3.4.21.37: leukocyte elastase
This is an abbreviated version!
For detailed information about leukocyte elastase, go to the full flat file.
Word Map on EC 3.4.21.37
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3.4.21.37
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pulmonary
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cathepsin
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airway
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pancreatic
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lavage
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myeloperoxidase
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hne
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emphysema
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fibrosis
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cystic
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bronchoalveolar
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granule
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elastin
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sputum
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bronchial
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thrombin
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chymotrypsin
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coagulation
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1-antitrypsin
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neutropenia
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interleukin-8
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1-proteinase
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degranulation
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c-reactive
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cardiopulmonary
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elastolytic
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antiprotease
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serpins
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mucus
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slpi
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alpha1-antitrypsin
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azurophilic
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aa
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neutrophil-derived
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elastases
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2-macroglobulin
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bronchiectasis
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fmlp
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elastase-induced
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netosis
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antineutrophil
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proteinase-3
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thrombin-antithrombin
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ulinastatin
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crevicular
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neutrophil-mediated
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ne-induced
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beta-thromboglobulin
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drug development
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wegener
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2-antiplasmin
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diagnostics
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medicine
- 3.4.21.37
- pulmonary
- cathepsin
- airway
- pancreatic
-
lavage
- myeloperoxidase
- hne
- emphysema
- fibrosis
-
cystic
-
bronchoalveolar
- granule
- elastin
- sputum
- bronchial
- thrombin
- chymotrypsin
- coagulation
-
1-antitrypsin
- neutropenia
- interleukin-8
-
1-proteinase
-
degranulation
-
c-reactive
-
cardiopulmonary
-
elastolytic
-
antiprotease
- serpins
- mucus
- slpi
- alpha1-antitrypsin
-
azurophilic
- aa
-
neutrophil-derived
- elastases
-
2-macroglobulin
- bronchiectasis
- fmlp
-
elastase-induced
-
netosis
-
antineutrophil
- proteinase-3
-
thrombin-antithrombin
- ulinastatin
-
crevicular
-
neutrophil-mediated
-
ne-induced
-
beta-thromboglobulin
- drug development
-
wegener
-
2-antiplasmin
- diagnostics
- medicine
Reaction
Hydrolysis of proteins, including elastin. Preferential cleavage Val-/- > Ala-/- =
Synonyms
bone marrow serine protease, EC 3.4.21.11, EC 3.4.4.7, ELA2, Elane, elastase, elaszym, granulocyte elastase, H2A specific protease, H2Asp, HLE, HNE, leukocyte elastase, lysosomal elastase, N-elastase, NE, neutrophil elastase, neutrophil-elastase, neutrophil-released elastase, PMN elastase, PMN-elastase, PMNE, polymorphonuclear leukocyte elastase, polymorphonuclear neutrophil elastase, serine elastase
ECTree
3.4.21.37 leukocyte elastaseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 3.4.21.37 - leukocyte elastase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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neutrophil elastase exists in high concentrations (0.001-0.02 mM) in airway secretions of patiens with chronic inflammatory airway diseases and induces overproduction of MUC5AC mucin
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leukocyte elastase-alpha1 protease inhibitor complex, quantitative determination, overview
additional information
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high enzyme levels in the airway fluid of patients with cystic fibrosis
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pulmonary artery endothelial cells and aortic endothelial cells
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647560, 664635, 664848, 665911, 666151, 666152, 683536, 683956, 708208, 708305, 708812, 708813, 709357, 710206
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lung secretions from lung of chronically infected patients suffering from bronchitis or cystic fibrosis
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the mature, processed neutrophile elastase is a major component of neutrophil primary granules
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647544, 647563, 647564, 647578, 663821, 664848, 683043, 683177, 683536, 696938, 697826, 699523, 700570, 700848, 707645, 707673, 707850, 708305, 708680, 708691, 709357, 709472, 709493, 709714, 717895, 718423, 731106, 731124, 731591, 731788, 731991, 753664, 754279, 754758, 755135, 755426
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enzyme released from neutrophils during phagocytosis and upon cell death
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activated neutrophils release the catabolic enzyme neutrophil elastase
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leukocyte elastase-alpha1 protease inhibitor complex, quantitative determination, overview
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additional information
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patients of preterm show increased levels of granulocyte elastase in cervical secretions from 16 to 33 weeks gestation
additional information
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Pseudomonas aeruginosa-positive cystic fibrosis bronchoalveolar lavage fluid contains lower neutrophil serine protease inhibitor SLPI levels and higher neutrophil elastase activity compared to Pseudomonas aeruginosa-negative samples
additional information
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the enzyme is commonly found in the bronchioalveolar lavage fluid of lungs of human cystic fibrosis patients, not of healthy human lungs
