Inhibitors | Comment | Organism | Structure |
---|---|---|---|
C1-inhibitor | a serpin, purified human protein, enzyme interaction rates and site specificity of the inhibitor, interaction rates under pseudo-first-order conditions, overview | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.015 | - |
complement component C2 P4-P1 fragment | pH 7.4, 37°C | Homo sapiens | |
0.0155 | - |
complement component C4 P4-P1 fragment | pH 7.4, 37°C | Homo sapiens | |
0.123 | - |
C1-inhibitor P4-P4' fragment | pH 7.4, 37°C | Homo sapiens | |
0.123 | - |
C1-inhibitor P4-P1 fragment | pH 7.4, 37°C | Homo sapiens | |
0.173 | - |
complement component C2 P4-P4' fragment | pH 7.4, 37°C | Homo sapiens | |
0.271 | - |
complement component C4 P4-P4' fragment | pH 7.4, 37°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C2 + H2O | Homo sapiens | - |
? | - |
? | |
complement component C4 + H2O | Homo sapiens | - |
? | - |
? | |
additional information | Homo sapiens | the enzyme binds to the mannan-binding lectin, the complex activates the lectin pathway of the complement system, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
C1-inhibitor P4-P1 fragment + H2O | - |
Homo sapiens | ? | - |
? | |
C1-inhibitor P4-P4' fragment + H2O | - |
Homo sapiens | ? | - |
? | |
complement component C2 + H2O | - |
Homo sapiens | ? | - |
? | |
complement component C2 P4-P1 fragment + H2O | - |
Homo sapiens | ? | - |
? | |
complement component C2 P4-P4' fragment + H2O | - |
Homo sapiens | ? | - |
? | |
complement component C4 + H2O | - |
Homo sapiens | ? | - |
? | |
complement component C4 P4-P1 fragment + H2O | - |
Homo sapiens | ? | - |
? | |
complement component C4 P4-P4' fragment + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | the enzyme binds to the mannan-binding lectin, the complex activates the lectin pathway of the complement system, overview | Homo sapiens | ? | - |
? | |
additional information | substrate specificity of MASP-2, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MASP-2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.04 | 1.97 | complement component C4 P4-P4' fragment | pH 7.4, 37°C | Homo sapiens | |
0.25 | - |
C1-inhibitor P4-P1 fragment | pH 7.4, 37°C | Homo sapiens | |
0.3 | - |
C1-inhibitor P4-P4' fragment | pH 7.4, 37°C | Homo sapiens | |
3.7 | - |
complement component C2 P4-P1 fragment | pH 7.4, 37°C | Homo sapiens | |
4.54 | - |
complement component C4 P4-P1 fragment | pH 7.4, 37°C | Homo sapiens | |
9.35 | - |
complement component C4 P4-P4' fragment | pH 7.4, 37°C | Homo sapiens | |
31.86 | - |
complement component C2 P4-P1 fragment | pH 7.4, 37°C | Homo sapiens | |
35.32 | - |
C1-inhibitor P4-P4' fragment | pH 7.4, 37°C | Homo sapiens | |
99.58 | - |
complement component C2 P4-P4' fragment | pH 7.4, 37°C | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | first order rate inhibition kinetics | Homo sapiens |