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Disease on EC 3.4.21.37 - leukocyte elastase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abruptio Placentae
[The study on mechanism of abruptio placentae caused by chorioamnionitis]
Abscess
Early diagnosis of a pancreatic abscess in acute pancreatitis.
Histochemical localization of neutral proteases released during development of rat periradicular lesion.
Investigation of neutrophils in the gut lumen by assay of granulocyte elastase in whole-gut lavage fluid.
Leukocyte elastase alpha 1-proteinase inhibitor complexes may diagnose pancreatic abscesses early.
Levels of leukocyte proteases in plasma and peritoneal exudate in severe, acute pancreatitis.
Uptake of immunoreactive leukocyte elastase-inhibitor complexes in macrophage-like cells in abscesses.
Acidosis
Pyrexia and acidosis act independently of neutrophil elastase reactive center loop cleavage to effect cortisol release from corticosteroid-binding globulin.
Acne Vulgaris
Altered Gene Expression in Acne Vulgaris Patients Treated by Oral Isotretinoin: A Preliminary Study.
Acquired Immunodeficiency Syndrome
How to spot cocaine-induced pseudovasculitis.
Spectrum of ELANE mutations in congenital neutropenia: a single-centre study in patients of Indian origin.
Acute Coronary Syndrome
In vitro and in vivo evidence for the role of elastase shedding of CD163 in human atherothrombosis.
The effects of non-surgical periodontal therapy on neutrophil elastase and elastase alpha-1 proteinase inhibitor levels in GCF in periodontitis patients with or without acute coronary syndrome.
Acute Lung Injury
A comparison of alpha 1-proteinase inhibitor methoxysuccinyl-Ala-Ala-Pro-Val-chloromethylketone and specific beta-lactam inhibitors in an acute model of human polymorphonuclear leukocyte elastase-induced lung hemorrhage in the hamster.
A neutrophil elastase inhibitor, sivelestat, improves leukocyte deformability in patients with acute lung injury.
A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1.
A novel oral neutrophil elastase inhibitor (ONO-6818) inhibits human neutrophil elastase-induced emphysema in rats.
Activation of MMP-9 by neutrophil elastase in an in vivo model of acute lung injury.
Activity-based Near-Infrared Fluorogenic Probe Enables In Vitro and In Vivo Profiling of Neutrophil Elastase.
Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice.
Alpha-1 Antitrypsin for COVID-19 Treatment: Dual Role in Antiviral Infection and Anti-Inflammation.
Beneficial effect of neutrophil elastase inhibitor on anti-Thy1.1 nephritis in rats.
Biochemical and pharmacological activities of SR 26831, a potent and selective elastase inhibitor.
Clinical utility of the neutrophil elastase inhibitor sivelestat for the treatment of acute respiratory distress syndrome.
Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats.
Continuous infusion of sivelestat sodium hydrate prevents lipopolysaccharide-induced intestinal paralysis and hypotension in conscious guinea-pigs.
Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters.
Detection of human neutrophil elastase by aptamer affinity capillary electrophoresis coupled with laser-induced fluorescence using specified site fluorescently labeled aptamer.
Direct interaction of ONO-5046 with human neutrophil elastase through ¹H NMR and molecular docking.
Early administration of sivelestat, the neutrophil elastase inhibitor, in adults for acute lung injury following gastric aspiration.
Effect of a neutrophil elastase inhibitor on acute lung injury after cardiopulmonary bypass.
Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury.
Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis.
Effects of a neutrophil elastase inhibitor (ONO-5046) on acute pulmonary injury induced by tumor necrosis factor alpha (TNFalpha) and activated neutrophils in isolated perfused rabbit lungs.
Effects of neutrophil elastase inhibitor on progression of acute lung injury after liver transplantation.
Effects of neutrophil elastase inhibitor on progression of acute lung injury following esophagectomy.
Effects of sivelestat treatment on acute lung injury in paraquat-intoxicated rats.
Effects of sivelestat, a new elastase inhibitor, on IL-8 and MCP-1 production from stimulated human alveolar epithelial type II cells.
Effects of the early administration of sivelestat sodium on bronchopulmonary dysplasia in infants: A retrospective cohort study.
Efficacy of early sivelestat administration on acute lung injury and acute respiratory distress syndrome.
Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters.
Endothelial cell xanthine oxidase-derived toxic oxygen metabolites contribute to acute lung injury from neutrophil elastase.
Evidence of increased matrix metalloproteinase-9 concentration in patients following cardiopulmonary bypass.
GAPDH/Siah1 cascade is involved in traumatic spinal cord injury and could be attenuated by sivelestat sodium.
Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19.
Inhaled neutrophil elastase inhibitor reduces oleic acid-induced acute lung injury in rats.
Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster.
Inhibition of neutrophil elastase contributes to attenuation of lipopolysaccharide-induced acute lung injury during neutropenia recovery in mice.
Leukocyte elastase: physiological functions and role in acute lung injury.
Near-infrared fluorescent probe with large stokes shift for detecting Human Neutrophil elastase in living cells.
Neutrophil azurophilic granule exocytosis is primed by TNF-? and partially regulated by NADPH oxidase.
Neutrophil elastase activity in acute lung injury and respiratory distress syndrome.
Neutrophil elastase activity in pulmonary venous blood during lung resection.
Neutrophil elastase ameliorates matrix metalloproteinase-9 to promote lipopolysaccharide-induced acute lung injury in mice 1.
Neutrophil elastase and acute lung injury: prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics.
Neutrophil elastase and systemic inflammatory response syndrome in the initiation and development of acute lung injury among critically ill patients.
Neutrophil elastase as a predicting factor for development of acute lung injury.
Neutrophil elastase contributes to acute lung injury induced by bilateral nephrectomy.
Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study.
Neutrophil elastase inhibitor improves postoperative clinical courses after thoracic esophagectomy.
Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.
Neutrophil elastase inhibitor improves survival rate after ischemia reperfusion injury caused by supravisceral aortic clamping in rats.
Neutrophil elastase inhibitor reduces ventilation-induced lung injury via nuclear factor-?B and NF-?B repressing factor in mice.
Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopulmonary bypass in the rabbit endotoxemia model.
Neutrophil elastase inhibitors, SC-37698 and SC-39026, reduce endotoxin-induced lung dysfunction in awake sheep.
Neutrophils mediate acute lung injury in rabbits: role of neutrophil elastase.
Phospholipase A in acute lung injury after trauma and sepsis: its relation to the inflammatory mediators PMN-elastase, C3a, and neopterin.
Predictors of the therapeutic effect of sivelestat in patients with acute lung injury associated with systemic inflammatory response syndrome.
Prevention of leukocyte activation by the neutrophil elastase inhibitor, sivelestat, in the hepatic microcirculation after ischemia-reperfusion.
Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy.
Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer.
Protection against acute lung injury by intravenous or intratracheal pretreatment with EPI-HNE-4, a new potent neutrophil elastase inhibitor.
Protective effects of a selective neutrophil elastase inhibitor (sivelestat) on lipopolysaccharide-induced acute dysfunction of the pulmonary microcirculation.
Proteolytic inactivation of dog lung surfactant-associated proteins by neutrophil elastase.
Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study.
Relationship between neutrophil elastase and acute lung injury in humans.
Role of neutrophil elastase in lung injury induced by burn-blast combined injury in rats.
Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice.
Sivelestat relaxes porcine coronary artery via inhibition of Ca2+ sensitization induced by a receptor agonist.
Sivelestat relaxes vascular smooth muscle contraction in human gastric arteries.
Sivelestat sodium hydrate improves post-traumatic knee osteoarthritis through nuclear factor-?B in a rat model.
Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury.
Sivelestat, a specific neutrophil elastase inhibitor, prevented phorbol myristate acetate-induced acute lung injury in conscious rabbits.
Specific neutrophil elastase inhibitor does not attenuate acute lung injury induced by air embolism in awake sheep.
The effect of sivelestat sodium hydrate on severe respiratory failure after thoracic aortic surgery with deep hypothermia.
The effects of nitric oxide and peroxynitrite on interleukin-8 and elastase from lipopolysaccharide-stimulated whole blood.
The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury: an electron spin resonance study.
The involvement of nitric oxide, nitric oxide synthase, neutrophil elastase, myeloperoxidase and proinflammatory cytokines in the acute lung injury caused by phorbol myristate acetate.
The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury.
The role of neutrophil elastase in acute lung injury.
The Role of Neutrophil Elastase Inhibitors in Lung Diseases.
The use of neutrophil elastase inhibitor in the treatment of acute lung injury after pneumonectomy.
Urinary Trypsin Inhibitor Attenuates Seawater-Induced Acute Lung Injury by Influencing the Activities of Nuclear Factor-?B and Its Related Inflammatory Mediators.
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
[Acute lung injury and chemical mediators]
[Case of possible transfusion-related acute lung injury during thoracic endovascular aortic repair].
[Efficacy of sivelestat for acute lung injury due to severe bacterial pneumonia with systemic inflammatory response syndrome]
[Improvement in research on mechanisms of acute lung injury induced by neutrophil elastase.]
[New findings on the physiopathology of acute hemolytic transfusion reactions]
[Pathophysiology and treatment of postoperative acute respiratory disturbance]
[Pathophysiology of acute lung injury]
[Prognostic significance of neutrophil elastase inhibitor in patients with acute lung injury and interstitial pneumonia]
[Prophylactic effects of neutrophil elastase inhibitor for patients undergoing surgery for thoracic aortic aneurysm: a retrospective study]
Adenocarcinoma
Early detection of pancreatic cancers in liquid biopsies by ultrasensitive fluorescence nanobiosensors.
EGCG reverses human neutrophil elastase-induced migration in A549 cells by directly binding to HNE and by regulating ?1-AT.
Inhibition of Neutrophil Elastase and Metalloprotease-9 of Human Adenocarcinoma Gastric Cells by Chamomile (Matricaria recutita L.) Infusion.
Salivary Proteome and Peptidome Profiling in Type 1 Diabetes Mellitus Using a Quantitative Approach.
Adenocarcinoma of Lung
Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of ?1-antitrypsin in lung cancer.
Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth.
Agammaglobulinemia
Autosomal-dominant primary immunodeficiencies.
Aggressive Periodontitis
Neutrophils in chronic and aggressive periodontitis in interaction with Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans.
Proinflammatory cytokines production and PMN-elastase release from activated PMN cells in the periodontal disease.
Serum and salivary matrix metalloproteinases, neutrophil elastase, myeloperoxidase in patients with chronic or aggressive periodontitis.
Agranulocytosis
Acute and chronic neutropenias. What is new?
Can mutations in ELA2, neutrophil elastase expression or differential cell toxicity explain sulphasalazine-induced agranulocytosis?
Airway Obstruction
Increased Lung Catalase Activity Confers Protection Against Experimental RSV Infection.
alpha 1-Antitrypsin Deficiency
Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysema.
Discovery of alpha 1-antitrypsin deficiency.
[Proteinases and antiproteinases: biomedical correlations]
Alveolar Bone Loss
Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis.
Alzheimer Disease
[Inflammatory markers in Alzheimer's disease and vascular dementia.]
[Quantification of the relationship between inflammatory markers and Alzheimer's disease].
[The use of cluster analysis and logistic regression for assessing the risk of Alzheimer's disease in patients with mild cognitive impairment, amnestic type].
Anemia
Local regulation of neutrophil elastase activity by endogenous ?1-antitrypsin in lipopolysaccharide-primed hematological cells.
Anemia, Diamond-Blackfan
Current insights into inherited bone marrow failure syndromes.
Anemia, Sickle Cell
Coexistence of sickle cell disease and severe congenital neutropenia: first impressions can be deceiving.
Evaluation of Alpha-1 Antitrypsin Levels and
Neutrophil extracellular trap regulators in sickle cell disease: Modulation of gene expression of PADI4, neutrophil elastase, and myeloperoxidase during vaso-occlusive crisis.
Aneurysm
Absence of plasma protease-antiprotease imbalance in the formation of saccular cerebral aneurysms.
Human neutrophil elastase: mediator and therapeutic target in atherosclerosis.
Magnetic resonance imaging assessment of proteolytic enzyme concentrations and biologic properties of intraluminal thrombus in abdominal aortic aneurysms.
Neutrophil chemotaxis and neutrophil elastase in the aortic wall in patients with abdominal aortic aneurysms.
Ruptured giant aneurysm of the left anterior descending coronary artery in Kawasaki disease.
[Examination of elastase concentration in the wall of abdominal aortic aneurysms]
Aneurysm, Dissecting
Efficacy of neutrophil elastase inhibitor on type A acute aortic dissection.
The effects of a neutrophil elastase inhibitor on the postoperative respiratory failure of acute aortic dissection.
Aneurysm, Ruptured
Absence of plasma protease-antiprotease imbalance in the formation of saccular cerebral aneurysms.
Angina, Stable
In vitro and in vivo evidence for the role of elastase shedding of CD163 in human atherothrombosis.
Neutrophil function in ischemic heart disease.
Angina, Unstable
Increased neutrophil elastase release in unstable angina pectoris and acute myocardial infarction.
Neutrophil function in ischemic heart disease.
Anthrax
Neutrophil elastase and syndecan shedding contribute to antithrombin depletion in murine anthrax.
Neutrophil elastase mediates pathogenic effects of anthrax lethal toxin in the murine intestinal tract.
Anti-Glomerular Basement Membrane Disease
Strength of the pulmonary blood-gas barrier.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Cocaine-induced midline destruction.
Antithrombin III Deficiency
Application of argatroban, direct thrombin inhibitor, in heparin-intolerant patients requiring extracorporeal circulation.
Aortic Aneurysm
Source of elastin-degrading enzymes in mycotic aortic aneurysms: bacteria or host inflammatory response?
Aortic Aneurysm, Abdominal
Isoflavone Ameliorated Oxidative Stress and Vascular Damages in Nicotine-Administrated Mice.
Neutrophil chemotaxis and neutrophil elastase in the aortic wall in patients with abdominal aortic aneurysms.
Paradoxical neutrophil elastase release in endovascular abdominal aortic aneurysm repair.
The calcium messenger system and the kinetics of elastase release from human neutrophils in patients with abdominal aortic aneurysms.
Aortic Aneurysm, Thoracic
[Prophylactic effects of neutrophil elastase inhibitor for patients undergoing surgery for thoracic aortic aneurysm: a retrospective study]
Arteritis
Human neutrophil elastase in temporal (giant cell) arteritis: plasma and immunohistochemical studies.
Arthritis
A Novel ELANE Mutation Associated with Inflammatory Arthritis, Defective NETosis, and Recurrent Parvoviral Infection.
Alpha-1-antitrypsin reduces inflammation and exerts chondroprotection in arthritis.
Binding characteristics of antitype II collagen antibody to the surface of diseased human cartilage as a probe for tissue damage.
Detection of human neutrophil elastase by aptamer affinity capillary electrophoresis coupled with laser-induced fluorescence using specified site fluorescently labeled aptamer.
Early cartilage degradation in cationic immune complex arthritis in mice: relative role of interleukin 1, the polymorphonuclear cell (PMN) and PMN elastase.
Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis.
Elevated Serum Concentrations of Polymorphonuclear Neutrophilic Leukocyte Elastase in Systemic Sclerosis: Association with Pulmonary Fibrosis.
Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis: association with pulmonary fibrosis.
Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis.
MRP8/14 and neutrophil elastase for predicting treatment response and occurrence of flare in patients with juvenile idiopathic arthritis.
Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase-activated receptor-2.
Pathogenesis of antigen-induced arthritis in mice deficient in neutrophil elastase and cathepsin G.
Polymorphonuclear leukocyte elastase activity is increased by bacterial lipopolysaccharide: a response inhibited by glucocorticoids.
Arthritis, Experimental
Induction of pulmonary thromboembolism by neutrophil elastase in collagen-induced arthritis mice and effect of recombinant human soluble thrombomodulin.
Inhibition of cartilage degradation in rat collagen-induced arthritis but not adjuvant arthritis by the neutrophil elastase inhibitor MDL 101,146.
Suppressive effect of a neutrophil elastase inhibitor on the development of collagen-induced arthritis.
Arthritis, Infectious
PMN elastase in bone and joint infections.
Arthritis, Juvenile
MRP8/14 and neutrophil elastase for predicting treatment response and occurrence of flare in patients with juvenile idiopathic arthritis.
Arthritis, Rheumatoid
Anti-inflammatory activity of neutrophil elastase inhibitors.
Antineutrophil cytoplasmic antibodies in Bulgarian patients with rheumatoid arthritis: characterization and clinical associations.
Antineutrophil cytoplasmic antibodies: a still-growing class of autoantibodies in inflammatory disorders.
Biochemical and pharmacological activities of SR 26831, a potent and selective elastase inhibitor.
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.
Circulating inhibitor bound elastase in patients with ankylosing spondylitis and rheumatoid arthritis and the influence of sulphasalazine treatment.
Effect of piroxicam therapy on granulocyte function and granulocyte elastase concentration in peripheral blood and synovial fluid of rheumatoid arthritis patients.
Effective anticoagulation by argatroban during immunoadsorption therapy for malignant rheumatoid arthritis with a high polymorphonuclear leukocyte elastase level.
Fibrin degradation in the synovial fluid of rheumatoid arthritis patients: a model for extravascular fibrinolysis.
Induction of pulmonary thromboembolism by neutrophil elastase in collagen-induced arthritis mice and effect of recombinant human soluble thrombomodulin.
Inhibition of human leukocyte elastase by chemically and naturally oversulfated galactosaminoglycans.
Inhibition of neutrophil elastase by the alpha1-proteinase inhibitor-immunoglobulin A complex.
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Measurement of plasma concentrations of polymorphonuclear elastase-alpha 1 proteinase inhibitor (elastase-alpha 1 antitrypsin) in patients with rheumatoid arthritis: interference by rheumatoid factor.
Neutrophil elastase and cathepsin G: structure, function, and biological control.
Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G.
ONO-6818 Cortech/Ono.
Phosphonic pseudopeptides as human neutrophil elastase inhibitors--a combinatorial approach.
Plasma lactoferrin and neutrophil elastase in rheumatoid arthritis and systemic lupus erythematosus.
Propeptide glycosylation and galectin-3 binding decrease proteolytic activation of human proMMP-9/progelatinase B.
Proteolytic cleavage of ICAM-1 by human neutrophil elastase.
Quantitation of human leukocyte elastase, cathepsin G, alpha-2-macroglobulin and alpha-1-proteinase inhibitor in osteoarthrosis and rheumatoid arthritis synovial fluids.
Sesquiterpene lactones as inhibitors of human neutrophil elastase.
Suppressive effect of a neutrophil elastase inhibitor on the development of collagen-induced arthritis.
Suppressive effects of Stephania tetrandra on the neutrophil function in patients with rheumatoid arthritis.
Asbestosis
Special neutrophil elastase inhibitory activity in BAL fluid from patients with silicosis and asbestosis.
Asthma
Absence of airway inflammation in a large proportion of adolescents with asthma.
Activity of leukocyte elastase in patients' plasma is a significant indicator of atopic diseases.
Biological markers in induced sputum of patients with different phenotypes of chronic airway obstruction.
Cytokine concentrations and neutrophil elastase activity in bronchoalveolar lavage and induced sputum from patients with cystic fibrosis, mild asthma and healthy volunteers.
Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma.
Elevated serum matrix metalloprotease (MMP-2) as a candidate biomarker for stable COPD.
Enhancement of ovalbumin-induced pulmonary eosinophilia by intranasal administration of alpha1-proteinase inhibitor type 2 antisense oligonucleotides.
Ex vivo Sputum Analysis Reveals Impairment of Protease-dependent Mucus Degradation by Plasma Proteins in Acute Asthma.
Hyaluronan blocks porcine pancreatic elastase-induced mucociliary dysfunction in allergic sheep.
Increased serum concentration of urinary trypsin inhibitor with asthma exacerbation.
Inhibition of human neutrophil elastase by ICI 200,355.
Neutrophil elastase inhibitor suppresses oxidative stress in obese asthmatic rats by activating Keap1/Nrf2 signaling pathway.
Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease.
Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation.
Role of neutrophil elastase in hypersecretion in asthma.
The role of inducible costimulatory molecular ligand (ICOSL) in children with neutrophilic asthma.
[Role of serum neutrophil elastase determination in the diagnosis of acute exacerbation of asthma in preschool children].
Asymptomatic Infections
Induction of immunoresponse by subclinical male genital tract infection?
Atherosclerosis
Age-dependent variations of human PMNL elastase activity as a function of pH, ionic strength and calcium concentration.
Detection of human neutrophil elastase by aptamer affinity capillary electrophoresis coupled with laser-induced fluorescence using specified site fluorescently labeled aptamer.
Elevated serum neutrophil elastase is related to prehypertension and airflow limitation in obese women.
Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis.
Human neutrophil elastase: mediator and therapeutic target in atherosclerosis.
In vitro and in vivo evidence for the role of elastase shedding of CD163 in human atherothrombosis.
Inhibition of human leukocyte elastase by chemically and naturally oversulfated galactosaminoglycans.
Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects.
Neutrophil elastase, von Willebrand factor, soluble thrombomodulin and percutaneous oxygen in peripheral atherosclerosis.
Plasma leukocyte elastase concentration and coronary artery disease.
Autoimmune Diseases
Correlation of PMN elastase and PMN elastase-to-neutrophil ratio with disease activity in patients with myositis.
Pyoderma gangrenosum and Wegener granulomatosis-like syndrome induced by cocaine.
The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo.
Bacteremia
Influence of the lysosomal elastase inhibitor eglin on the development of interstitial lung edema in E. coli bacteremia in pigs.
Peritonitis from perforated appendicitis: stress response after laparoscopic or open treatment.
Peritonitis from Perforated Peptic Ulcer and Immune Response.
Plasma neutrophil elastase alpha-1-proteinase inhibitor levels in premature neonates with coagulase-negative staphylococcal bacteremia.
Plasma neutrophil-activating peptide-1/interleukin-8 and neutrophil elastase in a primate bacteremia model.
Ultrasonic versus standard electric dissection in laparoscopic cholecystectomy in patients with acute calculous cholecystitis, complicated by peritonitis: influence on the postoperative systemic inflammation and immune response. A prospective randomized study.
Bacterial Infections
Alpha-1 Antitrypsin is Markedly Decreased Following Pulmonary F. tularensis Challenge.
Cytochemical determination of intracellular polymorphonuclear leukocyte elastase content in patients with severe bacterial infection and septicaemia correlated with coagulation parameters.
Diagnostic potential of neutrophil elastase inhibitor complex in the routine care of critically ill newborn infants.
Engineering synthetic breath biomarkers for respiratory disease.
Local regulation of neutrophil elastase activity by endogenous ?1-antitrypsin in lipopolysaccharide-primed hematological cells.
Lung Disease at Diagnosis in Infants with Cystic Fibrosis Detected by Newborn Screening.
Neutrophil elastase as a biomarker for bacterial infection in COPD.
Neutrophil Elastase Modulates Cytokine Expression: Contribution to Host defense against Pseudomonas aeruginosa-induced Pneumonia.
Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases.
Structural Basis for the Inhibition Mechanism of Ecotin against Neutrophil Elastase by Targeting the Active Site and Secondary Binding Site.
Thrombin-derived C-terminal fragments aggregate and scavenge bacteria and their proinflammatory products.
Trehalose does not affect the functions of human neutrophils in vitro.
[Clinical and genetic analysis of four patients with congenital neutropenia].
Behcet Syndrome
Assessment of Cytokine Release against Oral Mucosal Cell Line Culture (TR146) Stimulated by Neutrophil Elastase Associated with Behcet's Disease.
beta-Thalassemia
Neutrophil elastase in patients with homozygous beta-thalassemia and pseudoxanthoma elasticum-like syndrome.
Blister
A critical role for neutrophil elastase in experimental bullous pemphigoid.
Collagen XVII Processing and Blistering Skin Diseases.
Distinct compartmentalization of immune cells and mediators characterizes bullous pemphigoid disease.
Evidence of Neutrophil Functional Defect Despite Inflammation in Stable Cirrhosis.
Innate Immune Cell-Produced IL-17 Sustains Inflammation in Bullous Pemphigoid.
Respective contribution of neutrophil elastase and matrix metalloproteinase 9 in the degradation of BP180 (type XVII collagen) in human bullous pemphigoid.
The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo.
Bone Marrow Failure Disorders
Paternal Somatic Mosaicism of a Novel Frameshift Mutation in ELANE Causing Severe Congenital Neutropenia.
Role of neutrophil elastase in bone marrow failure syndromes: molecular genetic revival of the chalone hypothesis.
Bone Resorption
The expression of macrophage and neutrophil elastases in rat periradicular lesions.
Brain Diseases
Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy.
In response to letter to Editor by Nosaka et al. on our paper: Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy. J Neurol Sci 2015;349:190-195.
Letter to the Editor regarding the paper by Sun G et al: Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy. J Neuro Sci 2015;349:190-195.
Brain Injuries
S-100b as a screening marker of the severity of minor head trauma (MHT)--a pilot study.
Brain Injuries, Traumatic
Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock.
Brain Ischemia
Involvement of Progranulin and Granulin Expression in Inflammatory Responses after Cerebral Ischemia.
Mesenchymal stem cells transplantation suppresses inflammatory responses in global cerebral ischemia: contribution of TNF-?-induced protein 6.
Neutrophil elastase inhibitor prevents ischemic brain damage via reduction of vasogenic edema.
Neutrophil elastase mediates acute pathogenesis and is a determinant of long-term behavioral recovery after traumatic injury to the immature brain.
Possible involvement of progranulin in the protective effect of elastase inhibitor on cerebral ischemic injuries of neuronal and glial cells.
Thrombolytic properties of leukocytes from peripheral blood in healthy subjects and in patients with acute cerebral ischemia.
Brain Neoplasms
A Pilot Proteomic Analysis of Salivary Biomarkers in Autism Spectrum Disorder.
Proteomic profile of saliva and plasma from women with impalpable breast lesions.
Breast Neoplasms
Breast cancer cell uptake of the inflammatory mediator neutrophil elastase triggers an anticancer adaptive immune response.
Elevated expression of polymorphonuclear leukocyte elastase in breast cancer tissue is associated with tamoxifen failure in patients with advanced disease.
Free-form neutrophil elastase is an independent marker predicting recurrence in primary breast cancer.
Growth effect of neutrophil elastase on breast cancer: favorable action of sivelestat and application to anti-HER2 therapy.
Impact of cyclins E, neutrophil elastase and proteinase 3 expression levels on clinical outcome in primary breast cancer patients.
Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells.
Neutrophil elastase enhances antigen presentation by upregulating human leukocyte antigen class I expression on tumor cells.
Neutrophil elastase predicts trastuzumab responsiveness in metastatic breast cancer.
Prognostic significance of immunoreactive neutrophil elastase in human breast cancer: long-term follow-up results in 313 patients.
Prognostic significance of three novel biologic factors in a clinical trial of adjuvant therapy for node-negative breast cancer.
The neutrophil elastase inhibitor elafin triggers rb-mediated growth arrest and caspase-dependent apoptosis in breast cancer.
The prognostic value of polymorphonuclear leukocyte elastase in patients with primary breast cancer.
Bronchial Diseases
Bronchial inflammation: its relationship to colonizing microbial load and alpha(1)-antitrypsin deficiency.
New approaches to the management of COPD.
Bronchial Hyperreactivity
Macrolides as biological response modifiers in cystic fibrosis and bronchiectasis.
