3.4.21.37: leukocyte elastase
This is an abbreviated version!
For detailed information about leukocyte elastase, go to the full flat file.
Word Map on EC 3.4.21.37
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3.4.21.37
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pulmonary
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cathepsin
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airway
-
pancreatic
-
lavage
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myeloperoxidase
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hne
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emphysema
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fibrosis
-
cystic
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bronchoalveolar
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granule
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elastin
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sputum
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bronchial
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thrombin
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chymotrypsin
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coagulation
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1-antitrypsin
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neutropenia
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interleukin-8
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1-proteinase
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degranulation
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c-reactive
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cardiopulmonary
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elastolytic
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antiprotease
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serpins
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mucus
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slpi
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alpha1-antitrypsin
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azurophilic
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aa
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neutrophil-derived
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elastases
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2-macroglobulin
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bronchiectasis
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fmlp
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elastase-induced
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netosis
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antineutrophil
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proteinase-3
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thrombin-antithrombin
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ulinastatin
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crevicular
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neutrophil-mediated
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ne-induced
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beta-thromboglobulin
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drug development
-
wegener
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2-antiplasmin
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diagnostics
-
medicine
- 3.4.21.37
- pulmonary
- cathepsin
- airway
- pancreatic
-
lavage
- myeloperoxidase
- hne
- emphysema
- fibrosis
-
cystic
-
bronchoalveolar
- granule
- elastin
- sputum
- bronchial
- thrombin
- chymotrypsin
- coagulation
-
1-antitrypsin
- neutropenia
- interleukin-8
-
1-proteinase
-
degranulation
-
c-reactive
-
cardiopulmonary
-
elastolytic
-
antiprotease
- serpins
- mucus
- slpi
- alpha1-antitrypsin
-
azurophilic
- aa
-
neutrophil-derived
- elastases
-
2-macroglobulin
- bronchiectasis
- fmlp
-
elastase-induced
-
netosis
-
antineutrophil
- proteinase-3
-
thrombin-antithrombin
- ulinastatin
-
crevicular
-
neutrophil-mediated
-
ne-induced
-
beta-thromboglobulin
- drug development
-
wegener
-
2-antiplasmin
- diagnostics
- medicine
Reaction
Hydrolysis of proteins, including elastin. Preferential cleavage Val-/- > Ala-/- =
Synonyms
bone marrow serine protease, EC 3.4.21.11, EC 3.4.4.7, ELA2, Elane, elastase, elaszym, granulocyte elastase, H2A specific protease, H2Asp, HLE, HNE, leukocyte elastase, lysosomal elastase, N-elastase, NE, neutrophil elastase, neutrophil-elastase, neutrophil-released elastase, PMN elastase, PMN-elastase, PMNE, polymorphonuclear leukocyte elastase, polymorphonuclear neutrophil elastase, serine elastase
ECTree
3.4.21.37 leukocyte elastaseAdvanced search results
results (
results (KM Value
KM Value on EC 3.4.21.37 - leukocyte elastase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.0184
o-aminobenzoic acid-Ala-Pro-Glu-Glu-Ile-Met-Asp-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
-
0.0086
o-aminobenzoic acid-Val-Ala-Asp-Cys-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine
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-
0.04
tert-butyloxycarbonyl-L-Val-4-nitrophenyl ester
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pH 7.5, 25°C, proteinase 2A
-
0.3
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide
-
pH 7.5, 25°C, proteinase 2A
0.6
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide
-
pH 7.5, 25°C, proteinase 2B
0.06
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide
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mutant enzyme F215Y, in 500 mM NaCl and 200 mM Tris-HCl, pH 8, at 37°C
0.07
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide
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wild type enzyme, in 500 mM NaCl and 200 mM Tris-HCl, pH 8, at 37°C
0.09
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide
-
mutant enzyme N98T, in 500 mM NaCl and 200 mM Tris-HCl, pH 8, at 37°C
0.79
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide
-
mutant enzyme F192K, in 500 mM NaCl and 200 mM Tris-HCl, pH 8, at 37°C
1.04
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide
-
mutant enzyme F215A, in 500 mM NaCl and 200 mM Tris-HCl, pH 8, at 37°C
1.17
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide
-
mutant enzyme A213V, in 500 mM NaCl and 200 mM Tris-HCl, pH 8, at 37°C
5.02
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide
-
mutant enzyme F192A, in 500 mM NaCl and 200 mM Tris-HCl, pH 8, at 37°C
0.02
tert-butyloxycarbonyl-Ala-4-nitrophenyl ester
-
pH 7.5, 25°C, proteinase B
0.12
tert-butyloxycarbonyl-Ala-4-nitrophenyl ester
-
pH 7.5, 25°C, proteinase 2B
0.27
tert-butyloxycarbonyl-Ala-4-nitrophenyl ester
-
pH 7.5, 25°C, proteinase 2A
0.054
tosyl-Ala-3-hydroxy-5-phenylpyrrole
-
pH 7.0, in presence of 0.35 mM decanol
0.067
tosyl-Ala-3-hydroxy-5-phenylpyrrole
-
pH 8.0, in presence of 0.35 mM decanol
0.08
tosyl-Ala-3-hydroxy-5-phenylpyrrole
-
pH 9.0, in presence of 0.35 mM decanol
