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3.4.21.104: mannan-binding lectin-associated serine protease-2

This is an abbreviated version!
For detailed information about mannan-binding lectin-associated serine protease-2, go to the full flat file.

Word Map on EC 3.4.21.104

Reaction

Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-/-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-/-Ala-Leu-Glu-Ile) =

Synonyms

CCP1-CCP2-SP, Mannan-binding lectin associated serine protease-2, mannan-binding lectin-associated serine protease, mannan-binding lectin-associated serine protease 2, mannan-binding lectin-associated serine protease-2, mannose-binding lectin-associated serine protease 2, mannose-binding lectin-associated serine protease-2, mannose-binding lectin-associated-serine protease-2, Map19, MASP, MASP-2, MASP-2A, MASP-2K, MASP2, MBL-associated serine protease, MBL-associated serine protease 2, MBL-associated serine protease-2, MBL-associated-serine protease-2, MBL-MASP, MBL/ficolin-associated serine protease, MBP-associated serine protease, MBP-associated serine protease 2, MBP-associated serine protease-2, S01.229

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.104 mannan-binding lectin-associated serine protease-2

Reference

Reference on EC 3.4.21.104 - mannan-binding lectin-associated serine protease-2

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Feinberg, H.; Uitdehaag, J.C.M.; Davies, J.M.; Wallis, R.; Drickamer, K.; Weis, W.I.
Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2
EMBO J.
22
2348-2359
2003
Rattus norvegicus (Q9JJS8)
Manually annotated by BRENDA team
Chen, C.B.; Wallis, R.
Stoichiometry of complexes between mannose-binding protein and its associated serine proteases. Defining functional units for complement activation
J. Biol. Chem.
276
25894-25902
2001
Homo sapiens
Manually annotated by BRENDA team
Rossi, V.; Cseh, S.; Bally, I.; Thielens, N.M.; Jensenius, J.C.; Arlaud, G.J.
Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2
J. Biol. Chem.
276
40880-40887
2001
Homo sapiens
Manually annotated by BRENDA team
Matsushita, M.; Thiel, S.; Jensenius, J.C.; Terai, I.; Fujita, T.
Proteolytic activities of two types of mannose-binding lectin-associated serine protease
J. Immunol.
165
2637-2642
2000
Homo sapiens
Manually annotated by BRENDA team
Thielens, N.M.; Cseh, S.; Thiel, S.; Vorup-Jensen, T.; Rossi, V.; Jensenius, J.C.; Arlaud, G.J.
Interaction properties of human mannan-binding lectin (MBL)-associated serine proteases-1 and -2, MBL-associated protein 19, and MBL
J. Immunol.
166
5068-5077
2001
Homo sapiens
Manually annotated by BRENDA team
Cseh, S.; Vera, L.; Matsushita, M.; Fujita, T.; Arlaud, G.J.; Thielens, N.M.
Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2
J. Immunol.
169
5735-5743
2002
Homo sapiens
Manually annotated by BRENDA team
Ambrus, G.; Gal, P.; Kojima, M.; Szilagyi, K.; Balczer, J.; Antal, J.; Graf, L.; Laich, A.; Moffatt, B.E.; Schwaeble, W.; Sim, R.B.; Zavodszky, P.
Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments
J. Immunol.
170
1374-1382
2003
Homo sapiens
Manually annotated by BRENDA team
Wong, N.K.H.; Kojima, M.; Dobo, J.; Ambrus, G.; Sim, R.B.
Activities of the MBL-associated serine proteases (MASPs) and their regulation by natural inhibitors
Mol. Immunol.
36
853-861
1999
Homo sapiens
Manually annotated by BRENDA team
Thiel, S.; Vorup-Jensen, T.; Stover, C.M.; Schwaeble, W.; Laursen, S.B.; Poulsen, K.; Willis, A.C.; Eggleton, P.; Hansen, S.; Holmskov, U.; Reid, K.B.; Jensenius, J.C.
