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3.4.21.37: leukocyte elastase

This is an abbreviated version!
For detailed information about leukocyte elastase, go to the full flat file.

Word Map on EC 3.4.21.37

Reaction

Hydrolysis of proteins, including elastin. Preferential cleavage Val-/- > Ala-/- =

Synonyms

bone marrow serine protease, EC 3.4.21.11, EC 3.4.4.7, ELA2, Elane, elastase, elaszym, granulocyte elastase, H2A specific protease, H2Asp, HLE, HNE, leukocyte elastase, lysosomal elastase, N-elastase, NE, neutrophil elastase, neutrophil-elastase, neutrophil-released elastase, PMN elastase, PMN-elastase, PMNE, polymorphonuclear leukocyte elastase, polymorphonuclear neutrophil elastase, serine elastase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.37 leukocyte elastase

Expression

Expression on EC 3.4.21.37 - leukocyte elastase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
black walnut heartwood extract induces laminitis in skin and lamina and increases neutrophil elastase contents
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enzymatic activity of neutrophil elastase is markedly decreased until four hours after the stimulation with lipopolysaccharide
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enzyme activity is higher overall in patients with predicted severe acute pancreatitis than in those with predicted mild acute pancreatitis. Patients with respiratory failure have higher enzyme activity than those without
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enzyme expression is increased in colon of Brachyspira hyodysenteriae-infected pigs
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esophagectomy with elective lymphadenectomy may induce excessive release of neutrophil elastase
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neutrophils isolated from mice treated with anthrax lethal toxin in vivo and cultured ex vivo release greater amounts of neutrophil elastase than neutrophils from vehicle-treated controls
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stroke increases tissue neutrophil elastase activity and expression
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urinary trypsin inhibitor, UTI, a member of the inter-alpha trypsin inhibitor family, suppresses neutrophile leastase and granulocyte elastase in vivo
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