3.4.21.37: leukocyte elastase

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For detailed information about leukocyte elastase, go to the full flat file.

Word Map on EC 3.4.21.37

3.4.21.37

pulmonary

cathepsin

airway

pancreatic

lavage

myeloperoxidase

hne

emphysema

fibrosis

cystic

bronchoalveolar

granule

elastin

sputum

bronchial

thrombin

chymotrypsin

coagulation

1-antitrypsin

neutropenia

interleukin-8

1-proteinase

degranulation

c-reactive

cardiopulmonary

elastolytic

antiprotease

serpins

mucus

slpi

alpha1-antitrypsin

azurophilic

aa

neutrophil-derived

elastases

2-macroglobulin

bronchiectasis

fmlp

elastase-induced

netosis

antineutrophil

proteinase-3

thrombin-antithrombin

ulinastatin

crevicular

neutrophil-mediated

ne-induced

beta-thromboglobulin

drug development

wegener

2-antiplasmin

diagnostics

medicine

Reaction

Hydrolysis of proteins, including elastin. Preferential cleavage Val-/- > Ala-/- =

Synonyms

bone marrow serine protease, EC 3.4.21.11, EC 3.4.4.7, ELA2, Elane, elastase, elaszym, granulocyte elastase, H2A specific protease, H2Asp, HLE, HNE, leukocyte elastase, lysosomal elastase, N-elastase, NE, neutrophil elastase, neutrophil-elastase, neutrophil-released elastase, PMN elastase, PMN-elastase, PMNE, polymorphonuclear leukocyte elastase, polymorphonuclear neutrophil elastase, serine elastase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.37 leukocyte elastase

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Results	in table
17	Activating Compound
5	AA Sequence
22	Application
1	CAS Registry Number
8	Cloned(Commentary)
9	Crystallization (Commentary)
6529	Disease/ Diagnostics
8	Expression
40	General Information
147	IC50 Value
708	Inhibitors
143	Ki Value [mM]
60	KM Value [mM]
39	Localization
5	Metals/Ions
10	Molecular Weight [Da]
154	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
353	Organism
37	PDB ID
31	pH Optimum
1	pH Range
4	pI Value
7	Posttranslational Modification
39	Protein Variants
13	Purification (Commentary)
1	Reaction
1	Reaction Type
214	Reference
241	Source Tissue
4	Specific Activity [micromol/min/mg]
1	Storage Stability
389	Substrates and Products (Substrate)
18	Subunits
183	Synonyms
24	Temperature Optimum [°C]
1	Temperature Stability [°C]
55	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.4.21.37 - leukocyte elastase

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24000

SDS-PAGE

27000

x * 27000, SDS-PAGE

28520

unprocessed precursor consists of 267 amino acid residues

29000

30000

34400

x * 34400, SDS-PAGE

34970

x * 34970, calculation from amino acid composition

647547

60000

Mus musculus

SDS-PAGE

697960