A second serine protease associated with mannan-binding lectin that activates complement
Nature
386
506-510
1997
Homo sapiens
Manually annotated by BRENDA team
Chen, C.B.; Wallis, R.
Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases
J. Biol. Chem.
279
26058-26065
2004
Rattus norvegicus
Manually annotated by BRENDA team
Iwaki, D.; Fujita, T.
Production and purification of recombinants of mouse MASP-2 and sMAP
J. Endotoxin Res.
11
47-50
2005
Mus musculus
Manually annotated by BRENDA team
Matsushita, M.; Fujita, T.
Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-lik serine protease
J. Exp. Med.
176
1497-1502
1992
Homo sapiens
Manually annotated by BRENDA team
Moller-Kristensen, M.; Jensenius, J.C.; Jensen, L.; Thielens, N.; Rossi, V.; Arlaud, G.; Thiel, S.
Levels of mannan-binding lectin-associated serine protease-2 in healthy individuals
J. Immunol. Methods
282
159-167
2003
Homo sapiens
Manually annotated by BRENDA team
Harmat, V.; Gal, P.; Kardos, J.; Szilagyi, K.; Ambrus, G.; Vegh, B.; Naray-Szabo, G.; Zavodszky, P.
The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions
J. Mol. Biol.
342
1533-1546
2004
Homo sapiens (Q92876)
Manually annotated by BRENDA team
Presanis, J.S.; Hajela, K.; Ambrus, G.; Gal, P.; Sim, R.B.
Differential substrate and inhibitor profiles for human MASP-1 and MASP-2
Mol. Immunol.
40
921-929
2004
Homo sapiens
Manually annotated by BRENDA team
Verma, A.; Matta, A.; Shukla, N.K.; Deo, S.V.; Gupta, S.D.; Ralhan, R.
Clinical significance of mannose-binding lectin-associated serine protease-2 expression in esophageal squamous cell carcinoma
Int. J. Cancer
118
2930-2935
2006
Homo sapiens (O00187), Homo sapiens
Manually annotated by BRENDA team
Gal, P.; Harmat, V.; Kocsis, A.; Bian, T.; Barna, L.; Ambrus, G.; Vegh, B.; Balczer, J.; Sim, R.B.; Naray-Szabo, G.; Zavodszky, P.
A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations
J. Biol. Chem.
280
33435-33444
2005
Homo sapiens (O00187)
Manually annotated by BRENDA team
Rossi, V.; Teillet, F.; Thielens, N.M.; Bally, I.; Arlaud, G.J.
Functional characterization of complement proteases C1s/mannan-binding lectin-associated serine protease-2 (MASP-2) chimeras reveals the higher C4 recognition efficacy of the MASP-2 complement control protein modules
J. Biol. Chem.
280
41811-41818
2005
Homo sapiens (O00187)
Manually annotated by BRENDA team
Teillet, F.; Dublet, B.; Andrieu, J.P.; Gaboriaud, C.; Arlaud, G.J.; Thielens, N.M.
The Two Major Oligomeric Forms of Human Mannan-Binding Lectin: Chemical Characterization, Carbohydrate-Binding Properties, and Interaction with MBL-Associated Serine Proteases
J. Immunol.
174
2870-2877
2005
Homo sapiens (O00187), Homo sapiens
Manually annotated by BRENDA team
Sorensen, R.; Thiel, S.; Jensenius, J.C.
Mannan-binding-lectin-associated serine proteases, characteristics and disease associations
Semin. Immunopathol.
27
299-319
2005
Homo sapiens (O00187), Rattus norvegicus (Q9JJS8)
Manually annotated by BRENDA team
Lozano, F.; Suarez, B.; Munoz, A.; Jensenius, J.C.; Mensa, J.; Vives, J.; Horcajada, J.P.
