3.4.21.104: mannan-binding lectin-associated serine protease-2

This is an abbreviated version!
For detailed information about mannan-binding lectin-associated serine protease-2, go to the full flat file.

Reaction

Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-/-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-/-Ala-Leu-Glu-Ile) =

Synonyms

CCP1-CCP2-SP, Mannan-binding lectin associated serine protease-2, mannan-binding lectin-associated serine protease, mannan-binding lectin-associated serine protease 2, mannan-binding lectin-associated serine protease-2, mannose-binding lectin-associated serine protease 2, mannose-binding lectin-associated serine protease-2, mannose-binding lectin-associated-serine protease-2, Map19, MASP, MASP-2, MASP-2A, MASP-2K, MASP2, MBL-associated serine protease, MBL-associated serine protease 2, MBL-associated serine protease-2, MBL-associated-serine protease-2, MBL-MASP, MBL/ficolin-associated serine protease, MBP-associated serine protease, MBP-associated serine protease 2, MBP-associated serine protease-2, S01.229

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.104 mannan-binding lectin-associated serine protease-2

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Results	in table
21	Activating Compound
11	AA Sequence
6	Application
1	CAS Registry Number
31	Cloned(Commentary)
8	Crystallization (Commentary)
309	Disease/ Diagnostics
11	General Information
1	General Stability
32	Inhibitors
7	Ki Value [mM]
26	KM Value [mM]
10	Localization
15	Metals/Ions
28	Molecular Weight [Da]
70	Natural Substrates/ Products (Substrates)
70	Organism
10	PDB ID
11	pH Optimum
1	pH Range
1	pH Stability
2	pI Value
12	Posttranslational Modification
30	Protein Variants
18	Purification (Commentary)
5	Reaction
18	Reaction Type
69	Reference
2	Renatured (Commentary)
40	Source Tissue
5	Specific Activity [micromol/min/mg]
3	Storage Stability
158	Substrates and Products (Substrate)
28	Subunits
110	Synonyms
10	Temperature Optimum [°C]
2	Temperature Stability [°C]
27	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.4.21.104 - mannan-binding lectin-associated serine protease-2

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

alpha-2-Macroglobulin

2 entries

-

anti-thrombin III

Homo sapiens

-

recombinant enzyme, inhibition only in presence of heparin

659959

-

benzyloxycarbonyl-D-Phe-Pro-methoxypropylboroglycinepinanediol ester

Homo sapiens

-

-

680105

C1 inhibitor

2 entries

-

C1-inhibitor

6 entries

-

complement C1 inhibitor

Homo sapiens

O00187

-

665655, 666927

-

cyclic sunflower MASP inhibitor-1

Homo sapiens

-

-

717934

Kunitz-type inhibitor tissue factor pathway inhibitor

Homo sapiens

-

selective inhibitor of enzyme Masp-2, without affecting MASP-1 or the classical pathway proteases C1s and C1r. Kunitz-2 domain of the inhibitor is required for the inhibition of MASP-2

731745

-

L-Glu-Gly-L-Arg-chloromethylketone

Homo sapiens

-

-

718122

myelin basic protein

Rattus norvegicus

-

no activity with substrate C4-component of the enzyme complexed with myelin basic protein before activation of the complex by binding to a suitable carbohydrate ligand

659350

-

pefabloc

Homo sapiens

-

i.e. 4-(2-aminoethyl)-benzenesulphonyl fluoride

708697

PefablocSC

Homo sapiens

-

irreversible inhibition

653250

Schistocerca gregaria protease inhibitor-2 variant FCTRKLCY

Homo sapiens

O00187

randomization of positions P4, P2, P1, P1', P2', and P4' of the protease binding loop while keeping the structurally indispensable Cys at P3 and P3' leads to monospecific MASP inhibitors. Inhibitor variant FCTRKLCY is specific for isoform MASP-1

732057

-

Schistocerca gregaria protease inhibitor-2 variant VCTKLWCN

Homo sapiens

O00187

randomization of positions P4, P2, P1, P1', P2', and P4' of the protease binding loop while keeping the structurally indispensable Cys at P3 and P3' leads to monospecific MASP inhibitors. MASP-2 inhibitor variant VCTKLWCN completely blocks the lectin pathway activation

732057

-

sunflower MASP inhibitor-1

Homo sapiens

-

i.e. GICSRSLPPICIPD

717934

sunflower MASP inhibitor-2

Homo sapiens

-

i.e. GYCSRSYPPYCIPD

717934

additional information

8 entries

-

alpha-2-Macroglobulin

Homo sapiens

-

forms a stable complex with the enzyme, inhibits at a large molar excess, 40fold

652684

-

alpha-2-Macroglobulin

Homo sapiens

-

inhibition of recombinant, not native, enzyme at large molar excess

659959

-

C1 inhibitor

Homo sapiens

-

abolishes activity at a 1:1 inhibitor:protease concentration

652189

-

C1 inhibitor

Homo sapiens

-

recombinant enzyme, at pH 7.4, inhibitor from human, the protease-serpin complex in highly unstable at alkaline pH

659959

-

C1-inhibitor

Homo sapiens

-

forms equimolar complexes with the enzyme and inhibits its proteolytic activity

652674

-

C1-inhibitor

Homo sapiens

-

forms a stable complex with the enzyme, 1-3fold excess completely inactivates

652684

-

C1-inhibitor

Homo sapiens

-

linear relationship between inhibition and the molar ratio of inhibitor:enzyme up to about 50% inhibition

653250

-

C1-inhibitor

Homo sapiens

-

-

680105

-

C1-inhibitor

Homo sapiens

-

a serpin, purified human protein, enzyme interaction rates and site specificity of the inhibitor, interaction rates under pseudo-first-order conditions, overview

683891

-

C1-inhibitor

Rattus norvegicus

-

-

680105

-

additional information

Homo sapiens

-

no inhibitor: alpha-2-macroglobulin

652189

-

additional information

Homo sapiens

Q92876

no inhibition by Na+

659718

-

additional information

Homo sapiens

-

no inhibition of recombinant enzyme by thrombin inhibitor Z-D-Phe-Pro-methoxypropylboroglycinepinanediol ester, i.e. boroMpg, and hirudin

659959

-

additional information

Homo sapiens

-

MASP-3 might be able to downregulate MASP-2 activity

680105

-

additional information

Homo sapiens

-

hirudin does not inhibit MASP-2

708697

-

additional information

Homo sapiens

-

MASP-2 is not inhibited by SFTI

717934

-

additional information

Rattus norvegicus

-

MASP-3 might be able to downregulate MASP-2 activity

680105

-

additional information

Trypanosoma cruzi

-

the complement C2 receptor inhibitor trispanning protein extracellular domain 1 inhibits MASP2 cleavage of C2 complement factor, the addition of 0.0015 mM of ed1 peptide, a 3fold molar excess over C2, completely inhibits C2 cleavage by recombinant MASP2

709985

-