Bronchiectasis
A point-of-care neutrophil elastase activity assay identifies bronchiectasis severity, airway infection and risk of exacerbation.
Airway inflammation in cystic fibrosis.
AZD9668: pharmacological characterisation of a novel oral inhibitor of neutrophil elastase.
Bronchiectasis in Infants and Preschool Children Diagnosed with Cystic Fibrosis after Newborn Screening.
Cathepsin-G interferes with clearance of Pseudomonas aeruginosa from mouse lungs.
Clinical phenotypes in adult patients with bronchiectasis.
Diagnosis and early life risk factors for bronchiectasis in cystic fibrosis: a review.
Effects of human neutrophil elastase and Pseudomonas aeruginosa proteinases on human respiratory epithelium.
Evaluation of active neutrophil elastase in sputum of bronchiectasis and cystic fibrosis patients: A comparison among different techniques.
Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy.
Levels of neutrophil elastase and cathepsin B activities, and cystatins in human sputum: relationship to inflammation.
Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis.
Neutrophil Elastase Activity is Associated with Exacerbations and Lung Function Decline in Bronchiectasis.
Neutrophil Elastase and Chronic Lung Disease.
Neutrophil elastase gene polymorphisms: modulators of response to therapy in childhood bronchiectasis?
Neutrophil elastase in bronchiectasis.
Neutrophil elastase inhibitors: recent advances in the development of mechanism-based and nonelectrophilic inhibitors.
Personalised anti-inflammatory therapy for bronchiectasis and cystic fibrosis: selecting patients for controlled trials of neutrophil elastase inhibition.
Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis.
Phase II study of a neutrophil elastase inhibitor (AZD9668) in patients with bronchiectasis.
Safety and efficacy of the human neutrophil elastase inhibitor BAY 85-8501 for the treatment of non-cystic fibrosis bronchiectasis: A randomized controlled trial.
Sputum Neutrophil Elastase as a Biomarker for Disease Activity in Bronchiectasis.
Sputum Neutrophil Elastase associates with microbiota and P. aeruginosa in bronchiectasis.
Sputum neutrophil elastase in bronchiectasis: a Southern European cohort study.
Sputum sol neutrophil elastase activity in bronchiectasis: differential modulation by syndecan-1.
Sputum sol phase proteins and elastase activity in patients with clinically stable bronchiectasis.
[Clinical and pathophysiological significance of neutrophil elastase in sputum and the effect of erythromycin in chronic respiratory diseases]
[Early lung disease in cystic fibrosis].
[Early lung disease in infants with cystic fibrosis. Diagnostic tools and possible therapeutic pathways].
Bronchiolitis
Human neutrophil elastase in RSV bronchiolitis.
IL-8 and neutrophil elastase levels in the respiratory tract of infants with RSV bronchiolitis.
Neutrophil elastase and obliterative bronchiolitis.
Transforming growth factor-beta1 is a potent inhibitor of secretory leukoprotease inhibitor expression in a bronchial epithelial cell line. Munich Lung Transplant Group.
Bronchitis
Proteolytic inactivation of alpha 1-proteinase inhibitor in infected bronchial secretions from patients with cystic fibrosis.
Bronchitis, Chronic
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.
Chronic bronchitis: the antiproteinase/proteinase balance and the effect of infection and corticosteroids.
ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposure.
Inhibition of human neutrophil elastase by ICI 200,355.
Mucin-producing elements and inflammatory cells.
[Clinical and pathophysiological significance of neutrophil elastase in sputum and the effect of erythromycin in chronic respiratory diseases]
Bronchopulmonary Dysplasia
Effects of the early administration of sivelestat sodium on bronchopulmonary dysplasia in infants: A retrospective cohort study.
Neutrophil Elastase and Chronic Lung Disease.
Proteinase-antiproteinase balance in tracheal aspirates from neonates.
SERPINB1 upregulation is associated with in vivo complex formation with neutrophil elastase and cathepsin G in a baboon model of bronchopulmonary dysplasia.
The levels of the neutrophil elastase in the amniotic fluid of pregnant women whose infants develop bronchopulmonary dysplasia.
Campylobacter Infections
Induction of neutrophil extracellular traps by Campylobacter jejuni.
Capillary Leak Syndrome
The response of antithrombin III activity after supplementation decreases in proportion to the severity of sepsis and liver dysfunction.
Carcinogenesis
Alpha1-antitrypsin and neutrophil elastase imbalance and lung cancer risk.
Neutrophil elastase in the tumor microenvironment.
Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis.
Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase.
Carcinoma
A large-scale transcriptome analysis identified ELANE and PRTN3 as novel methylation prognostic signatures for clear cell renal cell carcinoma.
A potentially novel peptidase, resembling but distinct from neutrophil elastase, produced by carcinoma cells.
A Strong Neutrophil Elastase Proteolytic Fingerprint Marks the Carcinoma Tumor Proteome.
Assessment of Cytokine Release against Oral Mucosal Cell Line Culture (TR146) Stimulated by Neutrophil Elastase Associated with Behcet's Disease.
Complete inhibition of spontaneous pulmonary metastasis of human lung carcinoma cell line EBC-1 by a neutrophil elastase inhibitor (ONO-5046.Na).
Demonstration of skin-derived antileukoproteinase (SKALP) and its target enzyme human leukocyte elastase in squamous cell carcinoma.
Effect of type of resection on plasma granulocyte elastase levels following surgery for non-small cell lung carcinoma.
Human colon carcinoma cells synthesize and secrete alpha 1-proteinase inhibitor.
Latency of cathepsin B secreted by human colon carcinoma cells is not linked to secretion of cystatin C and is relieved by neutrophil elastase.
Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells.
Neutrophil elastase induces IL-8 gene transcription and protein release through p38/NF-{kappa}B activation via EGFR transactivation in a lung epithelial cell line.
Neutrophil elastase inhibitor (ONO-5046.Na) suppresses the proliferation, motility and chemotaxis of a pancreatic carcinoma cell line, Capan-1.
Polymorphonuclear elastase in human colorectal carcinoma.
Sivelestat, a specific neutrophil elastase inhibitor, suppresses the growth of gastric carcinoma cells by preventing the release of transforming growth factor-alpha.
The enigma PAI-2. Gene expression, evolutionary and functional aspects.
Carcinoma, Non-Small-Cell Lung
Adhesion molecule expression in vascular endothelial cells incubated with cancer cell line supernatant are inhibited by neutrophil elastase inhibitor (ONO-5046.Na).
Complete inhibition of spontaneous pulmonary metastasis of human lung carcinoma cell line EBC-1 by a neutrophil elastase inhibitor (ONO-5046.Na).
Effect of type of resection on plasma granulocyte elastase levels following surgery for non-small cell lung carcinoma.
Local increase in polymorphonuclear leukocyte elastase is associated with tumor invasiveness in non-small cell lung cancer.
Neutrophil Elastase as a Target in Lung Cancer.
Neutrophil elastase inhibitor (ONO-5046-Na) inhibits the growth of human lung cancer cell lines transplanted into severe combined immunodeficiency (scid) mice.
SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer.
Tumor neutrophil elastase is closely associated with the direct extension of non-small cell lung cancer into the aorta.
Carcinoma, Ovarian Epithelial
Neutrophil Granulocytes in Ovarian Cancer - Induction of Epithelial-To-Mesenchymal-Transition and Tumor Cell Migration.
Carcinoma, Renal Cell
A large-scale transcriptome analysis identified ELANE and PRTN3 as novel methylation prognostic signatures for clear cell renal cell carcinoma.
Carcinoma, Squamous Cell
Demonstration of skin-derived antileukoproteinase (SKALP) and its target enzyme human leukocyte elastase in squamous cell carcinoma.
The enigma PAI-2. Gene expression, evolutionary and functional aspects.
Cardiomyopathy, Dilated
Increased expression of promatrix metalloproteinase-9 and neutrophil elastase in canine dilated cardiomyopathy.
Cardiomyopathy, Hypertrophic
Neutrophil extracellular traps in feline cardiogenic arterial thrombi: a pilot study.
Cardiovascular Diseases
Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects.
Neutrophil elastase gene variation and coronary heart disease.
Relative value of inflammatory, hemostatic, and rheological factors for incident myocardial infarction and stroke: the Edinburgh Artery Study.
Serum tissue-degrading proteinases and incident cardiovascular disease events.
Central Nervous System Diseases
[Polymorphonuclear leukocyte elastase in the cerebrospinal fluid in the diagnosis of acute inflammatory central nervous system diseases]
Cerebral Hemorrhage
Increase in jugular levels of polymorphonuclear neutrophil elastase in patients with acute cerebral infarction.
Cerebral Infarction
Increase in jugular levels of polymorphonuclear neutrophil elastase in patients with acute cerebral infarction.
Neutrophil elastase inhibitor attenuates hippocampal neuronal damage after transient forebrain ischemia in rats.
Chediak-Higashi Syndrome
Neutrophil elastase and cathepsin G protein and messenger RNA expression in bone marrow from a patient with Chediak-Higashi syndrome.
Cholangitis, Sclerosing
Antineutrophil cytoplasmic antibodies: a still-growing class of autoantibodies in inflammatory disorders.
Cholecystolithiasis
Studies on the role of antileukoprotease in respiratory tract diseases.
Chorioamnionitis
Amniotic fluid neutrophil elastase and lactate dehydrogenase: association with histologic chorioamnionitis.
Impact of subclinical chorioamnionitis on maternal and neonatal outcomes.
Increased Risk of Intrauterine Transmission of HIV-1 Associated With Granulocyte Elastase in Endocervical Mucus.
Neutrophil elastase and interleukin-6 in amniotic fluid as indicators of chorioamnionitis and funisitis.
[The assessment of neutrophil elastase measurements usefulness in pregnant women with premature rupture of fetal membranes and chorioamnionitis suspicion]
[The study on mechanism of abruptio placentae caused by chorioamnionitis]
[Usefulness of determination of granulocyte elastase plasma level, c-reactive protein and white blood cell count in prediction in intrauterine infection in pregnant women after PROM]
Chronic Periodontitis
Degradation of noncollagenous components by neutrophil elastase reduces the mechanical strength of rat periodontal ligament.
Evaluation of Systemic Levels of Neutrophilic Enzymes in Hypertensive Patients With Chronic Periodontitis.
Granulocyte elastase activity and PGE2 levels in gingival crevicular fluid in relation to the presence of subgingival periodontopathogens in subjects with untreated adult periodontitis.
Interleukin-8 and granulocyte elastase in gingival crevicular fluid in relation to periodontopathogens in untreated adult periodontitis.
Methodological evaluation of gingival crevicular fluid volume and neutrophil elastase levels: sequential sampling, length of sampling time and two different sampling methods.
Neutrophil elastase is involved in the initial destruction of human periodontal ligament.
Neutrophil elastase levels in the gingival crevicular fluid following hyaluronan gel application in the treatment of chronic periodontitis: A randomized split-mouth study.
Oxidative stress, neutrophil elastase and IGFBP7 levels in patients with oropharyngeal cancer and chronic periodontitis.
Proinflammatory cytokines production and PMN-elastase release from activated PMN cells in the periodontal disease.
Relationship of changes in interleukin-8 levels and granulocyte elastase activity in gingival crevicular fluid to subgingival periodontopathogens following non-surgical periodontal therapy in subjects with chronic periodontitis.
Serum and salivary matrix metalloproteinases, neutrophil elastase, myeloperoxidase in patients with chronic or aggressive periodontitis.
Smoking and matrix metalloproteinases, neutrophil elastase and myeloperoxidase in chronic periodontitis.
Coinfection
Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections.
[Biochemical wound monitoring. PMN elastase in different healing stages after trauma surgery-orthopedic interventions]
Colic
Development of an enzyme-linked immunosorbent assay for equine neutrophil elastase measurement in blood: preliminary application to colic cases.
Colitis
Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease.
Colonic ulceration and increase of neutrophil elastase activity in the acetic acid-induced colitis model in Syrian hamsters.
Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters.
Faecal neutrophil elastase-antiprotease balance reflects colitis severity.
Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis.
Investigation of neutrophils in the gut lumen by assay of granulocyte elastase in whole-gut lavage fluid.
Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.
Neutrophil elastase in colitis: more than a marker of disease activity?
NEUTROPHIL ELASTASE INHIBITOR SUPPRESSES IL-17 BASED INFLAMMATION OF MURINE EXPERIMENTAL COLITIS.
Pathophysiological studies of trinitrobenzene sulfonic acid-induced colitis in Syrian hamsters (Mesocricetus auratus).
Thromboxane A2 up-regulates neutrophil elastase release in Syrian hamsters with trinitrobenzene sulfonic acid-induced colitis.
[Application of chosen granulocyte markers in diagnostics of Le?niowski-Crohn's disease and ulcerative colitis--preliminary research]
Colitis, Ulcerative
Antineutrophil cytoplasmic antibodies: a still-growing class of autoantibodies in inflammatory disorders.
Colonic proteinases: increased activity in patients with ulcerative colitis.
Comparison of 4 neutrophil-derived proteins in feces as indicators of disease activity in ulcerative colitis.
Fecal Lactoferrin, Calprotectin, PMN-Elastase, CRP and White Blood Cell Count as an Indicator for Mucosal Healing and Clinical Course of Disease in Patients with Mild to Moderate Ulcerative Colitis: Post HOC Analysis of a Prospective Clinical Trial.
Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies.
PMN-elastase in assessment of patients with inflammatory bowel disease.
Possible involvement of neutrophil elastase in impaired mucosal repair in patients with ulcerative colitis.
Respiratory burst of circulating polymorphonuclear leukocytes and plasma elastase levels in patients with inflammatory bowel disease in remission.
Serpin B1 protects colonic epithelial cell via blockage of neutrophil elastase activity and its expression is enhanced in patients with ulcerative colitis.
The forms and the levels of fecal PMN-elastase in patients with colorectal diseases.
The use of selected neutrophil protein plasma concentrations in the diagnosis of Crohn's disease and ulcerative colitis - a preliminary report.
[Application of chosen granulocyte markers in diagnostics of Le?niowski-Crohn's disease and ulcerative colitis--preliminary research]
[Neutrophil elastase activity in patients with ulcerative colitis]
Colonic Neoplasms
The forms and the levels of fecal PMN-elastase in patients with colorectal diseases.
Colorectal Neoplasms
Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers.
Polymorphonuclear elastase in human colorectal carcinoma.
Common Cold
Secretory leukocyte protease inhibitor in normal, allergic and virus induced nasal secretions.
Communicable Diseases
A possible pathogenic correlation between neutrophil elastase (NE) enzyme and inflammation in the pathogenesis of coronavirus disease 2019 (COVID-19).
Circulating neutrophil elastase in infectious diseases in geriatric patients.
Kallikrein-kinin in infection and cancer.
Connective Tissue Diseases
The role of inflammatory cells and their proteases in extravascular fibrinolysis.
Contracture
Elevated Serum Concentrations of Polymorphonuclear Neutrophilic Leukocyte Elastase in Systemic Sclerosis: Association with Pulmonary Fibrosis.
Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis: association with pulmonary fibrosis.
Corneal Ulcer
[PMN elastase determination in tear fluid in corneal ulcer]
Coronary Artery Disease
Plasma leukocyte elastase concentration and coronary artery disease.
Plasma leukocyte elastase concentration in angiographically diagnosed coronary artery disease.
[Activity of leukocyte elastase in coronary disease diagnosed by coronarography]
Coronary Disease
Neutrophil elastase gene variation and coronary heart disease.
[Activity of leukocyte elastase in coronary disease diagnosed by coronarography]
COVID-19
A possible pathogenic correlation between neutrophil elastase (NE) enzyme and inflammation in the pathogenesis of coronavirus disease 2019 (COVID-19).
Anti-protease Treatments Targeting Plasmin(ogen) and Neutrophil Elastase May Be Beneficial in Fighting COVID-19.
Elastase and exacerbation of neutrophil innate immunity are involved in multi-visceral manifestations of COVID-19.
Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients.
Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
Neutrophil Extracellular Traps (NETs) in Severe SARS-CoV-2 Lung Disease.
Craniocerebral Trauma
Neutrophil elastase may play a key role in developing symptomatic disseminated intravascular coagulation and multiple organ failure in patients with head injury.
Crohn Disease
Fecal leukocyte proteins in inflammatory bowel disease and irritable bowel syndrome.
Frequency of continuing mucosal inflammation in clinically inactive Crohn's disease.
Granulocyte elastase and systemic cytokine response after laparoscopic-assisted and open resections in Crohn's disease.
Gut luminal neutrophil migration is influenced by the anatomical site of Crohn's disease.
PMN-elastase in assessment of patients with inflammatory bowel disease.
Respiratory burst of circulating polymorphonuclear leukocytes and plasma elastase levels in patients with inflammatory bowel disease in remission.
The forms and the levels of fecal PMN-elastase in patients with colorectal diseases.
The use of selected neutrophil protein plasma concentrations in the diagnosis of Crohn's disease and ulcerative colitis - a preliminary report.
Cutis Laxa
Sweet's syndrome leading to acquired cutis laxa (Marshall's syndrome) in an infant with alpha 1-antitrypsin deficiency.
Cystic Fibrosis
2-O, 3-O-Desulfated Heparin Inhibits Neutrophil Elastase-Induced HMGB-1 Secretion and Airway Inflammation.
A novel locust (Schistocerca gregaria) serine protease inhibitor with a high affinity for neutrophil elastase.
A novel neutrophil elastase inhibitor prevents elastase activation and surface cleavage of the epithelial sodium channel expressed in Xenopus laevis oocytes.
A secretory leukocyte protease inhibitor variant with improved activity against lung infection.
A small molecule neutrophil elastase inhibitor, KRP-109, inhibits cystic fibrosis mucin degradation.
A specialized method of sputum collection and processing for therapeutic interventions in cystic fibrosis.
Acute lung injury induced by Pseudomonas aeruginosa elastase in hamsters.
Aerosol alpha 1-antitrypsin treatment for cystic fibrosis.
Aerosol treatment with MNEI suppresses bacterial proliferation in a model of chronic Pseudomonas aeruginosa lung infection.
Aerosolized prolastin suppresses bacterial proliferation in a model of chronic Pseudomonas aeruginosa lung infection.
Alginate, the slime exopolysaccharide of Pseudomonas aeruginosa, binds human leukocyte elastase, retards inhibition by alpha 1-proteinase inhibitor, and accelerates inhibition by secretory leukoprotease inhibitor.
Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications.
Alpha 1-antitrypsin Mitigates the Inhibition of Airway Epithelial Cell Repair by Neutrophil Elastase.
Alpha 1-proteinase inhibitor abrogates proteolytic and secretagogue activity of cystic fibrosis sputum.
alpha 1-Proteinase inhibitor, elastase activity, and lung disease severity in cystic fibrosis.
Alpha-1 Antitrypsin Therapy in Cystic Fibrosis and the Lung Disease Associated with Alpha-1 Antitrypsin Deficiency.
Annexin II mediates the neutrophil elastase-stimulated exocytosis of mucin 5ac.
Anti-inflammatory activity of neutrophil elastase inhibitors.
Anti-inflammatory effects of DX-890, a human neutrophil elastase inhibitor.
Attenuation of host defense function of lung phagocytes in young cystic fibrosis patients.
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.
Ceramide is Increased in the Lower Airway Epithelium of People with Advanced Cystic Fibrosis Lung Disease.
Changes in airway inflammation with pseudomonas eradication in early cystic fibrosis.
Chronic bacterial pulmonary infections in advanced cystic fibrosis differently affect the level of sputum neutrophil elastase, IL-8 and IL-6.
Cleavage of lymphocyte surface antigens CD2, CD4, and CD8 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis.
Colistin stimulates the activity of neutrophil elastase and Pseudomonas aeruginosa elastase.
Cytokine concentrations and neutrophil elastase activity in bronchoalveolar lavage and induced sputum from patients with cystic fibrosis, mild asthma and healthy volunteers.
Decreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation.
Diagnosis and early life risk factors for bronchiectasis in cystic fibrosis: a review.
Different susceptibility of elastase inhibitors to inactivation by proteinases from Staphylococcus aureus and Pseudomonas aeruginosa.
Direct assessment of gastrointestinal inflammation and mucosal immunity in children with cystic fibrosis.
DX-890 (Dyax).
Effect of nebulised recombinant DNase on neutrophil elastase load in cystic fibrosis.
Effect of neutrophil elastase and its inhibitor EPI-hNE4 on transepithelial sodium transport across normal and cystic fibrosis human nasal epithelial cells.
Effect of pro-inflammatory stimuli on mucin expression and inhibition by secretory leucoprotease inhibitor.
Effect of recombinant human DNase on alpha1-proteinase inhibitor function: an experimental approach to the combined clinical use of rhDNase and alpha1-PI in CF patients.
Effects of cystic fibrosis airway secretions on rat lung: role of neutrophil elastase.
Effects of native and oxidation-resistant secretory leukoprotease inhibitor on cystic fibrosis sputum: inhibition of neutrophil elastase activity and of sputum-induced secretion from porcine tracheal submucosal glands.
Effects of pentoxifylline on sputum neutrophil elastase and pulmonary function in patients with cystic fibrosis: preliminary observations.
Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis.
Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis.
EPI-hNE4, a proteolysis-resistant inhibitor of human neutrophil elastase and potential anti-inflammatory drug for treating cystic fibrosis.
ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposure.
Evaluation of active neutrophil elastase in sputum of bronchiectasis and cystic fibrosis patients: A comparison among different techniques.
Evidence that Pseudomonas aeruginosa elastase does not inactivate the bronchial inhibitor in the presence of leukocyte elastase. Studies with cystic fibrosis sputum and with pure proteins.
Glycosaminoglycans as Multifunctional Anti-Elastase and Anti-Inflammatory Drugs in Cystic Fibrosis Lung Disease.
Granulocyte elastase-alpha 1-antiproteinase complex in cystic fibrosis: sensitive plasma assay for monitoring pulmonary infections.
Granulocyte elastase-mediated proteolysis of alpha 1-antitrypsin in cystic fibrosis bronchopulmonary secretions.
Human neutrophil elastase and elastase/alpha 1-antiprotease complex in cystic fibrosis. Comparison with interstitial lung disease and evaluation of the effect of intravenously administered antibiotic therapy.
Hyaluronan blocks porcine pancreatic elastase-induced mucociliary dysfunction in allergic sheep.
In Vitro Activities against Cystic Fibrosis Pathogens of Synthetic Host Defence Propeptides Processed by Neutrophil Elastase.
In vitro inhibition of neutrophil elastase activity by inhaled anti-Pseudomonas antibiotics used in cystic fibrosis patients.
Increased expression of senescence markers in cystic fibrosis airways.
Induction of interleukin-8 release by lung epithelium with cystic fibrosis epithelial lining fluid is marginally affected by inhibitors of interleukin-1beta.
Inhaled porcine pancreatic elastase causes bronchoconstriction via a bradykinin-mediated mechanism.
Inhibition of human neutrophil elastase by ICI 200,355.
Interleukin-8 up-regulation by neutrophil elastase is mediated by MyD88/IRAK/TRAF-6 in human bronchial epithelium.
Lack of neutrophil elastase reduces inflammation, mucus hypersecretion and emphysema, but not mucus obstruction, in mice with CF-like lung disease.
Leukocyte elastase inhibition therapy in cystic fibrosis: role of glycosylation on the distribution of alpha-1-proteinase inhibitor in blood versus lung.
Levels of free granulocyte elastase in bronchial secretions from patients with cystic fibrosis: effect of antimicrobial treatment against Pseudomonas aeruginosa.
Levels of pro- and anti-inflammatory cytokines in cystic fibrosis patients with or without gingivitis.
Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis.
Modification of some markers of inflammation during treatment for acute respiratory exacerbation in cystic fibrosis.
Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor.
Molecular principles for heparin oligosaccharide-based inhibition of neutrophil elastase in cystic fibrosis.
Mucin overproduction in chronic inflammatory lung disease.
Neutrophil collagenase in sputum from patients with cystic fibrosis.
Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport.
Neutrophil Elastase and Chronic Lung Disease.
Neutrophil elastase and elastase-rich cystic fibrosis sputum degranulate human eosinophils in vitro.
Neutrophil elastase and matrix metalloproteinase 12 in cystic fibrosis lung disease.
Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch.
Neutrophil elastase correlates with increased sphingolipid content in cystic fibrosis sputum.
Neutrophil elastase degrades cystic fibrosis transmembrane conductance regulator via calpains and disables channel function in vitro and in vivo.
Neutrophil elastase enhances sputum solubilization in cystic fibrosis patients receiving DNase therapy.
Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line.
Neutrophil elastase inhibition of cell cycle progression in airway epithelial cells in vitro is mediated by p27kip1.
Neutrophil elastase inhibitors for cystic fibrosis.
Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway.
Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4.
Neutrophil plasticity enables the development of pathological microenvironments: implications for cystic fibrosis airway disease.
Non-peptidic inhibitors of human leukocyte elastase. 1. The design and synthesis of pyridone-containing inhibitors.
On the Process of Discovering Leads That Target the Heparin-Binding Site of Neutrophil Elastase in the Sputum of Cystic Fibrosis Patients.
Oncostatin M, but not interleukin-6 or leukemia inhibitory factor, stimulates expression of alpha1-proteinase inhibitor in A549 human alveolar epithelial cells.
Personalised anti-inflammatory therapy for bronchiectasis and cystic fibrosis: selecting patients for controlled trials of neutrophil elastase inhibition.
Phagocyte extracellular traps in children with neutrophilic airway inflammation.
Pharmacokinetics of recombinant secretory leukoprotease inhibitor aerosolized to normals and individuals with cystic fibrosis.
Phosphonic pseudopeptides as human neutrophil elastase inhibitors--a combinatorial approach.
Polymorphonuclear leukocyte elastase: its effects on the pathogenesis of Pseudomonas aeruginosa infection in cystic fibrosis.
Polysulfated Hyaluronan GlycoMira-1111 Inhibits Elastase and Improves Rheology in Cystic Fibrosis Sputum.
Prolastin aerosol therapy and sputum taurine in cystic fibrosis.
Protection against acute lung injury by intravenous or intratracheal pretreatment with EPI-HNE-4, a new potent neutrophil elastase inhibitor.
Proteinase 3, a potent secretagogue in airways, is present in cystic fibrosis sputum.
Proteolytic cleavage of ICAM-1 by human neutrophil elastase.
Proteolytic inactivation of alpha 1-proteinase inhibitor in infected bronchial secretions from patients with cystic fibrosis.
Pulmonary deposition and disappearance of aerosolised secretory leucocyte protease inhibitor.
Reduced neutrophil elastase inhibitor elafin and elevated transforming growth factor-?1 are linked to inflammatory response in sputum of cystic fibrosis patients with Pseudomonas aeruginosa.
Reduction in neutrophil elastase concentration by recombinant alphal-antitrypsin (recAAT) does not alter bacterial loading in the sputum of cystic fibrosis patients.
Safety and efficacy of recombinant alpha(1)-antitrypsin therapy in cystic fibrosis.
Sesquiterpene lactones as inhibitors of human neutrophil elastase.
Single dose escalation studies with inhaled POL6014, a potent novel selective reversible inhibitor of human neutrophil elastase, in healthy volunteers and subjects with cystic fibrosis.
Sputum and Plasma Neutrophil Elastase in Stable Adult Patients With Cystic Fibrosis in Relation to Chronic Pseudomonas Aeruginosa Colonization.