Novel MASP2 variants detected among North African and Sub-Saharan individuals
Tissue Antigens
66
131-135
2005
Homo sapiens (O00187), Homo sapiens
Manually annotated by BRENDA team
Takahashi, M.; Mori, S.; Shigeta, S.; Fujita, T.
Role of MBL-associated serine protease (MASP) on activation of the lectin complement pathway
Adv. Exp. Med. Biol.
598
93-104
2007
Homo sapiens, Homo sapiens (O00187), Mus musculus
Manually annotated by BRENDA team
Gal, P.; Barna, L.; Kocsis, A.; Zavodszky, P.
Serine proteases of the classical and lectin pathways: similarities and differences
Immunobiology
212
267-277
2007
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Moller-Kristensen, M.; Thiel, S.; Sjoeholm, A.; Matsushita, M.; Jensenius, J.C.
Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway
Int. Immunol.
19
141-149
2007
Homo sapiens
Manually annotated by BRENDA team
Teillet, F.; Lacroix, M.; Thiel, S.; Weilguny, D.; Agger, T.; Arlaud, G.J.; Thielens, N.M.
Identification of the site of human mannan-binding lectin involved in the interaction with its partner serine proteases: the essential role of Lys55
J. Immunol.
178
5710-5716
2007
Homo sapiens
Manually annotated by BRENDA team
Weiss, G.; Madsen, H.O.; Garred, P.
A novel mannose-binding lectin-associated serine protease 1/3 gene variant
Scand. J. Immunol.
65
430-434
2007
Homo sapiens (O00187)
Manually annotated by BRENDA team
Unterberger, C.; Hanson, S.; Klingenhoff, A.; Oesterle, D.; Frankenberger, M.; Endo, Y.; Matsushita, M.; Fujita, T.; Schwaeble, W.; Weiss, E.H.; Ziegler-Heitbrock, L.; Stover, C.
Stat3 is involved in control of gene expression
Biochem. Biophys. Res. Commun.
364
1022-1025
2007
Homo sapiens, Rattus norvegicus, Mus musculus (Q91WP0), Mus musculus
Manually annotated by BRENDA team
Sorensen, G.L.; Petersen, I.; Thiel, S.; Fenger, M.; Christensen, K.; Kyvik, K.O.; S?rensen, T.I.; Holmskov, U.; Jensenius, J.C.
Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity
Genet. Epidemiol.
31
31-41
2007
Homo sapiens
Manually annotated by BRENDA team
Wallis, R.
Interactions between mannose-binding lectin and MASPs during complement activation by the lectin pathway
Immunobiology
212
289-299
2007
Homo sapiens
Manually annotated by BRENDA team
Nakao, M.; Kajiya, T.; Sato, Y.; Somamoto, T.; Kato-Unoki, Y.; Matsushita, M.; Nakata, M.; Fujita, T.; Yano, T.
Lectin pathway of bony fish complement: identification of two homologs of the mannose-binding lectin associated with MASP2 in the common carp (Cyprinus carpio)
J. Immunol.
177
5471-5479
2006
Cyprinus carpio (Q3V5Q0), Cyprinus carpio
Manually annotated by BRENDA team
Iwaki, D.; Kanno, K.; Takahashi, M.; Endo, Y.; Lynch, N.J.; Schwaeble, W.J.; Matsushita, M.; Okabe, M.; Fujita, T.
Small mannose-binding lectin-associated protein plays a regulatory role in the lectin complement pathway
J. Immunol.
177
8626-8632
2006
Mus musculus
Manually annotated by BRENDA team
Girija, U.V.; Dodds, A.W.; Roscher, S.; Reid, K.B.; Wallis, R.
Localization and characterization of the mannose-binding lectin (MBL)-associated-serine protease-2 binding site in rat ficolin-A: equivalent binding sites within the collagenous domains of MBLs and ficolins
J. Immunol.
179
455-462
2007
Rattus norvegicus
Manually annotated by BRENDA team
Walsh, M.C.; Shaffer, L.A.; Guikema, B.J.; Body, S.C.; Shernan, S.K.; Fox, A.A.; Collard, C.D.; Fung, M.; Taylor, R.P.; Stahl, G.L.
