Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | stroke increases tissue neutrophil elastase activity and expression | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | genetic deletion of neutrophil elastase significantly reduce infarct volume, blood-brain barrier disruption, vasogenic edema, and leukocyte-endothelial adherence after transient middle cerebral artery occlusion | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ZN200355 | pharmacologic inhibition of neutrophil elastase significantly reduces infarct volume, blood-brain barrier disruption, vasogenic edema, and leukocyte-endothelial adherence after transient middle cerebral artery occlusion | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
wild-type 129SvEv mice and mutant mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
endothelial cell | - |
Mus musculus | - |
leukocyte | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
neutrophil elastase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | stroke increases tissue neutrophil elastase activity and expression | up |
General Information | Comment | Organism |
---|---|---|
malfunction | pharmacologic inhibition of neutrophil elastase and genetic deletion significantly reduce infarct volume, blood-brain barrier disruption, vasogenic edema, and leukocyte-endothelial adherence after transient middle cerebral artery occlusion | Mus musculus |