Stability of interleukin 8 and neutrophil elastase in bronchoalveolar lavage fluid following long-term storage.
Targeting neutrophil elastase in cystic fibrosis.
The effects of recombinant human DNase on neutrophil elastase activity and interleukin-8 levels in the sputum of patients with cystic fibrosis.
The role of neutrophil elastase in chronic inflammation.
Thioredoxin and dihydrolipoic acid inhibit elastase activity in cystic fibrosis sputum.
Towards better understanding of the heparin role in NETosis: feasibility of using native mass spectrometry to monitor interactions of neutrophil elastase with heparin oligomers.
Transport of bifunctional proteins across respiratory epithelial cells via the polymeric immunoglobulin receptor.
Unopposed neutrophil elastase in bronchoalveolar lavage from transplant recipients with cystic fibrosis.
Validation of an ELISA for determination of antibodies induced in monkeys against Epi-hNE4, a recombinant protein inhibitor of human neutrophil elastase.
Whole body periodic acceleration in normal and reduced mucociliary clearance of conscious sheep.
Cystitis, Interstitial
Increased concentration of neutrophil elastase in urine from patients with interstitial cystitis.
Dementia, Vascular
[Inflammatory markers in Alzheimer's disease and vascular dementia.]
Demyelinating Diseases
Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice.
Dengue
Plasma Neutrophil Elastase, ?1-Antitrypsin, ?2-Macroglobulin and Neutrophil Elastase-?1-Antitrypsin Complex Levels in patients with Dengue Fever.
RNA-Seq analysis of peripheral blood mononuclear cells reveals unique transcriptional signatures associated with disease progression in dengue patients.
Dental Plaque
Impact of Smoking on Neutrophil Enzyme Levels in Gingivitis: A Case-Control Study.
Dermatitis
Murine lupus is neutrophil elastase-independent in the MRL.Faslpr model.
Dermatitis Herpetiformis
A comparative study of expression of Fc receptors in relation to the autoantibody-mediated immune response and neutrophil elastase expression in autoimmune blistering dermatoses.
Cutaneous expressions of interleukin-6 and neutrophil elastase as well as levels of serum IgA antibodies to gliadin nonapeptides, tissue transglutaminase and epidermal transglutaminase: implications for both autoimmunity and autoinflammation involvement in dermatitis herpetiformis.
Dermatitis, Allergic Contact
Cutaneous expressions of interleukin-6 and neutrophil elastase as well as levels of serum IgA antibodies to gliadin nonapeptides, tissue transglutaminase and epidermal transglutaminase: implications for both autoimmunity and autoinflammation involvement in dermatitis herpetiformis.
Dermatitis, Atopic
Activity of leukocyte elastase in patients' plasma is a significant indicator of atopic diseases.
Starch nanocapsules containing a novel neutrophil elastase inhibitor with improved pharmaceutical performance.
Dermatomyositis
Correlation of PMN elastase and PMN elastase-to-neutrophil ratio with disease activity in patients with myositis.
Diabetes Mellitus
A Novel SERPINB1 Single-Nucleotide Polymorphism Associated With Glycemic Control and ?-Cell Function in Egyptian Type 2 Diabetic Patients.
Expression of neutrophil elastase and myeloperoxidase mRNA in patients with newly diagnosed type 2 diabetes mellitus.
Neutrophil activation detected by increased neutrophil elastase activity in type 1 (insulin-dependent) diabetes mellitus.
Neutrophil count and activation in vascular disease.
[Possible participation of angiotensin-converting enzyme and leukocyte elastase in the pathogenesis of insulin-independent diabetes mellitus]
Diabetes Mellitus, Type 1
Increased neutrophil elastase and proteinase 3 and augmented NETosis are closely associated with ?-cell autoimmunity in patients with type 1 diabetes.
Neutrophil count and activation in vascular disease.
Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice.
Neutrophil-Associated Inflammatory Changes in the Pre-Diabetic Pancreas of Early-Age NOD Mice.
Diabetes Mellitus, Type 2
A Novel SERPINB1 Single-Nucleotide Polymorphism Associated With Glycemic Control and ?-Cell Function in Egyptian Type 2 Diabetic Patients.
Concentration of leukocyte elastase in plasma and polymorphonuclear neutrophil extracts in type 2 diabetes.
Expression of neutrophil elastase and myeloperoxidase mRNA in patients with newly diagnosed type 2 diabetes mellitus.
Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
The relationship of neutrophil elastase and proteinase 3 with risk factors, and chronic complications in type 2 diabetes: A Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) sub-study.
[Possible participation of angiotensin-converting enzyme and leukocyte elastase in the pathogenesis of insulin-independent diabetes mellitus]
Diabetes, Gestational
Excessive Neutrophil Activity in Gestational Diabetes Mellitus: Could It Contribute to the Development of Preeclampsia?
Diabetic Angiopathies
Concentration of leukocyte elastase in plasma and polymorphonuclear neutrophil extracts in type 2 diabetes.
Diabetic Ketoacidosis
Changes in serum amylase, lipase and leukocyte elastase during diabetic ketoacidosis and poorly controlled diabetes.
Elevated Leukocyte Azurophilic Enzymes in Human Diabetic Ketoacidosis Plasma Degrade Cerebrovascular Endothelial Junctional Proteins.
Diabetic Retinopathy
Evaluation of Circulating Markers of Neutrophil Extracellular Trap (NET) Formation as Risk Factors for Diabetic Retinopathy in a Case-Control Association Study.
Neutrophil elastase contributes to the pathological vascular permeability characteristic of diabetic retinopathy.
Discitis
New inflammation markers for early detection of spondylodiscitis.
Disseminated Intravascular Coagulation
A low TAFI activity and insufficient activation of fibrinolysis by both plasmin and neutrophil elastase promote organ dysfunction in disseminated intravascular coagulation associated with sepsis.
Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients.
Degradation of cross-linked fibrin by leukocyte elastase as alternative pathway for plasmin-mediated fibrinolysis in sepsis-induced disseminated intravascular coagulation.
Disseminated intravascular coagulation at an early phase of trauma is associated with consumption coagulopathy and excessive fibrinolysis both by plasmin and neutrophil elastase.
Increased neutrophil elastase, persistent intravascular coagulation, and decreased fibrinolytic activity in patients with posttraumatic acute respiratory distress syndrome.
Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
Neutrophil elastase may play a key role in developing symptomatic disseminated intravascular coagulation and multiple organ failure in patients with head injury.
Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both ARDS and DIC patients.
Soluble thrombomodulin increases in patients with disseminated intravascular coagulation and in those with multiple organ dysfunction syndrome after trauma: role of neutrophil elastase.
Temporal changes in factors associated with neutrophil elastase and coagulation in intensive care patients with a biphasic waveform and disseminated intravascular coagulation.
Usefulness of circulating vascular endothelial growth factor and neutrophil elastase as diagnostic markers of disseminated intravascular coagulation in non-cancer patients.
Diverticulitis
Investigation of neutrophils in the gut lumen by assay of granulocyte elastase in whole-gut lavage fluid.
Dry Eye Syndromes
Release of membrane-associated mucins from ocular surface epithelia.
Dyskeratosis Congenita
Current insights into inherited bone marrow failure syndromes.
Dyspnea
[Valproate sodium and zonisamide associated interstitial pneumonitis in an infant]
Ectodermal Dysplasia
Autosomal-dominant primary immunodeficiencies.
Ehlers-Danlos Syndrome
Histomorphometric parameters and susceptibility to neutrophil elastase degradation of skin elastic fibres from healthy individuals and patients with Marfan syndrome, Ehlers-Danlos type IV, and pseudoxanthoma elasticum.
Embolism
How to lower perinatal mortality? Perinatal care in Japan.
Embolism, Air
Specific neutrophil elastase inhibitor does not attenuate acute lung injury induced by air embolism in awake sheep.
Embolism, Amniotic Fluid
How to lower perinatal mortality? Perinatal care in Japan.
Embolism, Fat
From neurogenic pulmonary edema to fat embolism syndrome: a brief review of experimental and clinical investigations of acute lung injury and acute respiratory distress syndrome.
Empyema
Significance of microbiological and biochemical analyses in empyema thoracis.
[PMN-elastase as a marker in diagnosis and follow-up of bone and joint infections]
Encephalitis
An alternative elastase-mediated degradation of fibrinogen and fibrin observed in a patient with herpes simplex encephalitis and pneumonia.
Encephalitis, Herpes Simplex
An alternative elastase-mediated degradation of fibrinogen and fibrin observed in a patient with herpes simplex encephalitis and pneumonia.
Encephalomyelitis
A TLR-CXCL1 pathway in DRG neurons induces neutrophil accumulation in the DRG and mechanical allodynia in EAE mice.
Encephalomyelitis, Autoimmune, Experimental
A TLR-CXCL1 pathway in DRG neurons induces neutrophil accumulation in the DRG and mechanical allodynia in EAE mice.
Endometriosis
Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals.
Endotoxemia
A Synergy Between Endotoxin and (1?3)-Beta-D-Glucan Enhanced Neutrophil Extracellular Traps in Candida Administered Dextran Sulfate Solution Induced Colitis in FcGRIIB-/- Lupus Mice, an Impact of Intestinal Fungi in Lupus.
Neutrophil Elastase Damages the Pulmonary Endothelial Glycocalyx in Lipopolysaccharide-Induced Experimental Endotoxemia.
Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopulmonary bypass in the rabbit endotoxemia model.
Neutrophil elastase inhibitors, SC-37698 and SC-39026, reduce endotoxin-induced lung dysfunction in awake sheep.
Peritonitis from perforated appendicitis: stress response after laparoscopic or open treatment.
Peritonitis from Perforated Peptic Ulcer and Immune Response.
Reversible lung neutrophil accumulation can cause lung injury by elastase-mediated mechanisms.
The elastase-inhibitor eglin has no effect in an ovine model of endotoxemia.
Ultrasonic versus standard electric dissection in laparoscopic cholecystectomy in patients with acute calculous cholecystitis, complicated by peritonitis: influence on the postoperative systemic inflammation and immune response. A prospective randomized study.
Eosinophilia
Functional characteristics of circulating granulocytes in severe congenital neutropenia caused by ELANE mutations.
Epididymitis
Chronic epididymitis: impact on semen parameters and therapeutic options.
Erythema
Skin-infiltrating neutrophils following exposure to solar-simulated radiation could play an important role in photoageing of human skin.
Esophageal Neoplasms
Influence of neutrophil elastase inhibitor on the postoperative course in patients with esophageal cancer after transthoracic esophagectomy.
Optimal Period for the Prophylactic Administration of Neutrophil Elastase Inhibitor for Patients with Esophageal Cancer Undergoing Esophagectomy.
Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer.
Pulmonary hypertension and polymorphonuclear leukocyte elastase after esophageal cancer operations.
The effect of prostaglandin E1 on the increase of serum lactate and plasma granulocyte elastase activity during radical surgery for esophageal cancer.
The effects of the early administration of sivelestat sodium, a selective neutrophil elastase inhibitor, on the postoperative course after radical surgery for esophageal cancer.
[Alteration of serum levels of endotoxin, polymorphonuclear leukocyte elastase, and the molecular markers of the coagulation and fibrinolytic system in the patients with esophageal cancer and lung cancer before and following operation]
Essential Hypertension
Neutrophil count and activation in vascular disease.
Eye Diseases
[PMN elastase determination in tear fluid in corneal ulcer]
Familial Primary Pulmonary Hypertension
Neutrophil Extracellular Traps Promote Angiogenesis: Evidence From Vascular Pathology in Pulmonary Hypertension.
Fanconi Anemia
Current insights into inherited bone marrow failure syndromes.
Fatty Liver
Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
Mice Deficient in the IL-1? Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD.
Fetal Death
Neuromyelitis optica IgG causes placental inflammation and fetal death.
Fetal Membranes, Premature Rupture
[Importance of plasma PMN granulocyte elastase concentration determination in pregnant patients with premature rupture of fetal membranes]
[The assessment of neutrophil elastase measurements usefulness in pregnant women with premature rupture of fetal membranes and chorioamnionitis suspicion]
[The value of leukocytes, C-reactive protein and granulocyte elastase in patients with premature rupture of fetal membranes and amniotic infection]
[Usefulness of determination of granulocyte elastase plasma level, c-reactive protein and white blood cell count in prediction in intrauterine infection in pregnant women after PROM]
Food Hypersensitivity
Expression of IL-17A concentration and effector functions of peripheral blood neutrophils in food allergy hypersensitivity patients.
Gas Gangrene
Behavior of leukocyte elastase and immunglobulins in septic toxic multiorgan involvement: observations on 50 gas gangrene cases.
Gastritis
Enhanced systemic matrix metalloproteinase response in Helicobacter pylori gastritis.
Genetic Diseases, Inborn
Molecular characterisation of the defective alpha 1-antitrypsin alleles PI Mwurzburg (Pro369Ser), Mheerlen (Pro369Leu), and Q0lisbon (Thr68Ile).
Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport.
SPARTA clinical trial design: Exploring the efficacy and safety of two dose regimens of alpha1-proteinase inhibitor augmentation therapy in alpha1-antitrypsin deficiency.
Strategies for aerosol therapy of alpha 1-antitrypsin deficiency by the aerosol route.
Tumor necrosis factor-? driven inflammation in alpha-1 antitrypsin deficiency: a new model of pathogenesis and treatment.
[Proteinases and antiproteinases: biomedical correlations]
Giant Cell Arteritis
Temporal arteritis in polymyalgia rheumatica: immune complex deposits and the role of the leukocyte elastase in the pathogenesis.
Gingival Overgrowth
Matrix metalloproteinases (MMP-8 and -9) and neutrophil elastase in gingival crevicular fluid of cyclosporin-treated patients.
Gingivitis
Altered relation between granulocyte elastase and alpha-2-macroglobulin in gingival crevicular fluid from sites with periodontal destruction.
Concentration of interleukin-1beta and neutrophil elastase activity in gingival crevicular fluid during experimental gingivitis.
Gingival Inflammation and Salivary or Serum Granulocyte Secreted Enzymes in Patients With Polycystic Ovary Syndrome.
Granulocyte elastase in gingival crevicular fluid. A possible discriminator between gingivitis and periodontitis.
Impact of Smoking on Neutrophil Enzyme Levels in Gingivitis: A Case-Control Study.
Neutrophil elastase and its inhibitors in human gingival crevicular fluid during experimental gingivitis.
Proinflammatory cytokines production and PMN-elastase release from activated PMN cells in the periodontal disease.
Regulation of Salivary Peptidoglycan Recognition Protein1in Adolescents.
Salivary levels of MPO, MMP-8 and TIMP-1 are associated with gingival inflammation response patterns during experimental gingivitis.
The defensive role of lysozyme in human gingiva in inflammatory periodontal disease.
[The treatment of periodontal diseases using Diplen-Denta films with chlorhexidine (a clinico-laboratory study)]
Glomerulonephritis
Beneficial effect of neutrophil elastase inhibitor on anti-Thy1.1 nephritis in rats.
Effect of sivelestat, an inhibitor of neutrophil elastase, on rapidly progressive glomerulonephritis.
Involvement of neutrophil elastase in crescentic glomerulonephritis.
Renal expression of matrix metalloproteinases in human ANCA-associated glomerulonephritis.
Role of neutrophil elastase in the development of renal necrotizing vasculitis.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Severe glucose-6-phosphate dehydrogenase deficiency leads to susceptibility to infection and absent NETosis.
Glucosephosphate Dehydrogenase Deficiency
Severe glucose-6-phosphate dehydrogenase deficiency leads to susceptibility to infection and absent NETosis.
Glycogen Storage Disease
A case of secondary acute myeloid leukemia on a background of glycogen storage disease with chronic neutropenia treated with granulocyte colony stimulating factor.
Gout
P2Y6 Receptor Antagonist MRS2578 Inhibits Neutrophil Activation and Aggregated Neutrophil Extracellular Trap Formation Induced by Gout-Associated Monosodium Urate Crystals.
Graft vs Host Disease
Elevated Neutrophil Elastase in Tears of Ocular Graft-Versus-Host Disease Patients.
Granuloma
[Characterization of structural and cellular components in pulmonary sarcoidosis granuloma]
Granulomatosis with Polyangiitis
Characterization and localization of the genes for mouse proteinase-3 (Prtn3) and neutrophil elastase (Ela2).
Eosinophil and neutrophil degranulation in ophthalmic lesions of Wegener's granulomatosis.
Neutrophil granule proteins as targets of leukemia-specific immune responses.
Structures of human proteinase 3 and neutrophil elastase--so similar yet so different.
Heart Arrest
Alterations of soluble L- and P-selectins during cardiac arrest and CPR.
Granulocyte elastase in acute myocardial infarction.
Increased neutrophil elastase release in patients with cardiopulmonary arrest: role of elastase inhibitor.
Insufficient production of urinary trypsin inhibitor for neutrophil elastase release after cardiac arrest.
Out-of-hospital cardiac arrest increases soluble vascular endothelial adhesion molecules and neutrophil elastase associated with endothelial injury.
Heart Defects, Congenital
Neutrophil activation and morbidity in young adults with cyanotic congenital heart disease.
Heart Diseases
Inflammatory response, neutrophil activation, and free radical production after acute myocardial infarction: effect of thrombolytic treatment.
Neutrophil activation and morbidity in young adults with cyanotic congenital heart disease.
Neutrophil count and activation in vascular disease.
Heart Failure
LTB4 is present in exudative pleural effusions and contributes actively to neutrophil recruitment in the inflamed pleural space.
Heart Rupture
Granulocyte elastase in acute myocardial infarction.
Increased pericardial fluid level of matrix metalloproteinase-9 activity in patients with acute myocardial infarction: possible role in the development of cardiac rupture.
Heart Septal Defects, Atrial
Granulocyte elastase release and pulmonary hemodynamics in patients with atrial septal defect.
HELLP Syndrome
Immunohistological study in cases of HELLP syndrome (hemolysis, elevated liver enzymes and low platelets) and acute fatty liver of pregnancy.
Hemangioendothelioma
Hepatic hemangioendothelioma in an infant with severe congenital neutropenia.
Hemorrhagic Fever with Renal Syndrome
Neutrophil Activation in Acute Hemorrhagic Fever With Renal Syndrome Is Mediated by Hantavirus-Infected Microvascular Endothelial Cells.
Hepatitis
Involvement of a serine protease, but not of neutrophil elastase, in tumor necrosis factor-induced lethal hepatitis and induction of platelet-activating factor.
Hepatitis B
Blockade of neutrophil elastase attenuates severe liver injury in hepatitis B transgenic mice.
Hepatitis C
Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors.
Hydrocephalus
Granulocyte elastase activity measurement in the cerebrospinal fluid of patients with purulent meningitis.
Hyperalgesia
A TLR-CXCL1 pathway in DRG neurons induces neutrophil accumulation in the DRG and mechanical allodynia in EAE mice.
Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis.
Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice.
Hyperemia
Blood viscosity, fibrinogen, and activation of coagulation and leukocytes in peripheral arterial disease and the normal population in the Edinburgh Artery Study.
Granulocyte elastase release and pulmonary hemodynamics in patients with mitral valvular disease.
Hyperglycemia
Neutrophil-Associated Inflammatory Changes in the Pre-Diabetic Pancreas of Early-Age NOD Mice.
Hypertension
Elevated serum neutrophil elastase is related to prehypertension and airflow limitation in obese women.
Innate Immune Cells and Hypertension: Neutrophils and Neutrophil Extracellular Traps (NETs).
Monocrotaline-induced cardiopulmonary injury in rats. Modification by the neutrophil elastase inhibitor SC39026.
Neutrophil count and activation in vascular disease.
Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model.
Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency.
The Role of Neutrophils and Neutrophil Elastase in Pulmonary Arterial Hypertension.
Hypertension, Pregnancy-Induced
Immunocytochemical localization of neutrophil elastase in term placenta decidua and myometrium in pregnancy-induced hypertension.
Neutrophil activation in pregnancy-induced hypertension.
Hypertension, Pulmonary
Ceramide is Increased in the Lower Airway Epithelium of People with Advanced Cystic Fibrosis Lung Disease.
Granulocyte elastase release and pulmonary hemodynamics in patients with mitral valvular disease.
Long-term treatment with oral N-acetylcysteine: affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled trial.
Neutrophil Extracellular Traps Promote Angiogenesis: Evidence From Vascular Pathology in Pulmonary Hypertension.
Pulmonary hypertension and polymorphonuclear leukocyte elastase after esophageal cancer operations.
Secretory leukoprotease inhibitor attenuates lung injury induced by continuous air embolization into sheep.
[Changes of neutrophil elastase in COPD and the role of elastase in experimental pulmonary hypertension]
Hyperthyroidism
Contact system activation and high thrombin generation in hyperthyroidism.
Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy.
Hypotension
Acute blood pressure effects of selected serine proteases in normotensive rats and dogs.
Effect of the elastase inhibitor eglin C in porcine endotoxin shock.
Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats.
[Case of possible transfusion-related acute lung injury during thoracic endovascular aortic repair].
Hypoxia-Ischemia, Brain
[Inflammatory and autoimmune reactions in different forms of nervous system functioning disorders].
Idiopathic Interstitial Pneumonias
ONO-5046 (Ono Pharmaceutical).
[Evaluation of the elastase burden in patients with idiopathic interstitial pneumonia]
[Pathophysiology of acute lung injury]
[The 74th Annual Meeting President Lecture. Pathogenesis and therapy of acute lung injury]
Idiopathic Pulmonary Fibrosis
Analysis of blood neutrophil elastase, glutathione levels and pathological findings in postoperative acute exacerbation of idiopathic pulmonary fibrosis associated with lung cancer: Two case reports.
Hepatocyte growth factor and neutrophil elastase in idiopathic pulmonary fibrosis.
[Lung injury in idiopathic pulmonary fibrosis and measurement of immunoreactive neutrophil elastase and alpha 1-protease inhibitor in blood]
Infarction, Middle Cerebral Artery
Neutrophil elastase inhibition reduces cerebral ischemic damage in the middle cerebral artery occlusion.
Infections
?2-integrin LFA1 mediates airway damage following neutrophil transepithelial migration during respiratory syncytial virus infection.
A Biofilm Matrix-Associated Protease Inhibitor Protects Pseudomonas aeruginosa from Proteolytic Attack.
A case of secondary acute myeloid leukemia on a background of glycogen storage disease with chronic neutropenia treated with granulocyte colony stimulating factor.
A kinetic study of the hydrolysis of the N-tosylalanine ester of 3-hydroxy-5-phenylpyrrole and related compounds by human leukocyte elastase.
A Novel ELANE Mutation Associated with Inflammatory Arthritis, Defective NETosis, and Recurrent Parvoviral Infection.
A point-of-care neutrophil elastase activity assay identifies bronchiectasis severity, airway infection and risk of exacerbation.
Aerosolized prolastin suppresses bacterial proliferation in a model of chronic Pseudomonas aeruginosa lung infection.
Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications.
alpha 1-Proteinase inhibitor, elastase activity, and lung disease severity in cystic fibrosis.
Alpha,-antitrypsin and leukocyte elastase in infected and noninfected sputum.
Alpha-1 Antitrypsin-A Target for MicroRNA-Based Therapeutic Development for Cystic Fibrosis.
Analysis of BAL fluid in M. avium-intracellulare infection in individuals without predisposing lung disease.
Antisperm antibodies and microorganisms in genital secretions--a clinically significant relationship?
Aptamer-capture based assays for human neutrophil elastase.
Are rhinovirus-induced airway responses in asthma aggravated by chronic allergen exposure?
Autosomal-dominant primary immunodeficiencies.
Blood polymorphonuclear leukocyte migration as a predictive marker for infections in severe trauma: comparison with various inflammation parameters.
Bronchiectasis in Infants and Preschool Children Diagnosed with Cystic Fibrosis after Newborn Screening.
Capillary plasma neutrophil elastase alpha-1-proteinase inhibitor as infection parameter in neonates.
Cathepsin G and neutrophil elastase contribute to lung-protective immunity against mycobacterial infections in mice.
Cathepsin G in Experimental Tuberculosis: Relevance for Antibacterial Protection and Potential for Immunotherapy.
Changes in airway inflammation with pseudomonas eradication in early cystic fibrosis.
Chlamydia trachomatis antibodies in serum and ejaculate of male patients without acute urethritis.
Chlamydia trachomatis infection in the genital tract is associated with inflammation and hypospermia in the infertile male of China.
Chronic bacterial pulmonary infections in advanced cystic fibrosis differently affect the level of sputum neutrophil elastase, IL-8 and IL-6.
Cleavage of lymphocyte surface antigens CD2, CD4, and CD8 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis.
Clinical and immunoregulatory effects of roxithromycin therapy for chronic respiratory tract infection.
Colistin stimulates the activity of neutrophil elastase and Pseudomonas aeruginosa elastase.
Congenital neutropenia: diagnosis, molecular bases and patient management.
Corticosteroid-binding globulin cleavage may be pathogen-dependent in bloodstream infection.
Cyclic neutropenia with a novel gene mutation presenting with a necrotizing soft tissue infection and severe sepsis: case report.
Diagnosis and early life risk factors for bronchiectasis in cystic fibrosis: a review.
DNA Methylation patterns of immune response-related genes in inflammatory external root resorption.
Effects of amoxicillin, gentamicin, and moxifloxacin on the hemolytic activity of Staphylococcus aureus in vitro and in vivo.
Engineering synthetic breath biomarkers for respiratory disease.
Evolution of pulmonary inflammation and nutritional status in infants and young children with cystic fibrosis.
Expression of neutrophil elastase and myeloperoxidase mRNA in patients with newly diagnosed type 2 diabetes mellitus.
Granulocyte elastase levels do not correlate with anaerobic and aerobic bacterial growth in seminal plasma from infertile men.
Granulocyte elastase, tumor necrosis factor-alpha and urokinase levels as prognostic markers in severe infection.
HSCT may lower leukemia risk in ELANE neutropenia: a before-after study from the French Severe Congenital Neutropenia Registry.
Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia.
Impact of lung disease on respiratory impedance in young children with cystic fibrosis.
Impact of Pseudomonas and Staphylococcus infection on inflammation and clinical status in young children with cystic fibrosis.
In Vitro Activities against Cystic Fibrosis Pathogens of Synthetic Host Defence Propeptides Processed by Neutrophil Elastase.
Induction of neutrophil extracellular traps by Campylobacter jejuni.
Inflammation and infection imaging with a 99mTc-neutrophil elastase inhibitor in monkeys.
Inhibitors of elastase and cathepsin G in Chédiak-Higashi (beige) neutrophils.
Interleukin 8 and granulocyte elastase alpha 1 proteinase inhibitor complex in the tracheobronchial aspirate of infants with chronic lung disease following inter-uterine infection.
Interleukin 8 and granulocyte elastase in the tracheobronchial aspirate of infants without respiratory distress syndrome or intrauterine infection and development of chronic lung disease.
JAGN1 is required for fungal killing in neutrophil extracellular traps: Implications for severe congenital neutropenia.
Long-term antibiotics in the management of non-CF bronchiectasis--do they improve outcome?
Lower airway inflammation in infants with cystic fibrosis detected by newborn screening.
Mannose-binding lectin is present in the infected airway: a possible pulmonary defence mechanism.
Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis.
Monocyte-derived extracellular trap (MET) formation induces aggregation and affects motility of human spermatozoa in vitro.
NETosis delays diabetic wound healing in mice and humans.
