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3.4.21.37: leukocyte elastase

This is an abbreviated version!
For detailed information about leukocyte elastase, go to the full flat file.

Word Map on EC 3.4.21.37

Reaction

Hydrolysis of proteins, including elastin. Preferential cleavage Val-/- > Ala-/- =

Synonyms

bone marrow serine protease, EC 3.4.21.11, EC 3.4.4.7, ELA2, Elane, elastase, elaszym, granulocyte elastase, H2A specific protease, H2Asp, HLE, HNE, leukocyte elastase, lysosomal elastase, N-elastase, NE, neutrophil elastase, neutrophil-elastase, neutrophil-released elastase, PMN elastase, PMN-elastase, PMNE, polymorphonuclear leukocyte elastase, polymorphonuclear neutrophil elastase, serine elastase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.37 leukocyte elastase

Engineering

Engineering on EC 3.4.21.37 - leukocyte elastase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A127P
a naturally occuring disease causing mutation, the mutation increase beta-aggregation propensity in the enzyme
A213V
-
the mutant shows increased kcat and Km values compared to the wild type enzyme
A57T
a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability
C151S
a naturally occuring disease causing mutation, the mutation causes loss of stability
C151Y
a naturally occuring disease causing mutation, the mutation causes loss of stability
C71R
a naturally occuring disease causing mutation, the mutation causes loss of stability
C71S
a naturally occuring disease causing mutation, the mutation causes loss of stability
down
-
severe congenital neutropenia is a heterogeneous disorder of myelopoiesis, which follows an autosomal dominant or autosomal recessive pattern of inheritance, and leads to suppression of neutrophil elastase and reduced enzyme protein levels in plasma
F192A
-
the mutant shows increased kcat and Km values compared to the wild type enzyme
F192K
-
the mutant shows increased kcat and Km values compared to the wild type enzyme
F215A
-
very low activity, the mutant shows decreased kcat and increased Km values compared to the wild type enzyme
F215Y
-
the mutant shows decreased kcat and Km values compared to the wild type enzyme
G185R
G210V
a naturally occuring disease causing mutation, the mutation increase beta-aggregation propensity in the enzyme
G214R
a naturally occuring disease causing mutation, the mutation affects enzyme stability
G85E
a naturally occuring disease causing mutation, the mutation causes loss of stability
H53L
a naturally occuring disease causing mutation, the mutation increase beta-aggregation propensity in the enzyme
I60T
a naturally occuring disease causing mutation, the mutation causes loss of stability
L121P
a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability
L152P
a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability
L47P
a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability
L84P
a naturally occuring disease causing mutation, the mutation causes loss of stability
N95A/N144A
-
the neutrophil elastase glycosylation variant is located in the nucleus
N98T
-
the mutant shows increased kcat and Km values compared to the wild type enzyme
P205R
a naturally occuring disease causing mutation, the mutation causes loss of stability
P42L
a naturally occuring disease causing mutation, the mutation increase beta-aggregation propensity in the enzyme
R220Q
a naturally occuring disease causing mutation, the mutation causes loss of stability
R81P
a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability
S46F
a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability, and the mutation increase beta-aggregation propensity in the enzyme
S97L
-
the mutation is associated with cyclic neutropenia
V101M
a naturally occuring disease causing mutation, the mutation affects enzyme stability
V82M
a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability
G185R
-
the mutation is associated with congenital neutropenia
S97L
-
the mutation is associated with cyclic neutropenia
additional information