Fluorochrome-linked immunoassay for functional analysis of the mannose binding lectin complement pathway to the level of C3 cleavage
J. Immunol. Methods
323
147-159
2007
Homo sapiens
Manually annotated by BRENDA team
Kerr, F.K.; Thomas, A.R.; Wijeyewickrema, L.C.; Whisstock, J.C.; Boyd, S.E.; Kaiserman, D.; Matthews, A.Y.; Bird, P.I.; Thielens, N.M.; Rossi, V.; Pike, R.N.
Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor
Mol. Immunol.
45
670-677
2008
Homo sapiens
Manually annotated by BRENDA team
Mayilyan, K.R.; Arnold, J.N.; Presanis, J.S.; Soghoyan, A.F.; Sim, R.B.
Increased complement classical and mannan-binding lectin pathway activities in schizophrenia
Neurosci. Lett.
404
336-341
2006
Homo sapiens
Manually annotated by BRENDA team
Krarup, A.; Wallis, R.; Presanis, J.S.; Gal, P.; Sim, R.B.
Simultaneous activation of complement and coagulation by MBL-associated serine protease 2
PLoS ONE
2
e623
2007
Rattus norvegicus
Manually annotated by BRENDA team
Ytting, H.; Christensen, I.J.; Thiel, S.; Jensenius, J.C.; Svendsen, M.N.; Nielsen, L.; Lottenburger, T.; Nielsen, H.J.
Biological variation in circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease-2 and the influence of age, gender and physical exercise
Scand. J. Immunol.
66
458-464
2007
Homo sapiens
Manually annotated by BRENDA team
Schafranski, M.D.; Pereira Ferrari, L.; Scherner, D.; Torres, R.; de Messias-Reason, I.J.
Functional MASP2 gene polymorphism in patients with history of rheumatic fever
Hum. Immunol.
69
41-44
2008
Homo sapiens
Manually annotated by BRENDA team
Swierzko, A.S.; Cedzynski, M.; Domzalska-Popadiuk, I.; Macdonald, S.L.; Borkowska-Klos, M.; Atkinson, A.P.; Szala, A.; Jopek, A.; Jensenius, J.C.; Kawakami, M.; Szczapa, J.; Matsushita, M.; Szemraj, J.; Turner, M.L.; Kilpatrick, D.C.
Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations
Mol. Immunol.
46
1696-1701
2009
Homo sapiens
Manually annotated by BRENDA team
Hamad, I.; Hunter, A.C.; Szebeni, J.; Moghimi, S.M.
Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process
Mol. Immunol.
46
225-232
2008
Homo sapiens
Manually annotated by BRENDA team
Zehnder, A.; Fisch, U.; Hirt, A.; Niggli, F.K.; Simon, A.; Ozsahin, H.; Schlapbach, L.J.; Ammann, R.A.
Prognosis in pediatric hematologic malignancies is associated with serum concentration of mannose-binding lectin-associated serine protease-2 (MASP-2)
Pediatr. Blood Cancer
53
53-57
2009
Homo sapiens
Manually annotated by BRENDA team
Miller, C.; Wilgenbusch, S.; Michaels, M.; Chi, D.S.; Youngberg, G.; Krishnaswamy, G.
Molecular defects in the mannose binding lectin pathway in dermatological disease: Case report and literature review
Clin. Mol. Allergy
8
6-6
2010
Homo sapiens
Manually annotated by BRENDA team
Gulla, K.C.; Gupta, K.; Krarup, A.; Gal, P.; Schwaeble, W.J.; Sim, R.B.; OConnor, C.D.; Hajela, K.
Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot
Immunology
129
482-495
2010
Homo sapiens
Manually annotated by BRENDA team
Venkatraman Girija, U.; Furze, C.; Toth, J.; Schwaeble, W.J.; Mitchell, D.A.; Keeble, A.H.; Wallis, R.
