability
C71R
a naturally occuring disease causing mutation, the mutation causes loss of stability
C71S
a naturally occuring disease causing mutation, the mutation causes loss of stability
down
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severe congenital neutropenia is a heterogeneous disorder of myelopoiesis, which follows an autosomal dominant or autosomal recessive pattern of inheritance, and leads to suppression of neutrophil elastase and reduced enzyme protein levels in plasma
F192A
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the mutant shows increased kcat and Km values compared to the wild type enzyme
F192K
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the mutant shows increased kcat and Km values compared to the wild type enzyme
F215A
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very low activity, the mutant shows decreased kcat and increased Km values compared to the wild type enzyme
F215Y
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the mutant shows decreased kcat and Km values compared to the wild type enzyme
G185R
G210V
a naturally occuring disease causing mutation, the mutation increase beta-aggregation propensity in the enzyme
G214R
a naturally occuring disease causing mutation, the mutation affects enzyme stability
G85E
a naturally occuring disease causing mutation, the mutation causes loss of stability
H53L
a naturally occuring disease causing mutation, the mutation increase beta-aggregation propensity in the enzyme
I60T
a naturally occuring disease causing mutation, the mutation causes loss of stability
L121P
a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability
L152P
a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability
L47P
a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability
L84P
a naturally occuring disease causing mutation, the mutation causes loss of stability
N95A/N144A
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the neutrophil elastase glycosylation variant is located in the nucleus
N98T
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the mutant shows increased kcat and Km values compared to the wild type enzyme
P205R
a naturally occuring disease causing mutation, the mutation causes loss of stability
P42L
a naturally occuring disease causing mutation, the mutation increase beta-aggregation propensity in the enzyme
R220Q
a naturally occuring disease causing mutation, the mutation causes loss of stability
R81P
a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability
S46F
a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability, and the mutation increase beta-aggregation propensity in the enzyme
V101M
a naturally occuring disease causing mutation, the mutation affects enzyme stability
V82M
a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability
additional information
mutations in the HNE gene ela2 cause cyclic and congenital neutropenia
additional information
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mutations in the HNE gene ela2 cause cyclic and congenital neutropenia
additional information
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nuclear localization of neutrophil elastase enhances Gfi1 corepressor activity in reporter assays in recombinant NIH 3T3 cells. Silencing of neutrophil elastase, Gfi1, or PFAAP5 upregulates ELA2 and AZU1 in HL-60 promyelocytes
additional information
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enzyme-deficient mice do not show inhibition of leukocyte transmigration through leukotriene B4-stimulated cremasteric venules after application of inhibitor ONO-5046, enzyme-deficient mice appear to exhibit compensatory mechanisms in regulation of leukocyte transmigration
additional information
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genetic deletion of neutrophil elastase significantly reduce infarct volume, blood-brain barrier disruption, vasogenic edema, and leukocyte-endothelial adherence after transient middle cerebral artery occlusion