Neutrophil elastase and IL17 expressed in the pig colon during Brachyspira hyodysenteriae infection synergistically with the pathogen induce increased mucus transport speed and production via MAPK3.
Neutrophil elastase and secretory leukocyte protease inhibitor in prelabor rupture of membranes, parturition and intra-amniotic infection.
Neutrophil elastase causes tissue damage that decreases host tolerance to lung infection with burkholderia species.
Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch.
Neutrophil elastase in the diagnosis of neonatal infection.
Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopulmonary bypass in the rabbit endotoxemia model.
Neutrophil elastase promotes Leishmania donovani infection via interferon-?.
Neutrophil elastase, an acid-independent serine protease, facilitates reovirus uncoating and infection in U937 promonocyte cells.
Neutrophil enzymes in urine for the detection of urethral infection in men.
Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain.
Neutrophil-Airway Epithelial Interactions Result in Increased Epithelial Damage and Viral Clearance during Respiratory Syncytial Virus Infection.
Nonchromogenic hydrolysis of elastase and cathepsin G p-nitroanilide substrates by Pseudomonas aeruginosa elastase.
Novel roles of protease inhibitors in infection and inflammation.
Oral immunization with polyvalent bacterial lysate and infection with Streptococcus pneumoniae: influence on interferon-gamma and PMN elastase concentrations in murine bronchoalveolar lavage fluid.
Oxidative burst and neutrophil elastase contribute to clearance of Aspergillus fumigatus pneumonia in mice.
Participation and interactions of neutrophil elastase in haemostatic disorders of patients with severe infections.
Phagocyte extracellular traps in children with neutrophilic airway inflammation.
PMN elastase in bone and joint infections.
Polymorphonuclear elastase in neonatal sepsis.
Polymorphonuclear leukocyte elastase: its effects on the pathogenesis of Pseudomonas aeruginosa infection in cystic fibrosis.
Preventive effect of ulinastatin on renal scarring in rat model of pyelonephritis induced by direct or ascending infection with Serratia marcescens or Escherichia coli.
Protease-Specific Biomarkers to Analyse Protease Inhibitors for Emphysema Associated with Alpha 1-Antitrypsin Deficiency. An Overview of Current Approaches.
Protective role of osteopontin in endodontic infection.
Reduced Neutrophil Elastase Activity and Neutrophil Extracellular Traps in Pediatric Acute Myeloid Leukemia May Increase the Rate of Infections.
Relationship between granulocyte elastase levels and perinatal infections.
Relationship of changes in interleukin-8 levels and granulocyte elastase activity in gingival crevicular fluid to subgingival periodontopathogens following non-surgical periodontal therapy in subjects with chronic periodontitis.
Relevance of the mouse model as a therapeutic approach for neutrophil proteinase 3-associated human diseases.
Role of inflammation in respiratory tract infections.
Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases.
SARS-CoV-2 mutation 614G creates an elastase cleavage site enhancing its spread in high AAT-deficient regions.
Selective Bacterial Targeting and Infection-Triggered Release of Antibiotic Colistin Conjugates.
Serpin A1 and CD91 as host instruments against HIV-1 infection: are extracellular antiviral peptides acting as intracellular messengers?
Systemic macrophage and neutrophil destruction by secondary necrosis induced by a bacterial exotoxin in a Gram-negative septicaemia.
Targeting neutrophil elastase in cystic fibrosis.
The antimicrobial/elastase inhibitor elafin regulates lung dendritic cells and adaptive immunity.
The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis.
The effects of sivelestat sodium hydrate on uterine contraction and the concentration of maternal and fetal blood cytokines in a sheep model of intra-amniotic infection induced by lipopolysaccharide.
The elimination of Anaplasma phagocytophilum requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms.
The evaluation of markers of prostatic inflammation and function of the prostate gland in patients with chronic prostatitis.
[Advances in researches on polymorphonuclear neutrophil elastase in semen].
[Diagnostic value of granulocyte elastase determination in cord blood of newborn infants at risk for maternofetal infection]
[Increased granulocyte elastase activity in emphysema. Effect of acute infections on the activity of this enzyme]
[Leukocyte elastase as an indicator for early detection of neonatal infection]
[Neutrophil elastase level in cord blood and diagnosis of infection in mature and premature neonates]
[PMN-elastase as a marker in diagnosis and follow-up of bone and joint infections]
[Polymorphonuclear leukocyte elastase (PMNE) levels in surgical patients with postoperative infections]
[Pretreatment of acid-induced lung injury with specific neutrophil elastase inhibitor ONO-5046 did not exasperate the subsequent bacterial lung infection by Pseudomonas aeruginosa]
[Significance of neutrophil elastase in diagnosis of male genital tract infection]
[The value of leukocytes, C-reactive protein and granulocyte elastase in patients with premature rupture of fetal membranes and amniotic infection]
[Usefulness of determination of granulocyte elastase plasma level, c-reactive protein and white blood cell count in prediction in intrauterine infection in pregnant women after PROM]
Infertility
Clinical relevance of polymorphonuclear (PMN-) elastase determination in semen and serum during infertility investigation.
Semen characteristics and inflammatory mediators in infertile men with different clinical diagnoses.
[Content of neutrophil elastase in EPS and seminal plasma: A combined predictor in the diagnosis of type IIIA prostatitis with secondary infertility].
Inflammatory Bowel Diseases
Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease.
Investigation of neutrophils in the gut lumen by assay of granulocyte elastase in whole-gut lavage fluid.
Neutrophil-elastase in chronic inflammatory bowel disease: a marker of disease activity?
Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices.
ONO-6818 Cortech/Ono.
PMN-elastase in assessment of patients with inflammatory bowel disease.
Prospective evaluation of faecal neutrophil-derived proteins in identifying intestinal inflammation: combination of parameters does not improve diagnostic accuracy of calprotectin.
TGF-?1 and granulocyte elastase in the evaluation of activity of inflammatory bowel disease. A pilot study.
The role of inflammatory cells and their proteases in extravascular fibrinolysis.
[Noninvasive Markers in the Assessment of Intestinal Inflammation in Inflammatory Bowel Diseases: Performance of Fecal Lactoferrin, Calprotectin, PMN-Elastase, CRP, and Clinical Indices.]
Influenza, Human
Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy.
Human mucus protease inhibitor in airway fluids is a potential defensive compound against infection with influenza A and Sendai viruses.
In response to letter to Editor by Nosaka et al. on our paper: Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy. J Neurol Sci 2015;349:190-195.
Letter to the Editor regarding the paper by Sun G et al: Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy. J Neuro Sci 2015;349:190-195.
No role for neutrophil elastase in influenza-induced cellular recruitment, cytokine production or airway hyperresponsiveness in mice.
Porphyromonas gingivalis enzymes enhance infection with human metapneumovirus in vitro.
The human mucus protease inhibitor and its mutants are novel defensive compounds against infection with influenza A and Sendai viruses.
Two-dimensional gel electrophoresis analysis in simultaneous influenza pneumonia and bacterial infection in mice.
Insulin Resistance
?1-Antitrypsin A treatment attenuates neutrophil elastase accumulation and enhances insulin sensitivity in adipose tissue of mice fed a high-fat diet.
Circulating SerpinB1 levels and clinical features in patients with type 2 diabetes.
Expression of neutrophil elastase and myeloperoxidase mRNA in patients with newly diagnosed type 2 diabetes mellitus.
Imbalance between neutrophil elastase and its inhibitor ?1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure.
Inhibition of NET Release Fails to Reduce Adipose Tissue Inflammation in Mice.
Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects.
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase.
Social Stress Increases Vulnerability to High-Fat Diet-Induced Insulin Resistance by Enhancing Neutrophil Elastase Activity in Adipose Tissue.
Surgical site peptidylarginine deaminase 4 (PAD4), a biomarker of NETosis, correlates with insulin resistance in total joint arthroplasty patients: A preliminary report.
Intellectual Disability
[Immunological reactions in different forms of mental disorders]
Intestinal Obstruction
Direct assessment of gastrointestinal inflammation and mucosal immunity in children with cystic fibrosis.
Invasive Pulmonary Aspergillosis
[Invasive pulmonary aspergillosis in a patient with acute leukemia--the role of neutrophil elastase in in cavity formation]
Irritable Bowel Syndrome
Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices.
Prospective evaluation of faecal neutrophil-derived proteins in identifying intestinal inflammation: combination of parameters does not improve diagnostic accuracy of calprotectin.
Ischemic Stroke
Evaluation of granulocyte elastase as a sensitive diagnostic parameter of inflammation in first ischemic stroke.
Joint Diseases
Changes in proteoglycan biosynthesis following leukocyte elastase treatment of bovine articular cartilage in culture.
Granulocyte elastase as a new biochemical marker in the diagnosis of chronic joint diseases.
[Modification of systemic signs and elastase in neutrophilic granulocytes in inflammatory rheumatic diseases in childhood by immunoglobulin therapy]
[New clinico-chemical values in chronic joint diseases. Granulocyte elastase and UDP-D-xylose:proteoglycan core protein-beta-D-xylosyltransferase of chondrocytes]
Keloid
Long-term organ culture of keloid disease tissue.
Keratitis
JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity.
Kidney Failure, Chronic
Leukopenia and rheological anomalies in leukocytes during hemodialysis in patients with chronic renal failure.
Molecular and functional aspects of alterations in the kallikrein-kinin system activity in human blood plasma at different stages of peritonitis and chronic renal failure.
Polymorphisms of the ELANE Gene Promoter Region in End-Stage Chronic Kidney Disease Patients.
Leg Ulcer
The use of proteases as prognostic markers for the healing of venous leg ulcers.
Leishmaniasis, Cutaneous
Neutrophil elastase promotes Leishmania donovani infection via interferon-?.
Leukemia
A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia.
Artificially controlled aggregation of proteins and targeting in hematopoietic cells.
Evidence of fibrinogen breakdown by leukocyte enzymes in a patient with acute promyelocytic leukemia.
Genetic heterogeneity in severe congenital neutropenia: how many aberrant pathways can kill a neutrophil?
HSCT may lower leukemia risk in ELANE neutropenia: a before-after study from the French Severe Congenital Neutropenia Registry.
Lymphoid enhancer factor-1 links two hereditary leukemia syndromes through core-binding factor alpha regulation of ELA2.
Neutrophil elastase and granulocyte colony-stimulating factor receptor mutation analyses and leukemia evolution in severe congenital neutropenia patients belonging to the original Kostmann family in northern Sweden.
Neutrophil elastase and its therapeutic effect on leukemia cells.
Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice.
Neutrophil elastase enhances the proliferation and decreases apoptosis of leukemia cells via activation of PI3K/Akt signaling.
Neutrophil elastase produces 52-kD and 30-kD glucocorticoid receptor fragments in the cytosol of human leukemia cells.
Neutrophil granule proteins as targets of leukemia-specific immune responses.
NLS?RAR? modulates acute promyelocytic leukemia NB4 cell proliferation and differentiation via the PI3K/AKT pathway.
PML-controlled responses in severe congenital neutropenia with ELANE-misfolding mutations.
PR1 peptide vaccine induces specific immunity with clinical responses in myeloid malignancies.
The Spectrum of ELANE Mutations and their Implications in Severe Congenital and Cyclic Neutropenia.
Urinary trypsin-inhibitor protects neutrophil chemotaxis in the inflammatory response.
[Role of PMN elastase in fibrinolytic activity in patients with acute promyelocytic leukemia]
Leukemia, Lymphoid
In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Clonal dominance of chronic myelogenous leukemia is associated with diminished sensitivity to the antiproliferative effects of neutrophil elastase.
Leukemia, Myeloid
An anti-PR1/HLA-A2 T cell receptor-like antibody mediates complement dependent cytotoxicity against acute myeloid leukemia progenitor cells.
Characterization of immunologic properties of a second HLA-A2 epitope from a granule protease in CML patients and HLA-A2 transgenic mice.
Cytochemical determination of granulocyte elastase and chymotrypsin in human myeloid cells and its application in acquired deficiency states and diagnosis of myeloid leukemia.
Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplant.
Identification and in vitro expansion of CD4+ and CD8+ T cells specific for human neutrophil elastase.
In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins.
PR1 peptide vaccine induces specific immunity with clinical responses in myeloid malignancies.
Proteolytic processing of cut homeobox 1 by neutrophil elastase in the MV4;11 myeloid leukemia cell line.
The role of antigen cross-presentation from leukemia blasts on immunity to the leukemia-associated antigen PR1.
Leukemia, Myeloid, Acute
A novel TCR-like CAR with specificity for PR1/HLA-A2 effectively targets myeloid leukemia in vitro when expressed in human adult peripheral blood and cord blood T cells.
Activity of 8F4, a T-cell receptor-like anti-PR1/HLA-A2 antibody, against primary human AML in vivo.
High expression of neutrophil elastase predicts improved survival in pediatric acute myeloid leukemia: a report from the Children's Oncology Group.
Lymphoid enhancer factor-1 links two hereditary leukemia syndromes through core-binding factor alpha regulation of ELA2.
Proteolytic processing of cut homeobox 1 by neutrophil elastase in the MV4;11 myeloid leukemia cell line.
Reduced Neutrophil Elastase Activity and Neutrophil Extracellular Traps in Pediatric Acute Myeloid Leukemia May Increase the Rate of Infections.
The Severe Chronic Neutropenia International Registry: 10-Year Follow-up Report.
Leukemia, Promyelocytic, Acute
A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia.
Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice.
[Role of PMN elastase in fibrinolytic activity in patients with acute promyelocytic leukemia]
leukocyte elastase deficiency
Murine lupus is neutrophil elastase-independent in the MRL.Faslpr model.
Neutrophil Elastase Deficiency Ameliorates Myocardial Injury Post Myocardial Infarction in Mice.
Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis.
White blood cell defects: molecular discoveries and clinical management.
Leukocytosis
Changes in plasma level of human leukocyte elastase during leukocytosis from physical effort.
Multi-cellular activation in vivo by endotoxin in humans--limited protection by adenosine infusion.
Leukopenia
Activated neutrophils impair gastric cytoprotection role of neutrophil elastase.
Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats.
Adult respiratory distress-like syndrome during hemodialysis: relationship between activation of complement, leukopenia, and release of granulocyte elastase.
Attenuation of endotoxin-induced pulmonary vascular injury by antithrombin III.
Biocompatibility of a new high-permeability modified cellulose membrane for haemodialysis.
Endotoxin-induced pulmonary vascular injury is mainly mediated by activated neutrophils in rats.
Leukopenia and rheological anomalies in leukocytes during hemodialysis in patients with chronic renal failure.
Performance and biocompatibility of a new hemodialysis membrane.
Recombinant human soluble thrombomodulin reduces endotoxin-induced pulmonary vascular injury via protein C activation in rats.
Role of granulocyte elastase in indomethacin-induced gastric mucosal lesion formation in rats.
Role of neutrophil elastase in stress-induced gastric mucosal injury in rats.
Liver Cirrhosis, Biliary
Evidence of an increased nitric oxide production in primary biliary cirrhosis.
Liver Diseases
A single-chain variable fragment intrabody prevents intracellular polymerization of Z ?1-antitrypsin while allowing its antiproteinase activity.
Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
Knockdown of Z Mutant Alpha-1 Antitrypsin In Vivo Using Modified DNA Antisense Oligonucleotides.
Neutrophil activation in chronic liver disease.
Protective effect of neutrophil elastase inhibitor (FR136706) in lethal acute liver failure induced by D-galactosamine and lipopolysaccharide in rats.
Liver Failure
Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury.
Liver Failure, Acute
Protective effect of neutrophil elastase inhibitor (FR136706) in lethal acute liver failure induced by D-galactosamine and lipopolysaccharide in rats.
Lung Diseases
2-O, 3-O-Desulfated Heparin Inhibits Neutrophil Elastase-Induced HMGB-1 Secretion and Airway Inflammation.
4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.
A novel class of cyclic beta-dicarbonyl leaving groups and their use in the design of benzisothiazolone human leukocyte elastase inhibitors.
A specialized method of sputum collection and processing for therapeutic interventions in cystic fibrosis.
Aerosolization of recombinant SLPI to augment antineutrophil elastase protection of pulmonary epithelium.
Airway inflammation in cystic fibrosis: molecular mechanisms and clinical implications.
Alpha 1-antitrypsin Mitigates the Inhibition of Airway Epithelial Cell Repair by Neutrophil Elastase.
alpha 1-Proteinase inhibitor, elastase activity, and lung disease severity in cystic fibrosis.
Alpha-1 Antitrypsin Deficiency: New Developments in Augmentation and Other Therapies.
Alpha-1 Antitrypsin Therapy in Cystic Fibrosis and the Lung Disease Associated with Alpha-1 Antitrypsin Deficiency.
Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro.
alpha1-Proteinase inhibitor therapy for the prevention of chronic lung disease of prematurity: a randomized, controlled trial.
An alpha1-antitrypsin enhancer polymorphism is a genetic modifier of pulmonary outcome in cystic fibrosis.
Anti-cytokines as a Strategy in Alpha-1 Antitrypsin Deficiency.
Anti-Proteases and Alpha-1 Antitrypsin Augmentation Therapy.
Changes in airway inflammation with pseudomonas eradication in early cystic fibrosis.
Characterisation of a type II functionally-deficient variant of alpha-1-antitrypsin discovered in the general population.
Comparison of urinary desmosine excretion in patients with chronic obstructive pulmonary disease or cystic fibrosis.
Complement effectors, C5a and C3a, in cystic fibrosis lung fluid correlate with disease severity.
CXC Receptor 1 and 2 and Neutrophil Elastase Inhibitors Alter Radiation-induced Lung Disease in the Mouse.
Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases.
DX-890 (Dyax).
Effect of expectoration on inflammation in induced sputum in alpha-1-antitrypsin deficiency.
Effect of neutrophil elastase and its inhibitor EPI-hNE4 on transepithelial sodium transport across normal and cystic fibrosis human nasal epithelial cells.
Effects of pentoxifylline on sputum neutrophil elastase and pulmonary function in patients with cystic fibrosis: preliminary observations.
Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis.
Elastase regulates the synthesis of its inhibitor, alpha 1-proteinase inhibitor, and exaggerates the defect in homozygous PiZZ alpha 1 PI deficiency.
Elevation of plasma truncated elastase alpha 1-proteinase inhibitor complexes in patients with inflammatory lung diseases.
Engineering synthetic breath biomarkers for respiratory disease.
Evaluation of airway and circulating inflammatory biomarkers for cystic fibrosis drug development.
Exhaled breath condensate MMP-9 levels in children with bronchiectasis.
Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY?85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases.
Gene therapy for alpha-1 antitrypsin deficiency.
Human Neutrophil Elastase Activated Fluorescent Probe for Pulmonary Diseases Based on Fluorescence Resonance Energy Transfer Using CdSe/ZnS Quantum Dots.
Human neutrophil elastase and elastase/alpha 1-antiprotease complex in cystic fibrosis. Comparison with interstitial lung disease and evaluation of the effect of intravenously administered antibiotic therapy.
Human neutrophil elastase releases two pools of mucinlike glycoconjugate from tracheal submucosal gland cells.
Identification of novel functional sequence variants in the gene for peptidase inhibitor 3.
Impact of lung disease on respiratory impedance in young children with cystic fibrosis.
Increased expression of senescence markers in cystic fibrosis airways.
Inhaled porcine pancreatic elastase causes bronchoconstriction via a bradykinin-mediated mechanism.
Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol.
Inhibition of human neutrophil elastase by pentacyclic triterpenes.
Inhibition of neutrophil elastase-induced interleukin-8 gene expression by urinary trypsin inhibitor in human bronchial epithelial cells.
Interleukin 8 and granulocyte elastase alpha 1 proteinase inhibitor complex in the tracheobronchial aspirate of infants with chronic lung disease following inter-uterine infection.
Interleukin 8 and granulocyte elastase alpha 1 proteinase inhibitor complex in the tracheobronchial aspirate of infants with chronic lung disease following respiratory distress syndrome.
Interleukin 8 and granulocyte elastase in the tracheobronchial aspirate of infants without respiratory distress syndrome or intrauterine infection and development of chronic lung disease.
Knockdown of Z Mutant Alpha-1 Antitrypsin In Vivo Using Modified DNA Antisense Oligonucleotides.
Lack of neutrophil elastase reduces inflammation, mucus hypersecretion and emphysema, but not mucus obstruction, in mice with CF-like lung disease.
Lung Disease at Diagnosis in Infants with Cystic Fibrosis Detected by Newborn Screening.
Measuring and Interpreting Serum AAT Concentration.
N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.
Naringenin attenuates mucous hypersecretion by modulating reactive oxygen species production and inhibiting NF-?B activity via EGFR-PI3K-Akt/ERK MAPKinase signaling in human airway epithelial cells.
Neutrophil Elastase and Chronic Lung Disease.
Neutrophil elastase and matrix metalloproteinase 12 in cystic fibrosis lung disease.
Neutrophil elastase in human atherosclerotic plaques: production by macrophages.
Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).
Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex.
Neutrophil elastase-initiated EGFR/MEK/ERK signaling counteracts stabilizing effect of autocrine TGF-beta on tropoelastin mRNA in lung fibroblasts.
Neutrophil elastase: mediator of extracellular matrix destruction and accumulation.
Neutrophil plasticity enables the development of pathological microenvironments: implications for cystic fibrosis airway disease.
Non-Antibiotic Macrolides Prevent Human Neutrophil Elastase-Induced Mucus Stasis and Airway Surface Liquid Volume Depletion.
Novel neutrophil elastase inhibitors as a treatment for neutrophil-predominant inflammatory lung diseases.
NullCanada: A novel ?1-antitrypsin allele with in cis variants Glu366Lys and Ile100Asn.
Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase.
Optimization of O3-acyl kojic acid derivatives as potent and selective human neutrophil elastase inhibitors.
Patterns of neutrophil serine protease-dependent cleavage of surfactant protein D in inflammatory lung disease.
Phagocyte enzymes in bronchoalveolar lavage from patients with pulmonary sarcoidosis and collagen vascular disorders.
Polysulfated Hyaluronan GlycoMira-1111 Inhibits Elastase and Improves Rheology in Cystic Fibrosis Sputum.
Protease-antiprotease imbalance in the lungs of children with cystic fibrosis.
Proteolytic activity in patients with hypercatabolic renal failure.
Pulmonary deposition and disappearance of aerosolised secretory leucocyte protease inhibitor.
Secretory leukocyte protease inhibitor in cystic fibrosis.
Secretory leukocyte proteinase inhibitor and elafin are resistant to degradation by MMP-8.
Separation of closely related peptide substrates of human proteinases by micellar electrokinetic chromatography with anionic and nonionic surfactants.
SPLUNC1 has Antimicrobial and Antibiofilm Activity against Burkholderia cepacia Complex.
Synthesis in yeast of a functional oxidation-resistant mutant of human alpha-antitrypsin.
Targeted delivery of antiprotease to the epithelial surface of human tracheal xenografts.
The clinical significance of oropharyngeal cultures in young children with cystic fibrosis.
The Role of Neutrophil Elastase Inhibitors in Lung Diseases.
Therapeutic potential of neutrophil-elastase inhibition in pulmonary disease.
Transport of bifunctional proteins across respiratory epithelial cells via the polymeric immunoglobulin receptor.
Use of modulators of airways inflammation in patients with CF.
Whole body periodic acceleration in normal and reduced mucociliary clearance of conscious sheep.
[The role of neutrophil elastase in pathophysiology of obturative pulmonary diseases]
Lung Diseases, Interstitial
Fibrinopeptide A reactive peptides and procoagulant activity in bronchoalveolar lavage: relationship to rheumatoid interstitial lung disease.
Human neutrophil elastase and elastase/alpha 1-antiprotease complex in cystic fibrosis. Comparison with interstitial lung disease and evaluation of the effect of intravenously administered antibiotic therapy.
Lung lavage neutrophils, neutrophil elastase and albumin in the prognosis of pulmonary sarcoidosis.
Phagocyte enzymes in bronchoalveolar lavage from patients with pulmonary sarcoidosis and collagen vascular disorders.
Serum neutrophil elastase levels predict initial clinical condition but do not correlate with the progression of interstitial lung disease.
[Prognostic significance of neutrophil elastase inhibitor in patients with acute lung injury and interstitial pneumonia]
[Strategy of therapy for interstitial lung disease due to chemotherapeutic drugs or radiation]
Lung Diseases, Obstructive
Biosynthesis of alpha1-proteinase inhibitor by human lung-derived epithelial cells.
Elevated serum neutrophil elastase is related to prehypertension and airflow limitation in obese women.
Lung Injury
A neutrophil elastase inhibitor improves lung function during ex vivo lung perfusion.
A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats.
A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1.
Administration of truncated secretory leukoprotease inhibitor ameliorates bleomycin-induced pulmonary fibrosis in hamsters.
Alleviation of lung injury by glycyrrhizic acid in benzo(a)pyrene exposed rats: Probable role of soluble epoxide hydrolase and thioredoxin reductase.
Beneficial effect of an inhibitor of leukocyte elastase (EPI-hNE-4) in presence of repeated lung injuries.
Combined effects of sivelestat and resveratrol on severe acute pancreatitis-associated lung injury in rats.
Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury.
Effects of a neutrophil elastase inhibitor (ONO-5046) on acute pulmonary injury induced by tumor necrosis factor alpha (TNFalpha) and activated neutrophils in isolated perfused rabbit lungs.
Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats.
Effects of granulocyte colony-stimulating factor (G-CSF) and neutrophil elastase inhibitor (ONO-5046) on acid-induced lung injury in rats.
Effects of lecithinized superoxide dismutase and a neutrophil elastase inhibitor (ONO-5046) on hyperoxic lung injury in rat.
Effects of neutrophil elastase inhibitor (ONO-5046) on lung injury after intestinal ischemia-reperfusion.
Effects of ONO-5046, a specific neutrophil elastase inhibitor, on endotoxin-induced lung injury in sheep.
Effects of pentoxifylline on sputum neutrophil elastase and pulmonary function in patients with cystic fibrosis: preliminary observations.
Effects of sivelestat sodium hydrate on the reduction of radiation pneumonitis.
Evidence of increased matrix metalloproteinase-9 concentration in patients following cardiopulmonary bypass.
Human neutrophil elastase within human alveolar macrophages. Implications for lung injury.
In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia.
Inhibition of human neutrophil elastase by polyguanylic acid and other synthetic RNA homopolymers.
Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster.
Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters.
Inhibition of the activity of human leukocyte elastase by lipids particularly oleic acid and retinoic acid.
Intratracheally-instilled antileukoprotease and alpha 1-proteinase inhibitor: effect on human neutrophil elastase-induced experimental emphysema and pulmonary localization.
Lung injury in Fischer but not Sprague-Dawley rats after short-term hyperoxia.
Neutrophil elastase and oxygen radicals: synergism in lung injury after hindlimb ischemia.
Neutrophil elastase augments acute edematous injury in isolated rat lungs perfused with neutrophil cytoplasts.
Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in rat model of cerulein pancreatitis.
Neutrophil elastase inhibitor reduces ventilation-induced lung injury via nuclear factor-?B and NF-?B repressing factor in mice.
Neutrophil elastase inhibitor, ONO-5046, modulates acid-induced lung and systemic injury in rabbits.
Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia.
Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60% O2-exposed neonatal rats.
Neutrophil elastase: alpha-1-proteinase inhibitor complex in serum and bronchoalveolar lavage fluid in patients with pulmonary fibrosis.
