3.4.21.37: leukocyte elastase
This is an abbreviated version!
For detailed information about leukocyte elastase, go to the full flat file.
Word Map on EC 3.4.21.37
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3.4.21.37
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pulmonary
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cathepsin
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airway
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pancreatic
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lavage
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myeloperoxidase
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hne
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emphysema
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fibrosis
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cystic
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bronchoalveolar
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granule
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elastin
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sputum
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bronchial
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thrombin
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chymotrypsin
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coagulation
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1-antitrypsin
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neutropenia
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interleukin-8
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1-proteinase
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degranulation
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c-reactive
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cardiopulmonary
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elastolytic
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antiprotease
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serpins
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mucus
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slpi
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alpha1-antitrypsin
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azurophilic
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aa
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neutrophil-derived
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elastases
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2-macroglobulin
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bronchiectasis
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fmlp
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elastase-induced
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netosis
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antineutrophil
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proteinase-3
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thrombin-antithrombin
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ulinastatin
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crevicular
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neutrophil-mediated
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ne-induced
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beta-thromboglobulin
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drug development
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wegener
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2-antiplasmin
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diagnostics
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medicine
- 3.4.21.37
- pulmonary
- cathepsin
- airway
- pancreatic
-
lavage
- myeloperoxidase
- hne
- emphysema
- fibrosis
-
cystic
-
bronchoalveolar
- granule
- elastin
- sputum
- bronchial
- thrombin
- chymotrypsin
- coagulation
-
1-antitrypsin
- neutropenia
- interleukin-8
-
1-proteinase
-
degranulation
-
c-reactive
-
cardiopulmonary
-
elastolytic
-
antiprotease
- serpins
- mucus
- slpi
- alpha1-antitrypsin
-
azurophilic
- aa
-
neutrophil-derived
- elastases
-
2-macroglobulin
- bronchiectasis
- fmlp
-
elastase-induced
-
netosis
-
antineutrophil
- proteinase-3
-
thrombin-antithrombin
- ulinastatin
-
crevicular
-
neutrophil-mediated
-
ne-induced
-
beta-thromboglobulin
- drug development
-
wegener
-
2-antiplasmin
- diagnostics
- medicine
Reaction
Hydrolysis of proteins, including elastin. Preferential cleavage Val-/- > Ala-/- =
Synonyms
bone marrow serine protease, EC 3.4.21.11, EC 3.4.4.7, ELA2, Elane, elastase, elaszym, granulocyte elastase, H2A specific protease, H2Asp, HLE, HNE, leukocyte elastase, lysosomal elastase, N-elastase, NE, neutrophil elastase, neutrophil-elastase, neutrophil-released elastase, PMN elastase, PMN-elastase, PMNE, polymorphonuclear leukocyte elastase, polymorphonuclear neutrophil elastase, serine elastase
ECTree
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Crystallization
Crystallization on EC 3.4.21.37 - leukocyte elastase
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ammonium sulfate precipitation, 2.3 A crystal structure of leukocyte elastase in a complex with methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone
complex of the enzyme with methoxysuccinyl-Ala-Ala-Pro-Ala chloromethyl ketone. The asymmetric distribution of positively charged residues on the surface of the enzyme suggests a mechanism for the specific incorporation of the enzyme into primary granules in the neutrophil
crystallized in complex with Pro44-eglin c, hanging drop vapour diffusion method using polyethylene glycol 4000 as the precipitating agent
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hanging drop vapour diffusion method, using 0.1 M HEPES (pH 7.5) and 20% PEG8000 or in 0.1 M HEPES (pH 7.5) and 35% PEG8000 containing 10 mM N-methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone inhibitor
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in complex with 1a, sitting drop vapor diffusion method, using 20% (w/v) PEG MME 5000, 0.2 M sodium sulfate
in complex with dihydropyrimidone inhibitor, sitting drop vapor diffusion method, using 20% (w/v) PEG 3350 and 0.2 M ammonium citrate (pH 5.0) or uncomplexed enzyme, sitting drop vapor diffusion method, using 1.9 M ammonium sulfate, 5% (w/v) PEG 400, 0.1 M 4-morpholine ethanesulfonic acid/NaOH (pH 6.5), and 20% (v/v) glycerol
in complex with the recombinant C-terminal domain of secretory leukocyte protease inhibitor (Arg58Ala107), sitting drop vapour diffusion method, using 2.0 M Na-formate at pH 4.5
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X-ray crystal structure of the complex of human leukocyte elastase and the third domain of the turkey ovomucoid inhibitor