3.4.21.37: leukocyte elastase

This is an abbreviated version!
For detailed information about leukocyte elastase, go to the full flat file.

Word Map on EC 3.4.21.37

3.4.21.37

pulmonary

cathepsin

airway

pancreatic

lavage

myeloperoxidase

hne

emphysema

fibrosis

cystic

bronchoalveolar

granule

elastin

sputum

bronchial

thrombin

chymotrypsin

coagulation

1-antitrypsin

neutropenia

interleukin-8

1-proteinase

degranulation

c-reactive

cardiopulmonary

elastolytic

antiprotease

serpins

mucus

slpi

alpha1-antitrypsin

azurophilic

aa

neutrophil-derived

elastases

2-macroglobulin

bronchiectasis

fmlp

elastase-induced

netosis

antineutrophil

proteinase-3

thrombin-antithrombin

ulinastatin

crevicular

neutrophil-mediated

ne-induced

beta-thromboglobulin

drug development

wegener

2-antiplasmin

diagnostics

medicine

Reaction

Hydrolysis of proteins, including elastin. Preferential cleavage Val-/- > Ala-/- =

Synonyms

bone marrow serine protease, EC 3.4.21.11, EC 3.4.4.7, ELA2, Elane, elastase, elaszym, granulocyte elastase, H2A specific protease, H2Asp, HLE, HNE, leukocyte elastase, lysosomal elastase, N-elastase, NE, neutrophil elastase, neutrophil-elastase, neutrophil-released elastase, PMN elastase, PMN-elastase, PMNE, polymorphonuclear leukocyte elastase, polymorphonuclear neutrophil elastase, serine elastase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.37 leukocyte elastase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
17	Activating Compound
5	AA Sequence
22	Application
1	CAS Registry Number
8	Cloned(Commentary)
9	Crystallization (Commentary)
6529	Disease/ Diagnostics
8	Expression
40	General Information
147	IC50 Value
708	Inhibitors
143	Ki Value [mM]
60	KM Value [mM]
39	Localization
5	Metals/Ions
10	Molecular Weight [Da]
154	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
353	Organism
37	PDB ID
31	pH Optimum
1	pH Range
4	pI Value
7	Posttranslational Modification
39	Protein Variants
13	Purification (Commentary)
1	Reaction
1	Reaction Type
214	Reference
241	Source Tissue
4	Specific Activity [micromol/min/mg]
1	Storage Stability
389	Substrates and Products (Substrate)
18	Subunits
183	Synonyms
24	Temperature Optimum [°C]
1	Temperature Stability [°C]
55	Turnover Number [1/s]

Localization

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Localization on EC 3.4.21.37 - leukocyte elastase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Localization Search

786

of polymorphonuclear neutrophils, mechanism of binding, inhibited by trypsin, chondroitinase ABC, and heparitinases, but not other glycanases, and purified chondroitin sulfates, heparan sulfate, and other sulfated molecules, but not with non-sulfated glycans, overview

neutrophil granule

additional information

Canis lupus familiaris

intracellular sorting/trafficking of neutrophil elastase in cyclic hematopoiesis dogs, neutrophils from cyclic hematopoiesis dogs accumulate large amounts of higher molecular weight elastase precursors compared to normal dogs, overview

708428