Engineering novel complement activity into a pulmonary surfactant protein
J. Biol. Chem.
285
10546-10552
2010
Rattus norvegicus
Manually annotated by BRENDA team
Skjoedt, M.O.; Hummelshoj, T.; Palarasah, Y.; Honore, C.; Koch, C.; Skjodt, K.; Garred, P.
A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation
J. Biol. Chem.
285
8234-8243
2010
Homo sapiens
Manually annotated by BRENDA team
Thiel, S.; Kolev, M.; Degn, S.; Steffensen, R.; Hansen, A.G.; Ruseva, M.; Jensenius, J.C.
Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity
J. Immunol.
182
2939-2947
2009
Homo sapiens
Manually annotated by BRENDA team
Phillips, A.E.; Toth, J.; Dodds, A.W.; Girija, U.V.; Furze, C.M.; Pala, E.; Sim, R.B.; Reid, K.B.; Schwaeble, W.J.; Schmid, R.; Keeble, A.H.; Wallis, R.
Analogous interactions in initiating complexes of the classical and lectin pathways of complement
J. Immunol.
182
7708-7717
2009
Rattus norvegicus (Q9JJS8)
Manually annotated by BRENDA team
Brouwer, N.; Frakking, F.N.; van de Wetering, M.D.; van Houdt, M.; Hart, M.; Budde, I.K.; Strengers, P.F.; Laursen, I.; Houen, G.; Roos, D.; Jensenius, J.C.; Caron, H.N.; Dolman, K.M.; Kuijpers, T.W.
Mannose-binding lectin (MBL) substitution: recovery of opsonic function in vivo lags behind MBL serum levels
J. Immunol.
183
3496-3504
2009
Homo sapiens
Manually annotated by BRENDA team
Cestari, I.d.o.s..S.; Krarup, A.; Sim, R.B.; Inal, J.M.; Ramirez, M.I.
Role of early lectin pathway activation in the complement-mediated killing of Trypanosoma cruzi
Mol. Immunol.
47
426-437
2009
Trypanosoma cruzi
Manually annotated by BRENDA team
Kocsis, A.; Kekesi, K.A.; Szasz, R.; Vegh, B.M.; Balczer, J.; Dobo, J.; Zavodszky, P.; Gal, P.; Pal, G.
Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation
J. Immunol.
185
4169-4178
2010
Homo sapiens
Manually annotated by BRENDA team
Duncan, R.C.; Bergstroem, F.; Coetzer, T.H.; Blom, A.M.; Wijeyewickrema, L.C.; Pike, R.N.
Multiple domains of MASP-2, an initiating complement protease, are required for interaction with its substrate C4
Mol. Immunol.
49
593-600
2012
Homo sapiens
Manually annotated by BRENDA team
Novovic, S.; Andersen, A.M.; Ersb?ll, A.K.; Jorgensen, L.N.; Nielsen, H.J.; Jensenius, J.C.; Hansen, M.B.
Mannan-binding lectin and mannan-binding lectin-associated serine protease 2 in acute pancreatitis
Pancreas
40
1097-1102
2011
Homo sapiens
Manually annotated by BRENDA team
Keizer, M.P.; Pouw, R.B.; Kamp, A.M.; Patiwael, S.; Marsman, G.; Hart, M.H.; Zeerleder, S.; Kuijpers, T.W.; Wouters, D.
TFPI inhibits lectin pathway of complement activation by direct interaction with MASP-2
Eur. J. Immunol.
45
544-550
2015
Homo sapiens
Manually annotated by BRENDA team
Asgari, E.; Farrar, C.; Lynch, N.; Ali, Y.; Roscher, S.; Stover, C.; Zhou, W.; Schwaeble, W.; Sacks, S.
Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4
FASEB J.