New properties of the soybean trypsin inhibitor: Inhibition of human neutrophil elastase and its effect on acute pulmonary injury.
Noninvasive in vivo quantification of neutrophil elastase activity in acute experimental mouse lung injury.
Novel Sulfonamide Analogs of Sivelestat as Potent Human Neutrophil Elastase Inhibitors.
Plasma elastase levels and the development of the adult respiratory distress syndrome.
Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats.
Preventive effect of erythromycin on experimental bleomycin-induced acute lung injury in rats.
Proteases and lung injury.
Protective effects of ONO-5046*Na, a specific neutrophil elastase inhibitor, on postperfusion lung injury.
Pulsatile extracorporeal circulation--let it be?
Reversible lung neutrophil accumulation can cause lung injury by elastase-mediated mechanisms.
Role of neutrophil elastase in lung injury induced by burn-blast combined injury in rats.
Role of neutrophils in xanthine/xanthine oxidase-induced oxidant injury in isolated rabbit lungs.
Roles of neutrophil elastase and superoxide anion in leukotriene B4-induced lung injury in rabbit.
Sivelestat Attenuates Lung Injury in Surgery for Congenital Heart Disease With Pulmonary Hypertension.
Sivelestat reduces myocardial ischemia and reperfusion injury in rat hearts even when administered after onset of myocardial ischemia.
Sivelestat sodium hydrate reduces radiation-induced lung injury in mice by inhibiting neutrophil elastase.
Streptococcus pneumoniae disrupts pulmonary immune defence via elastase release following pneumolysin-dependent neutrophil lysis.
Sulfated polysaccharides prevent human leukocyte elastase-induced acute lung injury and emphysema in hamsters.
Suppression of superantigen-induced lung injury and vasculitis by preadministration of human urinary trypsin inhibitor.
Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats.
The effects of a neutrophil elastase inhibitor (ONO-5046.Na) and neutrophil depletion using a granulotrap (G-1) column on lung reperfusion injury in dogs.
The high-mobility group protein B1-Toll-like receptor 4 pathway contributes to the acute lung injury induced by bilateral nephrectomy.
The use of neutrophil elastase inhibitor in the treatment of acute lung injury after pneumonectomy.
Triolein increases microvascular permeability in isolated perfused rabbit lungs: role of neutrophils.
Xanthine oxidase mediates elastase-induced injury to isolated lungs and endothelium.
[Diagnosis of acute respiratory distress syndrome: analysis of bronchoalveolar lavage fluid]
[Effect of sivelestat sodium on acute lung injury after acute aortic dissection]
[Lung injury in idiopathic pulmonary fibrosis and measurement of immunoreactive neutrophil elastase and alpha 1-protease inhibitor in blood]
[Pretreatment of acid-induced lung injury with specific neutrophil elastase inhibitor ONO-5046 did not exasperate the subsequent bacterial lung infection by Pseudomonas aeruginosa]
[Protective effects of ulinastatin on the lung injury during cardiopulmonary bypass]
[Responses of TNF alpha, IL-8, and leukocyte adhesion molecule CD18 to cardiopulmonary bypass]
Lung Neoplasms
Activity-based Near-Infrared Fluorogenic Probe Enables In Vitro and In Vivo Profiling of Neutrophil Elastase.
Adhesion molecule expression in vascular endothelial cells incubated with cancer cell line supernatant are inhibited by neutrophil elastase inhibitor (ONO-5046.Na).
Alpha-1-antitrypsin Phenotypes and Neutrophil Elastase Gene Promoter Polymorphisms in Lung Cancer.
Alpha1-antitrypsin and neutrophil elastase imbalance and lung cancer risk.
Analysis of blood neutrophil elastase, glutathione levels and pathological findings in postoperative acute exacerbation of idiopathic pulmonary fibrosis associated with lung cancer: Two case reports.
Complete inhibition of spontaneous pulmonary metastasis of human lung carcinoma cell line EBC-1 by a neutrophil elastase inhibitor (ONO-5046.Na).
Correlation between increased granulocyte elastase release and activation of blood coagulation in patients with lung cancer.
Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of ?1-antitrypsin in lung cancer.
Human Neutrophil Elastase Activated Fluorescent Probe for Pulmonary Diseases Based on Fluorescence Resonance Energy Transfer Using CdSe/ZnS Quantum Dots.
Insulin Receptor Substrate Regulation of Phosphoinositol-3 Kinase.
Local increase in polymorphonuclear leukocyte elastase is associated with tumor invasiveness in non-small cell lung cancer.
Local increase of antiprotease and neutrophil elastase-alpha 1-proteinase inhibitor complexes in lung cancer.
Near-infrared fluorescent probe with large stokes shift for detecting Human Neutrophil elastase in living cells.
Neutrophil Elastase as a Target in Lung Cancer.
Neutrophil elastase inhibitor (ONO-5046-Na) inhibits the growth of human lung cancer cell lines transplanted into severe combined immunodeficiency (scid) mice.
Neutrophil serine proteases: mediators of innate immune responses.
Opposite angiogenic outcome of curcumin against ischemia and Lewis lung cancer models: in silico, in vitro and in vivo studies.
Polymorphisms in the promoter region of neutrophil elastase gene and lung cancer risk.
Polymorphisms in the promoter region of the neutrophil elastase gene are associated with lung cancer development.
Serine Proteases Enhance Immunogenic Antigen Presentation on Lung Cancer Cells.
SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer.
Study on Perioperative Administration of a Neutrophil Elastase Inhibitor for Interstitial Pneumonias.
The role of inflammatory cells and their proteases in extravascular fibrinolysis.
Tumor neutrophil elastase is closely associated with the direct extension of non-small cell lung cancer into the aorta.
[Alteration of serum levels of endotoxin, polymorphonuclear leukocyte elastase, and the molecular markers of the coagulation and fibrinolytic system in the patients with esophageal cancer and lung cancer before and following operation]
[Strategy of therapy for interstitial lung disease due to chemotherapeutic drugs or radiation]
[Study on extravascular lung water and polymorphonuclear leukocyte elastase during acute phase following radical treatment of lung cancer: effect of ulinastatin on respiratory functions]
Lupus Erythematosus, Systemic
Changes of neutrophil elastase and alpha 1-antitrypsin in systemic lupus erythematosus.
Plasma lactoferrin and neutrophil elastase in rheumatoid arthritis and systemic lupus erythematosus.
Lymphoma
Can mutations in ELA2, neutrophil elastase expression or differential cell toxicity explain sulphasalazine-induced agranulocytosis?
Hemostatic abnormalities and leukocyte activation caused by infection in patients with malignant lymphoma during chemotherapy.
Leukocyte elastase in murine and human non-Hodgkin lymphomas.
Malaria
Activation of the coagulation cascade in severe falciparum malaria through the intrinsic pathway.
CXCR4 and MIF are required for neutrophil extracellular trap release triggered by Plasmodium-infected erythrocytes.
Polymorphonuclear leucocyte elastase in Plasmodium falciparum malaria.
Malaria, Cerebral
Removal of plasma polymorphonuclear leukocyte elastase and TNFalpha in a child with cerebral malaria by means of PD: a case report.
Malnutrition
[Survival by a young woman with malnutrition due to alcoholism and eating disorders and with acute respiratory distress syndrome due to severe pneumonia who showed increased serum neutrophil elastase activity]
Marfan Syndrome
Histomorphometric parameters and susceptibility to neutrophil elastase degradation of skin elastic fibres from healthy individuals and patients with Marfan syndrome, Ehlers-Danlos type IV, and pseudoxanthoma elasticum.
Maxillary Sinusitis
Antileukoprotease in patients with maxillary sinusitis.
Melanoma
Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplant.
Localization of MGSA/GRO protein in cutaneous lesions.
Loss of E-cadherin as Part of a Migratory Phenotype in Melanoma Is Associated With Ulceration.
Meningitis
Granulocyte elastase activity measurement in the cerebrospinal fluid of patients with purulent meningitis.
[The value of granulocyte elastase in the early diagnosis of infantile meningitis]
Meningitis, Aseptic
Granulocyte elastase activity measurement in the cerebrospinal fluid of patients with purulent meningitis.
Meningococcal Infections
Elastase and granzymes during meningococcal disease in children: correlation to disease severity.
Mucocutaneous Lymph Node Syndrome
Circulating matrix metalloproteinases and their inhibitors in patients with Kawasaki disease.
Immunoreactive polymorphonuclear leukocyte elastase in complex with alpha 1-antitrypsin in Kawasaki disease.
The role of bacterial lipopolysaccharide-bound neutrophils in the pathogenesis of Kawasaki disease.
Ulinastatin, a urinary trypsin inhibitor, for the initial treatment of patients with Kawasaki disease: a retrospective study.
Mucositis
Neutrophil elastase inhibitor (MPH-966) improves intestinal mucosal damage and gut microbiota in a mouse model of 5-fluorouracil-induced intestinal mucositis.
Multiple Sclerosis
Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain.
Mycobacterium avium-intracellulare Infection
Analysis of BAL fluid in M. avium-intracellulare infection in individuals without predisposing lung disease.
Myocardial Infarction
Granulocyte elastase in acute myocardial infarction.
Increased neutrophil elastase release in unstable angina pectoris and acute myocardial infarction.
Inflammatory response, neutrophil activation, and free radical production after acute myocardial infarction: effect of thrombolytic treatment.
Neutrophil Elastase Deficiency Ameliorates Myocardial Injury Post Myocardial Infarction in Mice.
Role of PMN elastase on ischemic myocardial injury in evolving myocardial infarction: correlation with clinical parameters and intervention by protease inhibitor ulinastatin.
[Clinical implication of plasma PMN elastase (alpha 1-proteinase inhibitor-elastase complex) in patients with early stage of acute myocardial infarction]
[Clinical value of PMN elastase activity before reperfusion therapy in acute myocardial infarction: comparison with clinical characteristics, reperfusion events and myocardial damage]
Myocardial Stunning
Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine.
Myositis
Correlation of PMN elastase and PMN elastase-to-neutrophil ratio with disease activity in patients with myositis.
Nasal Polyps
Allergic fungal sinusitis: an immunohistologic analysis.
[Expression of eosinophil major basic protein and neutrophil elastase in nasal polyp tissue and secretion]
Neonatal Sepsis
Distribution of human neutrophil elastase in diffuse alveolar damage and pneumonia in a case of neonatal sepsis.
Identification of Key mRNAs and lncRNAs in Neonatal Sepsis by Gene Expression Profiling.
Neoplasm Metastasis
A large-scale transcriptome analysis identified ELANE and PRTN3 as novel methylation prognostic signatures for clear cell renal cell carcinoma.
Complete inhibition of spontaneous pulmonary metastasis of human lung carcinoma cell line EBC-1 by a neutrophil elastase inhibitor (ONO-5046.Na).
Elastin in the Tumor Microenvironment.
Electrochemical sensing of human neutrophil elastase and polymorphonuclear neutrophil activity.
Elevated expression of polymorphonuclear leukocyte elastase in breast cancer tissue is associated with tamoxifen failure in patients with advanced disease.
Inhibition of PMN-elastase activity by semisynthetic glucan sulfates.
Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers.
Neutrophil elastase in the tumor microenvironment.
Neutrophil elastase inhibitor reduces hepatic metastases induced by ischaemia-reperfusion in rats.
Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis.
Prognostic significance of three novel biologic factors in a clinical trial of adjuvant therapy for node-negative breast cancer.
Role of imbalance between neutrophil elastase and alpha 1-antitrypsin in cancer development and progression.
The prognostic value of polymorphonuclear leukocyte elastase in patients with primary breast cancer.
The role of neutrophil death in chronic inflammation and cancer.
Tumor neutrophil elastase is closely associated with the direct extension of non-small cell lung cancer into the aorta.
Neoplasms
(-)Epigallocatechin-3-gallate inhibits leukocyte elastase: potential of the phyto-factor in hindering inflammation, emphysema, and invasion.
3,4,5-Trihydroxycinnamic acid attenuates lipopolysaccharide (LPS)-induced acute lung injury via downregulating inflammatory molecules and upregulating HO-1/AMPK activation.
5'-adenosine monophosphate-induced hypothermia attenuates brain ischemia/reperfusion injury in a rat model by inhibiting the inflammatory response.
A Cluster Analysis of Bronchiectasis Patients Based on the Airway Immune Profile.
A novel minimal invasive mouse model of extracorporeal circulation.
A pulmonary metastatic model of human non-small cell lung carcinoma cells that produce a neutrophil elastase-like molecule in severe combined immunodeficiency mice.
A repertoire of cytokines in human seminal plasma.
A Strong Neutrophil Elastase Proteolytic Fingerprint Marks the Carcinoma Tumor Proteome.
Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis.
Adhesion molecule expression in vascular endothelial cells incubated with cancer cell line supernatant are inhibited by neutrophil elastase inhibitor (ONO-5046.Na).
Adsorption of complement, cytokines, and proteins by different dialysis membrane materials: evaluation by confocal laser scanning fluorescence microscopy.
Airway inflammation and etiology of acute exacerbations of chronic bronchitis.
Anti-inflammatory effects of troxerutin are mediated through elastase inhibition.
Antithrombin can modulate coagulation, cytokine production, and expression of adhesion molecules in abdominal aortic aneurysm repair surgery.
Association between injury pattern of patients with multiple injuries and circulating levels of soluble tumor necrosis factor receptors, interleukin-6 and interleukin-10, and polymorphonuclear neutrophil elastase.
Balanced Ultrafiltration: Inflammatory Mediator Removal Capacity.
Biomimetic Liposome with Surface-Bound Elastase for Enhanced Tumor Penetration and Chemo-Immumotherapy.
Broad cross-presentation of the hematopoietically derived PR1 antigen on solid tumors leads to susceptibility to PR1-targeted immunotherapy.
Budesonide instillation immediately after reperfusion ameliorates ischemia/reperfusion-induced injury in the transplanted lung of rat.
Cancer-promoting mechanisms of tumor-associated neutrophils.
Cardiopulmonary bypass with modified fluid gelatin and heparin-coated circuits.
Cathepsin-G and leukocyte elastase inactivate human tumor necrosis factor and lymphotoxin.
Cell biologic factors and cancer spread.
Circulating interleukin 6 as a useful marker for predicting postoperative complications.
Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer.
Clathrin pit-mediated endocytosis of neutrophil elastase and cathepsin G by cancer cells.
Combined treatment of ulinastatin and tranexamic Acid provides beneficial effects by inhibiting inflammatory and fibrinolytic response in patients undergoing heart valve replacement surgery.
Comparative Analysis of Clinical Parameters and Sputum Biomarkers in Establishing the Relevance of Filamentous Fungi in Cystic Fibrosis.
Comparative Study on Pulmonary Toxicity in Mice Induced by Exposure to Unflavoured and Apple- and Strawberry-Flavoured Tobacco Waterpipe Smoke.
Comparison of therapeutic effects between topical 8-oxo-2'-deoxyguanosine and corticosteroid in ocular alkali burn model.
Cord blood cytokines and soluble adhesion molecules in vaginal and cesarean delivered neonates.
Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of ?1-antitrypsin in lung cancer.
Cytokine concentrations and neutrophil elastase activity in bronchoalveolar lavage and induced sputum from patients with cystic fibrosis, mild asthma and healthy volunteers.
Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase.
Direct interaction between caffeic acid phenethyl ester and human neutrophil elastase inhibits the growth and migration of PANC-1 cells.
Effect of cardiopulmonary bypass on systemic release of neutrophil elastase and tumor necrosis factor.
Effect of clarithromycin on airway obstruction and inflammatory markers in induced sputum in cystic fibrosis: a pilot study.
Effect of ex vivo extracorporeal membrane oxygenation flow dynamics on immune response.
Effect of pro-inflammatory stimuli on mucin expression and inhibition by secretory leucoprotease inhibitor.
Effect of sputum processing with dithiothreitol on the detection of inflammatory mediators in chronic bronchitis and bronchiectasis.
Effect of ulinastatin on interleukins and pulmonary function in bypass patients: a meta-analysis of randomized controlled trials.
Effects of a neutrophil elastase inhibitor (ONO-5046) on acute pulmonary injury induced by tumor necrosis factor alpha (TNFalpha) and activated neutrophils in isolated perfused rabbit lungs.
Effects of granulocyte colony-stimulating factor (G-CSF) and neutrophil elastase inhibitor (ONO-5046) on acid-induced lung injury in rats.
Effects of high-dose ulinastatin on inflammatory response and pulmonary function in patients with type-A aortic dissection after cardiopulmonary bypass under deep hypothermic circulatory arrest.
Effects of peritonitis exudates on chemotaxis and phagocytosis of human neutrophils.
Effects of ulinastatin treatment on the cardiopulmonary bypass-induced hemodynamic instability and pulmonary dysfunction.
Effects of urinary protease inhibitor on inflammatory response during on-pump coronary revascularisation. Effect of ulinastatin on inflammatory response.
Efficacy of ultrafiltration in removing inflammatory mediators during pediatric cardiac operations.
EGCG reverses human neutrophil elastase-induced migration in A549 cells by directly binding to HNE and by regulating ?1-AT.
Elafin is induced in epidermis in skin disorders with dermal neutrophilic infiltration: interleukin-1 beta and tumour necrosis factor-alpha stimulate its secretion in vitro.
Elastase expression by infiltrating neutrophils in gliomas.
Elastase inhibition assay with peptide substrates - an example for the limited comparability of in vitro results.
Electrochemical sensing of human neutrophil elastase and polymorphonuclear neutrophil activity.
Elevated expression of polymorphonuclear leukocyte elastase in breast cancer tissue is associated with tamoxifen failure in patients with advanced disease.
Elevated neutrophil elastase and acrolein-protein adducts are associated with W256 regression.
Elevation of cytokines during open heart surgery with cardiopulmonary bypass: participation of interleukin 8 and 6 in reperfusion injury.
Endothelial cells and extracellular calmodulin inhibit monocyte tumor necrosis factor release and augment neutrophil elastase release.
Endothelial Progenitor Cells Attenuate Ventilator-Induced Lung Injury with Large-Volume Ventilation.
Enzyme-activatable imaging probe reveals enhanced neutrophil elastase activity in tumors following photodynamic therapy.
Epigenetic Suppression of SERPINB1 Promotes Inflammation-Mediated Prostate Cancer Progression.
Establishment and characterization of an arsenic-sensitive monoblastic leukaemia cell line (SigM5).
Estrogen maintains myometrial tumors in a lymphangioleiomyomatosis model.
Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Increased interleukin-1, tumor necrosis factor-?, PMN-elastase, lysozyme and neopterin.
Evolution of pulmonary inflammation and nutritional status in infants and young children with cystic fibrosis.
Expression of transforming growth factor-beta1 and tumour necrosis factor-alpha in bronchoalveolar lavage cells in murine pulmonary fibrosis after intraperitoneal administration of bleomycin.
Faecal parameters in the assessment of activity in inflammatory bowel disease.
Free-form neutrophil elastase is an independent marker predicting recurrence in primary breast cancer.
Genomic analysis of the prognostic effect of tumor-associated neutrophil-related genes across 15 solid cancer types: an immune perspective.
Glutamine-enhanced bacterial killing by neutrophils from postoperative patients.
Glycoproteomic analysis of bronchoalveolar lavage (BAL) fluid identifies tumor-associated glycoproteins from lung adenocarcinoma.
Granulocyte elastase, tumor necrosis factor-alpha and urokinase levels as prognostic markers in severe infection.
Granulocyte-colony stimulating factor enhances chimeric antibody Nd2 dependent cytotoxicity against pancreatic cancer mediated by polymorphonuclear neutrophils.
Growth effect of neutrophil elastase on breast cancer: favorable action of sivelestat and application to anti-HER2 therapy.
High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis.
High-dose antithrombin III treatment of severely injured patients: results of a prospective study.
Histidine-Rich Glycoprotein Suppresses Hyperinflammatory Responses of Lung in a Severe Acute Pancreatitis Mouse Model.
Human colon carcinoma cells synthesize and secrete alpha 1-proteinase inhibitor.
Human gingival derived neuronal cells in the optimized caffeic acid hydrogel for hemitransection spinal cord injury model.
Human leukocyte elastase counteracts matrix metalloproteinase-7 induced apoptosis resistance of tumor cells.
Human neutrophil elastase degrades inter-alpha-trypsin inhibitor to liberate urinary trypsin inhibitor related proteins.
Human neutrophil elastase induces MUC5AC overexpression in chronic rhinosinusitis through tumour necrosis factor-? converting enzyme.
Human Neutrophil Elastase Mediates MUC5AC Hypersecretion via the Tumour Necrosis Factor-? Converting Enzyme-Epidermal Growth Factor Receptor Signalling Pathway in vivo.
Human neutrophil elastase regulates the expression and secretion of elafin (elastase-specific inhibitor) in type II alveolar epithelial cells.
Human neutrophil elastase releases a ligand-binding fragment from the 75-kDa tumor necrosis factor (TNF) receptor. Comparison with the proteolytic activity responsible for shedding of TNF receptors from stimulated neutrophils.
Human tumor cell urokinase-type plasminogen activator (uPA): degradation of the proenzyme form (pro-uPA) by granulocyte elastase prevents subsequent activation by plasmin.
Identification of novel functional sequence variants in the gene for peptidase inhibitor 3.
IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activation.
Impact of sputum bacteria on airway inflammation and health status in clinical stable COPD.
Inactivation of human tumor cell pro-urokinase by granulocyte elastase.
Increased matrix metalloproteinase-9 (MMP-9) activity observed in chronic wound fluid is related to the clinical severity of the ulcer.
Induced sputum in cystic fibrosis: within-week reproducibility of inflammatory markers.
Inflammatory markers in cystic fibrosis patients with transmissible Pseudomonas aeruginosa.
Inflammatory mediators in adults undergoing cardiopulmonary bypass: comparison of centrifugal and roller pumps.
Inflammatory profile of new bacterial strain exacerbations of chronic obstructive pulmonary disease.
Inflammatory response after implantation of a left ventricular assist device: comparison between the axial flow MicroMed DeBakey VAD and the pulsatile Novacor device.
Influence of a human protease inhibitor on surgical stress induced immunosuppression.
Inhibition of matrix-proteases by polyphenols: chemical insights for anti-inflammatory and anti-invasion drug design.
Inhibition of neutrophil elastase suppresses the development of skin tumors in hairless mice.
Insulin Receptor Substrate Regulation of Phosphoinositol-3 Kinase.
Interleukin-1beta, tumor necrosis factor-alpha levels and neutrophil elastase activity in peri-implant crevicular fluid.
Involvement of a serine protease, but not of neutrophil elastase, in tumor necrosis factor-induced lethal hepatitis and induction of platelet-activating factor.
Latency of cathepsin B secreted by human colon carcinoma cells is not linked to secretion of cystatin C and is relieved by neutrophil elastase.
Leukocyte/endothelium activation and interactions during femoral percutaneous transluminal angioplasty.
Local increase in polymorphonuclear leukocyte elastase is associated with tumor invasiveness in non-small cell lung cancer.
Lower airway inflammation in infants with cystic fibrosis detected by newborn screening.
LTB4 is present in exudative pleural effusions and contributes actively to neutrophil recruitment in the inflamed pleural space.
Matrix proteases, green tea, and St. John's wort: biomedical research catches up with folk medicine.
Monoclonal antibody to tumor necrosis factor--alpha prevents lethal endotoxin sepsis in adult rhesus monkeys.
N-acetylcysteine attenuates acute lung injury induced by fat embolism.
NET-producing CD16(high) CD62L(dim) neutrophils migrate to tumor sites and predict improved survival in patients with HNSCC.
Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells.
Neutrophil and cytokine activation with neonatal extracorporeal membrane oxygenation.
Neutrophil and nonneutrophil-mediated injury in intestinal ischemia-reperfusion.
Neutrophil apoptosis, proinflammatory mediators and cell counts in bronchiectasis.
Neutrophil elastase activity in pulmonary venous blood during lung resection.
Neutrophil elastase and cancer.
Neutrophil Elastase and Neutrophil Extracellular Traps in the Tumor Microenvironment.
Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers.
Neutrophil elastase enhances antigen presentation by upregulating human leukocyte antigen class I expression on tumor cells.
Neutrophil Elastase Facilitates Tumor Cell Intravasation and Early Metastatic Events.
Neutrophil elastase from myeloid cells promotes TSC2-null tumor growth.
Neutrophil elastase in the tumor microenvironment.
Neutrophil elastase inhibitor (sivelestat) attenuates subsequent ventilator-induced lung injury in mice.
Neutrophil elastase inhibitor (sivelestat) preserves antitumor immunity and reduces the inflammatory mediators associated with major surgery.
Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis.
Neutrophil elastase-dependent cleavage compromises the tumor suppressor role of EMILIN1.
Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth.
Neutrophil elastase-mediated proteolysis of the tumor suppressor p200 CUX1 promotes cell proliferation and inhibits cell differentiation in APL.
Neutrophil Extracellular Traps Associate with Clinical Stages in Breast Cancer.
Neutrophil Extracellular Traps Drive Mitochondrial Homeostasis in Tumors to Augment Growth.
Neutrophil Granulocytes in Ovarian Cancer - Induction of Epithelial-To-Mesenchymal-Transition and Tumor Cell Migration.
Normothermia has beneficial effects in cardiopulmonary bypass attenuating inflammatory reactions.
Olive oil-induced reduction of oxidative damage and inflammation promotes wound healing of pressure ulcers in mice.
Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist.
Parecoxib reduced ventilation induced lung injury in acute respiratory distress syndrome.
Perioperative pattern of peritoneal interleukin 8, tumour necrosis factor-alpha, and granulocyte elastase release in human secondary peritonitis.
Perioperative use of a neutrophil elastase inhibitor in video-assisted thoracoscopic oesophagectomy for cancer.
Phosphodiesterase 4 inhibitor cilomilast inhibits fibroblast-mediated collagen gel degradation induced by tumor necrosis factor-alpha and neutrophil elastase.
Phosphonic pseudopeptides as human neutrophil elastase inhibitors--a combinatorial approach.
Phosphorylcholine or heparin coating for pediatric extracorporeal circulation causes similar biologic effects in neonates and infants.
Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide?induced pulmonary inflammation by inhibiting interleukin?8 production and NF??B activation.
Platelet count, aspirin use, and characteristics of host inflammatory responses in colorectal cancer.
Platelets protect lung from injury induced by systemic inflammatory response.
Pleural fluid tests to identify complicated parapneumonic effusions.
Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats.
Premobilization of CD133+ progenitors is associated with attenuated inflammation-induced pulmonary dysfunction following extracorporeal circulation in mice.
Prognostic significance of immunoreactive neutrophil elastase in human breast cancer: long-term follow-up results in 313 patients.
Prognostic significance of three novel biologic factors in a clinical trial of adjuvant therapy for node-negative breast cancer.
Proteases and emphysema.
Recent Trends in the Design, Synthesis and Biological Exploration of ?-Lactams.
Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD.
Relationship between airway colonization, inflammation and exacerbation frequency in COPD.
Relationship between respiratory distress and cytokine response after cardiopulmonary bypass.
Release of cytokines, polymorphonuclear elastase and terminal C5b-9 complement complex by infusion of wound drainage blood.
Release of interleukin-8, interleukin-6, and colony-stimulating factors by upper airway epithelial cells: implications for cystic fibrosis.
Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils.
Role of imbalance between neutrophil elastase and alpha 1-antitrypsin in cancer development and progression.
Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases.
Role of neutrophil extracellular traps in regulation of lung cancer invasion and metastasis: Structural insights from a computational model.
Role of neutrophils in mucus hypersecretion in COPD and implications for therapy.
Serine Proteases Enhance Immunogenic Antigen Presentation on Lung Cancer Cells.
Sputum and salivary protein biomarkers and point-of-care biosensors for the management of COPD.
Systemic inflammation in chronic obstructive pulmonary disease and asthma: Similarities and differences.
Systemic release of neutrophil elastase and tumour necrosis factor alpha following ABO incompatible blood transfusion.
The anti-inflammatory effects of ulinastatin in trauma patients with hemorrhagic shock.
The effect of oral clarithromycin on bronchial airway inflammation in moderate-to-severe stable COPD: a randomized controlled trial.
The Effects of Leukocyte Filtration on Cell Salvaged Autologous Blood Transfusion on Lung Function and Lung Inflammatory and Oxidative Stress Reactions in Elderly Patients Undergoing Lumbar Spinal Surgery.
The host inflammatory response prior to death in patients with cystic fibrosis and chronic Pseudomonas aeruginosa infection.
The Immunomodulatory Effects of Macrolides-A Systematic Review of the Underlying Mechanisms.
The mechanism of hepatic cellular injury in sepsis: an in vitro study of the implications of cytokines and neutrophils in its pathogenesis.
The Neutrophil Elastase Inhibitor Sivelestat Suppresses Accelerated Gastrointestinal Tumor Growth via Peritonitis After Cecal Ligation and Puncture.
The prognostic value of polymorphonuclear leukocyte elastase in patients with primary breast cancer.
The role of neutrophil death in chronic inflammation and cancer.
The Serine Protease Neutrophil Elastase Selectively Kills Tumor Cells.
Transplantation of Endothelial Progenitor Cells Attenuates Lipopolysaccharide-Induced Lung Injury via Inhibiting the Inflammatory Secretion of Neutrophils in Rats.
Trehalose does not affect the functions of human neutrophils in vitro.
Tumor cell recognition by lymphocytes: is the MHC always essential?
Tumor neutrophil elastase is closely associated with the direct extension of non-small cell lung cancer into the aorta.
Upregulation of adhesion molecules in the bronchial mucosa of subjects with chronic obstructive bronchitis.
Whole blood model of meningococcal bacteraemia--a method for exploring host-bacterial interactions.
[Activation of endothelium in cardiac surgery: the circulating levels of soluble E-selectin as a marker of the activation of endothelium]
[Alteration of serum levels of endotoxin, polymorphonuclear leukocyte elastase, and the molecular markers of the coagulation and fibrinolytic system in the patients with esophageal cancer and lung cancer before and following operation]
[Characterization of structural and cellular components in pulmonary sarcoidosis granuloma]
[Clinical benefits of using the phosphorylcholine coating of an extracorporeal circuit in babies weighing less than 5 kg].
[Effect of heparin pretreatment on the level of neutrophil extracellular traps of serum and lung tissue in septic mice].
[Effect of ulinastatin on perioperative inflammatory response to coronary artery bypass grafting with cardiopulmonary bypass.]
[Influence of cardiopulmonary bypass on biological response]
[N01WA-735E, a human leukocyte elastase inhibitor from metabolites of microorganisms]
[Neutrophil elastase in postoperative pleural effusion of patients who had undergone pulmonary resections]
[Protective effects of ulinastatin on the lung injury during cardiopulmonary bypass]
[Systemic inflammation in COPD and asthma: similarities and differences]
[The relationship between opsonin, endotoxin and chemical mediators in postoperative complications after surgery]
[Urokinase-type plasminogen activator as a predictor for lymph nodes metastasis of uterine cervical cancer]
Nephritis
Beneficial effect of neutrophil elastase inhibitor on anti-Thy1.1 nephritis in rats.
Effects of a novel elastase inhibitor, ONO-5046, on nephrotoxic serum nephritis in rats.
Murine lupus is neutrophil elastase-independent in the MRL.Faslpr model.
Neuralgia
Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice.
Repurposing a leukocyte elastase inhibitor for neuropathic pain.
The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
Neuroinflammatory Diseases
The role of neutrophil granule proteins in neuroinflammation and Alzheimer's disease.
Neutropenia
A Case of Cyclic Neutropenia and Associated Amyloidosis.
A case of secondary acute myeloid leukemia on a background of glycogen storage disease with chronic neutropenia treated with granulocyte colony stimulating factor.
A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation.
A novel ELANE gene mutation in a patient with severe congenital neutropenia and intermittent thrombocytopenia.
A Novel ELANE Mutation Associated with Inflammatory Arthritis, Defective NETosis, and Recurrent Parvoviral Infection.
A Novel Homozygous HAX1 Mutation in a Child With Cyclic Neutropenia: A Case Report and Review.
A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia.
A Truncated Granulocyte Colony-stimulating Factor Receptor (G-CSFR) Inhibits Apoptosis Induced by Neutrophil Elastase G185R Mutant: IMPLICATION FOR UNDERSTANDING CSF3R GENE MUTATIONS IN SEVERE CONGENITAL NEUTROPENIA.
Aberrant subcellular targeting of the G185R neutrophil elastase mutant associated with severe congenital neutropenia induces premature apoptosis of differentiating promyelocytes.
Acquired cyclic neutropenia associated with cocaine-induced anti-neutrophil cytoplasmic antibodies binding to human neutrophil elastase.
Activation of the unfolded protein response is associated with impaired granulopoiesis in transgenic mice expressing mutant Elane.
Acute and chronic neutropenias. What is new?
Allogeneic Transplant in ELANE and MEFV Mutation Positive Severe Cyclic Neutropenia: Review of Prognostic Factors for Secondary Severe Events.
Bioinformatic analysis of protein structure-function relationships: case study of leukocyte elastase (ELA2) missense mutations.
Bone marrow failure syndromes in children.
Can mutations in ELA2, neutrophil elastase expression or differential cell toxicity explain sulphasalazine-induced agranulocytosis?
Characterisation of Neutropenia-Associated Neutrophil Elastase Mutations in a Murine Differentiation Model In Vitro and In Vivo.
Characterization of mutant neutrophil elastase in severe congenital neutropenia.
Clinical characteristics of severe congenital neutropenia caused by novel ELANE gene mutations.
Clinical implications of mutations of neutrophil elastase in congenital and cyclic neutropenia.
Coexistence of sickle cell disease and severe congenital neutropenia: first impressions can be deceiving.
Congenital Neutropenia Patient With Hypomorphic Biallelic CSF3R Mutation Responding to GCSF.
Congenital neutropenia.
Congenital neutropenia: diagnosis, molecular bases and patient management.
Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase.
Corticosteroid-binding globulin cleavage may be pathogen-dependent in bloodstream infection.
CRISPR-Cas9-Mediated ELANE Mutation Correction in Hematopoietic Stem and Progenitor Cells to Treat Severe Congenital Neutropenia.
CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients.
Current insights into inherited bone marrow failure syndromes.
Cyclic and chronic neutropenia.
Cyclic neutropenia and severe congenital neutropenia in patients with a shared ELANE mutation and paternal haplotype: evidence for phenotype determination by modifying genes.
Cyclic neutropenia associated with T cell immunity to granulocyte proteases and a double de novo mutation in GFI1, a transcriptional regulator of ELANE.
Cyclic Neutropenia From a Novel Mutation Ala57Asp of ELANE: Phenotypic Variability in Neutropenia From Mutated Ala57 Residue.
Cyclic neutropenia with a novel gene mutation presenting with a necrotizing soft tissue infection and severe sepsis: case report.
Cyclic neutropenia.
Defective G-CSFR signaling pathways in congenital neutropenia.
Description of an ELANE Mutation in a Girl with Severe Congenital Neutropenia: A Paradigm of Targeted Genetic Screening Based on Clinical Findings.
Different Clinical Phenotypes in Familial Severe Congenital Neutropenia Cases with Same Mutation of the ELANE Gene.
Dissecting ELANE neutropenia pathogenicity by human HSC gene editing.
Double de novo mutations of ELA2 in cyclic and severe congenital neutropenia.
Double de novo mutations of ELANE (ELA2) in a patient with severe congenital neutropenia requiring high-dose G-CSF therapy.
Ela2 mutations and clinical manifestations in familial congenital neutropenia.
ELANE gene mutation-induced cyclic neutropenia manifesting as recurrent fever with oral mucosal ulcer: A case report.
ELANE mutant-specific activation of different UPR pathways in congenital neutropenia.
ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology.
Elastase inhibitors as potential therapies for ELANE-associated neutropenia.
Enzyme-Agnostic Lysosomal Screen Identifies New Legumain-Cleavable ADC Linkers.
Four novel ELANE mutations in patients with congenital neutropenia.
Functional characteristics of circulating granulocytes in severe congenital neutropenia caused by ELANE mutations.
Functional interaction between mutations in the granulocyte colony-stimulating factor receptor in severe congenital neutropenia.
G-CSF receptor mutations in patients with congenital neutropenia.
Generation and characterization of a human iPSC line SANi007-A from a patient with a heterozygous dominant mutation in ELANE.
Genetic heterogeneity in severe congenital neutropenia: how many aberrant pathways can kill a neutrophil?
Genetics and pathophysiology of severe congenital neutropenia syndromes unrelated to neutrophil elastase.
HEMATOGONES IN A PERIPEHRAL BLOOD OF A 51/2-MONTH-OLD BOY WITH CYCLIC NEUTROPENIA DUE TO HETEROZYGOUS NOVEL ELANE GENE MUTATION p.Q97P, c.290 A>C.
Hereditary neutropenia: dogs explain human neutrophil elastase mutations.
Homozygous c.130-131 ins A (pW44X) mutation in the HAX1 gene as the most common cause of congenital neutropenia in Turkey: Report from the Turkish Severe Congenital Neutropenia Registry.
HSCT may lower leukemia risk in ELANE neutropenia: a before-after study from the French Severe Congenital Neutropenia Registry.
Human leukocyte elastase gene expression is regulated by PU.1 in conjunction with closely associated cytidine-rich and Myb binding sites.
Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia.
Inducible expression of a disease-associated ELANE mutation impairs granulocytic differentiation, without eliciting an unfolded protein response.
Inherited Neutrophil Disorders: Molecular Basis and New Therapies.
Inhibition of neutrophil elastase contributes to attenuation of lipopolysaccharide-induced acute lung injury during neutropenia recovery in mice.
Kostmann syndrome or infantile genetic agranulocytosis, part two: Understanding the underlying genetic defects in severe congenital neutropenia.
Lymphoid enhancer factor-1 links two hereditary leukemia syndromes through core-binding factor alpha regulation of ELA2.
Management of tooth extraction in a patient with ELANE gene mutation-induced cyclic neutropenia: A case report.
Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis.
Molecular basis and therapy of disorders associated with chronic neutropenia.
Molecular screening of the neutrophil elastase gene in congenital neutropenia.
Mosaicism of an ELANE mutation in an asymptomatic mother in a familial case of cyclic neutropenia.
Mosaicism of an ELANE Mutation in an Asymptomatic Mother.
Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase.
Mutations in neutrophil elastase causing congenital neutropenia lead to cytoplasmic protein accumulation and induction of the unfolded protein response.
Mutations in the ELA2 gene correlate with more severe expression of neutropenia: a study of 81 patients from the French Neutropenia Register.
Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease.
Mutations in the ELANE Gene are Associated with Development of Periodontitis in Patients with Severe Congenital Neutropenia.
Mutations in the gene encoding neutrophil elastase (ELA2) are not sufficient to cause the phenotype of congenital neutropenia.
Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia.
Mutations in the neutrophil elastase gene in cyclic and congenital neutropenia.
Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis.
Neutropenia in 6 ethnic groups from the Caribbean and the U.S.
Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms.
Neutrophil and nonneutrophil-mediated injury in intestinal ischemia-reperfusion.
Neutrophil elastase and granulocyte colony-stimulating factor receptor mutation analyses and leukemia evolution in severe congenital neutropenia patients belonging to the original Kostmann family in northern Sweden.
Neutrophil elastase converts human immature dendritic cells into transforming growth factor-beta1-secreting cells and reduces allostimulatory ability.
Neutrophil Elastase Defects in Congenital Neutropenia.
Neutrophil elastase depends on serglycin proteoglycan for localization in granules.
Neutrophil elastase gene mutations in cyclic neutropenia.
Neutrophil elastase in cyclic and severe congenital neutropenia.
Neutrophil elastase is associated with serglycin on its way to lysosomes in U937 cells.
Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1.
Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia.
Neutrophil elastase mutations in congenital neutropenia.
Neutrophil elastase mutations in severe congenital neutropenia patients of the original Kostmann family.
Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.
Neutrophil elastase-processing defect in cyclic hematopoietic dogs.
Neutrophil extracellular traps as a potential source of autoantigen in cocaine-associated autoimmunity.
Novel ELANE gene mutation in a Korean girl with severe congenital neutropenia.
Novel ELANE Gene Mutation in a Newborn with Severe Congenital Neutropenia: Case Report and Literature Review.
Novel insights from adaptor protein 3 complex deficiency.
Outcome and management of pregnancies in severe chronic neutropenia patients by the European Branch of the Severe Chronic Neutropenia International Registry.
Paternal mosaicism proves the pathogenic nature of mutations in neutrophil elastase in severe congenital neutropenia.
Paternal Somatic Mosaicism of a Novel Frameshift Mutation in ELANE Causing Severe Congenital Neutropenia.
Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells.
Plasma neutrophil-activating peptide-1/interleukin-8 and neutrophil elastase in a primate bacteremia model.
PML-controlled responses in severe congenital neutropenia with ELANE-misfolding mutations.
Prevalence of mutations in ELANE, GFI1, HAX1, SBDS, WAS and G6PC3 in patients with severe congenital neutropenia.
Role of CSF3R mutations in the pathomechanism of congenital neutropenia and secondary acute myeloid leukemia.
Role of neutrophil elastase in bone marrow failure syndromes: molecular genetic revival of the chalone hypothesis.
Screening of genetic variants in ELANE mutation negative congenital neutropenia by next generation sequencing.
Severe congenital neutropenia and the unfolded protein response.
Severe congenital neutropenia associated with the ELANE gene in Chinese children: case report.
Severe congenital neutropenia caused by the ELANE gene mutation in a Vietnamese boy with misdiagnosis of tuberculosis and autoimmune neutropenia: a case report.
Severe congenital neutropenia in a multigenerational family with a novel neutrophil elastase (ELANE) mutation.
Severe congenital neutropenia with a novel ELANE mutation in 2 Mexican patients.
Severe congenital neutropenia, a genetically heterogeneous disease group with an increased risk of AML/MDS.
Severe congenital neutropenia: a negative synergistic effect of multiple mutations of ELANE (ELA2) gene.
Severe congenital neutropenia: inheritance and pathophysiology.
Severe congenital neutropenia: new lane for ELANE.
Significance of neutrophil elastase mutations versus G-CSF receptor mutations for leukemic progression of congenital neutropenia.
Spectrum of ELANE mutations in congenital neutropenia: a single-centre study in patients of Indian origin.
Stage specific gene expression of serpins and their cognate proteases during myeloid differentiation.
Successful treatment with allogenic hematopoietic stem cell transplantation of a severe congenital neutropenia patient harboring a novel ELANE mutation.
The diversity of mutations and clinical outcomes for ELANE-associated neutropenia.
The role of apoptosis in the pathophysiology of chronic neutropenias associated with bone marrow failure.
The Severe Chronic Neutropenia International Registry: 10-Year Follow-up Report.
The Spectrum of ELANE Mutations and their Implications in Severe Congenital and Cyclic Neutropenia.
Three patients with glucose-6 phosphatase catalytic subunit 3 deficiency.
Two paternal mosaicism of mutation in ELANE causing severe congenital neutropenia exhibit normal neutrophil morphology and ROS production.
White blood cell defects: molecular discoveries and clinical management.
[A case report of cyclic neutropenia caused by novel double ELANE gene mutations].
[Clinical and genetic analysis of four patients with congenital neutropenia].
[Clinical and genetic analysis of two patients with congenital neutropenia caused by ELANE gene mutation].
[Cyclic neutropenia. Detection of a mutation in the gene for neutrophil elastase (ELA2)]
[Granulopoeisis and leukemogenesis : lessons from congenital neutropenia.]
[Mutations of the ELANE gene cause severe congenital neutropenia with periodontal disease: a case report].
Non-alcoholic Fatty Liver Disease
Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
Increased ratio of neutrophil elastase to ?1-antitrypsin is closely associated with liver inflammation in patients with nonalcoholic steatohepatitis.
Knockout of neutrophil elastase protects against western diet induced nonalcoholic steatohepatitis in mice by regulating hepatic ceramides metabolism.
Mice Deficient in the IL-1? Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD.
Neutrophils Play a Crucial Role in the Early Stage of Nonalcoholic Steatohepatitis via Neutrophil Elastase in Mice.
[Sivelestat alleviates nonalcoholic steatohepatitis in mice through inhibiting activation of Kupffer cells].
Obesity
Imbalance between neutrophil elastase and its inhibitor ?1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure.
Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects.
Neutrophil Elastase Regulates Emergency Myelopoiesis Preceding Systemic Inflammation in Diet-induced Obesity.
Surgical site peptidylarginine deaminase 4 (PAD4), a biomarker of NETosis, correlates with insulin resistance in total joint arthroplasty patients: A preliminary report.
Obstetric Labor, Premature
Changes in polymorphonuclear leukocytes in the vagina of patients with preterm labor.
Effect of urinary trypsin inhibitor on preterm labor with high granulocyte elastase concentration in cervical secretions.
How to lower perinatal mortality? Perinatal care in Japan.
Increased level of granulocyte elastase in cervical secretion is an independent predictive factor for preterm delivery.
Initial experience using Sivelestat to manage preterm labor with a bulging fetal membrane in pregnant women.
Matrix Metalloprotease-1 and Elastase Are Novel Uterotonic Agents Acting Through Protease-Activated Receptor 1.
Oropharyngeal Neoplasms
Oxidative stress, neutrophil elastase and IGFBP7 levels in patients with oropharyngeal cancer and chronic periodontitis.
Osteoarthritis
Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis.
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Neutrophil Elastase Induces Chondrocyte Apoptosis and Facilitates the Occurrence of Osteoarthritis via Caspase Signaling Pathway.
Quantitation of human leukocyte elastase, cathepsin G, alpha-2-macroglobulin and alpha-1-proteinase inhibitor in osteoarthrosis and rheumatoid arthritis synovial fluids.
The distribution of enzyme inhibitors in the joint in rheumatoid and experimental arthritis.
Osteomyelitis
PMN elastase in bone and joint infections.
[PMN-elastase as a marker in diagnosis and follow-up of bone and joint infections]
Otitis Externa
Inflammatory proteases in chronic otitis externa.
Otitis Media
Neutrophil elastase and its complex with alpha 1-antitrypsin in the pathogenesis of chronic suppurative otitis media.
Otitis Media with Effusion
Neutrophil elastase and its complex with alpha 1-antitrypsin in the pathogenesis of chronic suppurative otitis media.
Otitis Media, Suppurative
Neutrophil elastase and its complex with alpha 1-antitrypsin in the pathogenesis of chronic suppurative otitis media.
Treatment with a neutrophil elastase inhibitor and ofloxacin reduces P. aeruginosa burden in a mouse model of chronic suppurative otitis media.
Out-of-Hospital Cardiac Arrest
Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock.
Insufficient production of urinary trypsin inhibitor for neutrophil elastase release after cardiac arrest.
Out-of-hospital cardiac arrest increases soluble vascular endothelial adhesion molecules and neutrophil elastase associated with endothelial injury.
Ovarian Neoplasms
Overexpression of protease inhibitor-dead secretory leukocyte protease inhibitor causes more aggressive ovarian cancer in vitro and in vivo.
Overweight
Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects.
Pancreatic Neoplasms
Pancreatic elastase IIIA and its variants are expressed in pancreatic carcinoma cells.
[New aspects of the diagnosis of pancreatic cancer by determination of granulocyte elastase]
Pancreatitis
Activation of cellular immune response in acute pancreatitis.
Activity of neutrophil elastase reflects the progression of acute pancreatitis.
An impaired phagocytic function is associated with leucocyte activation in the early stages of severe acute pancreatitis.
Changes in polymorphonuclear neutrophil-elastase in pancreatitis.
Changes in serum amylase, lipase and leukocyte elastase during diabetic ketoacidosis and poorly controlled diabetes.
Clinical value of an automated granulocyte elastase assay in predicting severity of acute pancreatitis.
Combined effects of sivelestat and resveratrol on severe acute pancreatitis-associated lung injury in rats.
Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin.
Early diagnosis of a pancreatic abscess in acute pancreatitis.
Extracellular cleavage of E-cadherin by leukocyte elastase during acute experimental pancreatitis in rats.
Granulocyte elastase in assessment of severity of acute pancreatitis. Comparison with acute-phase proteins C-reactive protein, alpha 1-antitrypsin, and protease inhibitor alpha 2-macroglobulin.
Inflammatory mediators and cytokines--new aspects of the pathophysiology and assessment of severity of acute pancreatitis?
Inflammatory response in the early prediction of severity in human acute pancreatitis.
Laboratory markers of severe acute pancreatitis.
Leukocyte elastase alpha 1-proteinase inhibitor complexes may diagnose pancreatic abscesses early.
Levels of leukocyte proteases in plasma and peritoneal exudate in severe, acute pancreatitis.
Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in rat model of cerulein pancreatitis.
PMN-elastase in comparison with CRP, antiproteases, and LDH as indicators of necrosis in human acute pancreatitis.
Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats.
Protective effect of the combined treatment of pancreatic and neutrophil elastase inhibitors on acute pancreatitis elicited by lipopolysaccharide in rats given intraductal injection of taurocholate plus trypsin.
Protective effects of a PAF receptor antagonist and a neutrophil elastase inhibitor on multiple organ failure induced by cerulein plus lipopolysaccharide in rats.
Release of immunoreactive canine leukocyte elastase normally and in endotoxin and pancreatitic shock.
Renoprotective activity of sivelestat in severe acute pancreatitis in rats.
Significance of endothelial molecular markers in the evaluation of the severity of acute pancreatitis.
Surgical strategies in acute pancreatitis.
The effects of a new human leukocyte elastase inhibitor (recombinant guamerin) on cerulein-induced pancreatitis in rats.
[Inflammatory mediators in the acute pancreatitis]
[Influences of BN50739 on neutrophil elastase and phospholipase A2 in lung and tracheal mucosa of pigs with acute severe pancreatitis]
[Technique and outcome of surgical therapy in acute pancreatitis]
[Use of the urinary trypsin inhibitor ulinastatin for acute Kawasaki disease].
Pancreatitis, Acute Hemorrhagic
Effect of a specific synthetic inhibitor of neutrophil elastase (ONO-5046) on the course of acute hemorrhagic pancreatitis in dogs.
[Problems in intensive care posed by imbalance in the protease--protease inhibitor system]
Pancreatitis, Acute Necrotizing
Clinical picture and diagnosis of acute pancreatitis.
Parasitemia
Low levels of fibrin-stabilizing factor (factor XIII) in human Plasmodium falciparum malaria: correlation with clinical severity.
Pemphigoid, Bullous
A comparative study of expression of Fc receptors in relation to the autoantibody-mediated immune response and neutrophil elastase expression in autoimmune blistering dermatoses.
A critical role for neutrophil elastase in experimental bullous pemphigoid.
Basement membrane zone as a target for human neutrophil elastase in psoriasis.
Collagen XVII Processing and Blistering Skin Diseases.
Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid.
Respective contribution of neutrophil elastase and matrix metalloproteinase 9 in the degradation of BP180 (type XVII collagen) in human bullous pemphigoid.
The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo.
Pemphigus
A comparative study of expression of Fc receptors in relation to the autoantibody-mediated immune response and neutrophil elastase expression in autoimmune blistering dermatoses.
Periodontal Diseases
Active and alpha-1 proteinase inhibitor complexed leukocyte elastase levels in crevicular fluid from patients with periodontal diseases.
Chemically modified tetracycline-3 (CMT-3): A novel inhibitor of the serine proteinase, elastase.
Degradation of noncollagenous components by neutrophil elastase reduces the mechanical strength of rat periodontal ligament.
Granulocyte elastase activity and PGE2 levels in gingival crevicular fluid in relation to the presence of subgingival periodontopathogens in subjects with untreated adult periodontitis.
Influence of combinations of bacteria on the levels of prostaglandin E2, interleukin-1beta, and granulocyte elastase in gingival crevicular fluid and on the severity of periodontal disease.
Neutrophil elastase is involved in the initial destruction of human periodontal ligament.
Periodontal Disease in Patients From the Original Kostmann Family With Severe Congenital Neutropenia.
Proinflammatory cytokines production and PMN-elastase release from activated PMN cells in the periodontal disease.
Purification and characterization of a novel cysteine proteinase (periodontain) from Porphyromonas gingivalis. Evidence for a role in the inactivation of human alpha1-proteinase inhibitor.
Relationship between periodontal disease status and combination of biochemical assays of gingival crevicular fluid.
The defensive role of lysozyme in human gingiva in inflammatory periodontal disease.
[Granulocyte elastase activity and the content of acid-stable proteinase inhibitors in the oral fluid of patients with inflammatory periodontal diseases]
[Mutations of the ELANE gene cause severe congenital neutropenia with periodontal disease: a case report].
Periodontal Pocket
Granulocyte elastase activity and PGE2 levels in gingival crevicular fluid in relation to the presence of subgingival periodontopathogens in subjects with untreated adult periodontitis.
Periodontitis
Aggregatibacter actinomycetemcomitans induces detachment and death of human gingival epithelial cells and fibroblasts via elastase release following leukotoxin-dependent neutrophil lysis.
Altered relation between granulocyte elastase and alpha-2-macroglobulin in gingival crevicular fluid from sites with periodontal destruction.
Cleaved inflammatory lactoferrin peptides in parotid saliva of periodontitis patients.
Colorimetric Assay for the Detection of Typical Biomarkers for Periodontitis Using a Magnetic Nanoparticle Biosensor.
Cross-sectional analysis of risk factors for subclinical periodontitis; active matrix metalloproteinase-8 as a potential indicator in initial periodontitis in adolescents.
Elastase and alpha-1-proteinase inhibitor in gingival crevicular fluid and gingival tissue in adult and juvenile periodontitis.
Elastin derived peptides protect elastic fibres degradation by human neutrophil elastase: in vitro and in vivo studies using a mechanically induced rat gingival inflammatory model.
Granulocyte elastase in gingival crevicular fluid. A possible discriminator between gingivitis and periodontitis.
Granulocyte elastase in gingival crevicular fluid: improved monitoring of the site-specific response to treatment in patients with destructive periodontitis.
Granulocyte elastase, matrix metalloproteinase-8 and prostaglandin E2 in gingival crevicular fluid in matched clinical sites in smokers and non-smokers with persistent periodontitis.
Influence of combinations of bacteria on the levels of prostaglandin E2, interleukin-1beta, and granulocyte elastase in gingival crevicular fluid and on the severity of periodontal disease.
Inhibition of crevicular fluid neutrophil elastase by alpha 1-antitrypsin in periodontal health and disease.
Interleukin-8 and granulocyte elastase in gingival crevicular fluid in relation to periodontopathogens in untreated adult periodontitis.
