3.4.21.104: mannan-binding lectin-associated serine protease-2

This is an abbreviated version!
For detailed information about mannan-binding lectin-associated serine protease-2, go to the full flat file.

Reaction

Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-/-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-/-Ala-Leu-Glu-Ile) =

Synonyms

CCP1-CCP2-SP, Mannan-binding lectin associated serine protease-2, mannan-binding lectin-associated serine protease, mannan-binding lectin-associated serine protease 2, mannan-binding lectin-associated serine protease-2, mannose-binding lectin-associated serine protease 2, mannose-binding lectin-associated serine protease-2, mannose-binding lectin-associated-serine protease-2, Map19, MASP, MASP-2, MASP-2A, MASP-2K, MASP2, MBL-associated serine protease, MBL-associated serine protease 2, MBL-associated serine protease-2, MBL-associated-serine protease-2, MBL-MASP, MBL/ficolin-associated serine protease, MBP-associated serine protease, MBP-associated serine protease 2, MBP-associated serine protease-2, S01.229

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.104 mannan-binding lectin-associated serine protease-2

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Results	in table
21	Activating Compound
11	AA Sequence
6	Application
1	CAS Registry Number
31	Cloned(Commentary)
8	Crystallization (Commentary)
309	Disease/ Diagnostics
11	General Information
1	General Stability
32	Inhibitors
7	Ki Value [mM]
26	KM Value [mM]
10	Localization
15	Metals/Ions
28	Molecular Weight [Da]
70	Natural Substrates/ Products (Substrates)
70	Organism
10	PDB ID
11	pH Optimum
1	pH Range
1	pH Stability
2	pI Value
12	Posttranslational Modification
30	Protein Variants
18	Purification (Commentary)
5	Reaction
18	Reaction Type
69	Reference
2	Renatured (Commentary)
40	Source Tissue
5	Specific Activity [micromol/min/mg]
3	Storage Stability
158	Substrates and Products (Substrate)
28	Subunits
110	Synonyms
10	Temperature Optimum [°C]
2	Temperature Stability [°C]
27	Turnover Number [1/s]

KI Value

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KI Value on EC 3.4.21.104 - mannan-binding lectin-associated serine protease-2

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0000088

C1-inhibitor

Homo sapiens

-

37°C, pH 7.4

652684

-

0.00075

cyclic sunflower MASP inhibitor-1

Homo sapiens

-

in 20 mM HEPES, 140 mM NaCl, and 10 mM CaCl2 (pH 7.4), at 37°C

717934

0.058

Schistocerca gregaria protease inhibitor-2 variant FCTRKLCY

Homo sapiens

O00187

pH not specified in the publication, temperature not specified in the publication

732057

-

0.000006

Schistocerca gregaria protease inhibitor-2 variant VCTKLWCN

Homo sapiens

O00187

pH not specified in the publication, temperature not specified in the publication

732057

-

0.00103

sunflower MASP inhibitor-1

Homo sapiens

-

in 20 mM HEPES, 140 mM NaCl, and 10 mM CaCl2 (pH 7.4), at 37°C

717934

0.00018

sunflower MASP inhibitor-2

Homo sapiens

-

in 20 mM HEPES, 140 mM NaCl, and 10 mM CaCl2 (pH 7.4), at 37°C

717934

additional information

additional information

Homo sapiens

-

first order rate inhibition kinetics

683891

-