3.4.21.104: mannan-binding lectin-associated serine protease-2

This is an abbreviated version!
For detailed information about mannan-binding lectin-associated serine protease-2, go to the full flat file.

Word Map on EC 3.4.21.104

3.4.21.104

masps

spider

silk

ficolins

ampullate

dragline

spidroins

c1s

clavipes

nephila

collectins

m-ficolin

widow

hesperus

latrodectus

medicine

molecular biology

diagnostics

Reaction

Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-/-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-/-Ala-Leu-Glu-Ile) =

Synonyms

CCP1-CCP2-SP, Mannan-binding lectin associated serine protease-2, mannan-binding lectin-associated serine protease, mannan-binding lectin-associated serine protease 2, mannan-binding lectin-associated serine protease-2, mannose-binding lectin-associated serine protease 2, mannose-binding lectin-associated serine protease-2, mannose-binding lectin-associated-serine protease-2, Map19, MASP, MASP-2, MASP-2A, MASP-2K, MASP2, MBL-associated serine protease, MBL-associated serine protease 2, MBL-associated serine protease-2, MBL-associated-serine protease-2, MBL-MASP, MBL/ficolin-associated serine protease, MBP-associated serine protease, MBP-associated serine protease 2, MBP-associated serine protease-2, S01.229

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.104 mannan-binding lectin-associated serine protease-2

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Results	in table
21	Activating Compound
11	AA Sequence
6	Application
1	CAS Registry Number
31	Cloned(Commentary)
8	Crystallization (Commentary)
309	Disease/ Diagnostics
11	General Information
1	General Stability
32	Inhibitors
7	Ki Value [mM]
26	KM Value [mM]
10	Localization
15	Metals/Ions
28	Molecular Weight [Da]
70	Natural Substrates/ Products (Substrates)
70	Organism
10	PDB ID
11	pH Optimum
1	pH Range
1	pH Stability
2	pI Value
12	Posttranslational Modification
30	Protein Variants
18	Purification (Commentary)
5	Reaction
18	Reaction Type
69	Reference
2	Renatured (Commentary)
40	Source Tissue
5	Specific Activity [micromol/min/mg]
3	Storage Stability
158	Substrates and Products (Substrate)
28	Subunits
110	Synonyms
10	Temperature Optimum [°C]
2	Temperature Stability [°C]
27	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.21.104 - mannan-binding lectin-associated serine protease-2

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0.123

C1-inhibitor P4-P1 fragment, C1-inhibitor P4-P4' fragment

Homo sapiens

pH 7.4, 37°C

683891

0.0052 - 6.5

Complement component C2

5 entries

0.015

complement component C2 P4-P1 fragment

Homo sapiens

pH 7.4, 37°C

683891

0.173

complement component C2 P4-P4' fragment

Homo sapiens

pH 7.4, 37°C

683891

0.000085 - 74

Complement component C4

8 entries

0.0155

complement component C4 P4-P1 fragment

Homo sapiens

pH 7.4, 37°C

683891

0.271

complement component C4 P4-P4' fragment

Homo sapiens

pH 7.4, 37°C

683891

6.7

N-acetylglycine-L-lysine methyl ester

Homo sapiens

pH 7.4, 30°C

652189

N-carboxybenzoylglycine-L-arginine thiobenzyl ester

Homo sapiens

pH 7.4, 30°C

652189

4.4

Nalpha-benzoyl-L-arginine ethyl ester

Homo sapiens

pH 7.4, 30°C

652189

2.8

p-tosyl-L-arginine methyl ester

Homo sapiens

pH 7.4, 30°C

652189

additional information

3 entries