Intracytoplasmic enzymes in gingival crevicular fluid of patients with aggressive periodontitis.
Modification of cystatin C activity by bacterial proteinases and neutrophil elastase in periodontitis.
Mutations in the ELANE Gene are Associated with Development of Periodontitis in Patients with Severe Congenital Neutropenia.
Neutrophil elastase activity, levels of prostaglandin E2, and matrix metalloproteinase-8 in refractory periodontitis sites in smokers and non-smokers.
Neutrophil elastase in crevicular fluid: comparison of a middle-aged general population with healthy and periodontitis groups.
Oxidative stress, neutrophil elastase and IGFBP7 levels in patients with oropharyngeal cancer and chronic periodontitis.
Proinflammatory cytokines production and PMN-elastase release from activated PMN cells in the periodontal disease.
Regulation of Salivary Peptidoglycan Recognition Protein1in Adolescents.
Salivary proteins associated with periodontitis in patients with type 2 diabetes mellitus.
The defensive role of lysozyme in human gingiva in inflammatory periodontal disease.
The effects of non-surgical periodontal therapy on neutrophil elastase and elastase alpha-1 proteinase inhibitor levels in GCF in periodontitis patients with or without acute coronary syndrome.
Variations in crevicular fluid elastase levels in periodontitis patients on long-term maintenance.
[Evaluation of periodontitis treatment effectiveness based on indices of the activity of neutrophil elastase and its acid-stable inhibitor in the oral fluid of patients]
[The treatment of periodontal diseases using Diplen-Denta films with chlorhexidine (a clinico-laboratory study)]
Peripheral Nervous System Diseases
Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice.
Peripheral Vascular Diseases
ZD-0892 AstraZeneca.
Peritonitis
A multicenter study of phospholipase A2 in patients in intensive care units.
Diagnosis of spontaneous bacterial peritonitis in children using leukocyte esterase reagent strips and granulocyte elastase immunoassay.
Granulocyte elastase in cirrhotic patients with spontaneous bacterial peritonitis.
Molecular and functional aspects of alterations in the kallikrein-kinin system activity in human blood plasma at different stages of peritonitis and chronic renal failure.
Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis.
Perioperative pattern of peritoneal interleukin 8, tumour necrosis factor-alpha, and granulocyte elastase release in human secondary peritonitis.
Rapid detection of spontaneous bacterial peritonitis by granulocyte elastase latex immunoassay and reagent strip.
The Neutrophil Elastase Inhibitor Sivelestat Suppresses Accelerated Gastrointestinal Tumor Growth via Peritonitis After Cecal Ligation and Puncture.
Persistent Infection
Immunology of Pseudomonas aeruginosa infection in cystic fibrosis.
Kinetics of proteolysis of hog gastric mucin by human neutrophil elastase and by Pseudomonas aeruginosa elastase.
Plague
[Flow-cytofluorometric study of bactericidal granules in blood phagocytes of animals with various species sensitivity to experimental plague infection].
Pleural Effusion
Epithelial Neutrophil-Activating Peptide-78 Recruits Neutrophils into Pleural Effusion.
Interleukin-8 and markers of neutrophil degranulation in pleural effusions.
Neutrophil elastase alpha 1-proteinase inhibitor complexes in pleural effusions.
ONO-5046 is a potent inhibitor of neutrophil elastase in human pleural effusion after lobectomy.
Significance of microbiological and biochemical analyses in empyema thoracis.
[Neutrophil elastase in postoperative pleural effusion of patients who had undergone pulmonary resections]
Pleurisy
[Determination of lactate and granulocyte elastase can be useful in the diagnosis of pleuritis]
Pneumonia
A specific neutrophil elastase inhibitor (ONO-5046.Na) attenuates LPS-induced acute lung inflammation in the hamster.
Acute lung inflammation: neutrophil elastase versus neutrophils in the bronchoalveolar lavage--neutrophil elastase reflects better inflammatory intensity.
Airway proteins involved in bacterial clearance susceptible to cathepsin G proteolysis.
Alpha-1 antitrypsin reduces severity of pseudomonas pneumonia in mice and inhibits epithelial barrier disruption and pseudomonas invasion of respiratory epithelial cells.
Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro.
An alternative elastase-mediated degradation of fibrinogen and fibrin observed in a patient with herpes simplex encephalitis and pneumonia.
Antimicrobial activity of antiproteinases.
Association of plasma neutrophil elastase levels with other inflammatory mediators and clinical features in adult patients with moderate and severe pneumonia.
Distribution of human neutrophil elastase in diffuse alveolar damage and pneumonia in a case of neonatal sepsis.
Effects of specific neutrophil elastase inhibitor, sivelestat sodium hydrate, in murine model of severe pneumococcal pneumonia.
Increased release of transforming growth factor (TGF)-beta1, TGF-beta2, and chemoattractant mediators in pneumonia.
LTB4 is present in exudative pleural effusions and contributes actively to neutrophil recruitment in the inflamed pleural space.
Magnetic Resonance Imaging of Protease-Mediated Lung Tissue Inflammation and Injury.
Measurements of plasma elastase alpha 1-proteinase inhibitor complexes in patients receiving cancer chemotherapy with granulocyte colony-stimulating factor.
Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis.
Mutants of plasminogen activator inhibitor-1 designed to inhibit neutrophil elastase and cathepsin G are more effective in vivo than their endogenous inhibitors.
Neutrophil elastase inhibitor reduces ventilation-induced lung injury via nuclear factor-?B and NF-?B repressing factor in mice.
Neutrophil elastase inhibitor sivelestat ameliorates gefitinib-naphthalene-induced acute pneumonitis in mice.
Neutrophil Elastase Modulates Cytokine Expression: Contribution to Host defense against Pseudomonas aeruginosa-induced Pneumonia.
Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia.
Neutrophil-mediated inflammation in respiratory syncytial viral bronchiolitis.
Oxidative burst and neutrophil elastase contribute to clearance of Aspergillus fumigatus pneumonia in mice.
Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide?induced pulmonary inflammation by inhibiting interleukin?8 production and NF??B activation.
Plasma neutrophil elastase correlates with pulmonary vascular permeability: A prospective observational study in patients with pneumonia.
Pulmonary matrix metalloproteinase-9 activity in mechanically ventilated children with respiratory syncytial virus.
Regulation of hepatocyte growth factor in mice with pneumonia by peptidases and trans-alveolar flux.
Secretory leukocyte proteinase inhibitor is a major leukocyte elastase inhibitor in human neutrophils.
Silica particles enhance peripheral thrombosis: key role of lung macrophage-neutrophil cross-talk.
Streptococcus pneumoniae disrupts pulmonary immune defence via elastase release following pneumolysin-dependent neutrophil lysis.
Studies on the role of antileukoprotease in respiratory tract diseases.
The clinical significance of oropharyngeal cultures in young children with cystic fibrosis.
The methanol extract of Guettarda speciosa Linn. Ameliorates acute lung injury in mice.
The Role of Neutrophil Elastase Inhibitors in Lung Diseases.
[Survival by a young woman with malnutrition due to alcoholism and eating disorders and with acute respiratory distress syndrome due to severe pneumonia who showed increased serum neutrophil elastase activity]
[Treatment of aspiration pneumonia with low-dose methylprednisolone and antibiotics]
Pneumonia, Bacterial
Beneficial effect of an inhibitor of leukocyte elastase (EPI-hNE-4) in presence of repeated lung injuries.
In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia.
Pneumonia, Pneumococcal
Effects of specific neutrophil elastase inhibitor, sivelestat sodium hydrate, in murine model of severe pneumococcal pneumonia.
Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia.
Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia.
The Role of Neutrophils and Neutrophil Elastase in Pneumococcal Pneumonia.
Pneumonia, Viral
Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia.
Polycystic Ovary Syndrome
Gingival Inflammation and Salivary or Serum Granulocyte Secreted Enzymes in Patients With Polycystic Ovary Syndrome.
Polymyalgia Rheumatica
Temporal arteritis in polymyalgia rheumatica: immune complex deposits and the role of the leukocyte elastase in the pathogenesis.
Polymyositis
Correlation of PMN elastase and PMN elastase-to-neutrophil ratio with disease activity in patients with myositis.
Pouchitis
Luminal neutrophil migration in ileoanal pouches studied by whole gut lavage.
Pre-Eclampsia
Complement, neutrophil, and macrophage activation in women with severe preeclampsia and the syndrome of hemolysis, elevated liver enzymes, and low platelet count.
Correlation of Plasma Neutrophil Elastase Activity and Endogenous Protease Inhibitor Levels with the Severity of Pre-eclampsia.
Evidence of impaired microvascular function in pre-eclampsia: a non-invasive study.
Pathological uterine perfusion in the second trimester is not associated with neutrophil activation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Reduced Neutrophil Elastase Activity and Neutrophil Extracellular Traps in Pediatric Acute Myeloid Leukemia May Increase the Rate of Infections.
Prehypertension
Elevated serum neutrophil elastase is related to prehypertension and airflow limitation in obese women.
Premature Birth
Neutrophil elastase in amniotic fluid as a predictor of preterm birth after emergent cervical cerclage.
Pressure Ulcer
Accelerated wound closure of pressure ulcers in aged mice by chitosan scaffolds with and without bFGF.
Primary Immunodeficiency Diseases
Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia.
Prostatitis
Evaluation of seminal plasma parameters in patients with chronic prostatitis or leukocytospermia.
Granulocyte elastase levels do not correlate with anaerobic and aerobic bacterial growth in seminal plasma from infertile men.
The evaluation of markers of prostatic inflammation and function of the prostate gland in patients with chronic prostatitis.
The value of neutrophil elastase in diagnosis of type III prostatitis.
[Content of neutrophil elastase in EPS and seminal plasma: A combined predictor in the diagnosis of type IIIA prostatitis with secondary infertility].
Proteinuria
Efficacy of AT in pre-eclampsia: a case-control prospective trial.
Elastase deposits in the kidney and urinary elastase excretion in patients with glomerulonephritis - evidence for neutrophil involvement in renal injury.
Pseudomonas Infections
A secretory leukocyte protease inhibitor variant with improved activity against lung infection.
Bronchiectasis in Infants and Preschool Children Diagnosed with Cystic Fibrosis after Newborn Screening.
Polymorphonuclear leukocyte elastase: its effects on the pathogenesis of Pseudomonas aeruginosa infection in cystic fibrosis.
Relevance between clinical status and exhaled molecules related to neutrophilic inflammation in pediatric cystic fibrosis.
Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases.
Pseudoxanthoma Elasticum
Histomorphometric parameters and susceptibility to neutrophil elastase degradation of skin elastic fibres from healthy individuals and patients with Marfan syndrome, Ehlers-Danlos type IV, and pseudoxanthoma elasticum.
Psoriasis
Basement membrane zone as a target for human neutrophil elastase in psoriasis.
Decreased specific anti-elastase activity in the uninvolved skin of patients with psoriasis.
Differences in Staining for Neutrophil Elastase and its Controlling Inhibitor SLPI Reveal Heterogeneity among Neutrophils in Psoriasis.
Evaluation of serine alpha 1-antitrypsin and polymorphonuclear leukocyte elastase contents and their immunogenetic correlation in psoriasis.
Inhibition of Neutrophil Elastase and Cathepsin G As a New Approach to the Treatment of Psoriasis: From Fundamental Biology to Development of New Target-Specific Drugs.
Neutrophil elastase promotes proliferation of HaCaT cell line and transwell psoriasis organ culture model.
Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations for Psoriasis Management.
Phototriggered release of tetrapeptide AAPV from coumarinyl and pyrenyl cages.
Plasma polymorphonuclear leukocyte elastase levels and its relation to disease activity in psoriasis.
Starch nanocapsules containing a novel neutrophil elastase inhibitor with improved pharmaceutical performance.
Topographic relation between skin-derived antileukoproteinase (SKALP) and leukocyte elastase in a case of annular pustular psoriasis.
[Liberation of human leukocyte elastase by hypertonic saline baths in psoriasis]
Puerperal Infection
Possible prediction of neonatal and puerperal infections by intrapartum determination of polymorphonuclear granulocyte elastase levels in maternal blood.
Pulmonary Arterial Hypertension
Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model.
Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency.
The Role of Neutrophils and Neutrophil Elastase in Pulmonary Arterial Hypertension.
Pulmonary Aspergillosis
[Invasive pulmonary aspergillosis in a patient with acute leukemia--the role of neutrophil elastase in in cavity formation]
Pulmonary Disease, Chronic Obstructive
?-1-antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease.
A mathematical model of protease-antiprotease homeostasis failure in chronic obstructive pulmonary disease (COPD).
A Randomised, Placebo-Controlled, Dose-Finding Study Of AZD9668, An Oral Inhibitor of Neutrophil Elastase, in Patients with Chronic Obstructive Pulmonary Disease Treated with Tiotropium.
A randomised, placebo-controlled, dose-finding study of AZD9668, an oral inhibitor of neutrophil elastase, in patients with chronic obstructive pulmonary disease treated with tiotropium.
A?-Val360: A Marker of Neutrophil Elastase and COPD Disease Activity.
Alpha-1 antitrypsin deficiency targeted testing and augmentation therapy: a Canadian Thoracic Society clinical practice guideline.
Alpha-1 antitrypsin therapy modulates the neutrophil membrane proteome and secretome.
Altered protease and antiprotease balance during a COPD exacerbation contributes to mucus obstruction.
An analysis of the organ and species immunospecificity of elastin.
Analysis of sputum markers in the evaluation of lung inflammation and functional impairment in symptomatic smokers and COPD patients.
Anti-inflammatory activity of neutrophil elastase inhibitors.
Atrial arrhythmogenesis in a rabbit model of chronic obstructive pulmonary disease.
AZD9668, a neutrophil elastase inhibitor, plus ongoing budesonide/formoterol in patients with COPD.
AZD9668: pharmacological characterisation of a novel oral inhibitor of neutrophil elastase.
Biological markers in induced sputum of patients with different phenotypes of chronic airway obstruction.
Biomarkers in Alpha-1 Antitrypsin Deficiency Chronic Obstructive Pulmonary Disease.
Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD.
Budesonide mitigates pathological changes in animal model Of COPD through reducing neutrophil elastase expression.
Can hypertonic saline inhalation influence preformed chemokine and mediator release in induced sputum of chronic obstructive pulmonary disease patients? Comparison with isotonic saline.
Characterizing the Dynamics and Ligand-Specific Interactions in the Human Leukocyte Elastase through Molecular Dynamics Simulations.
Chronic Obstructive Pulmonary Disease, inflammation and co-morbidity--a common inflammatory phenotype?
Clickable 4-Oxo-?-lactam-Based Selective Probing for Human Neutrophil Elastase Related Proteomes.
Clinical utility of alpha-1 proteinase inhibitor in the management of adult patients with severe alpha-1 antitrypsin deficiency: a review of the current literature.
Combined Inhibition of PDE4 and PI3K? Modulates the Inflammatory Component Involved in the Progression of Chronic Obstructive Pulmonary Disease.
Concomitant elevations of MMP-9, NGAL, proMMP-9/NGAL and neutrophil elastase in serum of smokers with chronic obstructive pulmonary disease.
Decline in FEV(1) in community-based older volunteers with higher levels of neutrophil elastase in bronchoalveolar lavage fluid.
Delivery of Alpha-1 Antitrypsin to Airways.
DX-890 (Dyax).
Effect of expectoration on inflammation in induced sputum in alpha-1-antitrypsin deficiency.
Effects of MR889, a cyclic thiolic neutrophil elastase inhibitor, on rheologic properties of mucus.
Electrophoretic mobility of leukocyte elastase of normal subjects and patients with chronic obstructive pulmonary disease.
Elevated serum matrix metalloprotease (MMP-2) as a candidate biomarker for stable COPD.
Emerging drugs for the treatment of chronic obstructive pulmonary disease.
Expressions of MMP-12, TIMP-4, and Neutrophil Elastase in PBMCs and Exhaled Breath Condensate in Patients with COPD and Their Relationships with Disease Severity and Acute Exacerbations.
Feasibility of Computed Tomography in a Multicenter COPD Trial: A Study of the Effect of AZD9668 on Structural Airway Changes.
Genomics of Chronic Obstructive Pulmonary Disease (COPD); Exploring the SNPs of Protease-Antiprotease Pathway.
Glucocorticosteroids Differentially Regulate MMP-9 and Neutrophil Elastase in COPD.
Haplotypes of the alpha-1 antitrypsin gene in healthy controls and Z deficiency patients.
Hyaluronan blocks porcine pancreatic elastase-induced mucociliary dysfunction in allergic sheep.
Inflammatory mediators in exhaled breath condensate and peripheral blood of healthy donors and stable COPD patients.
Inhaled porcine pancreatic elastase causes bronchoconstriction via a bradykinin-mediated mechanism.
Interactions of neutrophil elastase, serum trypsin inhibitory activity, and smoking history as risk factors for chronic obstructive pulmonary disease in patients with MM, MZ, and ZZ phenotypes for alpha-antitrypsin.
Interactions of neutrophil elastase, serum trypsin inhibitory activity, and smoking history as risk factors for chronic obstructive pulmonary disease in patients with MM, MZ, and ZZ phenotypes for alpha1-antitrypsin.
Interrelationship between serum and sputum inflammatory mediators in chronic obstructive pulmonary disease.
Interrelationships between neutrophil elastase, serum alpha, -antitrypsin, lung function and chest radiography in patients with chronic airflow obstruction.
l-Carbocisteine reduces neutrophil elastase-induced mucin production.
Matrine reduces cigarette smoke-induced airway neutrophilic inflammation by enhancing neutrophil apoptosis.
Measurement of C-reactive protein, procalcitonin and neutrophil elastase in saliva of COPD patients and healthy controls: correlation to self-reported wellbeing parameters.
MMP-12 activates protease-activated receptor-1, upregulates placenta growth factor, and leads to pulmonary emphysema.
MMP-8, MMP-9 and Neutrophil Elastase in Peripheral Blood and Exhaled Breath Condensate in COPD.
Molecular characterisation of the defective alpha 1-antitrypsin alleles PI Mwurzburg (Pro369Ser), Mheerlen (Pro369Leu), and Q0lisbon (Thr68Ile).
MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: a double-blind, randomized, placebo-controlled clinical trial.
Neutrophil Elastase and Chronic Lung Disease.
Neutrophil elastase as a biomarker for bacterial infection in COPD.
Neutrophil Elastase as a Target in Lung Cancer.
Neutrophil Elastase Differentially Regulates Interleukin 8 (IL-8) and Vascular Endothelial Growth Factor (VEGF) Production by Cigarette Smoke Extract.
Neutrophil elastase increases MUC4 expression in normal human bronchial epithelial cells.
Neutrophil elastase inhibitors as treatment for COPD.
Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores.
Neutrophil elastase inhibitors.
Neutrophil elastase inhibitors: recent advances in the development of mechanism-based and nonelectrophilic inhibitors.
Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway.
Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex.
Neutrophil lysosomal elastase activity in normal subjects and in patients with chronic obstructive pulmonary disease.
Nicotine-stimulated elastase activity release by neutrophils in patients with abdominal aortic aneurysms.
ONO-6818 Cortech/Ono.
Pharmacokinetics and safety of AZD9668, an oral neutrophil elastase inhibitor, in healthy volunteers and patients with COPD.
PlGF mediates neutrophil elastase-induced airway epithelial cell apoptosis and emphysema.
Progranulin is a substrate for neutrophil-elastase and proteinase-3 in the airway and its concentration correlates with mediators of airway inflammation in COPD.
Proteases and antiproteases.
Proteinase/proteinase inhibitor imbalance in sputum sol phases from patients with chronic obstructive pulmonary disease. Suggestions for a key role played by antileukoprotease.
Quantification and evaluation of the role of antielastin autoantibodies in the emphysematous lung.
Relationship between airway colonization, inflammation and exacerbation frequency in COPD.
Role of elastases in the pathogenesis of chronic obstructive pulmonary disease: implications for treatment.
Role of neutrophil elastase in hypersecretion during COPD exacerbations, and proposed therapies.
Role of Proteases in Chronic Obstructive Pulmonary Disease.
Selective Imaging of Lung Macrophages Using [11C]PBR28-Based Positron Emission Tomography.
SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer.
Serum amyloid A opposes lipoxin A? to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease.
Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease.
Severity of chronic obstructive pulmonary disease with 'exacerbator with emphysema phenotype' is associated with potential biomarkers.
Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase.
Targeting COPD: Advances on low-molecular-weight inhibitors of human neutrophil elastase.
The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro.
The fibrinogen cleavage product A{alpha}-Val360, a specific marker of neutrophil elastase activity in vivo.
The Relationship of the Fibrinogen Cleavage Biomarker A?-Val360 with Disease Severity and Activity in Alpha-1-antitrypsin Deficiency.
The Serpin Superfamily and Their Role in the Regulation and Dysfunction of Serine Protease Activity in COPD and Other Chronic Lung Diseases.
Unexpected active-site flexibility in the structure of human neutrophil elastase in complex with a new dihydropyrimidone inhibitor.
Verification of zinc role in pathophysiology of chronic obstructive pulmonary disease.
ZD-0892 AstraZeneca.
[Changes of neutrophil elastase in COPD and the role of elastase in experimental pulmonary hypertension]
[CLINICAL AND PATHOGENETIC PECULIARITIES OF DEVELOPMENT OF ENDOTHELIAL DYSFUNCTION].
[Proteases involved in airway inflammation of COPD]
Pulmonary Edema
Decreased lung hyaluronan in a model of ARDS in the rat: Effect of an inhibitor of leukocyte elastase.
Effect of a selective neutrophil elastase inhibitor on mortality and ventilator-free days in patients with increased extravascular lung water: a post hoc analysis of the PiCCO Pulmonary Edema Study.
Effect of a synthetic leukocyte elastase inhibitor on thrombin-induced pulmonary edema in the rat.
Prevention of Pulmonary Edema after Minimally Invasive Cardiac Surgery with Mini-Thoracotomy Using Neutrophil Elastase Inhibitor.
Using a Caesalpinia echinata Lam. protease inhibitor as a tool for studying the roles of neutrophil elastase, cathepsin G and proteinase 3 in pulmonary edema.
[Pulmonary fibrosis after endotoxin-induced permeability edema]
Pulmonary Embolism
Changes in coagulation-fibrinolysis marker and neutrophil elastase following the use of tourniquet during total knee arthroplasty and the influence of neutrophil elastase on thromboembolism.
Induction of pulmonary thromboembolism by neutrophil elastase in collagen-induced arthritis mice and effect of recombinant human soluble thrombomodulin.
Pulmonary Emphysema
5-Methyl-4H-3,1-benzoxazin-4-one derivatives: specific inhibitors of human leukocyte elastase.
A novel class of cyclic beta-dicarbonyl leaving groups and their use in the design of benzisothiazolone human leukocyte elastase inhibitors.
A novel oral neutrophil elastase inhibitor (ONO-6818) inhibits human neutrophil elastase-induced emphysema in rats.
A randomized clinical trial of alpha(1)-antitrypsin augmentation therapy.
Alpha,-antitrypsin and leukocyte elastase in infected and noninfected sputum.
Alpha-1 Antitrypsin Deficiency: Have We Got the Right Proteinase?
Biochemical and pharmacological activities of SR 26831, a potent and selective elastase inhibitor.
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.
Biomarkers in Alpha-1 Antitrypsin Deficiency Chronic Obstructive Pulmonary Disease.
Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase.
Characterisation of human lung elastin-derived peptides.
Chronic Obstructive Pulmonary Disease. A Biomarker and a Potential Therapy.
Direct interaction of ONO-5046 with human neutrophil elastase through ¹H NMR and molecular docking.
Evidence for in vivo internalization of human leukocyte elastase by alveolar macrophages.
Hypoxic injury to human alveolar macrophages accelerates release of previously bound neutrophil elastase. Implications for lung connective tissue injury including pulmonary emphysema.
Increased leukocyte elastase of the tracheal aspirate at birth and neonatal pulmonary emphysema.
Inhibition of elastase-induced acute inflammation and pulmonary emphysema in hamsters by a novel neutrophil elastase inhibitor FR901277.
Inhibition of human leukocyte elastase bound to elastin: relative ineffectiveness and two mechanisms of inhibitory activity.
Isolation and partial characterization of a proteinase with elastolytic activity from mouse blood leukocytes.
Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema.
Neutrophil elastase activity and superoxide production are diminished in neutrophils of alcoholics.
Neutrophil elastase cleaves VEGF to generate a VEGF fragment with altered activity.
Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice.
Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G.
Orally bioavailable benzisothiazolone inhibitors of human leukocyte elastase.
Protection of rat lung from elastase-induced elastic fiber degradation in vitro and from emphysema in vivo by a trifluoroacetylpeptide anilide inhibitor.
Pulmonary deposition and disappearance of aerosolised secretory leucocyte protease inhibitor.
Search for drugs that may reduce the load of neutrophil azurophilic granule enzymes in the lungs of patients with emphysema.
Serine proteinase inhibitor therapy in alpha(1)-antitrypsin inhibitor deficiency and cystic fibrosis.
Structure, function, and control of neutrophil proteinases.
Synthesis in yeast of a functional oxidation-resistant mutant of human alpha-antitrypsin.
Synthetic elastase inhibitors: prospects for use in the treatment of emphysema.
The antielastase screen of the lower respiratory tract.
The beige mouse: role of neutrophil elastase in the development of pulmonary emphysema.
The elastase/alpha 1-proteinase inhibitor balance in the lung. A review.
The induction of pulmonary emphysema with human leukocyte elastase.
The role of free radicals and neutrophil elastase in development of pulmonary emphysema.
[Alpha 1-antiproteinase deficiency]
[Evaluation of desmosine excretion in urine and activity of elastase in neutrophils of patients with pulmonary emphysema]
[Neutrophil elastase and elastin-derived peptides in BAL fluid and emphysematous changes on CT scans]
[Problems in intensive care posed by imbalance in the protease--protease inhibitor system]
Pulmonary Fibrosis
A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice.
Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice.
Administration of truncated secretory leukoprotease inhibitor ameliorates bleomycin-induced pulmonary fibrosis in hamsters.
Effects of elastase inhibitor on the epithelial cell apoptosis in bleomycin-induced pulmonary fibrosis.
Effects of neutrophil elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice.
Elevated Serum Concentrations of Polymorphonuclear Neutrophilic Leukocyte Elastase in Systemic Sclerosis: Association with Pulmonary Fibrosis.
Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis: association with pulmonary fibrosis.
Granulocyte-macrophage colony-stimulating factor primes interleukin-13 production by macrophages via protease-activated receptor-2.
Inhibition of Leukocyte Elastase, Polymorphonuclear Chemoinvasion, and Inflammation-Triggered Pulmonary Fibrosis by a 4-Alkyliden-beta-lactam with a Galloyl Moiety.
Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis.
Neutrophil elastase-releasing factors in bronchoalveolar lavage from patients with adult respiratory distress syndrome.
Neutrophil elastase: alpha-1-proteinase inhibitor complex in serum and bronchoalveolar lavage fluid in patients with pulmonary fibrosis.
ONO-5046 (Ono Pharmaceutical).
Particulate Matter Increases the Severity of Bleomycin-Induced Pulmonary Fibrosis through KC-Mediated Neutrophil Chemotaxis.
[Strategy of therapy for interstitial lung disease due to chemotherapeutic drugs or radiation]
Purpura
Neutrophil extracellular traps as a potential source of autoantigen in cocaine-associated autoimmunity.
