3.4.21.104: mannan-binding lectin-associated serine protease-2

This is an abbreviated version!
For detailed information about mannan-binding lectin-associated serine protease-2, go to the full flat file.

Reaction

Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-/-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-/-Ala-Leu-Glu-Ile) =

Synonyms

CCP1-CCP2-SP, Mannan-binding lectin associated serine protease-2, mannan-binding lectin-associated serine protease, mannan-binding lectin-associated serine protease 2, mannan-binding lectin-associated serine protease-2, mannose-binding lectin-associated serine protease 2, mannose-binding lectin-associated serine protease-2, mannose-binding lectin-associated-serine protease-2, Map19, MASP, MASP-2, MASP-2A, MASP-2K, MASP2, MBL-associated serine protease, MBL-associated serine protease 2, MBL-associated serine protease-2, MBL-associated-serine protease-2, MBL-MASP, MBL/ficolin-associated serine protease, MBP-associated serine protease, MBP-associated serine protease 2, MBP-associated serine protease-2, S01.229

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.104 mannan-binding lectin-associated serine protease-2

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Results	in table
21	Activating Compound
11	AA Sequence
6	Application
1	CAS Registry Number
31	Cloned(Commentary)
8	Crystallization (Commentary)
309	Disease/ Diagnostics
11	General Information
1	General Stability
32	Inhibitors
7	Ki Value [mM]
26	KM Value [mM]
10	Localization
15	Metals/Ions
28	Molecular Weight [Da]
70	Natural Substrates/ Products (Substrates)
70	Organism
10	PDB ID
11	pH Optimum
1	pH Range
1	pH Stability
2	pI Value
12	Posttranslational Modification
30	Protein Variants
18	Purification (Commentary)
5	Reaction
18	Reaction Type
69	Reference
2	Renatured (Commentary)
40	Source Tissue
5	Specific Activity [micromol/min/mg]
3	Storage Stability
158	Substrates and Products (Substrate)
28	Subunits
110	Synonyms
10	Temperature Optimum [°C]
2	Temperature Stability [°C]
27	Turnover Number [1/s]

Application

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Application on EC 3.4.21.104 - mannan-binding lectin-associated serine protease-2

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

diagnostics

Homo sapiens

-

MASP-2 may have potential as clinical biomarkers in colorectal cancer

684060

medicine

4 entries

molecular biology

Homo sapiens

-

near monodisperse endotoxin-free polyethylene glycol, at concentrations relevant to therapeutic effects, trigger complement activation in human sera. Depending on polyethylene glycol concentration and average molecular weight, complement activation proceeds either exclusively through MASP-2 activation, and a likely role for the lectin pathway, or through both MASP-2-mediated C4 cleavage and accelerated alternative pathway turnover

700248

medicine

Homo sapiens

-

it is investigated whether the concentration of mannose-binding lectin and MASP-2 is associated with prognosis in pediatric patients with cancer. In the 372 patients studied, median serum concentration of mannose-binding lectin (MBL) is 2.808 mg/l and 391 mg/l for MASP-2. The estimated 4-year event-free survival is 0.60. In the entire, heterogeneous sample, MBL and MASP-2 are not significantly associated with overall survival or event-free survival. In patients with hematologic malignancies, higher MASP-2 is associated with better event-free survival in a significant and clinically relevant way. This is due to patients with lymphoma, but less for those with acute leukemia

700576

medicine

Homo sapiens

O00187

evaluation of the role of MASP-2 in HIV infection. The MASP-2 .126L variant is associated with MASP-2 levels <200 ng/ml and increases the susceptibility to HIV infection and to HIV plus hepatitis B virus positive status. p.126L in addition to other variants associated with low MASP-2 levels such as p.120G, p.377A and p.439H, presents a protective effect against AIDS, independently of age, sex, hepatic function andviral load. MASP-2 serum levels are lower in HIV positive and HIV plus hepatitis B virus positive patients than in controls. Among patients, MASP-2 levels are higher in patients with opportunistic diseases and AIDS. MASP-2 levels correlate positively with MBL/MASP2-mediated complement component C4 and negatively with CD4+ cell counts

754751

medicine

Homo sapiens

O00187

MASP-2 serum levels vary between younger children (12 years and less) and older children (above 12 years) and adults. Younger children with a patent infection with with Schistosoma haematobium have significantly lower MASP-2 serum levels than uninfected children. Older children and adults with a current infection have higher serum MASP-2 levels than controls. mannose-binding lectin serum levels correlate positively with MASP-2 serum levels. MASP2 secretor haplotypes are associated with MASP-2 serum levels in healthy subjects. The heterozygous MASP2 P126L variant is associated with reduced serum MASP-2 levels

755621

medicine

Homo sapiens

O00187

proteases MASP-1 and MASP-2 levels are significantly higher in children and adults with type 1 diabetes mellitus than in their respective control groups, whereas proteases MASP-3 and MAp44 levels do not differ between patients and controls. MASP-1 and MASP-2 levels correlate with hemoglobin HbA1c, and MASP levels decrease when glycaemic control improves

753309