28
3996-4003
2014
Mus musculus (Q91WP0), Mus musculus
Manually annotated by BRENDA team
Heja, D.; Harmat, V.; Fodor, K.; Wilmanns, M.; Dobo, J.; Kekesi, K.A.; Zavodszky, P.; Gal, P.; Pal, G.
Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 are essential for lectin pathway activation and reveal structural plasticity of MASP-2
J. Biol. Chem.
287
20290-20300
2012
Homo sapiens (O00187)
Manually annotated by BRENDA team
Degn, S.E.; Jensen, L.; Olszowski, T.; Jensenius, J.C.; Thiel, S.
Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44
J. Immunol.
191
1334-1345
2013
Homo sapiens (O00187)
Manually annotated by BRENDA team
Parej, K.; Hermann, A.; Donath, N.; Zavodszky, P.; Gal, P.; Dobo, J.
Dissociation and re-association studies on the interaction domains of mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, provide evidence for heterodimer formation
Mol. Immunol.
59
1-9
2014
Homo sapiens (O00187)
Manually annotated by BRENDA team
Jenny, L.; Ajjan, R.; King, R.; Thiel, S.; Schroeder, V.
Plasma levels of mannan-binding lectin-associated serine proteases MASP-1 and MASP-2 are elevated in type 1 diabetes and correlate with glycaemic control
Clin. Exp. Immunol.
180
227-232
2015
Homo sapiens (O00187)
Manually annotated by BRENDA team
Yaseen, S.; Demopulos, G.; Dudler, T.; Yabuki, M.; Wood, C.L.; Cummings, W.J.; Tjoelker, L.W.; Fujita, T.; Sacks, S.; Garred, P.; Andrew, P.; Sim, R.B.; Lachmann, P.J.; Wallis, R.; Lynch, N.; Schwaeble, W.J.
Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2
FASEB J.
31
2210-2219
2017
Homo sapiens (O00187)
Manually annotated by BRENDA team
Oroszlan, G.; Kortvely, E.; Szakacs, D.; Kocsis, A.; Dammeier, S.; Zeck, A.; Ueffing, M.; Zavodszky, P.; Pal, G.; Gal, P.; Dobo, J.
MASP-1 and MASP-2 do not activate pro-factor D in resting human blood, whereas MASP-3 is a potential activator kinetic analysis involving specific MASP-1 and MASP-2 inhibitors
J. Immunol.
196
857-865
2016
Mus musculus (Q91WP0)
Manually annotated by BRENDA team
Drentin, N.; Conroy, P.; Gunzburg, M.J.; Pike, R.N.; Wijeyewickrema, L.C.
Investigation of the mechanism of interaction between Mannose-binding lectin-associated serine protease-2 and complement C4
Mol. Immunol.
67
287-293
2015
Homo sapiens (O00187)
Manually annotated by BRENDA team
Boldt, A.B.; Beltrame, M.H.; Catarino, S.J.; Meissner, C.G.; Tizzot, R.; Messias-Reason, I.J.
A dual role for Mannan-binding lectin-associated serine protease 2 (MASP-2) in HIV infection
Mol. Immunol.
78
48-56
2016
Homo sapiens (O00187), Homo sapiens
Manually annotated by BRENDA team
Nan, R.; Furze, C.M.; Wright, D.W.; Gor, J.; Wallis, R.; Perkins, S.J.
Flexibility in mannan-binding lectin-associated serine proteases-1 and -2 provides insight on lectin pathway activation
Structure
25
364-375
2017
Rattus norvegicus (Q9JJS8)
Manually annotated by BRENDA team
Ojurongbe, O.; Antony, J.S.; Van Tong, H.; Meyer, C.G.; Akindele, A.A.; Sina-Agbaje, O.R.; Kremsner, P.G.; Velavan, T.P.
Low MBL-associated serine protease 2 (MASP-2) levels correlate with urogenital schistosomiasis in Nigerian children
Trop. Med. Int. Health
20
1311-1319
2015
Homo sapiens (O00187), Homo sapiens
Manually annotated by BRENDA team