Purpura, Thrombotic Thrombocytopenic
Elevated plasma neutrophil elastase concentration is associated with disease activity in patients with thrombotic thrombocytopenic purpura.
Pyelonephritis
The possible role of granulocyte elastase in renal damage from acute pyelonephritis.
Renal Insufficiency
Elastase and exacerbation of neutrophil innate immunity are involved in multi-visceral manifestations of COVID-19.
Renal Insufficiency, Chronic
Neutrophil Elastase Inhibitors and Chronic Kidney Disease.
Polymorphisms of the ELANE Gene Promoter Region in End-Stage Chronic Kidney Disease Patients.
Reperfusion Injury
A neutrophil elastase inhibitor improves lung function during ex vivo lung perfusion.
Activation of intracellular neutrophil elastase in the transplantation of ischemic liver.
Addition of a neutrophil elastase inhibitor to the organ flushing solution decreases lung reperfusion injury in rat lung transplantation.
Benefical effect of neutrophil elastase inhibitor on renal warm ischemia-reperfusion injury in the rat.
Early cellular brain damage and systemic inflammatory response after cardiopulmonary resuscitation or isolated severe head trauma: a comparative pilot study on common pathomechanisms.
Effects of a specific neutrophil elastase inhibitor (ONO-5046 Na) and neutrophil depletion using a G-1 column on lung reperfusion injury in dogs.
Effects of neutrophil elastase inhibitor on reperfusion injury in the canine liver.
Microvascular permeability of the non-heart-beating rabbit lung after warm ischemia and reperfusion: role of neutrophil elastase.
Neutrophil elastase activity in hepatic ischemia reperfusion injury.
Neutrophil elastase enhances intercellular adhesion molecule-1 expression.
Neutrophil elastase inhibitor (ONO-5046) attenuates reperfusion-induced hepatic microcirculatory derangement, energy depletion and lipid peroxidation in rats.
Neutrophil elastase inhibitor (ONO-5046) decreases cytokine-induced neutrophil chemoattractant after reperfusion of pancreaticoduodenal transplantation in rats.
Neutrophil elastase inhibitor ameliorates reperfusion injury in a canine model of lung transplantation.
Neutrophil elastase inhibitor improves survival rate after ischemia reperfusion injury caused by supravisceral aortic clamping in rats.
Neutrophil elastase inhibitor is a potent therapeutic agent to control renal ischemia-reperfusion injury.
Neutrophil elastase inhibitor reduces neutrophil chemoattractant production after ischemia-reperfusion in rat liver.
Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder.
Neutrophil elastase: a determinant of endothelial damage and reperfusion injury after liver transplantation?
Protective effect of Sivelestat in a porcine hepatectomy model prepared using an intermittent Pringle method.
Role of neutrophil depletion and elastase inhibition in modifying skeletal muscle reperfusion injury.
Sivelestat reduces reperfusion injury of lungs harvested from endotoxin-primed rats by inhibition of neutrophil-mediated inflammation.
Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury.
Sivelestat, a neutrophil elastase inhibitor, attenuates neutrophil priming after hepatoenteric ischemia in rabbits.
The effect of neutrophil elastase inhibitor in hepatectomy with ischemia in dogs.
The effect of neutrophil elastase inhibitor on acute tubular necrosis after renal ischemia-reperfusion injury.
The effects of a neutrophil elastase inhibitor (ONO-5046.Na) and neutrophil depletion using a granulotrap (G-1) column on lung reperfusion injury in dogs.
The effects of a specific neutrophil elastase inhibitor (ONO-5046) in pulmonary ischemia-reperfusion injury.
Reproductive Tract Infections
[Significance of neutrophil elastase in diagnosis of male genital tract infection]
Respiratory Distress Syndrome
5-Methyl-4H-3,1-benzoxazin-4-one derivatives: specific inhibitors of human leukocyte elastase.
A neutrophil elastase inhibitor improves lung function during ex vivo lung perfusion.
Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice.
Alveolar fluid neutrophil elastase activity in the adult respiratory distress syndrome is complexed to alpha-2-macroglobulin.
Anti-inflammatory activity of neutrophil elastase inhibitors.
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.
Clinical effects of a neutrophil elastase inhibitor, sivelestat, in patients with acute respiratory distress syndrome.
Clinical utility of the neutrophil elastase inhibitor sivelestat for the treatment of acute respiratory distress syndrome.
Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients.
Direct interaction of ONO-5046 with human neutrophil elastase through ¹H NMR and molecular docking.
Effect of a selective neutrophil elastase inhibitor on mortality and ventilator-free days in patients with increased extravascular lung water: a post hoc analysis of the PiCCO Pulmonary Edema Study.
Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis.
Efficacy of early sivelestat administration on acute lung injury and acute respiratory distress syndrome.
Elevation of pivaloylcarnitine by sivelestat sodium in two children.
Evaluation of appropriate indications for the use of sivelestat sodium in acute respiratory distress syndrome: a retrospective cohort study.
Imbalances between the levels of tissue factor and tissue factor pathway inhibitor in ARDS patients.
Increased neutrophil elastase, persistent intravascular coagulation, and decreased fibrinolytic activity in patients with posttraumatic acute respiratory distress syndrome.
Inhaled porcine pancreatic elastase causes bronchoconstriction via a bradykinin-mediated mechanism.
Interleukin 8 and granulocyte elastase alpha 1 proteinase inhibitor complex in the tracheobronchial aspirate of infants with chronic lung disease following respiratory distress syndrome.
Interleukin 8 and granulocyte elastase in the tracheobronchial aspirate of infants without respiratory distress syndrome or intrauterine infection and development of chronic lung disease.
Interleukin 8-related neutrophil elastase and the severity of the adult respiratory distress syndrome.
Neutrophil elastase activity in acute lung injury and respiratory distress syndrome.
Neutrophil elastase and acute lung injury: prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics.
Neutrophil elastase and acute pulmonary damage in neonates with severe respiratory distress syndrome.
Neutrophil elastase as a predicting factor for development of acute lung injury.
Neutrophil Elastase Damages the Pulmonary Endothelial Glycocalyx in Lipopolysaccharide-Induced Experimental Endotoxemia.
Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
Neutrophil elastase inhibitors, SC-37698 and SC-39026, reduce endotoxin-induced lung dysfunction in awake sheep.
Pilot study of the effects of ONO-5046 in patients with acute respiratory distress syndrome.
Plasma interleukin 8 and polymorphonuclear leukocyte elastase concentrations in patients with septic shock.
Plasma Neutrophil Elastase and Elafin as Prognostic Biomarker for Acute Respiratory Distress Syndrome: A Multicenter Survival and Longitudinal Prospective Observation Study.
Plasma neutrophil elastase and elafin imbalance is associated with acute respiratory distress syndrome (ARDS) development.
Relationship between alpha-tocopherol and polymorphonuclear leukocyte elastase in septic adult respiratory distress syndrome.
Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice.
Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both ARDS and DIC patients.
Successful management of postoperative acute respiratory distress syndrome in a patient with lung cancer.
Synthesis and evaluation of benzenesulfonic acid derivatives as human neutrophil elastase (hNE) inhibitors.
The potential efficacy of noninvasive ventilation with administration of a neutrophil elastase inhibitor for acute respiratory distress syndrome.
The presence of neutrophil elastase and evidence of oxidation activity in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome.
Usefulness of a selective neutrophil elastase inhibitor (sivelestat) in septic ARDS patients after gastrointestinal surgery.
[Dynamic changes in polymorphonuclear cell elastase-alpha 1 protease inhibitor complex, a stress marker, in various pulmonary diseases]
[Experimental research on the pathogenic mechanisms in adult respiratory distress syndrome]
[Prognostic significance of neutrophil elastase inhibitor in patients with acute lung injury and interstitial pneumonia]
[Survival by a young woman with malnutrition due to alcoholism and eating disorders and with acute respiratory distress syndrome due to severe pneumonia who showed increased serum neutrophil elastase activity]
[The role of neutrophil elastase and its inhibitors in acute respiratory distress syndrome: an update].
Respiratory Insufficiency
Design and synthesis of peptide-based carboxylic acid-containing transition-state inhibitors of human neutrophil elastase.
Diagnostic criteria for adult respiratory distress syndrome: time for reappraisal.
Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters.
Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia.
The effect of sivelestat sodium hydrate on severe respiratory failure after thoracic aortic surgery with deep hypothermia.
The effects of a neutrophil elastase inhibitor on the postoperative respiratory failure of acute aortic dissection.
[ARDS-like reactive respiratory failure after radical operation for esophageal cancer--with reference to PMN elastase and anaphylatoxin]
[Changes in polymorphonuclear leukocyte elastase (PMNE) during shock; the effect of PMNE on respiratory failure]
[Dynamic changes in polymorphonuclear cell elastase-alpha 1 protease inhibitor complex, a stress marker, in various pulmonary diseases]
[Effects of ulinastatin on plasma polymorphonuclear leukocyte elastase activity and respiratory function in patients undergoing cardiopulmonary bypass]
Respiratory Tract Infections
Clinical and immunoregulatory effects of roxithromycin therapy for chronic respiratory tract infection.
Role of inflammation in respiratory tract infections.
Rheumatic Diseases
Competitive neutrophil elastase inhibitory isoflavones from the roots of Flemingia philippinensis.
Frankincense--therapeutic properties.
Rhinitis
Reduction of TLR2 gene expression in allergic and nonallergic rhinitis.
Rhinitis, Allergic
Activity of leukocyte elastase in patients' plasma is a significant indicator of atopic diseases.
Nasal response to capsaicin in patients with allergic rhinitis and in healthy volunteers: effect of colchicine.
Secretory leukocyte protease inhibitor in normal, allergic and virus induced nasal secretions.
The effect of immediate-hypersensitivity reactions on the level of SLPI, granulocyte elastase, alpha1-antitrypsin, and albumin in nasal secretions, by the method of unilateral antigen challenge.
Sarcoidosis
Lung lavage neutrophils, neutrophil elastase and albumin in the prognosis of pulmonary sarcoidosis.
Neutrophil elastase-releasing factors in bronchoalveolar lavage from patients with adult respiratory distress syndrome.
Phagocyte enzymes in bronchoalveolar lavage from patients with pulmonary sarcoidosis and collagen vascular disorders.
Prognostic value of plasma neutrophil elastase levels in pulmonary sarcoidosis.
[Characterization of structural and cellular components in pulmonary sarcoidosis granuloma]
Sarcoidosis, Pulmonary
Lung lavage neutrophils, neutrophil elastase and albumin in the prognosis of pulmonary sarcoidosis.
Phagocyte enzymes in bronchoalveolar lavage from patients with pulmonary sarcoidosis and collagen vascular disorders.
Prognostic value of plasma neutrophil elastase levels in pulmonary sarcoidosis.
Scleroderma, Systemic
A potential contribution of trappin-2 to the development of vasculopathy in systemic sclerosis.
Elevated Serum Concentrations of Polymorphonuclear Neutrophilic Leukocyte Elastase in Systemic Sclerosis: Association with Pulmonary Fibrosis.
Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis: association with pulmonary fibrosis.
Scrub Typhus
Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with Scrub Typhus but Not Murine Typhus in Laos.
Seizures
Convulsions in hemodialysis (HD) patients with elevated polymorphonuclear leukocyte elastase (PMNE) levels.
Sepsis
A low TAFI activity and insufficient activation of fibrinolysis by both plasmin and neutrophil elastase promote organ dysfunction in disseminated intravascular coagulation associated with sepsis.
Complement activation and polymorphonuclear neutrophil leukocyte elastase in sepsis. Correlation with severity of disease.
Degradation of cross-linked fibrin by leukocyte elastase as alternative pathway for plasmin-mediated fibrinolysis in sepsis-induced disseminated intravascular coagulation.
Discrepancy between latex and ELISA D-dimer values in sepsis may be caused by human neutrophil elastase.
Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6.
Granulocyte elastase and white cell counts in septic pigs.
Granulocyte elastase compared to C-reactive protein for early diagnosis of septicemia in critically ill patients.
High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis.
Identification of Potential Biomarkers and Immune Features of Sepsis Using Bioinformatics Analysis.
Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia.
Imbalances between the levels of tissue factor and tissue factor pathway inhibitor in ARDS patients.
Inhibition of Efferocytosis by Extracellular CIRP-Induced Neutrophil Extracellular Traps.
Leukocyte function assessed via serial microlitre sampling of peripheral blood from sepsis patients correlates with disease severity.
Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis.
MiR-608 Exerts Anti-inflammatory Effects by Targeting ELANE in Monocytes.
Monoclonal antibody to tumor necrosis factor--alpha prevents lethal endotoxin sepsis in adult rhesus monkeys.
Neutrophil Elastase Inhibition Ameliorates Endotoxin-Induced Myocardial Injury Accompanying Degradation of Cardiac Capillary Glycocalyx.
Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.
Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis.
Neutrophil extracellular traps in the host defense against sepsis induced by Burkholderia pseudomallei (melioidosis).
Parameters influencing membrane CD14 expression and soluble CD14 levels in sepsis.
Phospholipase A in acute lung injury after trauma and sepsis: its relation to the inflammatory mediators PMN-elastase, C3a, and neopterin.
Plasmapheresis in Sepsis-induced Thrombotic Microangiopathy: A Case Series.
PMN elastase in bone and joint infections.
Proteinases in catabolism and malnutrition.
Released granulocytic elastase: an indicator of pathobiochemical alterations in septicemia after abdominal surgery.
Role of granulocyte elastase in tissue injury in patients with septic shock complicated by multiple-organ failure.
Serial changes in neutrophil-endothelial activation markers during the course of sepsis associated with disseminated intravascular coagulation.
Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both ARDS and DIC patients.
Syndecan-4-dependent signaling in the inhibition of endotoxin-induced endothelial adherence of neutrophils by antithrombin.
The activation of neutrophil elastase-mediated fibrinolysis is not sufficient to overcome the fibrinolytic shutdown of disseminated intravascular coagulation associated with systemic inflammation.
The inactivation of human plasma alpha 1-proteinase inhibitor by proteinases from Staphylococcus aureus.
The Proteolytic Inactivation of Protein Z-Dependent Protease Inhibitor by Neutrophil Elastase Might Promote the Procoagulant Activity of Neutrophil Extracellular Traps in Sepsis.
The role of bacterial lipopolysaccharide-bound neutrophils in the pathogenesis of Kawasaki disease.
The role of inflammatory cells and their proteases in extravascular fibrinolysis.
Time Series Gene Expression Profiles Analysis Identified Several Potential Biomarkers for Sepsis.
Tissue factor production not balanced by tissue factor pathway inhibitor in sepsis promotes poor prognosis.
Transcriptome Meta-Analysis Deciphers a Dysregulation in Immune Response-Associated Gene Signatures during Sepsis.
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
[Advancement in the diagnosis of disseminated intravascular coagulation for the surgeon]
[Current findings in the pathogenesis of the shock process in traumatology]
[Cytokine storm in the pathogenesis of multiple organ dysfunction syndrome associated with surgical insults]
[PMN-elastase as a marker in diagnosis and follow-up of bone and joint infections]
[Polymorphonuclear leukocyte elastase (PMNE) levels in sepsis; the effect of PMNE on multiple organ failure (MOF)]
[Reduction in leukocyte elastase levels in patients with sepsis by administration of urinastatin]
[Screening and identification of potential targets of carthamin against sepsis].
[Understanding the pathogenetic mechanisms of SIRS and sepsis and development of innovative therapies of sepsis]
Severe Acute Respiratory Syndrome
A possible pathogenic correlation between neutrophil elastase (NE) enzyme and inflammation in the pathogenesis of coronavirus disease 2019 (COVID-19).
Severe Combined Immunodeficiency
Neutrophil elastase inhibitor (ONO-5046-Na) inhibits the growth of human lung cancer cell lines transplanted into severe combined immunodeficiency (scid) mice.
Sexually Transmitted Diseases
Clinical relevance of polymorphonuclear (PMN-) elastase determination in semen and serum during infertility investigation.
Shock, Cardiogenic
Granulocyte elastase in acute myocardial infarction.
Shock, Septic
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.
Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model.
Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock.
Expression of endothelial leukocyte adhesion molecule-1 in septic but not traumatic/hypovolemic shock in the baboon.
Neutrophil elastase, thrombin and plasmin in septic shock.
Plasma interleukin 8 and polymorphonuclear leukocyte elastase concentrations in patients with septic shock.
Recombinant C1 inhibitor P5/P3 variants display resistance to catalytic inactivation by stimulated neutrophils.
Release of granulocyte elastase in lethal canine endotoxin shock.
Role of granulocyte elastase in tissue injury in patients with septic shock complicated by multiple-organ failure.
Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats.
The disturbance of hemostasis in septic shock: role of neutrophil elastase and thrombin, effects of antithrombin III and plasma substitution.
The role of inflammatory cells and their proteases in extravascular fibrinolysis.
Therapeutic effects of the combination of two proteinase inhibitors in endotoxin shock of the pig.
Tissue factor production not balanced by tissue factor pathway inhibitor in sepsis promotes poor prognosis.
Shwachman-Diamond Syndrome
Current insights into inherited bone marrow failure syndromes.
Silicosis
Special neutrophil elastase inhibitory activity in BAL fluid from patients with silicosis and asbestosis.
Sinusitis
Allergic fungal sinusitis: an immunohistologic analysis.
ELISA for determination of immunoreactive free elastase and elastase in complex with alpha 1-antitrypsin in nasal secretions with sinusitis.
Neutrophil elastase and its complex with alpha 1-antitrypsin in soluble and insoluble fractions of nasal secretions of chronic sinusitis.
Skin Diseases
A comparative study of expression of Fc receptors in relation to the autoantibody-mediated immune response and neutrophil elastase expression in autoimmune blistering dermatoses.
Immunoexpression of IgA receptors (CD89, CD71) in dermatitis herpetiformis.
Ultrastructural changes of the skin induced by human leukocyte elastase and cathepsin G.
Spinal Cord Injuries
A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats.
MiR-325-3p promotes locomotor function recovery in rats with spinal cord injury via inhibiting the expression of neutrophil elastase.
Neutrophil elastase inhibition effectively rescued angiopoietin-1 decrease and inhibits glial scar after spinal cord injury.
Neutrophil elastase mediates acute pathogenesis and is a determinant of long-term behavioral recovery after traumatic injury to the immature brain.
Role of neutrophil elastase in compression-induced spinal cord injury in rats.
Spondylarthropathies
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Spondylitis, Ankylosing
Circulating inhibitor bound elastase in patients with ankylosing spondylitis and rheumatoid arthritis and the influence of sulphasalazine treatment.
Squamous Cell Carcinoma of Head and Neck
Assessment of Cytokine Release against Oral Mucosal Cell Line Culture (TR146) Stimulated by Neutrophil Elastase Associated with Behcet's Disease.
ST Elevation Myocardial Infarction
Culprit site extracellular DNA and microvascular obstruction in ST-elevation myocardial infarction.
Starvation
Proteomic analysis of rainbow trout (Oncorhynchus mykiss) intestinal epithelia: physiological acclimation to short-term starvation.
Stroke
Increase in jugular levels of polymorphonuclear neutrophil elastase in patients with acute cerebral infarction.
Neutrophil elastase and neurovascular injury following focal stroke and reperfusion.
Polymorphonuclear leukocyte elastase in patients with stroke.
Risk of Thrombus Fragmentation during Endovascular Stroke Treatment.
Superinfection
The inflammasome potentiates influenza/Staphylococcus aureus superinfection in mice.
Sweet Syndrome
[Acute febrile neutrophilic dermatosis (Sweet syndrome). Case report and immunohistologic study of neutrophil-associated proteolytic enzymes and their inhibitors]
Synovitis
Measurement of plasma concentrations of polymorphonuclear elastase-alpha 1 proteinase inhibitor (elastase-alpha 1 antitrypsin) in patients with rheumatoid arthritis: interference by rheumatoid factor.
Syphilis
[Leukocyte elastase, alpha 1-proteinase inhibitor and C-reactive protein in patients with delayed negativation of serological reactions after treatment of early syphilis].
Thrombocytopenia
A novel ELANE gene mutation in a patient with severe congenital neutropenia and intermittent thrombocytopenia.
Application of argatroban, direct thrombin inhibitor, in heparin-intolerant patients requiring extracorporeal circulation.
Enzyme-Agnostic Lysosomal Screen Identifies New Legumain-Cleavable ADC Linkers.
The relation between fibrinogen level, neutrophil activity and nucleosomes in the onset of disseminated intravascular coagulation in the critically ill.
Thromboembolism
Changes in coagulation-fibrinolysis marker and neutrophil elastase following the use of tourniquet during total knee arthroplasty and the influence of neutrophil elastase on thromboembolism.
Thromboinflammation
Biological basis and pathological relevance of microvascular thrombosis.
Thrombophilia
[Regional biochemical and hematologic changes in patients after revascularization of the lower extremities in ischemia of the extremities]
Thrombosis
Association of calprotectin with other inflammatory parameters in the prediction of mortality for ischemic stroke.
DNAse-dependent, NET-independent pathway of thrombus formation in vivo.
Leukocyte elastase inhibition and t-PA-induced coronary artery thrombolysis in dogs: beneficial effects on myocardial histology.
Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy.
Neutrophil chemotaxis and neutrophil elastase in the aortic wall in patients with abdominal aortic aneurysms.
Plakalbumin, alpha 1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis.
Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases.
Risk of Thrombus Fragmentation during Endovascular Stroke Treatment.
Role of leucocytes in coagulation induced by artificial surfaces: investigation of expression of Mac-1, granulocyte elastase release and leucocyte adhesion on modified polyurethanes.
Role of leukocyte elastase in preventing cellular re-colonization of the mural thrombus.
Tooth Mobility
[Mutations of the ELANE gene cause severe congenital neutropenia with periodontal disease: a case report].
Tuberculosis
LTB4 is present in exudative pleural effusions and contributes actively to neutrophil recruitment in the inflamed pleural space.
Screening of potential biomarkers for distinguishing between latent and active tuberculosis in children using bioinformatics analysis.
Severe congenital neutropenia caused by the ELANE gene mutation in a Vietnamese boy with misdiagnosis of tuberculosis and autoimmune neutropenia: a case report.
[Leukocyte elastase in blood plasma from tuberculosis patients and its role in disturbances of blood coagulation regulatory processes]
Tuberculosis, Pleural
PARTICULAR QUALITIES OF THE PROTEOLYTIC SYSTEM IN PATIENTS WITH TUBERCULOSIS DEPENDING ON THE SENSITIVITY OF THE PATHOGEN.
Tuberculosis, Pulmonary
Neutrophil extracellular traps in patients with pulmonary tuberculosis.
PARTICULAR QUALITIES OF THE PROTEOLYTIC SYSTEM IN PATIENTS WITH TUBERCULOSIS DEPENDING ON THE SENSITIVITY OF THE PATHOGEN.
[Serum neutrophil elastase and activity of its inhibitors in patients with pulmonary tuberculosis]
Typhus, Endemic Flea-Borne
Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with Scrub Typhus but Not Murine Typhus in Laos.
Urethritis
Complement C3, coeruloplasmin and PMN-elastase in the ejaculate in chronic prostato-adnexitis and their diagnostic value.
Neutrophil enzymes in urine for the detection of urethral infection in men.
Urinary Bladder Neoplasms
Correlation of Immune Cells and Cytokines in the Tumor Microenvironment with Elevated Neutrophil-To-Lymphocyte Ratio in Blood: An Analysis of Muscle-Invasive Bladder Cancer.
Urinary Incontinence
The role of neutrophil elastase in elastin metabolism of pelvic tissues from women with stress urinary incontinence.
Urinary Tract Infections
A kinetic study of the hydrolysis of the N-tosylalanine ester of 3-hydroxy-5-phenylpyrrole and related compounds by human leukocyte elastase.
Uterine Prolapse
Gene expression and immunoreactivity of elastolytic enzymes in the uterosacral ligaments from women with uterine prolapse.
Varicose Ulcer
Prognostic value of markers of collagen remodeling in venous ulcers.
Vascular Diseases
Leucocyte mobilization and release of neutrophil elastase following acute insulin-induced hypoglycaemia in normal humans.
Neutrophil activation detected by increased neutrophil elastase activity in type 1 (insulin-dependent) diabetes mellitus.
Neutrophil elastase promotes neointimal hyperplasia by targeting toll-like receptor 4 (TLR4)-NF-?B signalling.
Phagocyte enzymes in bronchoalveolar lavage from patients with pulmonary sarcoidosis and collagen vascular disorders.
Vascular System Injuries
Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats.
Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute Rejection.
Endotoxin-induced pulmonary vascular injury is mainly mediated by activated neutrophils in rats.
FMLP causes eicosanoid-dependent vasoconstriction and edema in lungs from endotoxin-primed rats.
Recombinant human soluble thrombomodulin reduces endotoxin-induced pulmonary vascular injury via protein C activation in rats.
Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats.
Role of the endogenous elastase inhibitor, elafin, in cardiovascular injury: from epithelium to endothelium.
Vasculitis
Antibodies to neutrophil elastase: a study in patients with vasculitis.
Antineutrophil cytoplasmic antibodies reacting with human neutrophil elastase as a diagnostic marker for cocaine-induced midline destructive lesions but not autoimmune vasculitis.
Cocaine-related retiform purpura: evidence to incriminate the adulterant, levamisole.
Cutaneous vasculitis in breast cancer treated with chemotherapy.
How to spot cocaine-induced pseudovasculitis.
Molecular characteristics of anti-self antibody fragments against neutrophil cytoplasmic antigens from human V gene phage display libraries.
Role of neutrophil elastase in the development of renal necrotizing vasculitis.
Structure of the azurocidin, proteinase 3, and neutrophil elastase genes. Implications for inflammation and vasculitis.
Structures of human proteinase 3 and neutrophil elastase--so similar yet so different.
Suppression of Neutrophil-Mediated Tissue Damage-A Novel Skill of Mesenchymal Stem Cells.
The role of inflammatory cells and their proteases in extravascular fibrinolysis.
Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy.
Venous Thrombosis
Changes in coagulation-fibrinolysis marker and neutrophil elastase following the use of tourniquet during total knee arthroplasty and the influence of neutrophil elastase on thromboembolism.
Ventilator-Induced Lung Injury
Effect of a neutrophil elastase inhibitor on ventilator-induced lung injury in rats.
Neutrophil elastase inhibitor (sivelestat) attenuates subsequent ventilator-induced lung injury in mice.
Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury.
Virus Diseases
A Novel ELANE Mutation Associated with Inflammatory Arthritis, Defective NETosis, and Recurrent Parvoviral Infection.
Inhibition of human neutrophil elastase by pentacyclic triterpenes.
Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma.
What is the contribution of respiratory viruses and lung proteases to airway remodelling in asthma and chronic obstructive pulmonary disease?
Wilms Tumor
Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplant.
Wiskott-Aldrich Syndrome
Cyclic manner of neutropenia in a patient with HAX-1 mutation.
Wound Infection
PMN-related parameters for the monitoring of wound healing in traumatology.
Rapid enzyme analysis as a diagnostic tool for wound infection: Comparison between clinical judgment, microbiological analysis, and enzyme analysis.
Released PMN elastase: an indicator of postsurgical uneventful wound healing and early inflammatory complications. A contribution to the search for objective criteria in wound healing monitoring.
[Biochemical wound monitoring. PMN elastase in different healing stages after trauma surgery-orthopedic interventions]